Best TWAS P=4.1e-08 · Best GWAS P=1.19e-08 conditioned to 0.0735
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | PCNX | 0.09 | 0.04 | lasso | 2 | 0.03 | 9.9e-03 | -5.5 | 5.5 | 4.1e-08 | -0.89 | 0.01 | 0.96 | TRUE |
| 2 | GTEx | Artery Aorta | PCNX | 0.26 | 0.32 | enet | 32 | 0.29 | 3.7e-16 | -4.6 | 5.2 | 1.9e-07 | -0.76 | 0.25 | 0.74 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | PCNX | 0.22 | 0.12 | lasso | 7 | 0.13 | 6.8e-04 | -5.5 | 5.5 | 5.0e-08 | -0.87 | 0.02 | 0.90 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | PCNX | 0.11 | 0.11 | lasso | 3 | 0.07 | 1.3e-02 | -5.5 | 5.5 | 4.2e-08 | -0.85 | 0.03 | 0.71 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | PCNX | 0.18 | 0.18 | lasso | 4 | 0.19 | 1.7e-10 | -4.6 | 5.2 | 2.3e-07 | -0.83 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Testis | PCNX | 0.14 | 0.09 | enet | 12 | 0.07 | 3.2e-04 | -4.5 | 5.2 | 2.4e-07 | -0.81 | 0.02 | 0.98 | FALSE |
| 7 | METSIM | Adipose | PCNX | 0.13 | 0.11 | blup | 440 | 0.11 | 2.5e-16 | -4.2 | 5.2 | 1.8e-07 | -0.74 | 0.57 | 0.42 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCNX | 0.03 | 0.02 | blup | 92 | 0.03 | 4.9e-04 | -5.0 | 5.4 | 6.3e-08 | -0.90 | 0.05 | 0.93 | FALSE |