Best TWAS P=4.07e-22 · Best GWAS P=1.21e-21 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM165 | 0.22 | 0.20 | enet | 47 | 0.26 | 1.7e-31 | -6.0 | 6.9 | 4.2e-12 | 0.44 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | TMEM165 | 0.09 | 0.01 | lasso | 3 | 0.03 | 1.6e-03 | -7.8 | 8.7 | 2.6e-18 | 0.60 | 0.55 | 0.40 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | TMEM165 | 0.14 | 0.04 | enet | 20 | 0.06 | 3.3e-04 | 1.5 | 6.8 | 1.1e-11 | 0.35 | 0.10 | 0.24 | FALSE |
| 4 | GTEx | Artery Aorta | SRD5A3 | 0.34 | 0.05 | lasso | 12 | 0.23 | 1.0e-12 | -6.5 | -7.9 | 2.8e-15 | -0.45 | 0.67 | 0.22 | FALSE |
| 5 | GTEx | Artery Aorta | TMEM165 | 0.10 | 0.00 | lasso | 3 | 0.00 | 7.5e-01 | -6.5 | 8.3 | 9.5e-17 | 0.57 | 0.05 | 0.56 | TRUE |
| 6 | GTEx | Artery Coronary | SRD5A3 | 0.49 | -0.01 | enet | 29 | 0.16 | 6.3e-06 | -1.7 | -6.1 | 1.4e-09 | -0.25 | 0.15 | 0.27 | FALSE |
| 7 | GTEx | Artery Coronary | SRD5A3-AS1 | 0.28 | 0.00 | enet | 15 | 0.03 | 3.5e-02 | 3.9 | -6.7 | 1.8e-11 | -0.40 | 0.05 | 0.60 | FALSE |
| 8 | GTEx | Artery Tibial | TMEM165 | 0.07 | 0.02 | lasso | 5 | 0.01 | 3.2e-02 | 8.7 | 9.6 | 7.1e-22 | 0.75 | 0.22 | 0.49 | FALSE |
| 9 | GTEx | Brain Cortex | TMEM165 | 0.31 | 0.08 | lasso | 6 | 0.04 | 2.2e-02 | -7.1 | 7.4 | 1.1e-13 | 0.42 | 0.10 | 0.30 | FALSE |
| 10 | GTEx | Breast Mammary Tissue | TMEM165 | 0.10 | 0.12 | lasso | 5 | 0.12 | 6.4e-07 | -7.1 | 6.7 | 1.5e-11 | 0.38 | 0.77 | 0.02 | FALSE |
| 11 | GTEx | Breast Mammary Tissue (Male) | TMEM165 | 0.18 | 0.11 | lasso | 10 | 0.11 | 1.4e-03 | -7.1 | 7.1 | 1.2e-12 | 0.37 | 0.13 | 0.18 | FALSE |
| 12 | GTEx | Cells EBV-transformed lymphocytes | SRD5A3 | 0.19 | 0.06 | enet | 21 | 0.13 | 5.9e-05 | -7.1 | -7.9 | 2.0e-15 | -0.46 | 0.29 | 0.32 | FALSE |
| 13 | GTEx | Cells EBV-transformed lymphocytes | CLOCK | 0.21 | 0.06 | lasso | 3 | 0.04 | 1.5e-02 | 8.4 | -9.3 | 1.5e-20 | -0.97 | 0.02 | 0.90 | FALSE |
| 14 | GTEx | Cells EBV-transformed lymphocytes | SRD5A3-AS1 | 0.21 | 0.09 | lasso | 3 | 0.20 | 4.3e-07 | -7.1 | -6.9 | 6.7e-12 | -0.35 | 0.42 | 0.22 | FALSE |
| 15 | GTEx | Cells Transformed fibroblasts | SRD5A3 | 0.39 | 0.22 | enet | 51 | 0.36 | 2.9e-28 | -7.7 | -7.4 | 1.6e-13 | -0.36 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Cells Transformed fibroblasts | CLOCK | 0.19 | 0.09 | lasso | 6 | 0.11 | 2.0e-08 | 8.2 | -7.1 | 1.1e-12 | -0.66 | 0.74 | 0.25 | FALSE |
