Best TWAS P=9.55e-12 · Best GWAS P=1.88e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ALG10 | 0.11 | 0.06 | enet | 19 | 0.06 | 4.1e-08 | -6.1 | 5.7 | 9.9e-09 | -0.60 | 0.20 | 0.80 | FALSE |
2 | GTEx | Adipose Visceral Omentum | ALG10 | 0.06 | 0.04 | lasso | 6 | 0.02 | 3.5e-02 | -6.4 | 6.8 | 9.6e-12 | -0.95 | 0.08 | 0.87 | TRUE |
3 | GTEx | Brain Nucleus accumbens basal ganglia | ALG10 | 0.25 | 0.10 | lasso | 4 | 0.21 | 2.1e-06 | 3.7 | 6.1 | 8.9e-10 | -0.69 | 0.17 | 0.32 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ALG10 | 0.05 | 0.04 | lasso | 2 | 0.04 | 5.6e-04 | -6.0 | 6.2 | 5.8e-10 | -0.84 | 0.39 | 0.57 | FALSE |
5 | GTEx | Nerve Tibial | ALG10 | 0.08 | 0.04 | lasso | 8 | 0.04 | 9.7e-04 | -6.0 | 6.3 | 3.0e-10 | -0.78 | 0.11 | 0.81 | FALSE |
6 | METSIM | Adipose | ALG10 | 0.05 | 0.04 | blup | 224 | 0.05 | 4.2e-08 | -6.7 | 6.5 | 9.3e-11 | -0.85 | 0.07 | 0.93 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ALG10 | 0.02 | 0.02 | enet | 3 | 0.02 | 8.0e-05 | -6.0 | 5.7 | 1.6e-08 | -0.74 | 0.01 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ALG10 | 0.07 | 0.07 | blup | 26 | 0.07 | 1.1e-08 | -6.0 | 6.2 | 4.8e-10 | -0.82 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ALG10 | 0.11 | 0.06 | enet | 8 | 0.08 | 4.1e-05 | -5.8 | 6.1 | 1.3e-09 | -0.79 | 0.01 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ALG10 | 0.05 | 0.05 | blup | 26 | 0.06 | 2.3e-07 | -5.8 | 5.6 | 2.1e-08 | -0.67 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ALG10 | 0.12 | -0.01 | blup | 26 | 0.02 | 8.9e-02 | -6.0 | 5.4 | 7.6e-08 | -0.76 | 0.00 | 0.74 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | ALG10 | 0.13 | 0.04 | lasso | 1 | 0.04 | 1.4e-04 | -5.8 | 5.8 | 6.2e-09 | -0.81 | 0.01 | 0.98 | FALSE |