Best TWAS P=3.68e-19 · Best GWAS P=4.08e-22 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EDEM2 | 0.09 | 0.09 | enet | 12 | 0.09 | 5.8e-11 | -6.90 | 7.1 | 1.8e-12 | -0.32 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | UQCC | 0.07 | 0.04 | lasso | 2 | 0.05 | 1.4e-06 | -8.00 | 8.9 | 3.7e-19 | -0.88 | 0.15 | 0.85 | TRUE |
3 | GTEx | Adipose Subcutaneous | EDEM2 | 0.10 | 0.07 | lasso | 9 | 0.07 | 2.1e-06 | -7.00 | 7.0 | 3.3e-12 | -0.31 | 0.99 | 0.00 | FALSE |
4 | GTEx | Adipose Subcutaneous | TRPC4AP | 0.06 | 0.01 | lasso | 6 | 0.01 | 3.8e-02 | 4.21 | 5.2 | 2.2e-07 | -0.37 | 0.24 | 0.03 | FALSE |
5 | GTEx | Adipose Subcutaneous | PROCR | 0.13 | 0.05 | enet | 4 | 0.05 | 8.2e-05 | -7.00 | 7.3 | 2.2e-13 | -0.32 | 0.93 | 0.00 | TRUE |
6 | GTEx | Adipose Subcutaneous | UQCC1 | 0.09 | 0.12 | lasso | 2 | 0.11 | 4.5e-09 | -7.71 | 7.9 | 3.6e-15 | -0.90 | 0.96 | 0.04 | FALSE |
7 | GTEx | Adipose Visceral Omentum | UQCC1 | 0.15 | 0.08 | lasso | 7 | 0.07 | 1.6e-04 | -7.71 | 7.4 | 1.7e-13 | -0.87 | 0.48 | 0.37 | FALSE |
8 | GTEx | Adrenal Gland | MMP24-AS1 | 0.18 | 0.04 | enet | 10 | 0.13 | 2.2e-05 | -6.45 | 6.0 | 1.5e-09 | -0.74 | 0.22 | 0.21 | FALSE |
9 | GTEx | Artery Aorta | EDEM2 | 0.13 | 0.08 | enet | 10 | 0.07 | 6.3e-05 | -4.41 | 6.6 | 3.9e-11 | -0.37 | 0.84 | 0.06 | FALSE |
10 | GTEx | Artery Tibial | EDEM2 | 0.14 | 0.10 | lasso | 6 | 0.08 | 1.1e-06 | -7.00 | 6.2 | 6.4e-10 | -0.23 | 1.00 | 0.00 | FALSE |
11 | GTEx | Brain Cerebellar Hemisphere | MYH7B | 0.18 | 0.10 | lasso | 5 | 0.08 | 3.7e-03 | -4.26 | -5.4 | 7.8e-08 | 0.26 | 0.47 | 0.07 | FALSE |
12 | GTEx | Brain Cerebellum | GSS | 0.19 | 0.12 | enet | 15 | 0.19 | 2.9e-06 | -4.32 | -5.5 | 4.9e-08 | 0.33 | 0.28 | 0.16 | FALSE |
13 | GTEx | Brain Frontal Cortex BA9 | UQCC1 | 0.16 | 0.07 | lasso | 3 | 0.08 | 3.7e-03 | -8.00 | 6.2 | 5.6e-10 | -0.80 | 0.08 | 0.38 | FALSE |
14 | GTEx | Breast Mammary Tissue | UQCC1 | 0.10 | 0.06 | lasso | 8 | 0.08 | 5.3e-05 | 1.40 | 6.0 | 2.1e-09 | -0.66 | 0.45 | 0.30 | FALSE |
15 | GTEx | Breast Mammary Tissue (Male) | UQCC1 | 0.06 | 0.04 | lasso | 1 | 0.02 | 1.4e-01 | -7.77 | 7.8 | 7.8e-15 | -0.90 | 0.04 | 0.13 | FALSE |
16 | GTEx | Cells EBV-transformed lymphocytes | EDEM2 | 0.15 | 0.17 | lasso | 4 | 0.15 | 1.3e-05 | -6.90 | 6.9 | 5.4e-12 | -0.27 | 0.48 | 0.03 | FALSE |