| 17 | GTEx | Cells Transformed fibroblasts | SRD5A3-AS1 | 0.36 | 0.19 | enet | 52 | 0.30 | 1.2e-22 | -7.7 | -7.2 | 5.9e-13 | -0.38 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Colon Sigmoid | SRD5A3 | 0.34 | 0.18 | enet | 30 | 0.31 | 1.5e-11 | -7.7 | -6.2 | 4.5e-10 | -0.31 | 0.84 | 0.04 | FALSE |
| 19 | GTEx | Colon Sigmoid | SRD5A3-AS1 | 0.16 | 0.14 | enet | 18 | 0.13 | 2.9e-05 | -7.8 | -9.4 | 5.8e-21 | -0.58 | 0.28 | 0.35 | FALSE |
| 20 | GTEx | Esophagus Gastroesophageal Junction | SRD5A3-AS1 | 0.19 | 0.12 | lasso | 3 | 0.14 | 9.3e-06 | -4.0 | -5.9 | 4.1e-09 | -0.31 | 0.24 | 0.16 | FALSE |
| 21 | GTEx | Esophagus Mucosa | SRD5A3 | 0.20 | 0.12 | enet | 24 | 0.18 | 2.5e-12 | -7.7 | -5.7 | 1.2e-08 | -0.19 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Esophagus Mucosa | CLOCK | 0.12 | 0.11 | enet | 22 | 0.09 | 9.3e-07 | -7.8 | -8.5 | 1.3e-17 | -0.57 | 0.68 | 0.31 | FALSE |
| 23 | GTEx | Esophagus Mucosa | SRD5A3-AS1 | 0.18 | 0.12 | enet | 26 | 0.17 | 1.1e-11 | -7.7 | -5.9 | 3.5e-09 | -0.19 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Esophagus Muscularis | TMEM165 | 0.07 | 0.04 | lasso | 2 | 0.02 | 1.7e-02 | 9.4 | 9.3 | 9.1e-21 | 0.99 | 0.02 | 0.94 | FALSE |
| 25 | GTEx | Esophagus Muscularis | CLOCK | 0.11 | 0.00 | enet | 11 | 0.01 | 5.2e-02 | 8.5 | -6.8 | 8.3e-12 | -0.72 | 0.04 | 0.57 | FALSE |
| 26 | GTEx | Heart Left Ventricle | SRD5A3 | 0.41 | 0.14 | enet | 41 | 0.25 | 1.2e-13 | -4.0 | -5.3 | 1.1e-07 | -0.21 | 0.94 | 0.02 | FALSE |
| 27 | GTEx | Liver | SRD5A3 | 0.16 | 0.00 | lasso | 18 | 0.09 | 1.4e-03 | -7.8 | -5.2 | 2.1e-07 | -0.08 | 0.12 | 0.07 | FALSE |
| 28 | GTEx | Lung | TMEM165 | 0.09 | 0.01 | lasso | 6 | 0.01 | 3.4e-02 | -6.3 | 7.2 | 5.9e-13 | 0.53 | 0.05 | 0.79 | FALSE |
| 29 | GTEx | Lung | CLOCK | 0.07 | 0.02 | lasso | 4 | 0.03 | 3.0e-03 | 8.5 | -7.7 | 1.0e-14 | -0.69 | 0.17 | 0.65 | FALSE |
| 30 | GTEx | Lung | SRD5A3-AS1 | 0.19 | 0.07 | enet | 26 | 0.14 | 8.6e-11 | -7.1 | -5.8 | 5.5e-09 | -0.26 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Muscle Skeletal | SRD5A3-AS1 | 0.20 | 0.13 | enet | 25 | 0.20 | 1.4e-19 | -7.7 | -7.8 | 5.0e-15 | -0.44 | 1.00 | 0.00 | FALSE |
| 32 | GTEx | Nerve Tibial | TMEM165 | 0.18 | 0.22 | enet | 29 | 0.27 | 1.6e-19 | -6.0 | 7.2 | 8.2e-13 | 0.42 | 1.00 | 0.00 | TRUE |
