Best TWAS P=2.63e-14 · Best GWAS P=5.4e-14 conditioned to 0.256
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | AL132989.1 | 0.10 | 0.06 | enet | 13 | 0.05 | 4.6e-05 | 6.7 | 5.8 | 4.9e-09 | 0.83 | 0.07 | 0.93 | FALSE |
2 | GTEx | Artery Tibial | AL132989.1 | 0.05 | 0.05 | lasso | 1 | 0.01 | 2.4e-02 | 6.7 | 6.7 | 2.4e-11 | 0.95 | 0.11 | 0.86 | FALSE |
3 | GTEx | Breast Mammary Tissue | AL132989.1 | 0.10 | 0.10 | lasso | 4 | 0.10 | 8.7e-06 | 6.6 | 5.6 | 1.7e-08 | 0.86 | 0.09 | 0.86 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | AL132989.1 | 0.31 | 0.08 | lasso | 4 | 0.10 | 4.1e-04 | 6.6 | 7.1 | 1.4e-12 | 0.90 | 0.14 | 0.78 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | AL132989.1 | 0.07 | 0.03 | enet | 8 | 0.04 | 9.6e-04 | 6.7 | 7.0 | 1.9e-12 | 0.93 | 0.02 | 0.97 | FALSE |
6 | GTEx | Esophagus Mucosa | AL132989.1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 5.6e-04 | 7.5 | 7.6 | 2.6e-14 | 0.93 | 0.01 | 0.99 | TRUE |
7 | GTEx | Esophagus Muscularis | AL132989.1 | 0.08 | 0.09 | lasso | 3 | 0.07 | 3.6e-05 | 6.0 | 6.2 | 6.2e-10 | 0.92 | 0.02 | 0.98 | FALSE |
8 | GTEx | Muscle Skeletal | CTD-2002H8.2 | 0.09 | 0.05 | lasso | 4 | 0.02 | 1.7e-03 | 6.9 | 6.8 | 1.1e-11 | 0.74 | 0.10 | 0.80 | FALSE |
9 | GTEx | Nerve Tibial | AL132989.1 | 0.19 | 0.16 | lasso | 5 | 0.15 | 1.6e-10 | 6.6 | 6.5 | 8.1e-11 | 0.94 | 0.16 | 0.84 | FALSE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | C14orf37 | 0.15 | 0.00 | enet | 19 | 0.00 | 2.0e-01 | 6.6 | -5.4 | 7.3e-08 | -0.70 | 0.03 | 0.81 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | AL132989.1 | 0.10 | 0.07 | enet | 18 | 0.07 | 2.4e-06 | 6.6 | 5.8 | 4.8e-09 | 0.80 | 0.02 | 0.98 | FALSE |
12 | GTEx | Testis | AL132989.1 | 0.12 | 0.07 | enet | 10 | 0.08 | 2.9e-04 | 6.3 | 6.6 | 3.4e-11 | 0.94 | 0.03 | 0.96 | FALSE |
13 | GTEx | Thyroid | AL132989.1 | 0.10 | 0.06 | lasso | 4 | 0.05 | 6.3e-05 | 6.0 | 6.2 | 7.0e-10 | 0.94 | 0.02 | 0.98 | FALSE |
14 | YFS | Blood | ARID4A | 0.12 | 0.15 | lasso | 5 | 0.15 | 2.9e-45 | 6.5 | 6.7 | 2.5e-11 | 0.72 | 0.62 | 0.38 | FALSE |
15 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C14orf37 | 0.04 | 0.00 | blup | 167 | 0.02 | 6.9e-03 | 6.3 | -5.5 | 4.0e-08 | -0.76 | 0.03 | 0.68 | FALSE |