[Hub]/) : Traits : Waist Hip Ratio (WHR) :

chr7:76,058,767-78,122,616

Best TWAS P=2.14e-26 · Best GWAS P=1.35e-22 conditioned to 0.316

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CCDC146 0.05 0.00 bslmm 340 0.01 5.4e-02 0.76 6.6 3.2e-11 -0.36 0.04 0.07 FALSE
2 CommonMind Brain Pre-frontal Cortex PTPN12 0.21 0.09 lasso 9 0.14 5.4e-17 -8.82 5.9 4.3e-09 -0.40 0.98 0.02 FALSE
3 CommonMind Brain Pre-frontal Cortex RSBN1L 0.09 0.09 enet 9 0.09 2.0e-11 9.34 9.7 2.0e-22 -0.81 0.06 0.94 FALSE
4 GTEx Adipose Subcutaneous PTPN12 0.17 0.08 lasso 7 0.10 7.8e-09 1.59 5.5 4.8e-08 -0.29 0.91 0.08 FALSE
5 GTEx Adipose Subcutaneous TMEM60 0.08 0.05 lasso 4 0.05 7.3e-05 9.09 9.6 1.1e-21 -0.77 0.05 0.94 FALSE
6 GTEx Adipose Subcutaneous RSBN1L-AS1 0.23 0.13 enet 33 0.22 9.2e-18 -1.61 5.4 8.5e-08 -0.71 0.12 0.88 FALSE
7 GTEx Adipose Visceral Omentum PTPN12 0.19 0.04 enet 28 0.02 2.5e-02 -7.94 6.6 4.3e-11 -0.56 0.31 0.53 FALSE
8 GTEx Adipose Visceral Omentum TMEM60 0.20 0.13 lasso 8 0.11 2.3e-06 9.25 8.6 1.0e-17 -0.70 0.09 0.91 FALSE
9 GTEx Adrenal Gland PTPN12 0.16 0.10 lasso 4 0.04 1.0e-02 -8.82 8.7 3.7e-18 -0.55 0.35 0.27 FALSE
10 GTEx Artery Aorta PTPN12 0.22 0.03 enet 28 0.10 3.0e-06 1.10 5.8 5.1e-09 -0.30 0.65 0.25 FALSE
11 GTEx Artery Aorta RSBN1L-AS1 0.26 0.18 lasso 10 0.25 5.0e-14 -1.42 6.2 4.0e-10 -0.78 0.04 0.96 FALSE
12 GTEx Artery Coronary PTPN12 0.33 0.08 enet 26 0.24 1.6e-08 6.37 5.3 1.0e-07 -0.21 0.63 0.12 FALSE
13 GTEx Artery Coronary RSBN1L-AS1 0.37 0.09 enet 14 0.21 1.4e-07 -1.61 5.2 2.1e-07 -0.74 0.06 0.92 FALSE
14 GTEx Artery Tibial PTPN12 0.25 0.13 lasso 8 0.12 1.8e-09 -9.40 9.4 6.8e-21 -0.63 0.29 0.71 FALSE
15 GTEx Artery Tibial TMEM60 0.07 0.05 enet 12 0.02 6.6e-03 9.18 6.9 3.8e-12 -0.57 0.07 0.85 FALSE
16 GTEx Artery Tibial RSBN1L-AS1 0.28 0.13 enet 13 0.28 5.5e-22 -1.57 6.9 6.7e-12 -0.79 0.07 0.93 FALSE
17 GTEx Brain Cerebellum RSBN1L 0.14 0.12 lasso 2 0.13 1.3e-04 -9.52 -9.7 4.2e-22 0.93 0.03 0.94 FALSE
18 GTEx Brain Cortex RSBN1L-AS1 0.34 0.15 enet 23 0.23 5.8e-07 -1.57 6.8 1.2e-11 -0.78 0.04 0.95 FALSE
19 GTEx Breast Mammary Tissue TMEM60 0.13 0.04 lasso 4 0.04 5.4e-03 9.43 7.8 6.8e-15 -0.69 0.06 0.68 FALSE
20 GTEx Cells Transformed fibroblasts PTPN12 0.19 0.15 lasso 4 0.18 1.7e-13 1.74 5.5 3.1e-08 -0.32 0.97 0.03 FALSE
