TWAS hub - PPIEL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1550	0.0380	1.5e-10	0.108	0.109	0.112	0.111	0.100	4.2e-13	3.6e-13	1.6e-13	2.2e-13	3.5e-12
2	GTEx	Adrenal Gland	0.2906	0.1010	4.7e-03	0.005	NA	-0.008	NA	0.001	2.0e-01	NA	7.9e-01	NA	2.9e-01
3	GTEx	Esophagus Mucosa	0.1080	0.0400	5.2e-04	0.024	NA	0.024	NA	0.024	9.2e-03	NA	9.8e-03	NA	9.4e-03
4	TCGA	Breast Invasive Carcinoma	0.0303	0.0142	5.3e-08	0.024	0.029	0.027	NA	0.027	9.7e-06	9.0e-07	2.4e-06	NA	2.9e-06
5	TCGA	Cervical Squamous Cell Carcinoma	0.0570	0.0320	3.3e-03	0.083	0.034	0.016	NA	0.053	7.0e-05	8.1e-03	5.1e-02	NA	1.4e-03
6	TCGA	Colon Adenocarcinoma	0.0560	0.0330	2.8e-03	0.077	0.055	0.073	NA	0.073	3.3e-05	4.2e-04	5.1e-05	NA	5.1e-05
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0323	0.0173	2.9e-04	0.029	0.014	0.014	NA	0.016	2.9e-04	8.5e-03	8.7e-03	NA	5.1e-03
8	TCGA	Liver Hepatocellular Carcinoma	0.1140	0.0560	2.9e-03	0.056	0.042	0.043	NA	0.059	1.3e-03	4.7e-03	4.3e-03	NA	9.3e-04
9	TCGA	Pancreatic Adenocarcinoma	0.0970	0.0460	4.0e-04	0.081	0.099	0.067	NA	0.040	2.9e-04	5.9e-05	8.8e-04	NA	8.7e-03
10	TCGA	Prostate Adenocarcinoma	0.0356	0.0220	2.8e-03	0.024	0.012	0.014	NA	0.023	1.4e-03	1.7e-02	1.2e-02	NA	1.7e-03
11	TCGA	Stomach Adenocarcinoma	0.0410	0.0260	2.2e-03	0.028	0.025	0.025	NA	0.030	3.9e-03	5.8e-03	5.9e-03	NA	2.9e-03
12	TCGA	Testicular Germ Cell Tumors	0.1010	0.0530	1.4e-03	0.097	0.094	0.107	NA	0.096	2.7e-04	3.3e-04	1.3e-04	NA	2.9e-04
13	TCGA	Thyroid Carcinoma	0.0970	0.0600	7.3e-04	0.051	0.038	0.047	NA	0.040	1.0e-05	1.2e-04	2.0e-05	NA	8.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Type 2 Diabetes (T2D) (2018)	10.7	20.1	33.3	4.6	1.1	4.8	5.5	4.8	3.8	5.3	5.3	4.0	5.8	5.0	3.6	2.4
Alcohol intake versus 10 years previously	8.9	13.3	22.2	3.4	1.7	4.1	4.2	4.6	2.7	4.2	4.1	3.1	4.7	4.0	3.3	1.7
Long-standing illness, disability or infirmity	8.1	12.3	21.9	3.7	0.6	2.6	4.1	4.7	3.3	4.1	3.6	3.1	4.7	3.7	3.6	1.4
Diabetes diagnosed by doctor	7.9	13.0	20.8	3.4	0.2	4.2	4.2	3.7	3.3	4.0	4.2	3.2	4.6	4.2	2.9	2.5
Diabetes (self-reported)	7.7	11.8	18.1	3.3	0.2	3.9	4.1	3.2	3.3	3.6	4.3	3.2	4.1	4.1	2.9	2.5
Neck or shoulder pain in last month	7.1	10.0	15.5	3.4	1.8	3.8	3.8	3.1	2.7	3.2	3.9	2.4	3.8	3.7	3.0	1.3
HDL Cholesterol	7.0	11.7	25.3	-2.9	-2.0	-4.3	-4.7	-2.8	-2.3	-3.6	-5.0	-2.9	-3.6	-4.2	-2.2	-2.2
Medication: Metformin	6.7	9.4	15.5	3.1	-0.1	3.3	3.7	3.1	2.9	3.4	3.6	2.7	3.9	3.5	2.7	2.0
Lung FEV1/FVC ratio	6.2	31.6	75.2	-5.8	-1.5	-6.2	-7.3	-4.8	-4.1	-5.6	-8.7	-4.2	-6.1	-7.1	-5.0	-2.7
Pain experienced in last month	5.7	9.5	18.5	-2.9	-2.4	-4.0	-3.7	-3.4	-2.0	-3.2	-3.7	-1.7	-4.3	-3.4	-2.4	-0.9
Irritability	5.4	9.2	13.2	-2.8	1.2	-3.1	-3.0	-3.3	-3.6	-3.4	-2.3	-3.1	-2.9	-3.2	-3.2	-3.5
Impedance of leg (left)	5.3	26.0	59.4	-4.7	-7.4	-7.7	-4.6	-7.0	-2.5	-6.2	-4.0	-1.7	-6.9	-3.7	-2.5	-0.9
Prostate Cancer	5.2	7.3	11.7	2.6	-0.5	3.4	2.8	2.6	3.2	2.5	2.6	2.1	2.6	3.1	2.3	3.4
Triglycerides	5.2	8.5	20.8	2.1	0.9	3.7	4.0	2.0	2.5	2.2	4.6	2.5	2.9	3.7	2.6	2.3
Pulse rate, automated reading	5.2	16.8	33.4	4.0	1.1	3.9	5.0	4.7	3.4	4.9	4.3	3.7	5.8	4.7	3.5	1.9
Leg fat-free mass (left)	5.1	27.2	56.1	4.5	5.8	7.5	5.5	6.5	3.1	5.8	5.6	2.5	7.2	5.2	3.3	1.6
Leg fat-free mass (right)	5.1	27.4	55.2	4.5	5.8	7.4	5.5	6.4	3.1	5.8	5.6	2.5	7.3	5.2	3.3	1.6
Leg predicted mass (left)	5.0	26.4	55.5	4.3	5.7	7.5	5.3	6.3	3.0	5.7	5.6	2.4	7.1	5.1	3.2	1.6
Birth weight	4.9	10.7	18.7	-3.6	1.0	-2.2	-4.1	-2.4	-3.0	-3.2	-3.4	-4.3	-2.7	-4.1	-3.6	-3.3
Leg predicted mass (right)	4.9	26.4	53.9	4.3	5.8	7.3	5.3	6.3	3.0	5.7	5.5	2.4	7.2	5.0	3.2	1.6
Impedance of leg (right)	4.7	22.8	57.3	-4.3	-7.6	-7.0	-4.0	-6.6	-2.3	-5.9	-3.5	-1.2	-6.6	-3.1	-2.0	-0.6
Illness, injury, bereavement, stress in last 2 years	4.6	5.6	10.7	-2.7	-1.8	-1.4	-2.9	-2.9	-2.5	-3.1	-1.9	-1.8	-3.3	-2.1	-2.2	-1.0
Back pain experienced in last month	4.6	6.7	11.9	2.6	-0.7	2.3	3.5	2.2	2.2	3.0	3.3	2.6	2.8	3.1	2.4	1.7
Diabetes (father)	4.4	5.4	8.4	2.2	1.4	2.2	2.5	2.7	1.6	2.8	2.3	2.3	2.9	2.8	2.3	1.2
Diabetes (mother)	4.2	5.4	11.9	1.9	0.3	3.5	2.9	2.4	0.6	2.2	2.9	1.9	2.7	3.3	1.9	1.3
Waist circumference	4.2	15.4	25.7	3.5	3.5	4.4	4.6	4.9	2.9	4.9	4.6	2.6	5.1	3.8	2.9	1.3
Medication: Ramipril	4.2	5.5	10.8	2.1	-1.0	2.0	3.3	1.6	2.1	2.5	3.3	2.7	2.1	2.7	2.4	1.1
Illnesses of siblings	4.1	5.8	9.1	-2.6	-0.3	-1.6	-3.0	-2.4	-2.6	-2.6	-2.6	-2.6	-2.6	-2.7	-2.7	-1.5
Neuroticism (Nagel 2018)	4.0	9.4	12.8	-3.5	-0.2	-2.9	-3.1	-3.0	-3.3	-2.8	-2.7	-3.4	-3.3	-3.6	-3.6	-3.0
