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chr17:1,263,564-2,923,933

Best TWAS P=1.06e-10 · Best GWAS P=1.34e-09 conditioned to 0.0389

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Brain Caudate basal ganglia	SRR	0.26	0.03	lasso	3	0.02	8.6e-02	5.7	-6.5	1.1e-10	0.72	0.02	0.88	TRUE
7	GTEx	Brain Cerebellum	SMG6	0.24	0.03	enet	16	0.05	1.3e-02	4.7	5.7	1.1e-08	-0.70	0.03	0.73	FALSE
18	GTEx	Heart Atrial Appendage	SRR	0.35	0.30	lasso	7	0.29	1.4e-13	5.1	-5.7	1.2e-08	0.68	0.18	0.82	FALSE
27	GTEx	Whole Blood	SRR	0.09	0.03	enet	8	0.02	4.5e-03	5.1	-5.6	1.8e-08	0.66	0.02	0.97	FALSE
3	GTEx	Artery Coronary	SRR	0.44	0.28	lasso	8	0.26	2.5e-09	5.0	-5.5	4.0e-08	0.60	0.08	0.92	FALSE
23	GTEx	Skin Sun Exposed Lower leg	SRR	0.13	0.15	lasso	4	0.14	2.0e-11	5.1	-5.5	4.2e-08	0.58	0.19	0.81	FALSE
19	GTEx	Heart Left Ventricle	SRR	0.15	0.16	lasso	3	0.13	2.9e-07	5.1	-5.4	5.8e-08	0.54	0.14	0.86	FALSE
30	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SRR	0.15	0.11	blup	61	0.07	4.0e-04	5.1	-5.4	6.0e-08	0.44	0.00	0.98	FALSE
4	GTEx	Artery Tibial	SRR	0.22	0.23	lasso	4	0.24	3.9e-19	5.0	-5.4	6.1e-08	0.61	0.26	0.74	FALSE
21	GTEx	Nerve Tibial	SRR	0.15	0.13	lasso	3	0.13	2.9e-09	5.0	-5.4	7.2e-08	0.64	0.11	0.89	FALSE
26	GTEx	Vagina	SRR	0.18	0.13	lasso	2	0.11	1.6e-03	4.8	-5.4	8.1e-08	0.65	0.04	0.68	FALSE
6	GTEx	Brain Cerebellar Hemisphere	SRR	0.37	0.24	lasso	7	0.22	2.1e-06	5.1	-5.4	8.3e-08	0.63	0.05	0.92	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	SRR	0.39	0.34	lasso	5	0.35	3.1e-12	5.1	-5.4	8.3e-08	0.54	0.24	0.76	FALSE
16	GTEx	Esophagus Mucosa	SRR	0.23	0.24	lasso	5	0.24	2.0e-16	5.1	-5.3	1.0e-07	0.55	0.26	0.74	FALSE
11	GTEx	Breast Mammary Tissue (Female)	SRR	0.24	0.25	lasso	3	0.21	6.3e-07	5.1	-5.3	1.3e-07	0.58	0.15	0.81	FALSE
8	GTEx	Brain Cerebellum	SRR	0.26	0.20	lasso	3	0.21	8.7e-07	5.1	-5.3	1.4e-07	0.50	0.12	0.69	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	SRR	0.32	0.24	lasso	3	0.23	1.5e-13	5.1	-5.3	1.5e-07	0.56	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRR	0.30	0.35	lasso	3	0.36	7.5e-39	5.1	-5.2	1.6e-07	0.55	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	SRR	0.56	0.50	lasso	4	0.50	5.2e-55	5.1	-5.2	1.6e-07	0.54	0.00	1.00	FALSE
13	GTEx	Cells Transformed fibroblasts	SRR	0.36	0.38	lasso	4	0.38	8.2e-30	5.1	-5.2	1.7e-07	0.54	0.22	0.77	FALSE
17	GTEx	Esophagus Muscularis	SRR	0.30	0.39	lasso	3	0.38	3.4e-24	5.1	-5.2	1.7e-07	0.55	0.23	0.77	FALSE
14	GTEx	Colon Transverse	SRR	0.28	0.21	lasso	5	0.19	1.6e-09	5.1	-5.2	2.1e-07	0.55	0.22	0.78	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	SRR	0.40	0.35	lasso	3	0.36	1.1e-13	5.1	-5.2	2.2e-07	0.55	0.22	0.78	FALSE
10	GTEx	Breast Mammary Tissue	SRR	0.20	0.21	lasso	3	0.20	8.2e-11	5.1	-5.2	2.4e-07	0.59	0.22	0.78	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRR	0.10	0.10	lasso	2	0.09	1.0e-10	5.1	-5.2	2.4e-07	0.56	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SRR	0.22	0.23	lasso	2	0.21	2.3e-12	5.1	-5.2	2.4e-07	0.55	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SRR	0.08	0.09	enet	3	0.08	1.7e-04	5.1	-5.2	2.4e-07	0.56	0.00	0.97	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	SRR	0.14	0.18	lasso	2	0.18	4.3e-21	5.1	-5.2	2.4e-07	0.56	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	SRR	0.29	0.26	lasso	5	0.25	1.8e-13	5.1	-5.2	2.5e-07	0.56	0.22	0.78	FALSE
39	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRR	0.20	0.18	lasso	2	0.20	8.8e-12	5.1	-5.2	2.5e-07	0.56	0.00	1.00	FALSE
20	GTEx	Lung	SRR	0.24	0.28	lasso	2	0.26	3.4e-20	5.1	-5.1	2.6e-07	0.56	0.23	0.77	FALSE
29	YFS	Blood	SRR	0.17	0.22	lasso	7	0.23	2.5e-72	5.1	-5.2	2.6e-07	0.57	0.23	0.77	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SRR	0.27	0.48	lasso	1	0.48	3.5e-65	5.1	-5.1	2.7e-07	0.54	0.23	0.77	FALSE
22	GTEx	Pancreas	SRR	0.13	0.17	lasso	3	0.15	5.2e-07	5.1	-5.1	2.7e-07	0.57	0.16	0.83	FALSE
24	GTEx	Stomach	SRR	0.27	0.30	lasso	7	0.28	7.1e-14	5.0	-5.1	2.7e-07	0.59	0.22	0.78	FALSE
25	GTEx	Thyroid	SRR	0.26	0.27	lasso	4	0.25	2.0e-19	5.1	-5.1	2.7e-07	0.55	0.23	0.76	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	SRR	0.24	0.16	lasso	1	0.13	9.0e-05	5.1	-5.1	2.7e-07	0.54	0.00	0.95	FALSE
9	GTEx	Brain Frontal Cortex BA9	SRR	0.25	0.24	lasso	3	0.21	3.5e-06	5.1	-5.1	3.0e-07	0.51	0.10	0.67	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	SRR	0.25	0.39	lasso	3	0.39	5.6e-53	5.1	-5.1	3.0e-07	0.54	0.23	0.77	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRR	0.11	0.12	lasso	2	0.12	4.3e-13	5.1	-5.1	3.0e-07	0.54	0.00	1.00	FALSE