Best TWAS P=4.2e-11 · Best GWAS P=6.86e-11 conditioned to 0.026
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | HERC1 | 0.13 | 0.02 | lasso | 4 | 0.02 | 3.5e-02 | 4.7 | 6.3 | 2.8e-10 | 0.81 | 0.04 | 0.88 | FALSE |
| 2 | GTEx | Testis | USP3-AS1 | 0.31 | 0.27 | lasso | 4 | 0.30 | 1.3e-13 | 5.1 | -6.0 | 2.5e-09 | -0.79 | 0.50 | 0.50 | FALSE |
| 3 | METSIM | Adipose | HERC1 | 0.07 | 0.06 | lasso | 6 | 0.06 | 7.2e-10 | 4.9 | 5.1 | 3.1e-07 | 0.67 | 0.79 | 0.20 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HERC1 | 0.02 | 0.01 | blup | 99 | 0.02 | 3.6e-05 | -2.8 | 5.4 | 7.2e-08 | 0.86 | 0.18 | 0.64 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | HERC1 | 0.07 | 0.05 | lasso | 2 | 0.03 | 4.6e-03 | 6.2 | 6.6 | 4.2e-11 | 0.78 | 0.01 | 0.93 | TRUE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HERC1 | 0.03 | 0.01 | blup | 99 | 0.01 | 2.1e-02 | 5.2 | 6.1 | 8.9e-10 | 0.82 | 0.18 | 0.40 | FALSE |