Best TWAS P=5.35e-13 · Best GWAS P=1.96e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | DOT1L | 0.09 | 0.06 | lasso | 5 | 0.05 | 7.3e-05 | -6.9 | -7.0 | 1.7e-12 | -0.90 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Esophagus Muscularis | DOT1L | 0.12 | 0.03 | lasso | 5 | 0.05 | 6.3e-04 | -6.9 | -6.6 | 3.6e-11 | -0.83 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Nerve Tibial | IZUMO4 | 0.23 | 0.07 | lasso | 6 | 0.14 | 1.9e-10 | 3.6 | 5.8 | 7.5e-09 | 0.70 | 0.04 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOT1L | 0.08 | 0.12 | enet | 8 | 0.10 | 2.5e-11 | -6.9 | -7.2 | 5.4e-13 | -0.98 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOT1L | 0.09 | 0.08 | blup | 60 | 0.07 | 4.1e-04 | 6.3 | -6.5 | 6.6e-11 | -0.88 | 0.02 | 0.94 | FALSE |