TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Smoking Status
:
←
→
chr2:43,417,083-45,864,710
Best TWAS P=5.1e-19 · Best GWAS P=8.47e-19 conditioned to 1
43.5M
44M
44.5M
45M
45.5M
46M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
RP11-89K21.1
0.09
0.06
lasso
2
0.05
4.3e-07
-8.9
8.9
5.1e-19
-0.98
0.00
1.00
TRUE
3
YFS
Blood
LRPPRC
0.06
0.04
bslmm
548
0.04
1.4e-13
-5.2
5.4
6.9e-08
-0.12
0.00
0.99
TRUE
1
GTEx
Prostate
LRPPRC
0.16
0.10
lasso
3
0.05
1.8e-02
-4.8
5.2
2.1e-07
-0.13
0.03
0.69
FALSE