17 | GTEx | Cells EBV-transformed lymphocytes | PROCR | 0.19 | 0.05 | enet | 25 | 0.09 | 7.3e-04 | -0.76 | -5.2 | 2.4e-07 | 0.58 | 0.09 | 0.23 | FALSE |
18 | GTEx | Cells EBV-transformed lymphocytes | NCOA6 | 0.11 | 0.06 | enet | 15 | 0.06 | 3.9e-03 | -4.10 | 5.4 | 5.9e-08 | -0.31 | 0.17 | 0.35 | FALSE |
19 | GTEx | Cells Transformed fibroblasts | EDEM2 | 0.08 | 0.02 | lasso | 5 | 0.03 | 1.8e-03 | -4.26 | 7.8 | 6.3e-15 | -0.67 | 0.41 | 0.16 | FALSE |
20 | GTEx | Cells Transformed fibroblasts | UQCC1 | 0.23 | 0.24 | lasso | 8 | 0.25 | 9.4e-19 | -7.74 | 7.6 | 3.5e-14 | -0.88 | 1.00 | 0.00 | TRUE |
21 | GTEx | Colon Transverse | UQCC1 | 0.11 | 0.01 | lasso | 4 | 0.01 | 1.0e-01 | -8.19 | 7.5 | 9.1e-14 | -0.48 | 0.08 | 0.09 | FALSE |
22 | GTEx | Esophagus Mucosa | UQCC1 | 0.13 | 0.10 | enet | 10 | 0.07 | 1.1e-05 | -7.77 | 8.2 | 2.8e-16 | -0.89 | 0.45 | 0.54 | FALSE |
23 | GTEx | Esophagus Mucosa | CEP250 | 0.29 | 0.00 | lasso | 9 | 0.00 | 5.3e-01 | -0.61 | -5.9 | 4.7e-09 | 0.61 | 0.06 | 0.27 | FALSE |
24 | GTEx | Heart Left Ventricle | PROCR | 0.10 | 0.04 | enet | 8 | 0.05 | 1.6e-03 | -7.00 | 6.3 | 3.5e-10 | -0.24 | 0.26 | 0.07 | FALSE |
25 | GTEx | Lung | UQCC1 | 0.13 | 0.08 | lasso | 5 | 0.06 | 1.0e-05 | -7.71 | 7.9 | 2.7e-15 | -0.90 | 0.46 | 0.54 | FALSE |
26 | GTEx | Muscle Skeletal | UQCC1 | 0.10 | 0.04 | enet | 19 | 0.05 | 1.3e-05 | -6.78 | 7.1 | 1.0e-12 | -0.79 | 0.64 | 0.34 | FALSE |
27 | GTEx | Muscle Skeletal | CEP250 | 0.09 | 0.04 | lasso | 9 | 0.07 | 3.6e-07 | -3.56 | 5.3 | 9.8e-08 | -0.79 | 0.98 | 0.01 | FALSE |
28 | GTEx | Muscle Skeletal | ACSS2 | 0.04 | 0.04 | enet | 12 | 0.04 | 3.1e-05 | -3.46 | -5.1 | 3.1e-07 | 0.29 | 0.82 | 0.02 | FALSE |
29 | GTEx | Nerve Tibial | MYH7B | 0.21 | 0.12 | lasso | 8 | 0.12 | 9.7e-09 | -4.26 | -6.2 | 6.2e-10 | 0.33 | 1.00 | 0.00 | FALSE |
30 | GTEx | Nerve Tibial | EDEM2 | 0.21 | 0.19 | enet | 29 | 0.17 | 4.9e-12 | -7.34 | 6.4 | 1.9e-10 | -0.29 | 1.00 | 0.00 | FALSE |
31 | GTEx | Nerve Tibial | UQCC1 | 0.07 | 0.04 | enet | 6 | 0.03 | 2.7e-03 | -7.73 | 7.7 | 1.6e-14 | -0.88 | 0.23 | 0.73 | FALSE |
32 | GTEx | Nerve Tibial | MMP24-AS1 | 0.32 | 0.02 | enet | 49 | 0.13 | 1.3e-09 | -0.54 | -5.4 | 8.3e-08 | 0.38 | 0.04 | 0.07 | FALSE |
