Best TWAS P=1.87e-18 · Best GWAS P=1.44e-24 conditioned to 0.00302
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TCF7L2 | 0.19 | 0.09 | lasso | 6 | 0.05 | 1.0e-03 | 8.8 | -8.8 | 1.9e-18 | -0.94 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Esophagus Muscularis | RP11-57H14.2 | 0.20 | 0.19 | lasso | 2 | 0.18 | 2.3e-11 | -6.9 | -6.9 | 6.6e-12 | -0.25 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Heart Left Ventricle | RP11-57H14.2 | 0.19 | 0.13 | lasso | 4 | 0.11 | 2.9e-06 | -6.9 | -6.2 | 4.3e-10 | -0.24 | 0.64 | 0.06 | FALSE |
| 4 | GTEx | Lung | RP11-57H14.2 | 0.12 | 0.14 | lasso | 3 | 0.12 | 2.6e-09 | -6.9 | -6.9 | 5.0e-12 | -0.24 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Nerve Tibial | RP11-57H14.2 | 0.35 | 0.32 | lasso | 3 | 0.34 | 1.1e-24 | -6.9 | -7.1 | 1.1e-12 | -0.25 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Pituitary | RP11-57H14.2 | 0.43 | 0.27 | lasso | 10 | 0.32 | 9.2e-09 | -6.9 | -6.5 | 6.8e-11 | -0.24 | 0.45 | 0.04 | FALSE |
| 7 | GTEx | Thyroid | RP11-57H14.2 | 0.14 | 0.10 | lasso | 1 | 0.09 | 1.8e-07 | -6.9 | -7.0 | 3.7e-12 | -0.25 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Whole Blood | RP11-57H14.2 | 0.10 | 0.07 | lasso | 4 | 0.05 | 1.5e-05 | 5.1 | -5.9 | 4.5e-09 | -0.20 | 0.91 | 0.01 | TRUE |