| 33 | GTEx | Nerve Tibial | CLOCK | 0.14 | 0.06 | lasso | 4 | 0.10 | 1.6e-07 | -6.5 | -9.7 | 4.1e-22 | -0.76 | 0.02 | 0.98 | TRUE |
| 34 | GTEx | Pituitary | SRD5A3 | 0.42 | 0.17 | lasso | 8 | 0.33 | 4.5e-09 | 4.8 | -5.2 | 2.2e-07 | -0.19 | 0.09 | 0.12 | FALSE |
| 35 | GTEx | Pituitary | SRD5A3-AS1 | 0.36 | 0.18 | lasso | 4 | 0.26 | 3.5e-07 | 4.8 | -8.2 | 1.9e-16 | -0.60 | 0.09 | 0.37 | FALSE |
| 36 | GTEx | Prostate | SRD5A3-AS1 | 0.32 | 0.14 | enet | 41 | 0.22 | 3.1e-06 | -7.7 | -5.5 | 4.9e-08 | -0.39 | 0.21 | 0.16 | FALSE |
| 37 | GTEx | Skin Not Sun Exposed Suprapubic | CLOCK | 0.08 | 0.08 | lasso | 5 | 0.05 | 1.4e-03 | -7.8 | -7.8 | 6.2e-15 | -0.47 | 0.21 | 0.55 | FALSE |
| 38 | GTEx | Skin Sun Exposed Lower leg | CLOCK | 0.07 | 0.05 | lasso | 5 | 0.07 | 3.5e-06 | 8.5 | -9.7 | 4.7e-22 | -0.86 | 0.02 | 0.98 | FALSE |
| 39 | GTEx | Small Intestine Terminal Ileum | SRD5A3 | 0.38 | 0.28 | lasso | 4 | 0.25 | 2.2e-06 | -7.1 | -7.1 | 1.0e-12 | -0.35 | 0.20 | 0.08 | FALSE |
| 40 | GTEx | Small Intestine Terminal Ileum | SRD5A3-AS1 | 0.40 | 0.32 | lasso | 3 | 0.28 | 4.5e-07 | -7.1 | -7.1 | 1.1e-12 | -0.36 | 0.26 | 0.07 | FALSE |
| 41 | GTEx | Spleen | SRD5A3 | 0.28 | 0.07 | enet | 16 | 0.09 | 2.2e-03 | -4.0 | -5.4 | 8.3e-08 | -0.53 | 0.11 | 0.16 | FALSE |
| 42 | GTEx | Spleen | TMEM165 | 0.17 | 0.13 | enet | 10 | 0.11 | 7.7e-04 | -7.1 | 7.5 | 6.3e-14 | 0.40 | 0.13 | 0.08 | TRUE |
| 43 | GTEx | Stomach | SRD5A3 | 0.13 | 0.08 | enet | 17 | 0.09 | 3.0e-05 | -4.0 | -5.5 | 3.5e-08 | -0.22 | 0.78 | 0.01 | TRUE |
| 44 | GTEx | Stomach | SRD5A3-AS1 | 0.16 | 0.11 | lasso | 11 | 0.12 | 1.8e-06 | -7.8 | -6.5 | 6.1e-11 | -0.27 | 0.92 | 0.00 | FALSE |
| 45 | GTEx | Testis | SRD5A3-AS1 | 0.21 | 0.09 | enet | 16 | 0.09 | 6.6e-05 | 9.1 | -8.4 | 6.2e-17 | -0.76 | 0.06 | 0.90 | TRUE |
| 46 | GTEx | Thyroid | SRD5A3 | 0.45 | 0.06 | enet | 53 | 0.28 | 8.5e-22 | -7.7 | -5.5 | 4.1e-08 | -0.25 | 1.00 | 0.00 | FALSE |
| 47 | GTEx | Thyroid | TMEM165 | 0.10 | 0.03 | lasso | 5 | 0.03 | 1.9e-03 | -6.3 | 5.7 | 1.1e-08 | 0.39 | 0.31 | 0.50 | FALSE |
| 48 | GTEx | Thyroid | SRD5A3-AS1 | 0.32 | 0.14 | enet | 56 | 0.21 | 1.1e-15 | -6.0 | -6.8 | 1.3e-11 | -0.37 | 1.00 | 0.00 | FALSE |
| 49 | GTEx | Whole Blood | SRD5A3 | 0.37 | 0.19 | enet | 57 | 0.30 | 1.3e-27 | -7.7 | -6.6 | 3.5e-11 | -0.30 | 1.00 | 0.00 | FALSE |
