Best TWAS P=1.91e-11 · Best GWAS P=2.01e-08 conditioned to 0.557
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | SSC5D | 0.41 | 0.10 | enet | 30 | 0.26 | 1.2e-19 | -3.2 | 6.7 | 1.9e-11 | 0.78 | 0.02 | 0.98 | TRUE |
2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SSC5D | 0.11 | 0.05 | blup | 47 | 0.07 | 3.3e-06 | -3.2 | 5.4 | 8.0e-08 | 0.71 | 0.01 | 0.98 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SSC5D | 0.08 | 0.05 | blup | 47 | 0.10 | 1.8e-19 | 5.6 | 6.4 | 1.7e-10 | 0.77 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | SSC5D | 0.18 | 0.11 | enet | 11 | 0.10 | 3.4e-06 | 5.6 | 5.9 | 3.5e-09 | 0.90 | 0.00 | 1.00 | FALSE |
5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SSC5D | 0.11 | 0.07 | enet | 13 | 0.08 | 4.3e-09 | 5.1 | 5.2 | 2.4e-07 | 0.80 | 0.02 | 0.98 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NAT14 | 0.06 | 0.05 | enet | 10 | 0.07 | 3.9e-08 | -2.9 | 5.3 | 1.3e-07 | 0.63 | 0.02 | 0.97 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | SSC5D | 0.06 | 0.04 | enet | 6 | 0.03 | 4.7e-04 | 5.6 | 5.8 | 7.1e-09 | 0.95 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SSC5D | 0.05 | 0.02 | blup | 44 | 0.02 | 1.0e-03 | 5.1 | 6.3 | 3.2e-10 | 0.79 | 0.00 | 0.95 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SSC5D | 0.20 | 0.19 | enet | 9 | 0.19 | 2.2e-19 | 5.6 | 5.9 | 3.4e-09 | 0.94 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SSC5D | 0.17 | 0.08 | enet | 19 | 0.13 | 1.2e-09 | 5.6 | 5.3 | 1.1e-07 | 0.75 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | NAT14 | 0.07 | 0.08 | lasso | 1 | 0.07 | 2.5e-07 | 5.6 | 5.6 | 2.0e-08 | 1.00 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | SSC5D | 0.07 | 0.07 | lasso | 1 | 0.06 | 2.6e-06 | 5.6 | 5.6 | 2.0e-08 | 1.00 | 0.00 | 1.00 | FALSE |