Best TWAS P=8.67e-11 · Best GWAS P=1.57e-12 conditioned to 0.00194
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AAGAB | 0.06 | 0.05 | enet | 11 | 0.05 | 3.2e-07 | -5.0 | -5.9 | 4.2e-09 | 0.87 | 0.03 | 0.97 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | IQCH | 0.13 | 0.11 | bslmm | 597 | 0.10 | 5.9e-12 | -6.9 | 6.5 | 8.7e-11 | -0.81 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Brain Cerebellum | MAP2K5 | 0.27 | 0.12 | lasso | 5 | 0.14 | 7.9e-05 | -6.8 | 5.3 | 1.4e-07 | -0.85 | 0.03 | 0.93 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IQCH | 0.13 | 0.07 | blup | 112 | 0.10 | 5.2e-09 | -2.7 | 5.6 | 2.1e-08 | -0.68 | 0.07 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQCH | 0.06 | 0.05 | blup | 112 | 0.06 | 5.2e-12 | -6.8 | 5.8 | 5.2e-09 | -0.83 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IQCH | 0.35 | 0.04 | blup | 112 | 0.12 | 1.5e-05 | -2.7 | 5.8 | 7.2e-09 | -0.71 | 0.05 | 0.90 | FALSE |