Best TWAS P=4.2e-14 · Best GWAS P=1.09e-11 conditioned to 0.53
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CYBRD1 | 0.33 | 0.18 | lasso | 7 | 0.27 | 5.2e-33 | -2.8 | -5.4 | 8.5e-08 | -0.69 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | CYBRD1 | 0.35 | 0.19 | lasso | 6 | 0.24 | 7.3e-20 | 6.7 | -7.0 | 3.5e-12 | -0.77 | 0.00 | 1.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | CYBRD1 | 0.33 | 0.10 | lasso | 10 | 0.26 | 4.6e-14 | 3.9 | -5.9 | 3.2e-09 | -0.71 | 0.03 | 0.97 | FALSE |
4 | GTEx | Artery Aorta | CYBRD1 | 0.52 | 0.30 | lasso | 10 | 0.41 | 6.0e-24 | -2.8 | -5.6 | 2.3e-08 | -0.66 | 0.96 | 0.04 | FALSE |
5 | GTEx | Artery Tibial | CYBRD1 | 0.37 | 0.08 | lasso | 9 | 0.21 | 3.0e-16 | 4.9 | -6.4 | 1.8e-10 | -0.75 | 0.00 | 1.00 | FALSE |
6 | GTEx | Breast Mammary Tissue | CYBRD1 | 0.32 | 0.21 | enet | 16 | 0.27 | 2.0e-14 | 6.7 | -7.4 | 1.2e-13 | -0.74 | 0.00 | 1.00 | FALSE |
7 | GTEx | Breast Mammary Tissue (Male) | CYBRD1 | 0.35 | 0.24 | lasso | 6 | 0.20 | 2.4e-05 | 6.7 | -6.3 | 2.6e-10 | -0.72 | 0.00 | 0.98 | FALSE |
8 | GTEx | Breast Mammary Tissue (Female) | CYBRD1 | 0.20 | 0.07 | lasso | 2 | 0.14 | 4.5e-05 | 6.7 | -6.5 | 7.1e-11 | -0.78 | 0.00 | 0.98 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | CYBRD1 | 0.34 | 0.16 | enet | 27 | 0.26 | 6.3e-20 | 3.9 | -5.2 | 1.5e-07 | -0.57 | 1.00 | 0.00 | FALSE |
10 | GTEx | Esophagus Muscularis | CYBRD1 | 0.33 | 0.07 | lasso | 9 | 0.22 | 1.3e-13 | 4.9 | -7.0 | 1.9e-12 | -0.75 | 0.06 | 0.94 | FALSE |
11 | GTEx | Muscle Skeletal | CYBRD1 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-02 | 6.7 | -7.0 | 1.9e-12 | -0.71 | 0.00 | 0.99 | FALSE |
12 | GTEx | Nerve Tibial | CYBRD1 | 0.36 | 0.07 | lasso | 10 | 0.20 | 2.3e-14 | 6.7 | -6.2 | 7.7e-10 | -0.73 | 0.00 | 1.00 | FALSE |
13 | GTEx | Thyroid | CYBRD1 | 0.26 | 0.08 | enet | 26 | 0.12 | 1.4e-09 | 6.7 | -6.0 | 1.4e-09 | -0.72 | 0.00 | 1.00 | FALSE |
14 | GTEx | Whole Blood | CYBRD1 | 0.25 | 0.14 | enet | 19 | 0.15 | 1.4e-13 | -4.7 | -5.8 | 7.9e-09 | -0.52 | 0.99 | 0.01 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | CYBRD1 | 0.37 | 0.16 | lasso | 9 | 0.30 | 3.0e-39 | 5.1 | -6.3 | 2.3e-10 | -0.77 | 0.39 | 0.61 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | CYBRD1 | 0.10 | 0.06 | lasso | 4 | 0.06 | 6.2e-07 | 6.7 | -7.5 | 4.2e-14 | -0.86 | 0.00 | 1.00 | TRUE |