Alcohol intake frequency.	3.9	9.0	16.8	2.6	1.1	3.5	3.5	4.1	2.9	3.7	2.7	2.5	4.1	2.7	2.7	1.0
Osteoporosis (self-reported)	3.8	4.7	10.5	-2.4	-0.1	-2.4	-2.3	-2.7	-2.2	-2.0	-1.2	-2.0	-3.2	-2.2	-2.4	-1.0
Medication: Blood pressure	3.8	7.2	11.9	2.7	0.1	1.8	3.3	3.3	2.7	3.5	2.9	2.9	3.2	2.7	2.6	1.2
Neuroticism score	3.7	7.8	12.2	-2.9	1.2	-3.1	-2.5	-2.7	-3.3	-2.4	-1.9	-3.0	-2.7	-3.2	-3.1	-3.5
Illnesses of siblings: Diabetes	3.7	4.6	7.1	2.5	1.6	1.9	2.1	2.7	1.8	2.4	1.7	1.9	2.6	2.2	2.3	1.7
Had major operations	3.6	4.3	8.9	-3.0	0.4	-0.4	-2.1	-1.5	-2.7	-2.3	-1.2	-2.9	-1.7	-1.8	-2.6	-2.0
Medication for cholesterol	3.6	5.4	9.7	-2.4	-0.1	-1.3	-2.6	-2.9	-2.2	-2.9	-2.3	-2.5	-3.1	-2.5	-2.1	-1.6
Worrier / anxious feelings	3.5	6.6	10.5	-2.7	1.1	-2.1	-2.8	-2.4	-2.5	-2.2	-2.2	-3.0	-2.7	-3.2	-3.2	-2.6
Frequency of tiredness / lethargy in last 2 weeks	3.5	5.6	11.4	2.0	2.4	2.7	2.5	3.0	1.0	2.9	3.4	1.1	3.2	2.6	1.2	-0.2
Mouth/teeth dental problems: Dentures	3.5	5.9	11.3	-2.8	-1.7	-1.7	-2.5	-3.4	-2.1	-3.3	-2.5	-1.9	-3.0	-2.5	-2.2	-1.0
Qualifications: CSEs or equivalent	3.4	4.4	7.4	2.5	1.6	1.7	2.6	2.1	1.7	2.0	2.7	1.5	2.6	2.4	1.9	1.4
Sitting height	3.4	24.3	41.1	4.9	-0.7	4.6	5.7	4.8	4.8	4.4	5.0	5.5	5.9	6.4	5.7	3.1
Exposure to tobacco smoke outside home	3.4	4.5	9.6	2.5	0.2	1.3	2.4	3.1	1.8	2.9	2.0	1.9	2.9	2.0	1.9	0.7
Heart disease (mother)	3.4	4.2	6.6	2.5	0.3	1.4	2.2	2.2	2.5	2.2	1.6	1.8	2.6	2.1	2.2	1.9
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	7.8	2.6	-0.3	1.3	2.3	2.6	2.2	2.5	1.7	2.2	2.8	1.9	1.7	0.5
Average weekly fortified wine intake	3.3	3.9	9.1	-1.4	-2.1	-2.1	-2.4	-1.9	-1.6	-2.0	-3.0	-1.4	-2.2	-2.2	-1.9	-0.4
Knee pain experienced in last month	3.3	5.1	8.5	2.4	1.6	2.5	2.7	2.8	1.9	2.8	2.7	1.1	2.9	2.0	1.5	1.4
Mother’s age at death	3.3	4.1	10.9	-1.8	0.6	-1.9	-2.3	-2.3	-1.2	-1.4	-3.3	-1.5	-2.4	-3.0	-1.9	-0.7
Hypothyroidism (self reported)	3.2	7.3	12.1	-3.3	0.4	-3.5	-3.0	-3.2	-2.4	-3.2	-2.5	-2.6	-2.7	-2.9	-2.5	-1.5
Schizophrenia vs Biploar Disorder	3.1	4.1	8.1	-2.0	1.1	-2.6	-2.4	-1.6	-1.4	-1.4	-2.0	-2.1	-2.2	-2.8	-2.0	-2.2
High blood pressure (mother)	3.1	4.4	7.7	2.0	1.6	2.3	2.2	2.0	1.5	2.2	2.1	1.6	2.7	2.8	1.7	2.2
Weight	3.1	15.2	29.2	3.2	4.4	5.4	4.1	5.0	2.5	4.6	4.2	1.9	5.4	3.8	2.4	1.1
BMI	3.0	17.1	36.2	3.4	5.4	5.6	4.2	6.0	2.3	5.3	3.5	1.5	5.8	3.0	2.3	0.3
Hip circumference	3.0	12.9	23.0	3.0	3.9	4.8	3.8	4.7	2.7	4.4	3.6	2.1	4.7	3.3	2.5	1.3
Neuroticism	2.9	6.9	10.8	-2.9	0.7	-2.6	-2.5	-2.1	-2.9	-1.8	-1.8	-3.1	-2.7	-3.3	-3.2	-3.1
Mouth/teeth dental problems	2.9	4.5	9.0	2.5	0.3	1.3	2.0	3.0	2.1	2.9	2.1	2.0	2.4	2.4	2.0	0.4
Number of full brothers	2.9	3.7	8.8	2.0	1.1	3.0	2.3	1.4	1.4	1.8	1.9	1.7	2.1	2.3	1.7	1.6
Basal metabolic rate	2.9	16.3	38.8	3.1	4.8	6.2	4.1	5.0	2.2	4.4	4.2	1.8	5.7	4.0	2.4	1.2
Headache pain in last month	2.8	4.8	12.9	1.7	1.4	3.6	2.5	1.7	1.1	1.7	3.1	1.1	2.4	3.1	1.3	1.9
Medication: Omeprazole	2.8	3.3	6.8	2.1	-0.4	1.3	2.0	2.5	2.0	2.1	1.6	1.7	2.6	1.8	1.6	0.6
Financial difficulties in last 2 years	2.7	3.6	7.6	1.4	2.4	2.5	2.2	2.3	1.4	2.4	1.9	0.5	2.8	1.6	1.0	0.1
Whole body fat-free mass	2.7	15.5	38.4	2.9	4.7	6.2	3.9	4.8	2.0	4.2	4.0	1.8	5.5	3.9	2.3	1.1
Miserableness	2.7	4.6	9.4	-2.5	0.6	-2.4	-1.6	-1.8	-3.1	-1.9	-0.9	-2.3	-1.7	-2.1	-2.5	-3.0
Fed-up feelings	2.6	4.7	11.2	-2.3	1.5	-2.1	-2.0	-1.3	-2.9	-1.4	-1.7	-2.3	-1.4	-2.5	-2.4	-3.3
Depression (self-reported)	2.6	3.1	7.6	2.2	1.5	-0.4	1.9	2.1	0.9	2.5	1.5	1.7	2.7	1.9	1.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	7.6	-1.8	0.7	-1.5	-1.2	-2.4	-2.8	-1.7	-0.5	-1.7	-2.2	-1.5	-2.0	-1.6
Whole body water mass	2.6	15.1	37.8	2.9	4.6	6.2	3.9	4.8	2.0	4.1	3.9	1.8	5.4	3.9	2.4	1.1
Cholesterol lowering medication	2.6	3.8	6.7	2.6	0.4	0.9	2.5	1.9	2.0	2.2	1.6	2.5	2.5	1.9	2.1	0.6
Coronary Artery Disease (CAD)	2.5	2.9	4.3	1.6	-0.8	1.7	1.8	1.6	1.9	1.4	1.8	2.0	1.9	2.1	2.1	0.9
Neuroticism (2016)	2.5	3.5	6.2	-2.5	0.2	-2.0	-1.9	-1.5	-2.2	-1.6	-1.3	-2.0	-1.7	-2.0	-2.0	-2.4
Arm fat mass (right)	2.5	10.4	20.4	2.6	4.2	4.5	3.3	4.3	2.0	3.9	3.5	1.1	4.3	2.7	1.6	0.5
Respiratory disease	2.4	5.2	15.0	2.1	-0.4	2.8	3.1	1.8	1.4	2.2	3.9	1.5	2.5	3.0	1.7	0.9
Depressed Affect (Nagel 2018)	2.3	4.7	11.4	-2.4	0.4	-2.4	-1.9	-1.4	-2.9	-1.4	-1.4	-2.5	-1.7	-2.4	-2.6	-3.4
Trunk fat mass	2.3	9.9	17.4	2.6	3.0	3.8	3.6	4.0	2.3	3.8	3.9	1.7	4.2	3.2	2.0	0.9
Illnesses of mother	2.3	2.8	5.4	-2.0	-1.9	-1.0	-1.9	-1.9	-1.6	-2.2	-1.6	-1.1	-2.3	-1.5	-1.1	-1.0
Hair/balding pattern: Pattern 4	2.3	5.6	11.2	-2.4	0.6	-2.8	-2.6	-2.3	-2.2	-2.3	-2.2	-1.9	-3.4	-2.5	-2.0	-2.5
