[Hub]/) : Traits : Waist Hip Ratio (WHR) : ← →

chr7:76,058,767-78,122,616

Best TWAS P=2.14e-26 · Best GWAS P=1.35e-22 conditioned to 0.316

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC146	0.05	0.00	bslmm	340	0.01	5.4e-02	0.76	6.6	3.2e-11	-0.36	0.04	0.07	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PTPN12	0.21	0.09	lasso	9	0.14	5.4e-17	-8.82	5.9	4.3e-09	-0.40	0.98	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	9.34	9.7	2.0e-22	-0.81	0.06	0.94	FALSE
4	GTEx	Adipose Subcutaneous	PTPN12	0.17	0.08	lasso	7	0.10	7.8e-09	1.59	5.5	4.8e-08	-0.29	0.91	0.08	FALSE
5	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	9.09	9.6	1.1e-21	-0.77	0.05	0.94	FALSE
6	GTEx	Adipose Subcutaneous	RSBN1L-AS1	0.23	0.13	enet	33	0.22	9.2e-18	-1.61	5.4	8.5e-08	-0.71	0.12	0.88	FALSE
7	GTEx	Adipose Visceral Omentum	PTPN12	0.19	0.04	enet	28	0.02	2.5e-02	-7.94	6.6	4.3e-11	-0.56	0.31	0.53	FALSE
8	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	9.25	8.6	1.0e-17	-0.70	0.09	0.91	FALSE
9	GTEx	Adrenal Gland	PTPN12	0.16	0.10	lasso	4	0.04	1.0e-02	-8.82	8.7	3.7e-18	-0.55	0.35	0.27	FALSE
10	GTEx	Artery Aorta	PTPN12	0.22	0.03	enet	28	0.10	3.0e-06	1.10	5.8	5.1e-09	-0.30	0.65	0.25	FALSE
11	GTEx	Artery Aorta	RSBN1L-AS1	0.26	0.18	lasso	10	0.25	5.0e-14	-1.42	6.2	4.0e-10	-0.78	0.04	0.96	FALSE
12	GTEx	Artery Coronary	PTPN12	0.33	0.08	enet	26	0.24	1.6e-08	6.37	5.3	1.0e-07	-0.21	0.63	0.12	FALSE
13	GTEx	Artery Coronary	RSBN1L-AS1	0.37	0.09	enet	14	0.21	1.4e-07	-1.61	5.2	2.1e-07	-0.74	0.06	0.92	FALSE
14	GTEx	Artery Tibial	PTPN12	0.25	0.13	lasso	8	0.12	1.8e-09	-9.40	9.4	6.8e-21	-0.63	0.29	0.71	FALSE
15	GTEx	Artery Tibial	TMEM60	0.07	0.05	enet	12	0.02	6.6e-03	9.18	6.9	3.8e-12	-0.57	0.07	0.85	FALSE
16	GTEx	Artery Tibial	RSBN1L-AS1	0.28	0.13	enet	13	0.28	5.5e-22	-1.57	6.9	6.7e-12	-0.79	0.07	0.93	FALSE
17	GTEx	Brain Cerebellum	RSBN1L	0.14	0.12	lasso	2	0.13	1.3e-04	-9.52	-9.7	4.2e-22	0.93	0.03	0.94	FALSE
18	GTEx	Brain Cortex	RSBN1L-AS1	0.34	0.15	enet	23	0.23	5.8e-07	-1.57	6.8	1.2e-11	-0.78	0.04	0.95	FALSE
19	GTEx	Breast Mammary Tissue	TMEM60	0.13	0.04	lasso	4	0.04	5.4e-03	9.43	7.8	6.8e-15	-0.69	0.06	0.68	FALSE
20	GTEx	Cells Transformed fibroblasts	PTPN12	0.19	0.15	lasso	4	0.18	1.7e-13	1.74	5.5	3.1e-08	-0.32	0.97	0.03	FALSE
21	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	9.18	9.0	1.7e-19	-0.78	0.15	0.85	FALSE
22	GTEx	Cells Transformed fibroblasts	RSBN1L-AS1	0.23	0.19	lasso	6	0.21	5.7e-16	9.19	7.6	2.9e-14	-0.75	0.08	0.92	FALSE
23	GTEx	Colon Sigmoid	PTPN12	0.24	0.04	lasso	8	0.08	1.2e-03	1.10	5.9	4.5e-09	-0.30	0.24	0.13	FALSE
24	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	9.11	9.0	1.8e-19	-0.77	0.07	0.73	FALSE
25	GTEx	Colon Sigmoid	RSBN1L-AS1	0.46	0.48	lasso	6	0.50	5.0e-20	9.19	9.2	2.8e-20	-0.74	0.05	0.95	FALSE
26	GTEx	Colon Transverse	PTPN12	0.17	0.12	lasso	6	0.10	1.8e-05	-8.82	8.8	1.4e-18	-0.57	0.43	0.36	FALSE
27	GTEx	Colon Transverse	GSAP	0.14	0.02	lasso	7	0.05	2.2e-03	-9.01	-6.6	4.6e-11	0.41	0.12	0.19	FALSE