33 | GTEx | Pancreas | MYH7B | 0.24 | 0.00 | enet | 17 | 0.04 | 1.0e-02 | -2.19 | -6.4 | 1.6e-10 | 0.44 | 0.08 | 0.09 | FALSE |
34 | GTEx | Pancreas | EDEM2 | 0.20 | 0.23 | lasso | 8 | 0.23 | 3.5e-10 | -7.00 | -7.0 | 3.6e-12 | 0.36 | 1.00 | 0.00 | FALSE |
35 | GTEx | Pancreas | PROCR | 0.40 | 0.13 | lasso | 13 | 0.18 | 5.4e-08 | -6.60 | -6.4 | 1.7e-10 | 0.32 | 0.98 | 0.00 | FALSE |
36 | GTEx | Skin Sun Exposed Lower leg | UQCC1 | 0.19 | 0.13 | enet | 16 | 0.10 | 8.1e-09 | -7.73 | 7.8 | 8.0e-15 | -0.84 | 1.00 | 0.00 | FALSE |
37 | GTEx | Spleen | PROCR | 0.35 | 0.31 | lasso | 6 | 0.29 | 4.8e-08 | -7.00 | -6.8 | 7.5e-12 | 0.30 | 0.74 | 0.02 | FALSE |
38 | GTEx | Stomach | UQCC1 | 0.09 | 0.14 | lasso | 2 | 0.15 | 1.9e-07 | -7.71 | 7.5 | 4.8e-14 | -0.86 | 0.46 | 0.39 | FALSE |
39 | GTEx | Thyroid | MYH7B | 0.06 | 0.03 | enet | 15 | 0.06 | 3.6e-05 | -3.78 | -6.7 | 2.2e-11 | 0.40 | 0.85 | 0.02 | FALSE |
40 | GTEx | Thyroid | RP4-614O4.12 | 0.08 | 0.08 | lasso | 5 | 0.07 | 6.8e-06 | 4.27 | 6.0 | 2.5e-09 | -0.44 | 0.97 | 0.00 | FALSE |
41 | METSIM | Adipose | EDEM2 | 0.04 | 0.05 | lasso | 2 | 0.04 | 3.9e-07 | -7.00 | 7.0 | 2.6e-12 | -0.30 | 1.00 | 0.00 | FALSE |
42 | METSIM | Adipose | UQCC1 | 0.09 | 0.04 | enet | 18 | 0.05 | 1.5e-07 | -7.72 | 7.8 | 9.2e-15 | -0.90 | 0.14 | 0.86 | FALSE |
43 | NTR | Blood | UQCC | 0.01 | 0.01 | enet | 6 | 0.00 | 1.6e-02 | -7.72 | 7.9 | 2.9e-15 | -0.89 | 0.08 | 0.78 | FALSE |
44 | ROSMAP | Brain Pre-frontal Cortex | EDEM2 | 0.10 | 0.08 | lasso | 5 | 0.07 | 2.0e-09 | -6.90 | 6.9 | 7.1e-12 | -0.31 | 1.00 | 0.00 | FALSE |
45 | ROSMAP | Brain Pre-frontal Cortex | UQCC1 | 0.05 | 0.05 | lasso | 5 | 0.06 | 1.7e-08 | -7.78 | 7.3 | 3.0e-13 | -0.84 | 0.21 | 0.79 | FALSE |
46 | ROSMAP | Brain Pre-frontal Cortex | GDF5 | 0.10 | 0.13 | lasso | 2 | 0.12 | 2.9e-15 | -7.74 | -7.7 | 1.0e-14 | 0.90 | 0.83 | 0.17 | FALSE |
47 | YFS | Blood | EDEM2 | 0.08 | 0.09 | lasso | 4 | 0.10 | 1.2e-29 | -6.90 | 7.3 | 3.5e-13 | -0.45 | 1.00 | 0.00 | FALSE |
48 | YFS | Blood | PROCR | 0.01 | 0.00 | blup | 348 | 0.01 | 3.3e-03 | -7.65 | 7.0 | 1.9e-12 | -0.70 | 0.08 | 0.75 | FALSE |
49 | YFS | Blood | UQCC | 0.21 | 0.19 | lasso | 26 | 0.20 | 6.4e-64 | -7.71 | 7.7 | 1.9e-14 | -0.88 | 1.00 | 0.00 | FALSE |
50 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UQCC | 0.03 | 0.04 | blup | 67 | 0.03 | 2.6e-03 | -7.74 | 8.2 | 3.6e-16 | -0.91 | 0.02 | 0.91 | FALSE |