21 GTEx Cells Transformed fibroblasts TMEM60 0.25 0.20 lasso 4 0.20 1.5e-14 9.18 9.0 1.7e-19 -0.78 0.15 0.85 FALSE
22 GTEx Cells Transformed fibroblasts RSBN1L-AS1 0.23 0.19 lasso 6 0.21 5.7e-16 9.19 7.6 2.9e-14 -0.75 0.08 0.92 FALSE
23 GTEx Colon Sigmoid PTPN12 0.24 0.04 lasso 8 0.08 1.2e-03 1.10 5.9 4.5e-09 -0.30 0.24 0.13 FALSE
24 GTEx Colon Sigmoid RSBN1L 0.17 0.09 lasso 2 0.05 5.5e-03 9.11 9.0 1.8e-19 -0.77 0.07 0.73 FALSE
25 GTEx Colon Sigmoid RSBN1L-AS1 0.46 0.48 lasso 6 0.50 5.0e-20 9.19 9.2 2.8e-20 -0.74 0.05 0.95 FALSE
26 GTEx Colon Transverse PTPN12 0.17 0.12 lasso 6 0.10 1.8e-05 -8.82 8.8 1.4e-18 -0.57 0.43 0.36 FALSE
27 GTEx Colon Transverse GSAP 0.14 0.02 lasso 7 0.05 2.2e-03 -9.01 -6.6 4.6e-11 0.41 0.12 0.19 FALSE
28 GTEx Colon Transverse RSBN1L-AS1 0.32 0.24 lasso 9 0.22 5.7e-11 9.19 9.0 2.8e-19 -0.80 0.04 0.96 FALSE
29 GTEx Esophagus Gastroesophageal Junction RSBN1L-AS1 0.38 0.41 lasso 12 0.44 1.2e-17 9.25 9.5 3.0e-21 -0.78 0.04 0.96 FALSE
30 GTEx Esophagus Mucosa TMEM60 0.06 0.04 lasso 2 0.04 1.0e-03 9.18 9.0 2.0e-19 -0.78 0.06 0.92 FALSE
31 GTEx Esophagus Muscularis PTPN12 0.34 0.17 enet 48 0.20 4.3e-12 -8.66 5.8 8.0e-09 -0.29 0.89 0.11 FALSE
32 GTEx Esophagus Muscularis RSBN1L 0.07 0.03 lasso 3 0.01 4.3e-02 6.60 6.9 4.6e-12 -0.51 0.13 0.70 FALSE
33 GTEx Esophagus Muscularis RSBN1L-AS1 0.35 0.51 lasso 5 0.52 3.8e-36 9.19 9.1 1.2e-19 -0.72 0.06 0.94 FALSE
34 GTEx Heart Left Ventricle PTPN12 0.12 0.00 enet 21 0.01 5.6e-02 -8.82 6.8 1.5e-11 -0.36 0.06 0.13 FALSE
35 GTEx Heart Left Ventricle RSBN1L-AS1 0.24 0.15 lasso 7 0.14 6.3e-08 -1.42 5.5 3.8e-08 -0.69 0.10 0.90 FALSE
36 GTEx Lung PTPN12 0.10 0.05 enet 11 0.07 5.1e-06 -8.77 7.3 2.0e-13 -0.44 0.86 0.10 FALSE
37 GTEx Lung TMEM60 0.12 0.05 enet 16 0.07 3.4e-06 -8.44 6.9 4.9e-12 -0.53 0.12 0.86 FALSE
38 GTEx Muscle Skeletal TMEM60 0.11 0.12 lasso 4 0.12 4.6e-12 9.18 -9.7 3.9e-22 0.85 0.06 0.94 FALSE
39 GTEx Muscle Skeletal RSBN1L-AS1 0.22 0.18 lasso 4 0.22 7.3e-21 -9.52 7.3 2.1e-13 -0.85 0.03 0.97 FALSE
40 GTEx Nerve Tibial PTPN12 0.18 0.13 enet 20 0.14 2.9e-10 -8.66 6.9 4.0e-12 -0.47 0.92 0.08 FALSE
41 GTEx Nerve Tibial TMEM60 0.14 0.14 lasso 8 0.12 1.1e-08 9.18 9.6 1.0e-21 -0.82 0.04 0.96 FALSE
