TWAS hub - TCF7L2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.188	0.061	0.00069	0.087	NA	0.043	NA	0.049	1.6e-05	NA	0.0021	NA	0.001
2	GTEx	Esophagus Muscularis	0.186	0.062	0.00390	-0.004	NA	0.006	NA	0.009	8.1e-01	NA	0.1400	NA	0.084

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Type 2 Diabetes (T2D) (2018)	71.2	133.2	265.7	-16.3	0.9
Diabetes diagnosed by doctor	60.8	99.8	198.8	-14.1	0.9
Diabetes (self-reported)	51.8	80.0	158.8	-12.6	1.1
Diabetes (father)	46.3	57.4	114.5	-10.7	0.5
Medication: Metformin	46.1	65.1	130.0	-11.4	0.4
Diabetes (mother)	33.8	43.1	85.6	-9.2	-0.8
Medication: Gliclazide	32.8	37.1	67.6	-8.2	2.6
Illnesses of siblings: Diabetes	19.6	24.1	47.7	-6.9	0.7
Type 2 Diabetes (T2D) (2012)	16.9	19.5	39.0	-6.2	0.0
Breast Cancer	13.4	32.2	55.7	7.5	2.9
Eye problems/disorders: Diabetes related eye disease	9.4	10.3	20.5	-4.5	0.4
Waist Hip Ratio (WHR)	8.8	39.6	76.7	-8.8	1.6
Medication: Atorvastatin	7.7	9.5	18.9	-4.3	-0.2
Cholesterol lowering medication	7.6	11.2	22.3	-4.7	0.3
Hip circumference	7.5	32.3	62.8	7.9	-1.3
Medication: Simvastatin	6.2	9.0	16.3	-4.0	1.3
Medication: Cholesterol lowering	5.8	9.0	16.9	-4.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.8	6.9	11.9	3.5	-1.4
Breast cancer (self-reported)	5.8	6.9	11.5	-3.4	-1.5
Medication: Aspirin	4.9	6.4	9.2	-3.0	1.9
Leg fat percentage (left)	4.9	17.9	35.4	6.0	-0.6
Leg fat percentage (right)	4.7	17.1	33.3	5.8	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	4.7	5.0	9.8	3.1	-0.4
Qualifications: nursing, teaching	4.7	7.3	13.7	3.7	-0.9
Body Mass Index (BMI) (2010)	4.5	6.1	11.1	3.3	1.1
Fasting Glucose	4.5	5.4	10.5	-3.2	-0.5
Leg fat mass (left)	4.4	17.2	34.5	5.9	-0.1
Leg fat mass (right)	4.3	16.5	33.0	5.7	-0.2
Worrier / anxious feelings	4.2	7.9	12.1	3.5	1.9
Body mass index (BMI)	4.0	17.0	33.8	5.8	-0.4
BMI	3.8	21.9	43.0	6.6	0.9
Number of live births	3.5	4.9	8.6	-1.1	-2.9
Systolic Blood Pressure	3.3	16.7	27.2	-5.2	2.5
Medication for cholesterol, blood pressure or diabetes	3.3	5.5	8.7	2.9	-1.5
High cholesterol (Self-reported)	3.2	5.7	10.0	-3.2	1.2
Arm fat mass (right)	3.1	12.8	25.7	5.1	-0.0
HbA1C	3.0	3.4	4.9	-2.2	1.4
Allergy	3.0	7.0	13.6	-0.6	3.7
Illnesses of father: None of the above (group 1)	3.0	3.8	7.5	2.7	0.0
Average weekly champagne plus white wine intake	3.0	4.1	8.2	-2.9	-0.1
Whole body fat mass	2.9	12.2	24.3	4.9	-0.1
Arm fat mass (left)	2.9	11.8	23.6	4.9	0.1
Medication: Aspirin	2.8	3.7	5.3	-2.3	1.4
Arm fat percentage (left)	2.8	11.3	22.5	4.7	-0.1
Myopia	2.8	4.1	7.7	-2.8	0.7
Hayfever, allergic rhinitis or eczema	2.7	5.8	11.6	0.3	-3.4
Arm fat percentage (right)	2.7	10.6	21.2	4.6	0.1
Body fat percentage	2.7	10.5	20.9	4.6	-0.4
Mean Putamen Volume	2.6	3.0	5.9	0.2	-2.4
Birth weight	2.6	5.6	10.2	-3.2	-1.0
Alcohol usually taken with meals	2.5	4.0	7.5	-2.7	0.7
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	5.3	-1.2	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.4	8.4	-2.9	1.5
