Best TWAS P=8.97e-14 · Best GWAS P=1.33e-21 conditioned to 0.0626
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RBPJ | 0.06 | 0.01 | blup | 397 | 0.03 | 9.9e-05 | 9.4 | 7.1 | 1.3e-12 | 0.77 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Esophagus Mucosa | SMIM20 | 0.33 | 0.32 | enet | 5 | 0.33 | 2.0e-22 | -5.2 | 5.3 | 1.2e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Nerve Tibial | SEL1L3 | 0.27 | 0.18 | enet | 35 | 0.20 | 8.1e-14 | -4.9 | 6.4 | 1.4e-10 | 0.04 | 1.00 | 0.00 | TRUE |
| 4 | METSIM | Adipose | SEL1L3 | 0.08 | 0.03 | bslmm | 520 | 0.04 | 1.5e-06 | -5.1 | 6.1 | 1.3e-09 | 0.06 | 0.85 | 0.00 | FALSE |
| 5 | METSIM | Adipose | STIM2 | 0.05 | 0.01 | blup | 431 | 0.01 | 1.1e-02 | -3.3 | 7.1 | 1.3e-12 | 0.42 | 0.18 | 0.38 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RBPJ | 0.10 | 0.02 | bslmm | 469 | 0.05 | 5.3e-07 | 9.0 | 7.5 | 9.0e-14 | 0.60 | 0.04 | 0.95 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCKAR | 0.03 | 0.00 | blup | 63 | 0.01 | 4.8e-03 | 7.4 | -5.1 | 3.0e-07 | -0.61 | 0.01 | 0.07 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | C4orf52 | 0.11 | 0.08 | lasso | 4 | 0.05 | 5.8e-04 | -5.1 | 5.3 | 1.2e-07 | 0.03 | 0.00 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C4orf52 | 0.12 | 0.12 | enet | 5 | 0.14 | 1.1e-15 | -5.1 | 5.4 | 6.0e-08 | 0.04 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RBPJ | 0.08 | 0.00 | blup | 70 | 0.00 | 1.4e-01 | 9.4 | 6.9 | 5.3e-12 | 0.62 | 0.01 | 0.44 | TRUE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C4orf52 | 0.31 | 0.30 | lasso | 4 | 0.32 | 3.1e-34 | -5.1 | 5.3 | 1.4e-07 | 0.05 | 0.01 | 0.99 | FALSE |