42 GTEx Nerve Tibial RSBN1L-AS1 0.35 0.20 lasso 12 0.27 1.8e-19 -1.61 5.3 9.0e-08 -0.70 0.26 0.74 FALSE
43 GTEx Ovary TMEM60 0.23 0.19 enet 7 0.13 5.2e-04 6.58 7.5 8.0e-14 -0.60 0.10 0.52 FALSE
44 GTEx Ovary RSBN1L-AS1 0.21 0.22 enet 20 0.16 8.1e-05 9.19 8.7 3.8e-18 -0.72 0.07 0.79 FALSE
45 GTEx Pancreas PTPN12 0.26 0.13 lasso 3 0.08 2.7e-04 -8.66 7.2 6.9e-13 -0.52 0.38 0.10 FALSE
46 GTEx Pancreas TMEM60 0.19 0.03 enet 15 0.10 3.4e-05 9.18 6.0 1.4e-09 -0.52 0.07 0.71 FALSE
47 GTEx Pituitary TMEM60 0.19 0.06 lasso 6 0.04 2.8e-02 -9.30 10.1 3.5e-24 -0.95 0.04 0.91 FALSE
48 GTEx Skin Not Sun Exposed Suprapubic TMEM60 0.14 0.08 lasso 4 0.03 1.4e-02 9.18 8.6 9.9e-18 -0.77 0.13 0.78 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic RSBN1L-AS1 0.34 0.14 enet 25 0.29 2.8e-16 -1.61 6.5 8.1e-11 -0.72 0.02 0.98 FALSE
50 GTEx Skin Sun Exposed Lower leg TMEM60 0.10 0.10 lasso 3 0.09 1.4e-07 9.18 9.2 4.3e-20 -0.77 0.08 0.92 FALSE
51 GTEx Skin Sun Exposed Lower leg RSBN1L-AS1 0.25 0.18 enet 22 0.28 4.1e-23 -9.53 7.2 6.0e-13 -0.81 0.03 0.97 FALSE
52 GTEx Spleen PTPN12 0.41 0.07 lasso 11 0.14 2.2e-04 -8.66 5.8 5.3e-09 -0.23 0.38 0.23 FALSE
53 GTEx Spleen RSBN1L-AS1 0.36 0.02 enet 20 0.06 1.5e-02 -7.89 6.8 7.5e-12 -0.66 0.05 0.60 FALSE
54 GTEx Stomach RSBN1L-AS1 0.11 0.04 enet 5 0.11 9.0e-06 9.19 6.7 2.7e-11 -0.72 0.05 0.91 FALSE
55 GTEx Testis RSBN1L-AS1 0.16 0.12 lasso 8 0.16 1.5e-07 9.58 9.5 1.8e-21 -0.65 0.05 0.95 FALSE
56 GTEx Thyroid PTPN12 0.13 0.08 lasso 7 0.08 9.5e-07 -8.81 7.4 1.4e-13 -0.44 0.64 0.34 FALSE
57 GTEx Thyroid TMEM60 0.06 0.04 lasso 8 0.04 8.2e-04 6.60 7.0 2.4e-12 -0.55 0.08 0.91 FALSE
58 GTEx Uterus RSBN1L-AS1 0.33 0.08 lasso 7 0.05 3.0e-02 -9.52 6.8 1.3e-11 -0.80 0.04 0.62 FALSE
59 GTEx Whole Blood TMEM60 0.05 0.04 enet 7 0.03 5.4e-04 9.34 9.2 4.8e-20 -0.77 0.09 0.91 FALSE
60 METSIM Adipose TMEM60 0.10 0.07 enet 9 0.08 2.1e-12 -9.53 9.6 8.8e-22 -0.92 0.03 0.97 FALSE
61 NTR Blood CCDC146 0.05 0.03 enet 13 0.05 8.4e-16 -4.96 5.1 2.8e-07 -0.01 1.00 0.00 FALSE
62 NTR Blood FGL2 0.03 0.02 lasso 3 0.02 3.7e-07 4.31 5.4 8.4e-08 0.01 0.87 0.01 FALSE
63 ROSMAP Brain Pre-frontal Cortex RSBN1L 0.09 0.07 enet 42 0.08 9.9e-11 9.19 9.1 6.7e-20 -0.66 0.05 0.95 FALSE
64 ROSMAP Brain Pre-frontal Cortex RSBN1L-AS1 0.25 0.24 lasso 6 0.26 1.3e-33 -1.42 5.5 3.2e-08 -0.69 1.00 0.00 FALSE