Diastolic blood pressure, automated reading	2.4	7.5	12.2	3.5	1.7
Waist circumference	2.3	8.3	16.6	4.1	0.2
Weight	2.3	11.3	22.4	4.7	0.3
Falls in the last year	2.3	3.1	5.5	2.4	0.8
Illnesses of mother	2.3	2.9	5.7	2.4	0.2
Medication: Ramipril	2.2	2.8	4.0	-1.3	2.0
Medication: Seretide 50 evohaler	2.2	2.6	3.9	2.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	6.4	-2.5	1.6
Chronotype (morning person)	2.1	4.8	6.4	-2.5	1.8
Eye problems/disorders: None of the above	2.1	2.4	4.7	2.2	0.3
Heart attack/myocardial infarction (self-reported)	2.1	2.7	5.1	-2.3	-0.6
Impedance of arm (right)	2.0	9.2	17.3	-4.2	1.1
Impedance of arm (left)	2.0	9.0	17.8	-4.2	0.5
Long-standing illness, disability or infirmity	2.0	3.1	5.7	-2.4	0.6
Primary Biliary Cirrhosis	1.9	2.8	2.8	1.7	-1.7
Trunk fat mass	1.9	8.2	16.2	4.0	0.3
Pulse rate, automated reading	1.9	6.0	10.8	-3.3	1.1
Had menopause	1.8	2.3	3.5	1.1	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	7.7	-2.8	0.7
Heart attack	1.8	2.4	4.6	-2.1	-0.4
Age at first live birth	1.8	3.1	3.6	1.6	1.9
Migraine (self-reported)	1.8	2.2	4.4	2.1	0.3
Medication: Lisinopril	1.8	2.4	4.6	0.3	2.2
Serious illness, injury or assault to yourself	1.7	2.0	3.7	-1.9	-0.6
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.5	-0.8	-1.9
Birth weight of first child	1.7	3.2	6.3	-2.5	-0.3
Medication: Levothyroxine sodium	1.6	2.7	4.5	1.0	2.1
Alcohol intake versus 10 years previously	1.6	2.4	2.9	-1.7	-1.4
Pulse wave reflection index	1.6	2.0	3.8	2.0	-0.3
Eye problems/disorders: Glaucoma	1.6	1.9	3.4	-0.7	1.9
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	2.5	1.2	-1.6
Rheumatoid Arthritis	1.5	2.1	3.0	1.1	-1.7
Medication for hormone replacement therapy	1.5	1.6	1.7	1.3	-1.3
Townsend deprivation index at recruitment	1.5	2.2	2.4	1.4	-1.5
Number of full brothers	1.5	1.8	3.6	-1.9	-0.4
Number of full sisters	1.5	1.8	2.3	1.2	-1.5
Verbal and Numeric Reasoning (VNR)	1.4	3.3	6.2	-2.5	-0.6
Bipolar Disorder (2011)	1.4	1.3	2.4	0.5	1.6
Allergy or Eczema	1.4	3.6	7.1	-0.2	-2.7
Number of treatments/medications taken	1.4	2.4	3.5	-1.9	1.2
Trunk fat percentage	1.4	5.6	11.1	3.3	-0.2
Fed-up feelings	1.4	2.6	2.7	1.6	1.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.3	1.8	0.2
Age at last live birth	1.4	2.1	4.2	-0.0	2.0
Impedance of whole body	1.4	7.2	14.4	-3.8	-0.1
Hearing difficulty/problems: Yes	1.3	2.0	3.9	0.1	-2.0
Supplements: Zinc	1.3	1.4	2.8	-0.2	-1.7
Hand grip strength (right)	1.3	3.6	7.0	2.7	-0.3
Blood clot in the leg (DVT)	1.3	1.7	2.4	0.9	-1.6
Headache pain in last month	1.3	2.2	3.8	2.0	0.7
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.2	0.1	1.8
Medication: Bendroflumethiazide	1.3	2.0	4.0	-0.0	2.0
Commuting to job workplace: Cycle	1.3	1.5	2.7	-1.6	-0.6
Relative age of first facial hair	1.2	2.5	4.1	-2.0	-0.9
Stomach or abdominal pain in last month	1.2	1.5	2.6	-1.6	-0.6
Hair/balding pattern: Pattern 3	1.2	1.8	3.0	0.8	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.4	1.9	-0.5
Chronic bronchitis/emphysema (mother)	1.2	1.3	2.0	-0.8	-1.4
