Best TWAS P=8.09e-25 · Best GWAS P=7.82e-45 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Uterus | ATP5G2 | 0.47 | 0.35 | enet | 34 | 0.38 | 8.5e-09 | -2.95 | -6.3 | 3.2e-10 | -0.34 | 0.49 | 0.18 | TRUE |
2 | GTEx | Whole Blood | HNRNPA1 | 0.10 | 0.00 | enet | 24 | 0.00 | 1.1e-01 | -0.55 | 7.5 | 7.5e-14 | 0.28 | 0.06 | 0.04 | TRUE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ12825 | 0.32 | 0.29 | lasso | 5 | 0.32 | 1.7e-67 | 6.22 | 6.3 | 2.6e-10 | 0.09 | 1.00 | 0.00 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HOTAIR | 0.02 | 0.03 | lasso | 5 | 0.03 | 3.2e-06 | 4.40 | 5.5 | 3.8e-08 | 0.58 | 0.74 | 0.20 | TRUE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC100240734 | 0.05 | 0.05 | enet | 9 | 0.05 | 8.4e-11 | -6.08 | -6.1 | 1.1e-09 | -0.08 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FLJ12825 | 0.35 | 0.21 | lasso | 5 | 0.26 | 5.5e-13 | 6.22 | 5.9 | 3.0e-09 | 0.08 | 1.00 | 0.00 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | FLJ12825 | 0.26 | 0.13 | lasso | 5 | 0.19 | 2.9e-11 | 6.34 | 5.6 | 2.5e-08 | 0.07 | 0.99 | 0.00 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | SMUG1 | 0.05 | 0.03 | lasso | 3 | 0.05 | 7.2e-04 | -2.57 | -5.4 | 7.8e-08 | -0.06 | 0.01 | 0.85 | FALSE |
9 | The Cancer Genome Atlas | Esophageal Carcinoma | FLJ12825 | 0.12 | 0.05 | blup | 59 | 0.02 | 6.9e-02 | -3.76 | 6.4 | 1.4e-10 | 0.10 | 0.03 | 0.13 | FALSE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ12825 | 0.35 | 0.27 | lasso | 5 | 0.29 | 7.4e-33 | 6.22 | 5.2 | 1.8e-07 | 0.08 | 1.00 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FLJ12825 | 0.54 | 0.56 | enet | 12 | 0.57 | 2.5e-78 | 6.22 | 6.1 | 9.9e-10 | 0.10 | 1.00 | 0.00 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOTAIR | 0.08 | 0.13 | enet | 12 | 0.13 | 1.1e-14 | 4.96 | 6.8 | 1.1e-11 | 0.60 | 1.00 | 0.00 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC6 | 0.03 | 0.02 | blup | 50 | 0.03 | 3.9e-04 | 7.79 | -7.4 | 1.3e-13 | 0.10 | 0.04 | 0.80 | TRUE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC8 | 0.03 | 0.05 | enet | 5 | 0.04 | 2.4e-05 | 7.79 | -8.7 | 4.3e-18 | 0.03 | 0.02 | 0.95 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC100240734 | 0.11 | 0.10 | lasso | 4 | 0.09 | 4.2e-10 | -6.08 | -6.1 | 1.2e-09 | -0.08 | 0.01 | 0.99 | TRUE |
16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FLJ12825 | 0.52 | 0.36 | lasso | 4 | 0.37 | 2.1e-22 | 6.22 | 6.6 | 4.3e-11 | 0.10 | 1.00 | 0.00 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC400043 | 0.05 | 0.05 | lasso | 3 | 0.04 | 4.1e-05 | 5.11 | 5.8 | 7.2e-09 | 0.06 | 0.09 | 0.85 | FALSE |
18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLJ12825 | 0.25 | 0.09 | lasso | 4 | 0.12 | 1.6e-05 | -6.17 | 5.8 | 8.2e-09 | 0.08 | 0.44 | 0.04 | FALSE |
19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FLJ12825 | 0.35 | 0.23 | lasso | 2 | 0.21 | 8.8e-09 | 6.22 | 6.7 | 2.0e-11 | 0.10 | 0.97 | 0.00 | FALSE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HOTAIR | 0.10 | 0.12 | lasso | 3 | 0.11 | 1.8e-11 | 4.40 | 5.5 | 3.4e-08 | 0.45 | 1.00 | 0.00 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HOXC11 | 0.09 | 0.04 | lasso | 2 | 0.03 | 9.3e-04 | -9.99 | 10.3 | 8.1e-25 | -0.09 | 0.27 | 0.05 | TRUE |
22 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FLJ12825 | 0.19 | 0.06 | enet | 7 | 0.11 | 3.9e-07 | 6.09 | 7.6 | 3.4e-14 | 0.11 | 0.98 | 0.00 | TRUE |
23 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | HOXC10 | 0.33 | 0.02 | blup | 56 | 0.06 | 8.2e-03 | -6.65 | -7.5 | 7.7e-14 | -0.38 | 0.01 | 0.06 | FALSE |
24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FLJ12825 | 0.18 | 0.11 | lasso | 3 | 0.16 | 1.4e-11 | -2.57 | 5.2 | 2.3e-07 | 0.07 | 1.00 | 0.00 | TRUE |
25 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FLJ12825 | 0.15 | 0.02 | lasso | 5 | 0.06 | 8.9e-03 | 7.78 | 8.8 | 1.5e-18 | -0.04 | 0.02 | 0.28 | TRUE |