65 YFS Blood RSBN1L 0.03 0.02 enet 13 0.02 1.1e-06 -9.58 -9.1 6.2e-20 0.87 0.04 0.96 FALSE
66 YFS Blood TMEM60 0.14 0.16 lasso 4 0.18 1.8e-55 9.18 8.7 2.6e-18 -0.79 0.08 0.92 FALSE
67 The Cancer Genome Atlas Breast Invasive Carcinoma FGL2 0.03 0.01 blup 27 0.02 6.2e-05 -4.96 5.3 9.6e-08 0.00 0.01 0.98 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma PHTF2 0.02 0.01 lasso 1 0.01 3.0e-03 -9.36 9.4 7.7e-21 -0.68 0.16 0.72 FALSE
69 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM60 0.02 0.02 lasso 1 0.02 2.3e-05 -9.47 9.5 2.8e-21 -0.83 0.03 0.97 FALSE
70 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TMEM60 0.08 0.06 blup 29 0.05 2.1e-03 -9.47 7.5 8.3e-14 -0.47 0.01 0.41 FALSE
71 The Cancer Genome Atlas Glioblastoma Multiforme TMEM60 0.10 0.10 blup 29 0.09 1.4e-03 -9.58 8.3 1.1e-16 -0.94 0.01 0.82 FALSE
72 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMEM60 0.08 0.02 blup 29 0.04 1.2e-05 9.58 6.1 9.1e-10 -0.52 0.02 0.98 FALSE
73 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PHTF2 0.02 0.03 lasso 1 0.02 8.0e-04 -9.30 9.3 1.3e-20 -0.65 0.12 0.63 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM60 0.05 0.01 enet 7 0.02 1.9e-03 9.34 6.5 8.5e-11 -0.40 0.02 0.92 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM60 0.05 0.02 blup 29 0.03 7.9e-03 -9.47 7.8 5.2e-15 -0.51 0.01 0.52 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma FGL2 0.10 0.10 lasso 1 0.10 5.8e-11 -5.38 5.4 7.4e-08 -0.01 0.00 0.99 TRUE
77 The Cancer Genome Atlas Brain Lower Grade Glioma RSBN1L 0.02 0.02 blup 58 0.02 3.4e-03 9.18 -10.6 2.1e-26 0.87 0.03 0.76 TRUE
78 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM60 0.02 0.03 blup 29 0.02 6.8e-03 -9.47 9.5 1.7e-21 -0.74 0.02 0.79 FALSE
79 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM60 0.12 0.05 blup 29 0.02 3.1e-02 9.58 6.8 1.4e-11 -0.46 0.01 0.64 FALSE
80 The Cancer Genome Atlas Soft Tissue Sarcoma PHTF2 0.06 0.04 blup 72 0.04 2.0e-03 -7.94 9.9 4.7e-23 -0.89 0.02 0.84 FALSE
81 The Cancer Genome Atlas Thyroid Carcinoma PTPN12 0.04 0.04 enet 4 0.04 1.0e-04 -9.01 9.0 1.8e-19 -0.62 0.02 0.97 FALSE
82 The Cancer Genome Atlas Thyroid Carcinoma TMEM60 0.12 0.06 enet 6 0.06 1.2e-06 9.18 6.9 5.7e-12 -0.58 0.05 0.95 FALSE