28	GTEx	Colon Transverse	RSBN1L-AS1	0.32	0.24	lasso	9	0.22	5.7e-11	9.19	9.0	2.8e-19	-0.80	0.04	0.96	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	9.25	9.5	3.0e-21	-0.78	0.04	0.96	FALSE
30	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	9.18	9.0	2.0e-19	-0.78	0.06	0.92	FALSE
31	GTEx	Esophagus Muscularis	PTPN12	0.34	0.17	enet	48	0.20	4.3e-12	-8.66	5.8	8.0e-09	-0.29	0.89	0.11	FALSE
32	GTEx	Esophagus Muscularis	RSBN1L	0.07	0.03	lasso	3	0.01	4.3e-02	6.60	6.9	4.6e-12	-0.51	0.13	0.70	FALSE
33	GTEx	Esophagus Muscularis	RSBN1L-AS1	0.35	0.51	lasso	5	0.52	3.8e-36	9.19	9.1	1.2e-19	-0.72	0.06	0.94	FALSE
34	GTEx	Heart Left Ventricle	PTPN12	0.12	0.00	enet	21	0.01	5.6e-02	-8.82	6.8	1.5e-11	-0.36	0.06	0.13	FALSE
35	GTEx	Heart Left Ventricle	RSBN1L-AS1	0.24	0.15	lasso	7	0.14	6.3e-08	-1.42	5.5	3.8e-08	-0.69	0.10	0.90	FALSE
36	GTEx	Lung	PTPN12	0.10	0.05	enet	11	0.07	5.1e-06	-8.77	7.3	2.0e-13	-0.44	0.86	0.10	FALSE
37	GTEx	Lung	TMEM60	0.12	0.05	enet	16	0.07	3.4e-06	-8.44	6.9	4.9e-12	-0.53	0.12	0.86	FALSE
38	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	9.18	-9.7	3.9e-22	0.85	0.06	0.94	FALSE
39	GTEx	Muscle Skeletal	RSBN1L-AS1	0.22	0.18	lasso	4	0.22	7.3e-21	-9.52	7.3	2.1e-13	-0.85	0.03	0.97	FALSE
40	GTEx	Nerve Tibial	PTPN12	0.18	0.13	enet	20	0.14	2.9e-10	-8.66	6.9	4.0e-12	-0.47	0.92	0.08	FALSE
41	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	9.18	9.6	1.0e-21	-0.82	0.04	0.96	FALSE
42	GTEx	Nerve Tibial	RSBN1L-AS1	0.35	0.20	lasso	12	0.27	1.8e-19	-1.61	5.3	9.0e-08	-0.70	0.26	0.74	FALSE
43	GTEx	Ovary	TMEM60	0.23	0.19	enet	7	0.13	5.2e-04	6.58	7.5	8.0e-14	-0.60	0.10	0.52	FALSE
44	GTEx	Ovary	RSBN1L-AS1	0.21	0.22	enet	20	0.16	8.1e-05	9.19	8.7	3.8e-18	-0.72	0.07	0.79	FALSE
45	GTEx	Pancreas	PTPN12	0.26	0.13	lasso	3	0.08	2.7e-04	-8.66	7.2	6.9e-13	-0.52	0.38	0.10	FALSE
46	GTEx	Pancreas	TMEM60	0.19	0.03	enet	15	0.10	3.4e-05	9.18	6.0	1.4e-09	-0.52	0.07	0.71	FALSE
47	GTEx	Pituitary	TMEM60	0.19	0.06	lasso	6	0.04	2.8e-02	-9.30	10.1	3.5e-24	-0.95	0.04	0.91	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	TMEM60	0.14	0.08	lasso	4	0.03	1.4e-02	9.18	8.6	9.9e-18	-0.77	0.13	0.78	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	RSBN1L-AS1	0.34	0.14	enet	25	0.29	2.8e-16	-1.61	6.5	8.1e-11	-0.72	0.02	0.98	FALSE
50	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	9.18	9.2	4.3e-20	-0.77	0.08	0.92	FALSE
51	GTEx	Skin Sun Exposed Lower leg	RSBN1L-AS1	0.25	0.18	enet	22	0.28	4.1e-23	-9.53	7.2	6.0e-13	-0.81	0.03	0.97	FALSE
52	GTEx	Spleen	PTPN12	0.41	0.07	lasso	11	0.14	2.2e-04	-8.66	5.8	5.3e-09	-0.23	0.38	0.23	FALSE
53	GTEx	Spleen	RSBN1L-AS1	0.36	0.02	enet	20	0.06	1.5e-02	-7.89	6.8	7.5e-12	-0.66	0.05	0.60	FALSE
54	GTEx	Stomach	RSBN1L-AS1	0.11	0.04	enet	5	0.11	9.0e-06	9.19	6.7	2.7e-11	-0.72	0.05	0.91	FALSE
55	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	9.58	9.5	1.8e-21	-0.65	0.05	0.95	FALSE
56	GTEx	Thyroid	PTPN12	0.13	0.08	lasso	7	0.08	9.5e-07	-8.81	7.4	1.4e-13	-0.44	0.64	0.34	FALSE
