[Hub]/) : Traits : Type 2 Diabetes (T2D) (2018) : →

chr1:39,182,130-40,737,589

Best TWAS P=1.65e-11 · Best GWAS P=3.35e-10 conditioned to 0.00788

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BMP8A	0.05	0.03	lasso	3	0.02	8.8e-04	6.1	6.2	7.4e-10	0.98	0.01	0.98	FALSE
2	GTEx	Adipose Subcutaneous	PABPC4	0.15	0.04	lasso	8	0.04	3.3e-04	5.3	-5.6	2.2e-08	-0.86	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	RP11-69E11.4	0.14	0.08	enet	22	0.10	1.4e-08	6.3	5.8	5.2e-09	0.86	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	BMP8A	0.06	0.05	lasso	1	0.04	3.5e-04	5.6	5.6	2.5e-08	0.70	0.04	0.76	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-69E11.4	0.10	0.07	lasso	2	0.07	1.3e-04	5.4	5.1	2.7e-07	0.67	0.18	0.77	FALSE
6	GTEx	Adrenal Gland	PABPC4	0.20	0.09	lasso	8	0.06	3.0e-03	6.3	-6.2	5.5e-10	-0.95	0.01	0.94	FALSE
7	GTEx	Adrenal Gland	RP11-69E11.4	0.11	0.05	lasso	3	0.00	2.4e-01	5.6	5.7	1.2e-08	0.76	0.03	0.74	FALSE
8	GTEx	Artery Aorta	RP11-69E11.4	0.13	0.10	enet	14	0.14	2.5e-08	6.1	6.2	7.2e-10	0.86	0.00	0.99	FALSE
9	GTEx	Artery Tibial	PABPC4	0.10	0.10	lasso	4	0.10	3.4e-08	6.3	-6.4	1.3e-10	-0.99	0.00	1.00	FALSE
10	GTEx	Artery Tibial	RP11-69E11.4	0.15	0.16	lasso	6	0.16	8.3e-13	5.4	5.6	1.7e-08	0.76	0.22	0.78	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-69E11.4	0.22	0.08	enet	16	0.08	4.5e-03	5.4	5.3	1.4e-07	0.71	0.15	0.64	FALSE
12	GTEx	Brain Frontal Cortex BA9	RP11-69E11.4	0.23	0.10	lasso	6	0.11	7.2e-04	5.3	5.7	1.4e-08	0.71	0.04	0.74	FALSE
13	GTEx	Brain Hypothalamus	RP11-69E11.4	0.23	0.12	lasso	6	0.20	1.5e-05	5.0	5.5	3.9e-08	0.65	0.11	0.64	FALSE
14	GTEx	Breast Mammary Tissue	PABPC4	0.13	0.02	enet	14	0.04	3.4e-03	6.1	-5.7	1.0e-08	-0.93	0.01	0.98	FALSE
15	GTEx	Breast Mammary Tissue	RP11-69E11.4	0.15	0.05	enet	32	0.05	8.8e-04	5.1	6.7	1.7e-11	0.63	0.33	0.61	TRUE
16	GTEx	Cells Transformed fibroblasts	PABPC4	0.07	0.09	lasso	1	0.06	2.7e-05	6.3	-6.3	3.3e-10	-1.00	0.00	1.00	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-69E11.4	0.15	0.08	enet	17	0.11	9.9e-09	4.1	5.2	1.5e-07	0.71	0.42	0.58	FALSE
18	GTEx	Colon Sigmoid	RP11-69E11.4	0.20	0.16	lasso	5	0.20	1.1e-07	5.2	5.8	5.4e-09	0.78	0.12	0.86	FALSE
19	GTEx	Colon Transverse	RP11-69E11.4	0.23	0.12	lasso	4	0.15	1.8e-07	6.1	5.8	7.8e-09	0.89	0.01	0.99	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	BMP8A	0.11	0.04	lasso	4	0.01	1.1e-01	5.1	5.2	2.0e-07	0.69	0.19	0.40	FALSE
21	GTEx	Esophagus Mucosa	PABPC4	0.06	0.06	lasso	3	0.08	7.3e-06	6.1	-6.4	1.7e-10	-0.98	0.00	1.00	FALSE
22	GTEx	Esophagus Mucosa	RP11-69E11.4	0.18	0.06	lasso	9	0.07	2.2e-05	5.4	6.0	2.0e-09	0.77	0.24	0.75	FALSE
23	GTEx	Esophagus Muscularis	RP11-69E11.4	0.11	0.14	enet	16	0.15	2.6e-09	4.2	5.5	4.8e-08	0.71	0.68	0.32	FALSE
24	GTEx	Esophagus Muscularis	BMP8A	0.08	0.05	enet	10	0.05	3.5e-04	4.2	5.4	8.3e-08	0.77	0.10	0.87	FALSE
25	GTEx	Heart Left Ventricle	RP11-69E11.4	0.10	0.10	lasso	4	0.08	3.8e-05	5.4	5.3	1.2e-07	0.69	0.05	0.92	FALSE
26	GTEx	Lung	PABPC4	0.05	0.03	lasso	3	0.02	1.3e-02	6.3	-6.2	5.3e-10	-0.96	0.01	0.98	FALSE
27	GTEx	Nerve Tibial	PABPC4	0.17	0.08	enet	12	0.05	2.7e-04	6.3	-5.9	2.9e-09	-0.85	0.00	1.00	FALSE
28	GTEx	Nerve Tibial	RP11-69E11.4	0.18	0.08	lasso	5	0.18	1.3e-12	4.8	6.2	5.7e-10	0.88	0.01	0.99	FALSE
