Best TWAS P=1.69e-24 · Best GWAS P=2.89e-28 conditioned to 1.41e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | CALCRL | 0.16 | 0.17 | lasso | 2 | 0.15 | 8.4e-09 | -7.49 | -7.9 | 2.4e-15 | 0.66 | 0.95 | 0.04 | FALSE |
| 2 | GTEx | Artery Tibial | CALCRL | 0.27 | 0.33 | lasso | 3 | 0.32 | 1.1e-25 | -7.49 | -7.8 | 7.1e-15 | 0.63 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Brain Cerebellum | CALCRL | 0.11 | 0.10 | enet | 23 | 0.08 | 2.1e-03 | -7.96 | 6.0 | 2.6e-09 | -0.54 | 0.05 | 0.73 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | AC007319.1 | 0.16 | 0.08 | lasso | 7 | 0.10 | 9.9e-04 | -9.58 | -9.0 | 2.8e-19 | 0.76 | 0.04 | 0.87 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | TFPI | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.6e-03 | -8.42 | -8.3 | 7.9e-17 | 0.83 | 0.33 | 0.48 | FALSE |
| 6 | GTEx | Nerve Tibial | CALCRL | 0.09 | 0.04 | enet | 9 | 0.08 | 5.2e-06 | -7.43 | -6.7 | 2.5e-11 | 0.50 | 0.51 | 0.04 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | AC007319.1 | 0.17 | 0.10 | lasso | 3 | 0.13 | 1.9e-07 | -6.41 | -7.0 | 3.1e-12 | 0.62 | 0.89 | 0.08 | FALSE |
| 8 | NTR | Blood | CALCRL | 0.02 | 0.03 | lasso | 7 | 0.02 | 3.6e-08 | -9.40 | 9.0 | 2.1e-19 | -0.81 | 0.74 | 0.26 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | TFPI | 0.06 | 0.01 | bslmm | 292 | 0.01 | 4.8e-03 | 0.95 | -6.1 | 1.1e-09 | 0.58 | 0.16 | 0.52 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | TFPI | 0.08 | 0.04 | blup | 51 | 0.03 | 6.0e-03 | -6.41 | -7.7 | 1.3e-14 | 0.63 | 0.03 | 0.34 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CALCRL | 0.03 | 0.04 | blup | 62 | 0.04 | 1.4e-05 | -8.59 | 10.2 | 1.7e-24 | -0.87 | 0.38 | 0.61 | TRUE |