57	GTEx	Thyroid	TMEM60	0.06	0.04	lasso	8	0.04	8.2e-04	6.60	7.0	2.4e-12	-0.55	0.08	0.91	FALSE
58	GTEx	Uterus	RSBN1L-AS1	0.33	0.08	lasso	7	0.05	3.0e-02	-9.52	6.8	1.3e-11	-0.80	0.04	0.62	FALSE
59	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	9.34	9.2	4.8e-20	-0.77	0.09	0.91	FALSE
60	METSIM	Adipose	TMEM60	0.10	0.07	enet	9	0.08	2.1e-12	-9.53	9.6	8.8e-22	-0.92	0.03	0.97	FALSE
61	NTR	Blood	CCDC146	0.05	0.03	enet	13	0.05	8.4e-16	-4.96	5.1	2.8e-07	-0.01	1.00	0.00	FALSE
62	NTR	Blood	FGL2	0.03	0.02	lasso	3	0.02	3.7e-07	4.31	5.4	8.4e-08	0.01	0.87	0.01	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	RSBN1L	0.09	0.07	enet	42	0.08	9.9e-11	9.19	9.1	6.7e-20	-0.66	0.05	0.95	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	RSBN1L-AS1	0.25	0.24	lasso	6	0.26	1.3e-33	-1.42	5.5	3.2e-08	-0.69	1.00	0.00	FALSE
65	YFS	Blood	RSBN1L	0.03	0.02	enet	13	0.02	1.1e-06	-9.58	-9.1	6.2e-20	0.87	0.04	0.96	FALSE
66	YFS	Blood	TMEM60	0.14	0.16	lasso	4	0.18	1.8e-55	9.18	8.7	2.6e-18	-0.79	0.08	0.92	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	FGL2	0.03	0.01	blup	27	0.02	6.2e-05	-4.96	5.3	9.6e-08	0.00	0.01	0.98	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHTF2	0.02	0.01	lasso	1	0.01	3.0e-03	-9.36	9.4	7.7e-21	-0.68	0.16	0.72	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	-9.47	9.5	2.8e-21	-0.83	0.03	0.97	FALSE
70	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM60	0.08	0.06	blup	29	0.05	2.1e-03	-9.47	7.5	8.3e-14	-0.47	0.01	0.41	FALSE
71	The Cancer Genome Atlas	Glioblastoma Multiforme	TMEM60	0.10	0.10	blup	29	0.09	1.4e-03	-9.58	8.3	1.1e-16	-0.94	0.01	0.82	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM60	0.08	0.02	blup	29	0.04	1.2e-05	9.58	6.1	9.1e-10	-0.52	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PHTF2	0.02	0.03	lasso	1	0.02	8.0e-04	-9.30	9.3	1.3e-20	-0.65	0.12	0.63	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM60	0.05	0.01	enet	7	0.02	1.9e-03	9.34	6.5	8.5e-11	-0.40	0.02	0.92	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM60	0.05	0.02	blup	29	0.03	7.9e-03	-9.47	7.8	5.2e-15	-0.51	0.01	0.52	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	FGL2	0.10	0.10	lasso	1	0.10	5.8e-11	-5.38	5.4	7.4e-08	-0.01	0.00	0.99	TRUE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	9.18	-10.6	2.1e-26	0.87	0.03	0.76	TRUE
78	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	-9.47	9.5	1.7e-21	-0.74	0.02	0.79	FALSE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM60	0.12	0.05	blup	29	0.02	3.1e-02	9.58	6.8	1.4e-11	-0.46	0.01	0.64	FALSE
80	The Cancer Genome Atlas	Soft Tissue Sarcoma	PHTF2	0.06	0.04	blup	72	0.04	2.0e-03	-7.94	9.9	4.7e-23	-0.89	0.02	0.84	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	PTPN12	0.04	0.04	enet	4	0.04	1.0e-04	-9.01	9.0	1.8e-19	-0.62	0.02	0.97	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM60	0.12	0.06	enet	6	0.06	1.2e-06	9.18	6.9	5.7e-12	-0.58	0.05	0.95	FALSE