Peak expiratory flow (PEF)	2.3	5.3	13.5	-2.1	0.8	-1.9	-2.9	-2.1	-2.2	-2.8	-3.7	-2.2	-1.9	-2.8	-2.1	-0.6
Overall health rating	2.3	5.0	10.6	1.5	1.6	2.4	2.5	3.3	1.3	3.1	3.2	0.8	3.0	2.1	1.3	-0.2
Arm fat mass (left)	2.3	9.3	19.7	2.4	4.4	4.4	3.1	4.0	1.9	3.6	3.2	0.9	4.0	2.4	1.5	0.6
Sensitivity / hurt feelings	2.2	3.7	7.1	-2.0	2.7	-1.2	-1.4	-1.8	-2.6	-1.4	-0.6	-2.3	-1.5	-2.0	-1.9	-2.6
Hearing difficulty/problems with background noise	2.2	3.6	5.8	-2.4	0.2	-1.7	-1.9	-1.8	-1.9	-2.0	-2.0	-1.4	-2.2	-2.2	-1.6	-2.2
Falls in the last year	2.2	2.9	6.6	1.7	-1.5	0.7	2.1	1.2	1.9	0.7	2.3	1.9	1.2	2.3	2.6	0.3
Pulse wave Arterial Stiffness index	2.2	2.6	4.8	1.4	-1.2	1.3	1.9	1.6	1.8	1.8	1.6	2.2	1.2	1.8	1.7	0.8
Basal cell carcinoma (self-reported)	2.2	2.6	5.3	-2.2	-0.3	-1.7	-1.3	-1.8	-1.5	-1.8	-1.3	-1.6	-2.3	-1.8	-1.5	-1.0
Breast Cancer	2.1	5.1	7.6	-2.4	0.7	-2.4	-2.6	-1.8	-2.8	-1.7	-2.3	-2.1	-2.3	-2.6	-2.7	-2.3
Ovarian Cancer	2.1	2.8	7.2	1.5	-0.5	2.7	2.0	1.4	1.0	2.0	1.7	1.4	1.5	1.9	0.7	1.9
HbA1C	2.1	2.3	5.1	1.8	0.4	1.4	2.2	1.7	0.3	1.8	2.3	1.4	1.8	1.5	1.4	-0.0
Number of children fathered	2.1	2.4	6.4	1.2	-2.5	1.0	1.5	1.0	0.8	1.0	1.7	2.2	0.7	2.2	1.8	1.1
Heel T-Score	2.0	15.8	26.4	4.5	2.9	5.1	3.5	4.2	3.6	4.6	3.5	2.8	4.8	3.9	2.0	4.9
Cardiovascular Disease	2.0	6.7	16.6	1.8	0.1	3.4	3.4	2.2	1.9	2.6	4.1	2.3	2.7	3.3	2.0	1.4
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	7.8	2.7	1.7	1.7	2.3	2.6	2.0	2.8	1.9	1.9	2.5	1.8	1.1	2.0
Allergy	2.0	4.5	9.8	-2.1	-0.9	-3.1	-2.2	-2.3	-1.4	-2.5	-2.6	-1.1	-2.4	-2.4	-1.6	-1.7
Arm fat percentage (right)	2.0	8.0	14.9	2.5	3.6	3.4	3.0	3.9	2.1	3.6	3.2	1.0	3.6	2.3	1.4	0.6
Hearing aid user	2.0	2.3	5.4	-1.5	1.0	-0.3	-2.1	-1.3	-0.6	-1.5	-1.8	-2.3	-1.6	-2.0	-1.7	0.5
Lung FVC	1.9	9.5	21.2	-2.5	1.7	-2.3	-3.7	-2.4	-2.8	-3.0	-4.6	-3.2	-3.1	-4.4	-2.7	-2.3
Body mass index (BMI)	1.9	8.1	23.7	1.9	4.9	4.2	2.3	4.1	1.4	3.6	2.3	0.1	3.8	1.5	0.7	0.2
Tense / ‘highly strung’	1.9	3.2	6.1	-2.1	-0.7	-1.3	-2.1	-2.1	-1.6	-2.5	-1.6	-1.8	-2.4	-1.5	-1.7	-1.0
High blood pressure (siblings)	1.9	2.8	5.5	1.8	0.2	1.4	2.3	1.6	1.7	1.6	2.3	1.8	1.6	1.8	1.6	0.9
Worry too long after embarrassment	1.9	3.3	5.1	-1.9	-1.1	-1.6	-1.8	-2.3	-1.7	-1.8	-2.2	-1.8	-1.9	-2.2	-2.1	-0.6
Illnesses of father: High blood pressure	1.9	2.4	6.0	1.3	0.1	1.7	1.2	2.5	1.8	2.0	1.3	0.8	2.2	1.4	1.0	1.0
LDL Cholesterol	1.8	2.8	5.2	2.2	1.9	1.9	2.2	1.3	1.0	2.3	2.2	1.7	1.1	1.4	0.8	0.7
Trunk fat-free mass	1.8	10.5	29.5	2.2	3.9	5.4	3.1	4.0	1.5	3.3	3.1	1.5	4.5	3.3	1.9	0.9
Whole body fat mass	1.8	7.4	13.9	2.1	3.4	3.7	2.8	3.6	1.8	3.3	3.1	0.8	3.7	2.4	1.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	5.2	1.3	2.3	1.8	1.1	1.8	0.8	1.4	0.6	1.0	1.9	1.6	1.4	0.8
Arm fat percentage (left)	1.8	7.3	13.8	2.3	3.7	3.5	2.8	3.6	2.0	3.4	2.9	0.7	3.5	2.1	1.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.7	11.4	-1.3	0.1	-2.4	-2.5	-1.2	-1.5	-1.6	-3.4	-1.4	-2.1	-2.8	-1.4	-1.0
Diastolic blood pressure, automated reading	1.8	5.6	10.6	2.4	3.1	2.5	2.4	3.3	2.1	2.6	2.5	0.8	3.2	1.7	1.6	0.9
Impedance of whole body	1.8	9.3	38.6	-1.8	-6.2	-5.4	-1.4	-4.3	-0.5	-3.5	-0.7	0.4	-4.0	-0.8	-0.1	0.2
Bipolar Disorder (2018)	1.7	2.7	8.4	1.9	-0.5	1.3	2.1	1.4	1.0	1.1	2.9	1.7	1.3	2.2	1.7	0.4
Lupus	1.7	2.6	5.6	1.3	-1.2	0.7	1.9	1.0	1.7	0.7	2.2	1.7	1.8	2.4	2.4	0.8
Trunk predicted mass	1.7	9.9	28.5	2.1	3.9	5.3	3.0	3.9	1.4	3.2	3.0	1.4	4.4	3.2	1.9	0.9
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.7	1.6	1.3	1.7	1.8	1.1	0.9	1.6	2.4	1.0	1.5	1.5	1.2	0.2
Wheeze or whistling in the chest in last year	1.7	3.1	9.6	1.6	1.1	1.4	2.5	1.6	0.9	1.3	3.1	1.0	2.0	2.0	1.9	-1.3
Qualifications: nursing, teaching	1.7	2.6	5.4	-1.6	-1.9	-0.7	-1.8	-2.0	-1.2	-2.3	-1.7	-1.2	-2.2	-1.6	-1.5	0.1
Ever depressed for a whole week	1.7	2.1	4.4	-1.8	0.8	-1.8	-0.9	-1.9	-1.7	-0.9	-0.1	-1.7	-1.3	-1.5	-2.1	-0.9
Chronotype (morning person)	1.6	3.8	7.4	-1.3	2.7	-1.2	-2.2	-1.9	-2.3	-1.7	-1.8	-1.9	-1.4	-2.1	-2.3	-1.9
Trunk fat percentage	1.6	6.4	11.8	2.2	1.9	2.5	3.1	3.1	2.2	3.1	3.4	1.5	3.2	2.6	1.7	0.8
Heart attack	1.6	2.0	5.0	0.9	-0.2	2.2	1.8	1.1	1.0	0.9	2.2	0.8	1.7	1.9	1.4	-0.2
Medication: Simvastatin	1.6	2.3	5.2	2.1	-0.9	0.6	2.0	1.1	1.0	1.6	1.4	2.3	1.5	1.7	1.8	-0.2
Pulse wave peak to peak time	1.6	1.9	3.9	-1.3	1.0	-0.9	-1.6	-1.5	-1.7	-1.7	-1.2	-2.0	-0.9	-1.4	-1.5	-0.6
Medication: Blood pressure	1.6	2.8	5.6	1.4	-1.5	2.4	1.8	1.5	1.8	1.5	1.5	1.4	1.7	1.8	1.3	1.8
Chest pain or discomfort	1.6	2.3	4.8	1.7	1.6	0.5	2.1	1.9	0.2	1.6	2.2	0.8	1.6	1.4	1.4	-1.4