51 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EDEM2 | 0.09 | 0.03 | enet | 10 | 0.05 | 1.7e-10 | -7.34 | 5.6 | 2.7e-08 | -0.27 | 0.98 | 0.02 | TRUE |
52 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UQCC | 0.08 | 0.11 | blup | 67 | 0.12 | 1.1e-22 | -7.77 | 8.3 | 1.3e-16 | -0.89 | 1.00 | 0.00 | FALSE |
53 | The Cancer Genome Atlas | Glioblastoma Multiforme | UQCC | 0.15 | 0.02 | blup | 67 | 0.04 | 2.0e-02 | -2.78 | 7.0 | 2.2e-12 | -0.74 | 0.02 | 0.64 | FALSE |
54 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CEP250 | 0.02 | 0.01 | blup | 43 | 0.02 | 8.0e-04 | -3.65 | -5.8 | 6.8e-09 | 0.79 | 0.03 | 0.83 | FALSE |
55 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UQCC | 0.05 | 0.06 | blup | 66 | 0.06 | 3.6e-07 | -6.47 | 7.4 | 1.7e-13 | -0.87 | 0.13 | 0.87 | FALSE |
56 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CEP250 | 0.03 | 0.01 | blup | 43 | 0.03 | 2.6e-04 | -9.67 | -5.3 | 9.2e-08 | 0.77 | 0.01 | 0.89 | FALSE |
57 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UQCC | 0.09 | 0.10 | blup | 67 | 0.10 | 7.2e-11 | -7.55 | 8.1 | 7.7e-16 | -0.88 | 0.97 | 0.03 | FALSE |
58 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | UQCC | 0.08 | 0.01 | lasso | 3 | 0.01 | 9.0e-02 | -6.78 | 7.1 | 1.7e-12 | -0.72 | 0.04 | 0.85 | FALSE |
59 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EDEM2 | 0.07 | 0.02 | blup | 102 | 0.04 | 2.1e-05 | -7.34 | 7.6 | 2.7e-14 | -0.37 | 0.42 | 0.47 | TRUE |
60 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GDF5 | 0.09 | 0.11 | blup | 76 | 0.12 | 1.0e-13 | -7.59 | -8.2 | 2.9e-16 | 0.83 | 0.14 | 0.86 | TRUE |
61 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UQCC | 0.04 | 0.06 | lasso | 6 | 0.05 | 2.3e-06 | -7.73 | 7.7 | 1.1e-14 | -0.90 | 0.66 | 0.34 | FALSE |
62 | The Cancer Genome Atlas | Lung Adenocarcinoma | UQCC | 0.10 | 0.07 | enet | 10 | 0.07 | 1.5e-08 | -7.78 | 7.3 | 2.3e-13 | -0.89 | 0.09 | 0.91 | FALSE |
63 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MMP24 | 0.04 | 0.04 | blup | 62 | 0.02 | 7.4e-04 | -3.48 | 5.3 | 1.4e-07 | -0.55 | 0.48 | 0.37 | FALSE |
64 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UQCC | 0.07 | 0.08 | blup | 67 | 0.07 | 1.1e-08 | -7.55 | 6.4 | 2.0e-10 | -0.82 | 0.05 | 0.95 | FALSE |
