Best TWAS P=1.98e-09 · Best GWAS P=2.41e-09 conditioned to 0.344
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | RASIP1 | 0.19 | 0.14 | lasso | 6 | 0.20 | 6.1e-15 | 5.1 | 5.8 | 8.0e-09 | 0.92 | 0.03 | 0.97 | FALSE |
2 | GTEx | Esophagus Mucosa | RASIP1 | 0.13 | 0.13 | lasso | 4 | 0.13 | 9.0e-09 | -5.2 | 5.3 | 9.4e-08 | 0.92 | 0.04 | 0.96 | FALSE |
3 | GTEx | Skin Not Sun Exposed Suprapubic | RASIP1 | 0.15 | 0.04 | lasso | 6 | 0.08 | 2.9e-05 | 5.9 | 5.3 | 1.5e-07 | 0.87 | 0.01 | 0.98 | FALSE |
4 | GTEx | Skin Not Sun Exposed Suprapubic | NTN5 | 0.19 | 0.07 | lasso | 5 | 0.08 | 2.5e-05 | 4.8 | 5.5 | 4.9e-08 | 0.89 | 0.06 | 0.93 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | RASIP1 | 0.21 | 0.13 | enet | 19 | 0.17 | 1.1e-13 | -5.2 | 5.3 | 1.2e-07 | 0.92 | 0.02 | 0.98 | FALSE |
6 | GTEx | Testis | RASIP1 | 0.29 | 0.20 | lasso | 8 | 0.30 | 7.5e-14 | -5.3 | 5.8 | 5.7e-09 | 0.96 | 0.02 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FUT2 | 0.05 | 0.01 | blup | 52 | 0.01 | 6.1e-02 | 6.0 | -6.0 | 2.0e-09 | -0.94 | 0.00 | 0.86 | TRUE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FUT2 | 0.03 | 0.05 | blup | 54 | 0.05 | 1.9e-10 | 5.1 | -5.2 | 2.5e-07 | -0.85 | 0.18 | 0.82 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RASIP1 | 0.02 | 0.02 | blup | 56 | 0.03 | 3.8e-07 | 4.9 | 5.5 | 5.1e-08 | 0.92 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | SEC1 | 0.05 | 0.04 | enet | 11 | 0.01 | 8.5e-02 | 4.7 | -5.5 | 5.2e-08 | -0.73 | 0.02 | 0.75 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FUT2 | 0.11 | 0.22 | blup | 52 | 0.22 | 6.3e-24 | 5.1 | -5.3 | 1.3e-07 | -0.86 | 0.23 | 0.77 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FUT2 | 0.10 | 0.01 | blup | 51 | 0.05 | 9.8e-04 | 4.7 | -5.8 | 8.6e-09 | -0.82 | 0.03 | 0.81 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | NTN5 | 0.11 | 0.02 | blup | 41 | 0.07 | 1.2e-04 | -3.5 | 5.7 | 9.3e-09 | 0.73 | 0.02 | 0.70 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SEC1 | 0.16 | 0.11 | lasso | 4 | 0.11 | 2.1e-12 | -4.9 | 5.5 | 4.2e-08 | 0.51 | 0.04 | 0.96 | FALSE |
15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | IZUMO1 | 0.16 | 0.17 | lasso | 7 | 0.15 | 1.4e-06 | -5.1 | 5.2 | 2.0e-07 | 0.85 | 0.13 | 0.86 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FUT2 | 0.05 | 0.06 | blup | 52 | 0.06 | 8.6e-07 | 5.1 | -5.6 | 2.2e-08 | -0.91 | 0.04 | 0.96 | FALSE |
17 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FUT2 | 0.26 | 0.28 | lasso | 10 | 0.22 | 5.2e-06 | 4.9 | -5.3 | 1.5e-07 | -0.86 | 0.08 | 0.86 | FALSE |
18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FUT2 | 0.22 | 0.09 | lasso | 8 | 0.13 | 3.0e-05 | -3.6 | -5.3 | 1.4e-07 | -0.72 | 0.09 | 0.87 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | FUT2 | 0.06 | 0.04 | blup | 54 | 0.06 | 1.1e-06 | -4.4 | -5.6 | 2.0e-08 | -0.88 | 0.03 | 0.97 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | NTN5 | 0.11 | 0.07 | blup | 43 | 0.09 | 2.6e-09 | 4.7 | 5.6 | 1.9e-08 | 0.75 | 0.03 | 0.96 | FALSE |