Medication: Aspirin	1.6	2.1	3.4	1.3	-0.5	1.2	1.6	1.6	1.8	1.8	1.4	1.7	1.5	1.6	1.2	0.8
Ever highly irritable/argumentative for 2 days	1.5	1.8	16.2	-0.3	-0.5	-4.0	-0.3	-0.5	0.5	0.0	-1.1	0.1	-1.2	-1.8	-0.1	-1.1
Shortness of breath walking on level ground	1.5	1.8	3.0	1.5	1.2	0.5	1.7	1.5	1.2	1.6	1.5	1.1	1.6	0.9	1.5	-0.7
Heart disease (siblings)	1.5	1.9	3.5	1.9	-0.5	0.6	1.6	0.8	1.6	1.3	0.9	1.9	1.4	1.4	1.9	1.2
Crohns Disease (2012)	1.4	2.2	5.8	1.7	0.3	1.1	2.3	1.1	1.2	1.7	2.4	1.2	1.6	1.6	1.1	0.4
Fasting Glucose	1.4	1.7	5.7	0.7	0.6	2.4	1.7	1.2	0.0	1.5	1.2	1.0	1.6	1.6	0.7	0.9
Waist Hip Ratio (WHR)	1.4	6.4	14.6	2.5	-2.2	0.1	3.3	1.5	2.2	2.4	3.8	3.1	2.2	3.1	2.4	2.0
Medication: Co-codamol	1.4	1.6	4.1	1.2	-0.4	0.8	1.4	1.1	2.0	1.1	0.9	1.3	1.3	1.3	1.6	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.5	2.3	1.9	1.6	1.7	2.3	1.2	2.7	1.5	1.2	2.1	1.3	0.5	1.6
Pulse rate	1.4	2.3	5.3	1.3	-0.1	1.4	2.1	1.6	1.1	2.3	1.4	1.3	2.1	1.6	0.9	1.1
Medication: Ibuprofen	1.4	1.7	4.4	-1.6	0.9	-0.2	-1.7	-0.7	-1.8	-1.1	-0.9	-2.0	-0.8	-1.0	-2.1	-0.7
Breast cancer (self-reported)	1.4	1.7	3.5	1.9	0.4	0.7	1.7	1.3	1.5	1.8	0.8	1.7	1.2	0.8	1.2	0.6
Ever taken oral contraceptive pill	1.4	1.5	5.8	0.9	2.4	1.2	0.6	1.9	-0.4	1.4	0.6	-0.5	2.1	0.3	-0.5	-0.6
Pain type(s) experienced in last month: Hip pain	1.4	1.7	4.2	0.8	1.4	1.6	1.6	1.6	0.2	1.1	2.1	0.5	1.6	1.4	1.2	-0.4
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.7	0.8	-0.3	2.1	1.7	1.0	0.9	0.8	2.2	0.7	1.6	1.8	1.3	-0.2
Worry (Nagel 2018)	1.3	2.8	6.4	-1.9	-1.0	-1.5	-1.7	-2.1	-1.3	-1.7	-1.0	-1.7	-2.5	-1.7	-1.8	-1.1
Schizophrenia (2014)	1.3	2.8	5.7	-2.4	0.4	-1.2	-1.6	-2.1	-1.8	-2.3	-0.2	-1.6	-2.3	-1.3	-1.4	-1.7
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.6	0.8	-0.0	1.5	1.4	1.4	0.9	1.6	1.0	1.2	1.9	1.4	0.8	0.5
Time employed in main current job	1.3	1.5	5.0	-0.5	0.0	-0.9	-2.0	0.0	-0.7	-0.3	-2.2	-1.3	-0.9	-1.8	-1.4	-1.0
Arm predicted mass (right)	1.3	6.4	21.9	1.4	3.6	4.7	2.2	3.0	0.9	2.5	2.3	0.5	3.7	2.3	1.2	0.6
Mineral and other dietary supplements	1.3	1.7	6.2	-1.1	2.1	-2.5	-1.3	-1.2	-1.1	-1.2	-0.3	-1.1	-0.5	-1.1	-1.0	-1.1
Medication: Bendroflumethiazide	1.3	2.0	3.5	1.5	-0.5	0.5	1.5	1.9	1.8	1.8	1.1	1.8	1.3	1.4	1.8	0.5
Arm predicted mass (left)	1.3	6.6	19.4	1.5	3.5	4.4	2.4	3.3	0.9	2.6	2.5	0.7	3.7	2.4	1.4	0.4
Number of treatments/medications taken	1.2	2.2	5.9	1.2	0.2	1.8	1.6	2.4	0.7	2.0	1.8	0.5	2.1	1.3	0.6	-0.8
Hayfever, allergic rhinitis or eczema	1.2	2.5	5.3	2.3	1.4	1.9	1.2	1.8	1.5	2.0	1.2	0.9	1.5	1.3	1.3	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	12.3	-0.3	2.5	-1.0	-0.5	0.2	-0.9	-0.2	0.1	-1.2	-0.0	-1.1	-0.7	-3.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	7.7	-1.0	-0.3	-2.8	-0.9	-1.0	-1.1	-0.2	-0.6	-1.2	-1.1	-1.5	-1.1	-1.2
Medication: Amlodipine	1.2	1.6	5.4	-1.2	-2.3	-0.3	-1.3	-1.0	-1.1	-1.5	-2.2	-0.4	-1.0	-1.1	-1.0	0.2
Emphysema/chronic bronchitis	1.2	1.4	2.3	1.2	-0.5	1.0	1.5	1.0	1.3	1.0	1.5	0.8	1.1	1.4	1.3	1.0
Comparative height size at age 10	1.2	6.4	12.3	2.5	-0.9	1.8	3.0	2.2	1.8	2.6	3.2	2.9	2.9	3.5	2.2	2.0
Hypertension (Self-reported)	1.2	3.3	7.0	1.6	-0.1	2.1	2.5	1.8	1.7	1.9	2.6	1.6	2.0	2.1	1.5	0.8
Number of self-reported non-cancer illnesses	1.2	2.2	6.5	1.2	0.8	1.4	1.9	1.7	0.5	1.9	2.5	0.7	1.7	1.5	0.8	-0.8
Guilty feelings	1.2	1.8	3.4	-1.1	1.2	-1.3	-1.2	-1.2	-1.5	-1.1	-1.8	-1.4	-1.0	-1.8	-1.5	-1.1
Arm fat-free mass (left)	1.2	5.9	18.3	1.4	3.0	4.3	2.3	3.1	1.0	2.5	2.3	0.8	3.5	2.3	1.3	0.5
Number of operations (self-reported)	1.2	1.7	5.4	-1.0	2.1	1.4	-0.3	0.5	-1.8	0.1	0.6	-1.6	-0.1	-0.3	-1.6	-2.3
Age started oral contraceptive pill	1.2	1.5	5.2	1.1	-1.0	-0.6	-0.2	0.5	2.1	0.4	-2.0	1.2	0.0	-0.2	1.4	2.3
Verbal and Numeric Reasoning (VNR)	1.1	2.6	6.0	2.1	-1.3	0.0	1.9	1.2	1.6	1.6	0.9	2.5	1.0	1.8	2.0	1.5
Blood Red Count	1.1	10.8	18.6	2.8	2.1	3.5	4.1	4.3	1.9	3.8	3.4	2.8	4.2	3.8	3.4	0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.7	1.0	1.3	0.5	1.4	1.5	0.5	1.4	1.3	1.2	1.6	1.3	1.3	-1.0
Multivitamins +/- minerals	1.1	1.5	4.3	1.2	-1.4	1.5	0.7	0.8	1.8	0.9	0.6	0.9	0.7	1.0	1.0	2.1
Happiness	1.1	1.4	3.5	-0.5	1.4	-1.9	-1.2	-0.1	-1.2	-0.3	-0.9	-1.2	-0.7	-1.4	-1.0	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.2	-1.5	0.5	-0.2	-1.5	-0.6	-1.8	-1.0	-0.6	-1.8	-0.7	-0.8	-2.0	-0.7
Arm fat-free mass (right)	1.1	5.5	18.3	1.2	3.5	4.3	2.0	2.9	0.8	2.3	2.0	0.5	3.5	2.0	1.1	0.4
Angina (self-reported)	1.1	1.4	3.0	1.6	-0.1	1.0	1.0	1.6	0.1	1.7	0.9	1.2	1.5	1.7	0.9	0.2
Supplements: Calcium	1.1	1.3	3.4	-1.0	-1.0	-0.5	-1.3	-1.5	-0.9	-1.5	-0.7	-1.2	-1.9	-0.9	-0.9	-0.2
