Best TWAS P=1.12e-28 · Best GWAS P=7.08e-29 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | 11.2 | -11.1 | 1.1e-28 | -0.99 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Colon Sigmoid | RPS6KA5 | 0.16 | 0.09 | lasso | 5 | 0.08 | 7.1e-04 | 8.5 | 8.6 | 1.1e-17 | 0.72 | 0.23 | 0.42 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | C14orf159 | 0.18 | 0.10 | lasso | 4 | 0.06 | 1.6e-03 | 5.7 | 6.5 | 7.7e-11 | 0.51 | 0.08 | 0.79 | FALSE |
| 4 | GTEx | Heart Left Ventricle | RPS6KA5 | 0.13 | 0.00 | enet | 38 | 0.02 | 2.2e-02 | 5.8 | 6.5 | 1.1e-10 | 0.57 | 0.03 | 0.74 | FALSE |
| 5 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | 7.5 | -7.7 | 1.8e-14 | -0.76 | 0.09 | 0.31 | FALSE |
| 6 | METSIM | Adipose | C14orf159 | 0.04 | 0.00 | blup | 464 | 0.01 | 4.0e-03 | 5.9 | -7.8 | 9.1e-15 | -0.69 | 0.04 | 0.86 | FALSE |