29	GTEx	Nerve Tibial	RP11-69E11.8	0.05	0.00	lasso	3	0.01	6.9e-02	6.3	-6.4	1.5e-10	-0.99	0.01	0.95	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	PABPC4	0.12	0.10	lasso	3	0.05	1.0e-03	6.1	-6.2	7.4e-10	-0.97	0.00	0.99	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	RP11-69E11.4	0.16	0.18	lasso	3	0.15	1.0e-08	5.2	5.2	2.0e-07	0.67	0.45	0.55	FALSE
32	GTEx	Skin Sun Exposed Lower leg	PABPC4	0.11	0.09	lasso	7	0.08	2.7e-07	6.1	-6.2	4.6e-10	-0.96	0.00	1.00	FALSE
33	GTEx	Skin Sun Exposed Lower leg	RP11-69E11.4	0.13	0.12	lasso	6	0.15	1.3e-12	5.3	6.0	1.5e-09	0.75	0.34	0.66	FALSE
34	GTEx	Spleen	RP11-69E11.4	0.25	0.12	lasso	4	0.15	9.3e-05	5.4	6.0	2.7e-09	0.73	0.10	0.78	FALSE
35	GTEx	Stomach	RP11-69E11.4	0.31	0.20	lasso	4	0.20	4.0e-10	5.4	5.5	3.4e-08	0.74	0.16	0.84	FALSE
36	GTEx	Thyroid	RP11-69E11.4	0.17	0.04	lasso	9	0.06	4.4e-05	5.4	5.8	8.2e-09	0.81	0.01	0.98	FALSE
37	METSIM	Adipose	PABPC4	0.05	0.02	lasso	6	0.03	6.0e-05	6.1	-5.9	3.5e-09	-0.89	0.01	0.99	FALSE
38	NTR	Blood	KIAA0754	0.03	0.00	bslmm	366	0.01	1.6e-03	-2.1	5.4	5.9e-08	0.52	0.15	0.60	FALSE
39	YFS	Blood	PABPC4	0.04	0.03	enet	44	0.03	3.2e-11	6.1	-5.4	6.4e-08	-0.83	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	BMP8A	0.05	0.01	lasso	6	0.02	5.5e-05	6.1	5.7	1.2e-08	0.81	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC4	0.03	0.03	lasso	2	0.04	1.3e-08	6.3	-6.2	7.2e-10	-0.92	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPIEL	0.03	0.02	blup	41	0.03	9.0e-07	5.3	5.5	5.0e-08	0.78	0.37	0.63	FALSE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PABPC4	0.07	0.02	blup	31	0.04	3.3e-03	3.9	-5.4	5.4e-08	-0.84	0.01	0.75	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BMP8A	0.04	0.03	blup	48	0.04	3.5e-05	5.4	5.8	7.7e-09	0.75	0.06	0.89	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PABPC4	0.03	0.01	enet	4	0.02	4.3e-03	6.3	-6.3	3.7e-10	-0.98	0.00	0.99	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BMP8A	0.09	0.10	lasso	3	0.12	9.7e-14	4.5	5.3	1.0e-07	0.78	0.65	0.35	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PABPC4	0.04	0.05	blup	31	0.04	1.2e-05	5.3	-6.2	6.2e-10	-0.84	0.02	0.97	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPIEL	0.03	0.03	lasso	4	0.02	5.1e-03	5.3	5.3	1.1e-07	0.71	0.08	0.79	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PABPC4	0.05	0.05	enet	4	0.05	5.5e-04	6.1	-5.8	5.0e-09	-0.94	0.00	0.95	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	PABPC4	0.02	0.01	blup	31	0.02	4.7e-03	6.3	-5.6	2.2e-08	-0.86	0.00	0.85	FALSE
51	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIEL	0.11	0.06	lasso	3	0.06	9.3e-04	4.6	5.3	1.4e-07	0.87	0.01	0.93	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	PABPC4	0.04	0.03	enet	8	0.04	4.5e-05	6.1	-6.5	1.1e-10	-0.93	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	BMP8A	0.07	0.06	enet	7	0.07	5.8e-08	4.2	5.4	8.2e-08	0.67	0.27	0.73	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	PABPC4	0.14	0.03	enet	8	0.08	2.3e-08	6.3	-5.2	1.6e-07	-0.81	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPIEL	0.04	0.02	lasso	4	0.02	1.7e-03	5.4	5.8	7.9e-09	0.74	0.04	0.47	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	BMP8A	0.05	0.05	enet	6	0.04	9.1e-05	5.2	5.3	1.4e-07	0.66	0.17	0.80	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	PABPC4	0.09	0.07	enet	5	0.08	4.1e-08	6.3	-6.0	1.5e-09	-0.87	0.00	1.00	FALSE