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.1	0.7	0.3	1.4	1.4	0.8	0.5	0.9	1.0	0.7	1.7	1.8	0.6	1.3
Serious illness, injury or assault to yourself	1.0	1.2	3.1	1.1	-0.7	0.8	1.0	1.6	1.8	1.2	0.8	0.9	1.2	0.9	1.1	0.6
Had menopause	1.0	1.2	4.5	-0.5	-0.7	-1.7	-1.3	-1.1	-0.6	-1.0	-2.1	-0.2	-1.4	-1.1	-0.2	-0.8
Standing height	1.0	10.1	24.0	2.6	-0.8	3.1	4.0	2.2	2.4	2.1	4.3	3.7	3.5	4.9	3.5	1.9
Leg fat mass (right)	1.0	4.0	9.9	1.2	3.1	3.0	1.7	2.9	1.1	2.5	1.9	-0.0	2.8	1.3	0.4	0.2
Medication: Aspirin	1.0	1.3	2.7	1.1	-0.8	0.8	1.3	1.1	1.6	1.4	1.2	1.4	1.1	1.2	0.9	0.7
Mood swings	1.0	1.7	3.1	-1.4	1.5	-1.3	-0.8	-1.3	-1.7	-1.1	-0.6	-1.3	-1.3	-1.2	-1.4	-1.8
Medication: Gliclazide	1.0	1.1	3.8	0.8	0.5	1.9	0.7	1.2	1.2	1.0	0.5	0.4	1.3	1.0	0.4	1.3
Leg fat mass (left)	1.0	4.1	10.9	1.2	3.3	3.0	1.7	2.8	1.1	2.6	2.0	-0.1	2.8	1.3	0.4	0.1
Alzheimer’s Disease (in mother)	0.9	1.0	6.2	-0.0	2.5	-0.4	-0.6	1.4	-0.1	0.8	-1.0	-0.7	0.8	-1.1	-0.4	-0.8
Crohns Disease (2017)	0.9	1.9	4.4	1.5	0.1	0.9	2.0	1.0	1.2	1.7	2.1	1.1	1.5	1.5	0.9	1.1
Bipolar Disorder (2011)	0.9	0.9	2.3	0.6	-0.0	0.8	1.3	0.7	0.7	0.9	1.5	0.9	1.1	1.2	0.8	1.0
Blood Platelet Count	0.9	10.7	21.7	3.0	-0.8	0.9	4.7	2.5	3.3	2.6	4.4	3.7	3.2	4.2	4.1	2.3
Angina	0.9	1.2	2.6	1.4	-0.1	1.2	0.8	1.4	-0.1	1.5	0.9	0.9	1.3	1.6	0.7	0.1
Fluid intelligence score	0.9	1.9	4.3	2.1	-0.1	0.8	1.3	1.9	1.0	1.5	0.7	1.7	1.4	1.6	1.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.2	1.4	1.0	0.1	1.2	1.4	0.6	1.8	1.6	0.7	1.6	1.2	0.5	0.1
Loud music exposure frequency	0.9	1.0	5.0	0.4	0.7	0.5	1.2	1.3	0.1	1.6	2.2	-0.1	0.7	0.8	0.2	-0.2
Body fat percentage	0.9	3.5	6.9	1.5	2.0	2.1	2.1	2.6	1.6	2.5	2.3	0.6	2.5	1.6	0.9	0.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.1	-1.2	-1.8	-1.4	-0.6	-1.1	-0.8	-0.9	-0.7	-0.5	-1.2	-1.2	-0.6	-0.6
Number of full sisters	0.9	1.0	5.4	-0.3	2.3	0.2	0.7	0.8	-0.2	0.5	0.2	0.2	0.9	0.1	0.6	-2.3
Family relationship satisfaction	0.9	1.1	4.0	-0.2	1.6	-0.5	-0.6	0.5	-1.9	0.5	0.8	-0.8	0.2	-0.1	-1.1	-2.0
Schizophrenia (2018)	0.8	1.6	3.0	-1.7	1.6	-0.5	-0.7	-1.4	-1.5	-1.7	0.8	-1.4	-1.3	-0.4	-1.0	-1.5
Systolic Blood Pressure	0.8	4.1	6.0	2.4	-0.0	1.8	2.0	1.7	2.4	1.6	2.1	2.2	2.1	2.4	2.3	2.2
Townsend deprivation index at recruitment	0.8	1.1	3.3	0.8	0.9	1.8	1.2	1.3	0.2	1.1	1.2	0.7	1.3	1.1	0.5	-0.1
High blood pressure	0.8	2.3	5.2	1.0	0.1	2.3	2.0	1.6	1.1	1.5	2.3	1.0	1.8	1.8	0.9	0.6
Medication: Levothyroxine sodium	0.8	1.4	6.5	-1.3	-0.1	-2.5	-1.2	-1.1	-0.4	-1.0	-1.8	-0.5	-0.9	-1.3	-0.4	-0.3
Nervous feelings	0.8	1.5	3.4	-1.2	-1.1	-1.3	-1.0	-1.8	-1.0	-1.5	-1.2	-0.7	-1.7	-1.2	-1.0	-0.7
Hair/balding pattern: Pattern 2	0.8	1.0	2.1	0.7	0.4	1.4	0.9	1.1	1.2	0.9	1.2	0.3	1.2	0.9	0.4	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	1.5	1.0	-0.3	0.9	1.2	0.5	1.1	-0.6	1.2	1.5	0.2	0.8	-0.6
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.6	-1.5	0.4	-2.4	-1.3	-1.3	-0.9	-1.4	-1.0	-1.1	-1.0	-1.3	-0.8	-1.0
Eye problems/disorders: Cataract	0.8	0.9	2.4	-1.3	0.1	-1.1	-0.9	-1.3	-0.2	-1.6	-0.7	-0.8	-1.3	-1.0	-0.2	-0.3
Medication: Lisinopril	0.8	1.0	2.6	1.1	0.3	1.6	1.0	1.0	0.8	0.7	1.4	0.7	1.2	1.2	0.6	0.7
Risk taking	0.8	1.2	3.3	-0.9	0.1	0.5	-1.0	-0.6	-1.8	-0.9	-0.2	-1.8	-0.7	-0.8	-1.8	-1.1
Myopia	0.8	1.1	3.4	1.5	-1.1	0.6	0.9	0.5	0.9	0.8	-0.4	1.8	0.5	1.0	1.4	1.3
Vascular/heart problems diagnosed by doctor	0.8	2.3	5.1	-1.0	-0.4	-2.3	-1.9	-1.7	-0.6	-1.8	-2.3	-0.9	-1.9	-1.9	-0.6	-0.2
Average weekly spirits intake	0.7	0.9	7.6	0.0	-2.8	-0.8	0.2	-0.6	0.7	0.2	0.2	0.8	-0.7	0.1	0.2	1.1
Impedance of arm (right)	0.7	3.5	16.6	0.7	-4.1	-2.6	1.3	-1.5	1.0	-0.9	2.1	2.0	-1.3	1.7	1.6	0.6
Noisy workplace	0.7	0.9	3.0	1.1	0.0	1.1	0.8	1.4	0.4	1.7	0.8	0.3	1.5	0.6	-0.1	-0.2
Impedance of arm (left)	0.7	3.4	16.7	0.6	-4.1	-2.3	1.1	-1.8	1.2	-1.1	1.8	1.9	-1.4	1.5	1.5	1.0
Breastfed as a baby	0.7	0.8	2.0	-1.4	0.1	0.0	-1.0	-1.0	-1.3	-1.0	-1.4	-0.5	-0.6	-0.7	-0.7	-0.7
Glaucoma (self-reported)	0.7	0.8	2.6	1.1	-0.4	1.1	0.9	0.8	0.8	0.9	1.6	0.5	0.7	0.9	0.5	1.0
Health satisfaction	0.7	0.9	2.8	0.8	1.2	0.6	0.8	1.7	-0.0	1.0	1.2	0.2	1.1	0.8	0.5	-1.0
Medication for pain relief, constipation, heartburn	0.7	1.2	5.2	-1.2	-0.7	-0.9	-0.6	-2.3	-0.4	-1.7	-0.9	-0.0	-1.7	-0.8	0.0	0.4
Supplements: Vitamin C	0.7	0.8	1.5	-0.5	0.4	-1.2	-0.8	-0.8	-0.9	-0.8	-1.1	-0.6	-1.2	-1.1	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.6	0.4	0.2	1.8	1.2	1.5	0.3	1.0	2.1	0.6	1.5	1.8	0.7	0.8
Average weekly red wine intake	0.7	1.0	3.3	-0.5	-1.8	-0.8	-0.8	-1.8	-0.2	-1.5	-1.1	-0.1	-1.0	-0.6	-0.4	0.5