| 50 | GTEx | Whole Blood | SRD5A3-AS1 | 0.33 | 0.17 | lasso | 9 | 0.21 | 4.1e-19 | -7.8 | -7.3 | 3.1e-13 | -0.29 | 1.00 | 0.00 | FALSE |
| 51 | METSIM | Adipose | TMEM165 | 0.07 | 0.07 | enet | 12 | 0.07 | 1.1e-10 | -7.8 | 7.7 | 1.2e-14 | 0.46 | 1.00 | 0.00 | FALSE |
| 52 | NTR | Blood | CLOCK | 0.02 | 0.01 | lasso | 2 | 0.01 | 5.4e-05 | -7.1 | -7.2 | 7.3e-13 | -0.42 | 0.90 | 0.01 | FALSE |
| 53 | NTR | Blood | SRD5A3 | 0.10 | 0.04 | bslmm | 407 | 0.08 | 2.3e-24 | -7.8 | -7.0 | 2.4e-12 | -0.35 | 1.00 | 0.00 | FALSE |
| 54 | ROSMAP | Brain Pre-frontal Cortex | TMEM165 | 0.09 | 0.07 | blup | 404 | 0.08 | 4.9e-11 | -5.9 | 7.5 | 6.3e-14 | 0.58 | 1.00 | 0.00 | FALSE |
| 55 | ROSMAP | Brain Pre-frontal Cortex | SRD5A3-AS1 | 0.09 | 0.04 | enet | 29 | 0.04 | 6.7e-06 | 9.1 | -6.1 | 8.7e-10 | -0.51 | 0.07 | 0.91 | FALSE |
| 56 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SRD5A3 | 0.18 | 0.08 | blup | 44 | 0.09 | 1.0e-07 | -7.8 | -7.1 | 1.5e-12 | -0.29 | 0.99 | 0.00 | FALSE |
| 57 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SRD5A3 | 0.11 | 0.04 | enet | 15 | 0.04 | 1.8e-09 | -7.8 | -6.5 | 7.6e-11 | -0.31 | 0.97 | 0.02 | FALSE |
| 58 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM165 | 0.02 | 0.04 | lasso | 3 | 0.03 | 1.0e-07 | -7.8 | 7.8 | 5.0e-15 | 0.50 | 0.88 | 0.11 | FALSE |
| 59 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SRD5A3 | 0.09 | 0.08 | lasso | 4 | 0.09 | 2.7e-05 | -7.7 | -7.2 | 7.7e-13 | -0.24 | 0.06 | 0.07 | FALSE |
| 60 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMEM165 | 0.06 | 0.07 | enet | 11 | 0.06 | 2.1e-04 | -7.8 | 6.4 | 2.0e-10 | 0.29 | 0.29 | 0.04 | FALSE |
| 61 | The Cancer Genome Atlas | Glioblastoma Multiforme | SRD5A3 | 0.22 | 0.14 | blup | 44 | 0.12 | 1.9e-04 | -7.1 | -7.2 | 4.6e-13 | -0.30 | 0.17 | 0.06 | FALSE |
| 62 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SRD5A3 | 0.04 | 0.03 | blup | 44 | 0.03 | 1.1e-04 | -7.8 | -7.7 | 2.0e-14 | -0.36 | 0.57 | 0.03 | FALSE |
| 63 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CLOCK | 0.02 | 0.02 | enet | 5 | 0.02 | 1.9e-03 | -5.9 | -6.2 | 4.6e-10 | -0.30 | 0.16 | 0.06 | FALSE |
| 64 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SRD5A3 | 0.21 | 0.14 | lasso | 4 | 0.14 | 2.6e-15 | -7.7 | -7.8 | 7.2e-15 | -0.37 | 1.00 | 0.00 | FALSE |
