Best TWAS P=5.58e-12 · Best GWAS P=1.94e-08 conditioned to 5.4e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PPP6C | 0.03 | 0.01 | bslmm | 315 | 0.01 | 2.2e-02 | -4.8 | 6.9 | 5.6e-12 | -0.16 | 0.09 | 0.23 | TRUE |
2 | GTEx | Artery Aorta | PRPS1P2 | 0.08 | 0.10 | lasso | 4 | 0.08 | 2.1e-05 | 5.5 | -5.7 | 1.2e-08 | 0.18 | 0.05 | 0.90 | FALSE |
3 | GTEx | Artery Tibial | GAPVD1 | 0.11 | 0.16 | enet | 19 | 0.16 | 6.4e-13 | 4.8 | 5.3 | 9.0e-08 | -0.15 | 0.22 | 0.78 | FALSE |
4 | GTEx | Brain Cerebellum | PRPS1P2 | 0.09 | 0.08 | enet | 16 | 0.04 | 2.8e-02 | 4.9 | -5.7 | 1.2e-08 | 0.16 | 0.14 | 0.43 | FALSE |
5 | GTEx | Muscle Skeletal | PPP6C | 0.03 | 0.03 | enet | 6 | 0.01 | 3.0e-02 | -4.9 | 5.1 | 2.9e-07 | 0.02 | 0.18 | 0.67 | FALSE |
6 | GTEx | Nerve Tibial | GAPVD1 | 0.17 | 0.08 | lasso | 10 | 0.10 | 9.3e-08 | -4.2 | 5.3 | 1.2e-07 | -0.05 | 0.19 | 0.80 | FALSE |
7 | GTEx | Nerve Tibial | PRPS1P2 | 0.11 | 0.11 | enet | 9 | 0.10 | 1.4e-07 | -4.8 | -5.3 | 1.1e-07 | 0.04 | 0.27 | 0.72 | FALSE |
8 | GTEx | Ovary | PRPS1P2 | 0.14 | 0.14 | lasso | 2 | 0.05 | 2.9e-02 | -4.8 | -5.1 | 3.1e-07 | -0.01 | 0.12 | 0.40 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | GAPVD1 | 0.04 | 0.01 | lasso | 4 | 0.01 | 3.8e-02 | -4.6 | 5.4 | 5.1e-08 | -0.07 | 0.20 | 0.69 | FALSE |
10 | GTEx | Thyroid | GAPVD1 | 0.05 | 0.05 | enet | 13 | 0.01 | 6.6e-02 | 4.8 | 5.1 | 2.9e-07 | -0.17 | 0.20 | 0.77 | FALSE |
11 | GTEx | Thyroid | PRPS1P2 | 0.08 | 0.09 | enet | 18 | 0.07 | 4.0e-06 | -4.7 | -5.3 | 1.4e-07 | 0.01 | 0.24 | 0.76 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WDR38 | 0.04 | 0.01 | blup | 32 | 0.02 | 9.5e-04 | 3.7 | 5.6 | 2.2e-08 | -0.65 | 0.02 | 0.48 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP6C | 0.08 | 0.13 | enet | 9 | 0.13 | 5.5e-13 | -4.9 | 5.1 | 2.9e-07 | 0.03 | 0.02 | 0.97 | FALSE |