Ever had bowel cancer screening	0.7	0.8	2.0	-0.3	-1.1	-1.1	-1.1	-1.1	-0.5	-0.7	-1.4	-0.4	-0.9	-0.6	-0.7	-0.7
Commuting to job workplace: Walk	0.7	0.7	1.7	1.3	-0.9	-0.3	0.4	0.4	1.3	0.5	-0.0	1.2	0.5	0.7	1.2	1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.1	-1.3	0.3	-1.3	-1.3	-1.0	-1.0	-1.2	-1.4	-1.0	-0.9	-1.2	-0.9	-0.4
Asthma (self-reported)	0.7	1.4	6.6	0.7	-0.1	1.8	1.6	0.4	0.3	0.5	2.6	0.4	1.2	1.7	0.9	0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	1.0	-1.1	0.8	0.2	1.4	1.2	1.0	-0.7	0.9	0.6	0.6	0.6	1.0
Fractured/broken bones in last 5 years	0.7	0.9	2.6	-1.4	-1.3	0.6	-0.7	-1.3	-1.1	-1.6	-0.2	-0.5	-0.9	0.3	-0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.8	1.7	-2.2	0.4	1.4	0.9	0.8	0.9	0.5	2.0	1.3	1.4	1.4	0.7
Age at First Birth	0.6	0.9	4.2	-0.6	-0.6	-2.0	-0.9	-0.8	0.0	-0.5	-1.3	-0.4	-0.8	-1.4	-0.3	0.1
Height	0.6	11.1	22.6	2.4	-1.2	2.3	4.3	3.2	2.5	3.0	4.5	3.8	3.9	4.8	3.8	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	-1.3	0.2	0.9	-0.9	-1.1	-0.6	-0.9	-0.3	-0.8	-0.9	-0.5	-1.0	0.1
Systolic blood pressure, automated reading	0.6	1.8	4.1	1.9	0.7	1.1	1.0	1.6	2.0	1.2	0.6	1.2	1.0	1.1	1.6	1.6
Maternal smoking around birth	0.6	0.8	3.5	-0.2	1.9	-1.0	-0.5	1.1	-0.8	0.1	0.2	-1.2	-0.2	-0.7	-0.4	-1.3
Taking other prescription medications	0.6	0.9	3.8	0.8	-0.4	0.8	1.2	1.0	0.8	0.8	2.0	0.3	1.1	1.2	0.7	-0.7
Age when periods started (menarche)	0.6	1.3	4.1	-1.2	1.5	-1.1	-1.1	-0.5	-1.5	-0.9	-0.9	-1.1	-0.5	-0.9	-0.9	-2.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	1.0	0.1	1.1	0.9	1.2	0.6	0.9	0.9	0.5	0.9	0.7	0.8	-0.1
Qualifications: None of the above	0.6	1.2	3.4	-1.8	-1.7	-0.8	-0.8	-1.2	-0.6	-0.8	0.1	-1.3	-0.8	-1.0	-0.9	-1.5
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.8	-1.0	0.9	-1.4	-1.7	-1.0	-1.5	-1.7	-2.4	-1.0	-1.0	-1.7	-1.1	-0.6
Medication: Cholesterol lowering	0.6	0.9	2.3	-1.0	-1.5	-0.3	-0.6	-1.1	-1.1	-1.0	0.4	-0.6	-1.2	-0.3	-1.0	-1.1
Pulse wave reflection index	0.6	0.7	1.5	0.6	-0.9	0.3	0.8	1.0	1.2	0.7	0.7	1.2	0.3	0.9	1.1	0.2
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.4	0.9	0.2	-0.2	0.9	1.1	0.8	1.0	1.2	0.5	1.1	0.6	0.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	1.1	0.5	-1.1	0.6	1.3	-0.2	1.4	-0.1	0.9	1.3	0.5	0.5	-0.9
Migraine (self-reported)	0.6	0.7	2.1	1.1	0.4	0.7	0.6	0.9	0.8	1.5	0.4	0.4	1.1	0.8	0.2	0.9
Suffer from ‘nerves’	0.6	0.9	1.8	-1.1	-0.0	-0.7	-0.8	-1.4	-1.2	-1.0	-0.3	-1.1	-1.1	-0.8	-1.0	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	-1.4	0.4	0.7	-0.6	-0.5	-1.2	-0.5	0.1	-1.0	-0.6	-0.4	-1.3	-0.8
Financial situation satisfaction	0.6	0.8	4.1	0.5	0.3	0.7	1.3	0.5	0.2	1.1	2.0	0.4	0.5	1.1	0.5	0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.0	0.6	-1.7	1.3	0.5	0.7	1.0	0.7	-0.8	0.7	-0.1	0.1	0.4	1.2
Average weekly beer plus cider intake	0.6	0.8	2.4	0.1	0.4	1.3	0.8	1.6	0.3	0.9	0.9	0.0	1.3	1.0	0.6	0.8
Body Mass Index (BMI) (2010)	0.5	0.7	4.8	-0.1	2.2	1.4	0.4	0.3	-0.3	0.0	0.7	-0.3	0.7	0.2	0.1	-1.0
Primary Biliary Cirrhosis	0.5	0.7	1.8	-0.5	1.4	-0.6	-0.4	-0.9	-0.8	-0.7	-0.4	-0.9	-0.6	-1.2	-0.9	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.8	0.6	1.7	-1.2	-0.6	0.5	0.1	-0.0	-1.3	0.0	-0.0	-0.5	0.2	-1.3
Relative age voice broke	0.5	0.8	2.7	-1.2	1.0	-1.3	-0.4	-0.6	-0.9	-0.6	0.2	-0.6	-1.0	-0.7	-0.6	-1.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	0.6	1.2	-0.2	0.7	0.7	0.1	0.7	0.2	0.8	1.0	0.5	0.8	-0.8
Medication: Atenolol	0.5	0.6	1.6	0.4	0.3	1.3	0.7	1.2	0.9	0.7	1.2	0.1	0.4	0.8	0.6	0.5
Number of incorrect matches in round	0.5	0.8	3.8	0.4	-1.9	-0.3	0.3	-0.8	1.3	-0.4	-0.4	0.9	-0.7	-0.1	1.3	1.0
Past tobacco smoking	0.5	1.0	2.5	1.1	0.8	1.3	0.3	0.8	1.3	0.6	-0.9	0.8	1.3	0.4	1.0	1.6
Father’s age at death	0.5	0.7	2.4	-0.5	-0.6	-0.9	-0.5	-1.2	0.1	-0.8	-1.3	0.3	-0.7	-0.5	0.1	1.6
Number of live births	0.5	0.7	1.9	-1.4	-1.0	-0.2	-0.8	-1.1	-0.5	-0.7	-1.0	-0.7	-0.7	-0.5	-0.9	-0.2
Asthma	0.5	1.0	5.5	0.3	-0.0	1.6	1.3	-0.1	-0.1	0.1	2.3	0.1	0.8	1.3	0.5	-0.3
Medication: Paracetamol	0.5	0.9	3.4	0.1	1.3	0.1	-0.2	1.9	-0.6	0.9	0.1	-1.1	1.3	-0.3	-0.7	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.9	-0.4	2.0	-1.4	-0.7	-0.6	-0.7	-0.7	-1.1	-0.7	-0.6	-1.0	-0.3	-0.4
Age at first live birth	0.5	0.8	2.1	-0.8	-0.4	-1.3	-1.0	-1.1	-0.5	-1.1	-1.4	-0.5	-1.0	-0.9	-0.6	-0.1
Medication: Seretide 50 evohaler	0.5	0.6	1.3	-1.1	-0.8	0.5	-1.1	-0.1	-1.0	-0.6	-0.6	-1.0	-0.3	-0.2	-1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	1.1	-0.3	-0.1	0.9	1.1	0.7	1.1	-0.2	0.9	1.0	0.2	0.7	-0.0
