Best TWAS P=6.72e-40 · Best GWAS P=1.6e-55 conditioned to 0.019
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | COBLL1 | 0.05 | 0.01 | lasso | 6 | 0.03 | 3.3e-04 | 13.5 | -9.4 | 7.6e-21 | 0.41 | 0.40 | 0.06 | TRUE |
| 2 | GTEx | Breast Mammary Tissue | SLC38A11 | 0.20 | 0.19 | lasso | 4 | 0.17 | 4.7e-09 | -3.2 | -5.6 | 2.5e-08 | 0.50 | 0.96 | 0.02 | TRUE |
| 3 | GTEx | Esophagus Muscularis | GRB14 | 0.14 | 0.09 | lasso | 7 | 0.06 | 1.6e-04 | -11.3 | 11.1 | 1.1e-28 | -0.46 | 0.31 | 0.39 | TRUE |
| 4 | GTEx | Stomach | SLC38A11 | 0.25 | 0.18 | enet | 13 | 0.26 | 1.0e-12 | -5.3 | -7.3 | 3.9e-13 | 0.18 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Thyroid | COBLL1 | 0.07 | 0.05 | lasso | 3 | 0.05 | 1.5e-04 | 13.0 | -13.2 | 6.7e-40 | 0.57 | 0.59 | 0.22 | TRUE |
| 6 | METSIM | Adipose | GRB14 | 0.04 | 0.00 | bslmm | 376 | 0.01 | 1.6e-02 | 2.5 | 8.9 | 7.9e-19 | -0.28 | 0.11 | 0.20 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | GRB14 | 0.09 | 0.01 | blup | 82 | 0.03 | 4.6e-03 | -14.3 | 9.6 | 6.9e-22 | -0.58 | 0.02 | 0.64 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC38A11 | 0.06 | 0.02 | blup | 60 | 0.02 | 1.4e-03 | -3.2 | -5.5 | 4.6e-08 | 0.49 | 0.21 | 0.23 | FALSE |