65 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GDF5 | 0.05 | 0.02 | blup | 76 | 0.04 | 1.4e-03 | -7.74 | -8.4 | 3.0e-17 | 0.89 | 0.03 | 0.91 | FALSE |
66 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | UQCC | 0.12 | 0.03 | blup | 67 | 0.09 | 1.7e-04 | -7.55 | 8.1 | 5.2e-16 | -0.83 | 0.02 | 0.89 | FALSE |
67 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | UQCC | 0.22 | 0.21 | lasso | 7 | 0.18 | 1.9e-07 | -7.55 | 7.9 | 3.2e-15 | -0.84 | 0.32 | 0.68 | FALSE |
68 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM83C | 0.16 | 0.10 | lasso | 4 | 0.11 | 2.1e-11 | -8.35 | 7.9 | 4.1e-15 | -0.58 | 0.00 | 1.00 | FALSE |
69 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GDF5 | 0.05 | 0.05 | lasso | 5 | 0.04 | 7.2e-05 | -9.67 | -8.6 | 8.8e-18 | 0.95 | 0.00 | 1.00 | FALSE |
70 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UQCC | 0.07 | 0.10 | lasso | 8 | 0.11 | 1.3e-11 | -7.58 | 8.2 | 3.0e-16 | -0.90 | 0.37 | 0.63 | FALSE |
71 | The Cancer Genome Atlas | Soft Tissue Sarcoma | UQCC | 0.07 | 0.06 | blup | 66 | 0.07 | 5.2e-05 | -7.73 | 7.5 | 5.5e-14 | -0.89 | 0.02 | 0.97 | FALSE |
72 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GDF5 | 0.09 | 0.04 | enet | 13 | 0.05 | 2.4e-04 | -9.67 | -7.1 | 9.1e-13 | 0.85 | 0.00 | 0.99 | FALSE |
73 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UQCC | 0.07 | 0.06 | lasso | 10 | 0.06 | 2.8e-05 | -8.00 | 7.9 | 2.0e-15 | -0.88 | 0.04 | 0.95 | FALSE |
74 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PROCR | 0.18 | 0.00 | blup | 44 | 0.14 | 1.7e-05 | -6.63 | 6.4 | 1.3e-10 | -0.38 | 0.01 | 0.87 | FALSE |
75 | The Cancer Genome Atlas | Thyroid Carcinoma | CEP250 | 0.05 | 0.03 | blup | 43 | 0.04 | 5.8e-05 | -3.66 | -5.7 | 1.3e-08 | 0.78 | 0.12 | 0.83 | TRUE |
76 | The Cancer Genome Atlas | Thyroid Carcinoma | GDF5 | 0.02 | 0.00 | blup | 76 | 0.00 | 1.9e-01 | -7.77 | -7.6 | 3.8e-14 | 0.90 | 0.02 | 0.88 | FALSE |
77 | The Cancer Genome Atlas | Thyroid Carcinoma | UQCC | 0.15 | 0.21 | blup | 67 | 0.22 | 1.2e-20 | -7.77 | 8.2 | 2.2e-16 | -0.88 | 0.51 | 0.49 | FALSE |
78 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | UQCC | 0.13 | 0.15 | lasso | 1 | 0.11 | 7.1e-04 | -6.67 | 6.7 | 2.5e-11 | -0.74 | 0.04 | 0.65 | FALSE |