Illnesses of father: Heart disease	0.5	0.8	3.7	0.8	0.1	0.3	0.3	1.7	0.8	1.9	-0.2	0.7	1.0	0.2	0.5	-0.2
Smoking status: Previous	0.5	0.8	2.1	-0.7	-0.8	-1.2	-0.5	-0.6	-0.8	-0.5	0.4	-1.0	-1.1	-0.7	-0.9	-1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	3.8	-0.8	-0.8	2.0	-0.2	0.1	0.1	-0.0	0.1	-0.8	0.0	0.1	-0.6	1.1
Commuting to job workplace: Public transport	0.5	0.5	2.2	0.5	-0.1	0.5	0.6	-0.2	1.5	-0.4	0.7	0.3	-0.2	0.6	1.3	1.1
Medication: Paracetamol	0.5	0.8	3.9	0.5	0.8	0.9	0.3	2.0	0.4	1.2	0.6	-0.4	1.6	0.6	0.0	0.2
Alcohol drinker status: Never	0.5	0.6	2.0	-1.0	0.2	0.7	-1.0	0.4	-0.9	0.0	-0.7	-1.0	-0.5	-0.4	-0.9	-1.4
Alzheimer’s Disease (including proxy)	0.4	0.6	2.8	0.6	1.7	-0.3	0.6	1.1	0.0	1.1	0.1	0.6	0.7	-0.1	0.3	0.2
Major Depression (MDD)	0.4	0.5	1.2	-0.7	1.0	-0.5	-0.6	-0.4	-1.0	-0.4	-0.3	-1.0	-0.1	-0.6	-1.1	-0.7
Reaction Time	0.4	0.7	2.6	-0.8	-0.9	-1.0	-1.0	-0.8	-0.1	-0.7	-1.6	-0.3	-1.0	-1.1	-0.3	-0.2
Rheumatoid Arthritis	0.4	0.5	1.0	-0.7	-0.1	-0.9	-0.7	-0.7	-0.9	-0.9	-0.4	-1.0	-0.6	-0.7	-0.5	-1.0
Blood Eosinophil Count	0.4	2.8	6.8	1.1	0.8	2.6	2.2	1.6	1.0	1.6	2.5	0.9	1.9	2.0	1.4	0.7
Pack years adult smoking proportion	0.4	0.5	1.2	0.7	-0.3	0.2	0.8	0.8	0.8	1.0	0.6	0.5	1.0	0.7	0.4	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	4.0	-0.2	0.4	-1.1	0.7	-0.0	-0.3	-0.2	1.0	0.2	0.1	0.0	0.3	-2.0
Had other major operations	0.4	0.4	1.3	0.5	-0.2	0.6	0.8	1.1	-0.1	1.1	0.5	0.5	0.4	0.3	0.0	-1.1
Medication: Lansoprazole	0.4	0.4	0.9	0.0	0.3	-0.9	-0.5	-0.1	-0.6	0.0	-0.4	-0.9	-0.8	-0.9	-1.0	-0.9
Birth weight of first child	0.4	0.6	5.9	-0.1	2.4	0.3	-0.3	-0.0	-0.8	0.0	-0.5	-0.1	0.2	-0.3	-0.2	-1.1
Loneliness, isolation	0.4	0.6	3.7	0.5	0.3	-1.1	0.2	0.7	-0.9	0.6	0.0	0.1	0.4	-0.3	-0.2	-1.9
Smoking status: Current	0.4	0.6	3.1	-0.6	1.7	-0.4	0.1	-0.1	-1.3	0.0	1.0	-0.2	0.0	0.0	-0.7	-1.2
Eye problems/disorders: Glaucoma	0.4	0.5	2.5	0.7	1.3	0.8	0.6	0.5	-0.1	0.5	1.6	-0.2	0.2	0.3	-0.2	-0.2
Commuting to job workplace: Cycle	0.4	0.5	2.5	0.0	1.6	-0.6	-0.5	-0.2	-0.7	-0.3	-0.3	-0.6	-0.2	-0.6	-0.7	-0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	5.8	-0.1	1.0	0.4	0.7	-0.2	-0.5	-0.6	2.4	-0.0	-0.2	1.1	0.2	-0.9
Depression (Nagel 2018)	0.3	0.5	2.5	-0.3	-0.7	-0.4	0.8	0.2	0.0	0.2	0.8	0.5	0.6	0.5	0.3	-1.6
Alzheimer’s Disease (in father)	0.3	0.4	1.2	0.7	-0.5	-1.1	0.8	-0.3	0.2	0.5	0.4	1.1	-0.4	0.2	0.6	0.3
Ulcerative Colitis (UC)	0.3	0.5	1.0	-0.6	0.1	-0.9	-0.7	-0.8	-0.6	-0.5	-0.3	-0.7	-0.9	-1.0	-0.8	-1.0
Mean Putamen Volume	0.3	0.3	1.0	0.4	-0.5	0.7	0.2	0.7	0.8	0.7	0.1	0.5	0.3	0.5	0.6	1.0
Smoking Status	0.3	0.6	1.7	-0.5	1.2	-0.6	0.2	-0.0	-1.3	0.3	1.2	-0.4	0.0	0.2	-1.0	-1.3
Allergy or Eczema	0.3	0.8	1.9	1.2	0.7	1.2	0.8	1.1	0.4	1.4	1.4	0.3	0.5	0.8	0.4	0.7
Tanning	0.3	3.3	6.2	-1.9	-1.6	-1.9	-2.4	-1.8	-1.0	-2.2	-2.3	-1.2	-2.5	-2.0	-1.3	0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.2	-0.0	-0.0	-1.5	-0.6	-0.3	0.9	0.2	-0.7	-0.2	-0.9	-0.9	0.1	0.3
Supplements: Zinc	0.3	0.4	1.4	-0.2	-0.5	-1.2	-0.4	-0.7	-0.1	-0.4	-1.1	0.3	-0.8	-0.5	0.1	0.3
Current tobacco smoking	0.3	0.5	1.7	-0.8	1.3	-0.3	0.2	-0.5	-1.2	-0.2	1.0	-0.2	-0.2	0.0	-0.7	-1.0
Supplements: Glucosamine	0.3	0.4	1.8	-0.3	-0.4	1.0	-0.4	0.6	-0.4	-0.0	-1.3	-0.6	-0.2	-0.4	-0.7	-0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.7	-0.3	1.3	-0.1	0.1	0.1	-0.6	0.2	0.8	-0.6	0.6	0.4	-0.5	-0.1
Pain all over the body in last month	0.3	0.4	1.2	-0.4	-0.6	-1.1	-0.3	-0.8	-0.4	-0.9	-0.6	0.0	-0.7	-0.1	0.3	-0.5
Exposure to tobacco smoke at home	0.3	0.3	1.8	-0.1	-1.3	-1.2	0.2	-0.1	0.3	-0.1	0.2	0.5	-0.0	0.3	0.4	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.7	0.3	1.7	0.2	0.4	-0.1	-0.2	0.4	-0.2	-0.5	0.9	-0.3	-0.3	0.8
Comparative body size at age 10	0.3	1.0	2.8	0.7	-1.5	1.2	0.4	1.1	1.5	0.7	0.3	0.4	0.6	0.5	0.7	1.7
Mean time to correctly identify matches	0.3	0.6	2.8	-0.5	-1.0	-1.0	-0.7	-0.5	0.1	-0.6	-1.7	0.2	-0.8	-1.1	0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	2.3	0.2	1.5	0.4	-0.4	0.7	-0.1	0.5	0.5	-0.6	0.4	0.1	-0.3	-0.2
Friendships satisfaction	0.3	0.4	1.6	0.1	1.1	-1.3	-0.9	0.4	-0.4	0.2	-0.6	-0.6	0.1	-0.3	-0.4	-0.2
Osteoarthritis (self-reported)	0.3	0.4	1.6	0.3	1.2	1.2	0.7	0.5	0.5	0.8	0.3	0.1	0.2	0.0	0.3	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	2.4	-0.2	-0.7	1.5	-0.3	0.7	-0.5	0.1	0.1	-0.4	0.4	0.6	-0.7	0.5
Ever smoked	0.3	0.5	1.3	-0.7	-0.8	-0.9	0.1	-1.1	-0.8	-0.6	1.0	-0.2	-1.0	0.2	-0.6	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.7	1.0	0.2	0.2	1.1	0.5	0.8	1.1	1.3	0.5	0.7	0.5	0.4	0.3
