Best TWAS P=5.59e-26 · Best GWAS P=2.28e-24 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | -9.4 | -8.4 | 3.1e-17 | 0.85 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | -7.2 | -7.8 | 7.4e-15 | 0.81 | 0.10 | 0.89 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | NSUN5 | 0.07 | 0.03 | enet | 11 | 0.04 | 4.0e-03 | -10.0 | -9.4 | 7.6e-21 | 0.74 | 0.02 | 0.77 | FALSE |
| 4 | GTEx | Artery Tibial | BCL7B | 0.18 | 0.07 | lasso | 3 | 0.06 | 1.4e-05 | -6.2 | 6.3 | 2.3e-10 | -0.59 | 0.23 | 0.05 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | -7.0 | -9.3 | 1.0e-20 | 0.93 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Heart Left Ventricle | MLXIPL | 0.14 | 0.00 | enet | 24 | 0.01 | 1.3e-01 | -1.8 | -6.9 | 6.9e-12 | 0.51 | 0.05 | 0.75 | FALSE |
| 7 | GTEx | Lung | MLXIPL | 0.10 | 0.07 | enet | 14 | 0.07 | 6.3e-06 | -9.4 | -8.7 | 2.9e-18 | 0.75 | 0.03 | 0.92 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | -7.0 | -6.7 | 1.6e-11 | 0.75 | 0.02 | 0.95 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | -7.2 | -8.3 | 6.6e-17 | 0.83 | 0.34 | 0.65 | FALSE |
| 10 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | -4.6 | 7.6 | 3.2e-14 | -0.88 | 0.02 | 0.70 | FALSE |
| 11 | GTEx | Testis | MLXIPL | 0.10 | 0.00 | lasso | 3 | 0.00 | 3.3e-01 | -6.4 | -8.9 | 8.3e-19 | 0.74 | 0.02 | 0.64 | FALSE |
| 12 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | -9.4 | -8.9 | 4.1e-19 | 0.89 | 0.01 | 0.99 | FALSE |
| 13 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | -10.2 | -10.1 | 8.1e-24 | 0.96 | 0.01 | 0.99 | FALSE |
| 14 | NTR | Blood | WBSCR22 | 0.03 | 0.01 | bslmm | 270 | 0.01 | 1.2e-05 | -4.5 | -8.2 | 3.7e-16 | 0.63 | 0.20 | 0.74 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | POM121B | 0.09 | 0.02 | blup | 18 | 0.04 | 4.6e-06 | -5.8 | 5.7 | 1.6e-08 | -0.62 | 0.01 | 0.54 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | -10.0 | -10.5 | 5.6e-26 | 0.99 | 0.00 | 1.00 | TRUE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCL7B | 0.02 | 0.01 | blup | 5 | 0.02 | 2.7e-03 | -10.0 | 10.3 | 6.7e-25 | -0.84 | 0.00 | 0.73 | FALSE |
| 18 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BCL7B | 0.08 | 0.04 | blup | 5 | 0.06 | 1.0e-03 | -10.0 | 9.2 | 4.0e-20 | -0.86 | 0.00 | 0.90 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | -10.0 | -10.0 | 1.5e-23 | 0.99 | 0.00 | 0.98 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | -10.0 | -10.1 | 6.8e-24 | 0.94 | 0.00 | 1.00 | FALSE |