Best TWAS P=7.16e-12 · Best GWAS P=1.32e-11 conditioned to 0.00556
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | HAX1 | 0.17 | 0.02 | lasso | 3 | 0.03 | 1.2e-02 | -6.26 | -5.9 | 4.6e-09 | 0.86 | 0.02 | 0.88 | FALSE |
| 2 | GTEx | Artery Tibial | HAX1 | 0.23 | 0.08 | lasso | 8 | 0.08 | 7.3e-07 | -6.72 | -5.9 | 4.0e-09 | 0.92 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | HAX1 | 0.27 | -0.01 | enet | 29 | -0.01 | 5.0e-01 | -0.64 | -5.3 | 1.5e-07 | 0.51 | 0.05 | 0.21 | FALSE |
| 4 | GTEx | Esophagus Muscularis | HAX1 | 0.12 | 0.10 | lasso | 5 | 0.09 | 2.7e-06 | -6.14 | -5.5 | 4.0e-08 | 0.79 | 0.05 | 0.93 | FALSE |
| 5 | GTEx | Heart Left Ventricle | HAX1 | 0.09 | 0.03 | lasso | 3 | 0.04 | 3.2e-03 | 2.15 | -5.2 | 1.7e-07 | 0.74 | 0.05 | 0.76 | FALSE |
| 6 | METSIM | Adipose | HAX1 | 0.04 | 0.00 | bslmm | 351 | 0.01 | 3.3e-02 | -3.86 | -5.9 | 2.9e-09 | 0.55 | 0.06 | 0.32 | FALSE |
| 7 | YFS | Blood | HAX1 | 0.03 | 0.01 | bslmm | 344 | 0.02 | 1.2e-08 | -6.72 | -6.9 | 7.2e-12 | 0.70 | 0.01 | 0.99 | TRUE |
| 8 | YFS | Blood | UBAP2L | 0.28 | 0.14 | bslmm | 364 | 0.17 | 2.3e-53 | 5.05 | -6.2 | 6.8e-10 | 0.37 | 0.99 | 0.01 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | HAX1 | 0.09 | 0.02 | enet | 10 | 0.06 | 1.9e-06 | 0.79 | -5.4 | 8.6e-08 | 0.62 | 0.00 | 0.89 | FALSE |