Best TWAS P=2.22e-19 · Best GWAS P=2.43e-17 conditioned to 0.185
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MNS1 | 0.05 | 0.02 | blup | 303 | 0.02 | 5.8e-04 | 8.2 | -8.3 | 9.9e-17 | -0.81 | 0.02 | 0.96 | FALSE |
2 | GTEx | Adrenal Gland | TEX9 | 0.22 | 0.09 | lasso | 14 | 0.16 | 2.0e-06 | 7.9 | -9.0 | 2.6e-19 | -0.93 | 0.02 | 0.98 | FALSE |
3 | GTEx | Esophagus Mucosa | TEX9 | 0.07 | 0.03 | lasso | 4 | 0.03 | 3.9e-03 | 8.1 | -9.0 | 2.2e-19 | -0.87 | 0.04 | 0.88 | TRUE |
4 | GTEx | Nerve Tibial | TEX9 | 0.13 | 0.00 | lasso | 10 | 0.00 | 6.8e-01 | 8.4 | -7.9 | 3.9e-15 | -0.95 | 0.02 | 0.90 | FALSE |
5 | GTEx | Ovary | TEX9 | 0.19 | -0.01 | enet | 25 | 0.01 | 2.3e-01 | 8.2 | -7.3 | 3.4e-13 | -0.73 | 0.04 | 0.66 | FALSE |
6 | GTEx | Pancreas | TEX9 | 0.20 | 0.09 | lasso | 11 | 0.08 | 1.9e-04 | 8.4 | -8.3 | 1.4e-16 | -0.85 | 0.02 | 0.96 | FALSE |
7 | GTEx | Pituitary | TEX9 | 0.36 | 0.19 | lasso | 4 | 0.35 | 9.2e-10 | 8.0 | -6.4 | 1.4e-10 | -0.73 | 0.04 | 0.96 | FALSE |
8 | GTEx | Thyroid | TEX9 | 0.11 | 0.05 | enet | 17 | 0.04 | 2.9e-04 | 8.4 | -7.6 | 3.7e-14 | -0.90 | 0.01 | 0.99 | FALSE |
9 | YFS | Blood | RFX7 | 0.07 | 0.02 | bslmm | 414 | 0.03 | 2.7e-11 | -3.1 | -7.1 | 9.6e-13 | -0.72 | 0.12 | 0.88 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TEX9 | 0.09 | 0.07 | lasso | 3 | 0.06 | 2.5e-07 | 8.0 | -7.7 | 1.5e-14 | -0.83 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TEX9 | 0.04 | 0.00 | lasso | 3 | 0.01 | 1.0e-02 | -4.9 | -7.2 | 6.0e-13 | -0.49 | 0.03 | 0.45 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TEX9 | 0.09 | 0.03 | enet | 5 | 0.07 | 2.0e-07 | -2.0 | -5.9 | 4.0e-09 | -0.67 | 0.04 | 0.95 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | TEX9 | 0.22 | 0.12 | lasso | 2 | 0.15 | 2.1e-14 | -1.7 | -5.3 | 1.3e-07 | -0.62 | 0.42 | 0.57 | FALSE |