| 65 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SRD5A3 | 0.14 | 0.07 | blup | 44 | 0.08 | 3.4e-09 | -7.8 | -8.3 | 1.1e-16 | -0.47 | 0.94 | 0.05 | FALSE |
| 66 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM165 | 0.19 | 0.16 | lasso | 4 | 0.17 | 2.1e-18 | -7.8 | 6.8 | 8.3e-12 | 0.35 | 1.00 | 0.00 | FALSE |
| 67 | The Cancer Genome Atlas | Lung Adenocarcinoma | SRD5A3 | 0.04 | 0.03 | lasso | 4 | 0.02 | 1.0e-03 | -7.7 | -7.8 | 4.4e-15 | -0.42 | 0.22 | 0.28 | TRUE |
| 68 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SRD5A3 | 0.03 | 0.03 | enet | 4 | 0.05 | 3.1e-06 | 4.8 | -7.3 | 2.9e-13 | -0.52 | 0.36 | 0.14 | FALSE |
| 69 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CLOCK | 0.62 | 0.07 | enet | 9 | 0.11 | 1.2e-07 | 7.2 | -5.9 | 4.8e-09 | -0.32 | 0.17 | 0.07 | FALSE |
| 70 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SRD5A3 | 0.12 | 0.07 | lasso | 2 | 0.06 | 4.2e-05 | -7.7 | -8.0 | 1.2e-15 | -0.43 | 0.09 | 0.47 | FALSE |
| 71 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SRD5A3 | 0.26 | 0.12 | lasso | 6 | 0.10 | 7.0e-05 | -7.7 | -7.1 | 1.3e-12 | -0.34 | 0.33 | 0.08 | FALSE |
| 72 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SRD5A3 | 0.19 | 0.07 | blup | 44 | 0.11 | 5.5e-12 | -7.7 | -7.0 | 2.3e-12 | -0.48 | 0.76 | 0.24 | FALSE |
| 73 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM165 | 0.05 | 0.06 | enet | 5 | 0.05 | 4.3e-06 | -7.8 | 5.5 | 3.9e-08 | 0.19 | 0.84 | 0.01 | FALSE |
| 74 | The Cancer Genome Atlas | Rectum Adenocarcinoma | TMEM165 | 0.40 | 0.05 | enet | 19 | 0.12 | 9.4e-04 | 9.4 | 8.3 | 1.4e-16 | 0.60 | 0.00 | 0.63 | FALSE |
| 75 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SRD5A3 | 0.15 | 0.01 | enet | 12 | 0.06 | 2.5e-04 | -7.7 | -5.7 | 1.3e-08 | -0.32 | 0.08 | 0.07 | FALSE |
| 76 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CLOCK | 0.08 | 0.07 | enet | 9 | 0.06 | 4.5e-05 | -5.5 | -5.2 | 2.6e-07 | -0.31 | 0.53 | 0.02 | FALSE |
| 77 | The Cancer Genome Atlas | Thyroid Carcinoma | PDCL2 | 0.07 | 0.03 | blup | 50 | 0.02 | 5.4e-03 | 7.1 | 8.9 | 3.9e-19 | 0.80 | 0.12 | 0.48 | TRUE |
| 78 | The Cancer Genome Atlas | Thyroid Carcinoma | SRD5A3 | 0.36 | 0.14 | enet | 28 | 0.18 | 2.2e-17 | -7.8 | -7.3 | 3.5e-13 | -0.39 | 1.00 | 0.00 | FALSE |
| 79 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM165 | 0.12 | 0.08 | enet | 12 | 0.08 | 2.1e-08 | -7.8 | 6.2 | 7.7e-10 | 0.31 | 1.00 | 0.00 | FALSE |