Best TWAS P=9.73e-11 · Best GWAS P=6.66e-09 conditioned to 0.651
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | USP53 | 0.16 | 0.13 | lasso | 11 | 0.20 | 3.5e-23 | 5.8 | 5.3 | 1.1e-07 | 0.84 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Thyroid | PDE5A | 0.09 | 0.04 | lasso | 3 | 0.04 | 6.9e-04 | 4.7 | 5.2 | 2.3e-07 | 0.86 | 0.06 | 0.77 | FALSE |
| 3 | GTEx | Whole Blood | USP53 | 0.09 | 0.05 | enet | 11 | 0.06 | 3.1e-06 | 5.5 | 5.6 | 1.7e-08 | 0.96 | 0.02 | 0.98 | FALSE |
| 4 | NTR | Blood | USP53 | 0.10 | 0.10 | bslmm | 482 | 0.11 | 2.6e-34 | 5.5 | 5.7 | 9.8e-09 | 0.89 | 0.02 | 0.98 | FALSE |
| 5 | YFS | Blood | USP53 | 0.06 | 0.05 | bslmm | 479 | 0.06 | 8.1e-20 | 5.5 | 6.5 | 9.7e-11 | 0.86 | 0.01 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | USP53 | 0.25 | 0.05 | lasso | 5 | 0.08 | 6.5e-09 | -3.2 | 5.5 | 4.8e-08 | 0.75 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | USP53 | 0.11 | 0.03 | blup | 88 | 0.07 | 5.8e-07 | 5.5 | 6.0 | 2.2e-09 | 0.91 | 0.01 | 0.99 | FALSE |