Blood White Count	0.2	1.6	3.2	0.4	0.5	0.7	1.8	1.7	0.7	1.4	1.8	1.1	1.8	1.8	0.8	-0.1
Hair Pigment	0.2	6.8	15.4	2.0	0.9	3.0	3.4	2.7	2.2	3.0	3.9	1.8	3.1	3.1	2.1	0.8
Medication for hormone replacement therapy	0.2	0.3	1.1	0.1	0.3	-0.0	-0.1	1.0	0.3	1.0	0.1	-0.4	1.0	-0.2	-0.3	-0.0
Vitamin and mineral supplements	0.2	0.3	2.2	-0.1	0.5	-1.5	0.2	-0.1	-0.6	0.0	0.1	0.4	0.3	-0.2	0.1	-1.0
Severe depression (siblings)	0.2	0.2	0.6	0.8	0.2	-0.7	0.2	0.4	0.6	0.6	0.4	-0.0	0.1	-0.2	0.1	0.5
Hand grip strength (right)	0.2	0.6	2.3	-0.0	1.1	1.5	0.6	0.7	0.1	0.8	0.7	-0.0	1.4	0.6	-0.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.1	-0.0	0.9	0.7	0.4	0.1	0.5	0.1	1.1	0.3	0.2	0.6	0.6	0.0
Stomach or abdominal pain in last month	0.2	0.3	1.3	1.1	0.4	-0.3	0.4	0.4	0.7	0.3	-0.2	0.1	0.9	-0.1	0.0	-0.3
Alcohol usually taken with meals	0.2	0.2	2.2	0.3	-1.5	-0.2	-0.2	0.4	0.0	0.2	-0.1	0.4	0.1	0.6	0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.3	0.4	-1.2	-1.1	-0.7	-0.1	0.4	-0.5	-1.5	0.3	-0.6	-0.7	0.0	0.3
Lung cancer (father)	0.2	0.2	0.6	0.2	0.8	0.1	0.6	0.3	-0.1	0.2	0.4	-0.1	0.6	0.3	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	4.7	-0.4	0.1	-0.5	-1.2	-0.4	-0.4	-1.0	-2.2	-0.3	-0.6	-1.0	-0.3	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.5	0.6	-0.7	-0.5	0.5	0.2	-0.1	0.0	0.1	1.2	0.0	0.7	0.9	-0.1
Blood clot in the leg (DVT)	0.2	0.3	1.0	-1.0	-0.1	0.9	-0.3	-0.0	-0.5	-0.2	0.3	-0.7	0.2	0.1	-0.5	-0.5
Gout (self-reported)	0.2	0.3	1.3	0.1	0.5	-0.9	0.2	0.7	-0.0	0.6	0.1	0.2	-0.0	-0.3	0.4	-1.2
Forced vital capacity (FVC), Best measure	0.2	0.6	1.1	1.0	0.6	1.1	0.6	0.8	0.5	0.5	0.1	0.7	1.0	0.7	0.7	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.1	0.2	-1.0	-0.2	-0.3	-0.1	0.1	0.3	-1.1	0.3	-0.0	-0.1	-0.1	0.9
Eye problems/disorders: None of the above	0.2	0.2	0.8	0.7	0.1	0.3	0.4	0.5	0.0	0.9	-0.3	0.6	0.6	0.2	0.3	-0.2
Age at last live birth	0.2	0.3	1.0	-0.8	-0.4	-0.2	-0.5	-0.9	-0.1	-1.0	-0.5	-0.4	-0.7	-0.3	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.5	0.6	-0.3	-0.4	0.4	-0.7	0.2	-0.4	-0.2	0.3	-0.2	-0.7	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.2	-0.6	-0.1	-0.0	-1.0	-0.1	-0.9	-0.5	0.2	-0.6	-0.1	0.1	0.2
Wears glasses or contact lenses	0.2	0.3	0.9	-0.5	-0.0	0.3	-0.8	-0.6	-0.4	-0.6	-0.9	-0.5	-0.5	-0.3	-0.7	0.0
High cholesterol (Self-reported)	0.2	0.4	1.7	0.4	-0.7	0.1	0.8	0.2	-0.3	0.4	1.3	0.7	0.4	0.8	0.3	-0.2
Unable to work because of sickness or disability	0.2	0.3	1.5	-0.6	-1.2	-0.9	0.2	-0.2	0.0	-0.1	0.8	-0.1	-0.2	0.1	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.0	-0.7	-0.5	1.0	-0.0	0.2	-0.2	0.1	0.4	-0.4	0.5	0.4	-0.3	-0.2
Alcohol drinker status: Previous	0.2	0.3	1.0	0.6	1.0	-0.4	0.4	0.6	0.4	0.9	0.2	-0.0	0.5	-0.2	-0.1	-0.4
Pack years of smoking	0.2	0.3	0.8	0.5	-0.9	-0.1	0.6	0.5	0.6	0.8	0.2	0.4	0.7	0.4	0.3	0.7
Ulcerative Colitis	0.1	0.2	0.5	-0.2	-0.7	-0.7	-0.3	-0.4	-0.2	-0.1	-0.2	-0.4	-0.5	-0.6	-0.5	-0.3
Hand grip strength (left)	0.1	0.3	1.1	-0.7	0.8	1.1	0.1	0.1	0.0	0.2	0.3	-0.6	0.3	-0.1	-0.5	0.4
Relative age of first facial hair	0.1	0.3	1.3	-0.9	0.3	-0.3	-0.3	-0.2	-0.4	-0.7	0.2	-0.5	-0.3	-0.3	-0.4	-1.1
Forced vital capacity (FVC)	0.1	0.2	1.4	0.4	1.2	-0.1	0.1	-0.0	-0.8	-0.4	-0.3	-0.1	0.2	-0.0	-0.1	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	-0.0	0.7	0.1	-0.5	-0.4	-0.3	-0.4	-0.3	-0.3	-0.1	-0.4	-0.2	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	0.2	-0.5	-0.6	-0.1	0.6	0.2	0.2	-0.7	0.1	0.4	-0.2	0.4	-0.1
Length of working week for main job	0.1	0.2	0.5	-0.2	0.0	0.7	0.1	-0.1	-0.3	0.0	0.6	-0.6	0.3	0.0	-0.5	-0.5
Leg fat percentage (right)	0.1	0.3	1.0	-0.3	1.0	0.7	0.1	0.9	0.3	0.7	0.1	-0.8	0.5	-0.3	-0.5	-0.2
Qualifications: College or University degree	0.1	0.3	0.8	0.8	0.7	-0.7	-0.4	0.6	0.4	0.2	-0.9	0.2	0.4	-0.1	0.2	0.9
Medication: Allopurinol	0.1	0.2	1.3	-0.4	0.0	-1.1	0.2	0.1	0.3	0.4	-0.1	0.2	-0.3	-0.5	0.2	-0.3
Leg pain on walking	0.1	0.1	0.4	-0.2	0.6	-0.1	0.3	0.2	-0.2	0.5	0.6	-0.2	0.2	0.0	-0.1	-0.6
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.9	-0.2	-0.1	0.2	0.0	0.9	0.4	0.6	0.4	-0.4	0.3	0.0	-0.2	0.2
Medication: Atorvastatin	0.1	0.1	0.4	-0.2	-0.5	0.3	0.2	-0.1	0.2	0.4	0.2	0.2	0.2	0.1	-0.6	0.6
Leg fat percentage (left)	0.1	0.4	1.6	-0.4	1.3	0.5	-0.1	0.8	0.2	0.7	0.0	-1.1	0.5	-0.6	-0.7	-0.4
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.3	-0.2	0.3	-0.3	-0.3	0.1	-0.4	0.1	0.0	-0.4	0.0	0.1	0.3
Prospective memory result	0.0	0.0	0.2	0.3	0.4	0.2	0.1	0.1	0.2	-0.0	-0.0	0.2	0.0	0.2	0.4	-0.2

Hub : Genes

PPIEL

Models

Trait associations