Medication: Blood pressure	1.2	2.1	2.9	-1.2	1.7
Angina (self-reported)	1.2	1.5	2.6	-1.6	0.6
Smoking status: Current	1.2	1.9	2.4	-1.2	1.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.0	1.7	-0.0
Basal metabolic rate	1.2	6.5	12.2	3.5	0.8
Arm fat-free mass (left)	1.2	5.9	11.6	3.4	0.4
Heel T-Score	1.1	8.7	10.3	-3.2	2.7
Hypothyroidism (self reported)	1.1	2.4	3.8	1.0	2.0
Impedance of leg (right)	1.1	5.3	9.4	-3.1	-1.1
Leg fat-free mass (left)	1.1	5.8	10.7	3.3	0.9
Taking other prescription medications	1.1	1.6	2.1	-1.1	1.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.3	-0.0	1.5
Leg predicted mass (left)	1.1	5.9	10.9	3.3	0.9
Financial difficulties in last 2 years	1.1	1.4	2.8	1.7	0.2
Hair/balding pattern: Pattern 4	1.1	2.8	4.7	-2.2	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	1.3	-1.1	1.1
Medication for pain relief, constipation, heartburn	1.1	1.9	2.8	1.0	-1.7
Supplements: Vitamin C	1.1	1.4	1.4	-1.1	-1.2
Friendships satisfaction	1.1	1.3	2.4	1.5	0.5
Leg predicted mass (right)	1.1	5.6	9.6	3.1	1.3
Commuting to job workplace: Public transport	1.1	1.3	2.6	0.2	1.6
Medication: Blood pressure	1.1	2.0	2.6	-1.2	1.6
Pain experienced in last month	1.1	1.8	3.4	-1.9	-0.3
Ovarian Cancer	1.0	1.3	2.6	-1.6	-0.1
Angina	1.0	1.3	2.5	-1.6	0.4
Age when periods started (menarche)	1.0	2.5	3.5	-1.2	1.9
High blood pressure	1.0	2.8	5.2	-0.7	2.3
Prospective memory result	1.0	1.2	2.0	-0.7	1.4
Comparative body size at age 10	1.0	2.6	5.2	2.3	-0.2
Leg fat-free mass (right)	1.0	5.6	9.4	3.1	1.3
Arm predicted mass (left)	1.0	5.2	10.1	3.2	0.6
Alzheimer’s Disease (in father)	0.9	1.0	2.0	1.4	-0.0
Coronary Artery Disease (CAD)	0.9	1.1	1.4	-1.2	-0.9
Ever had hysterectomy (womb removed)	0.9	1.1	1.1	-1.0	-1.0
Systolic blood pressure, automated reading	0.9	2.5	4.7	-2.2	0.6
Breastfed as a baby	0.9	1.1	1.3	0.9	1.1
Medication: Paracetamol	0.9	1.5	2.7	1.6	0.6
Arm fat-free mass (right)	0.9	4.6	9.1	3.0	0.4
Hypertension (Self-reported)	0.9	2.5	4.6	-0.6	2.1
Whole body fat-free mass	0.9	5.0	8.8	3.0	1.1
Medication for cholesterol	0.9	1.3	1.6	1.3	-1.0
Osteoporosis (self-reported)	0.9	1.1	2.2	-0.3	1.5
Whole body water mass	0.9	4.9	8.5	2.9	1.1
Miserableness	0.9	1.5	2.7	1.6	0.5
Ever taken oral contraceptive pill	0.9	1.0	1.6	0.6	1.2
Fractured/broken bones in last 5 years	0.9	1.1	1.5	-0.9	1.2
Alzheimer’s Disease (in mother)	0.8	0.9	1.3	1.1	0.8
Lung FEV1/FVC ratio	0.8	4.0	5.1	-2.2	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.7	-1.3	-0.7
Supplements: Glucosamine	0.8	1.1	1.6	0.8	1.2
Impedance of leg (left)	0.8	3.8	6.9	-2.6	-0.8
Qualifications: None of the above	0.8	1.8	2.2	-1.2	-1.5
Fluid intelligence score	0.8	1.7	3.2	-1.8	0.3
Father’s age at death	0.8	1.1	1.5	1.2	-0.9
Glaucoma (self-reported)	0.8	0.9	1.6	-0.6	1.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.8	0.4	1.7
Arm predicted mass (right)	0.8	4.2	8.2	2.9	0.5
Alcohol intake frequency.	0.8	1.8	2.6	1.6	-1.0
Overall health rating	0.8	1.8	2.7	-1.6	0.9
Eye problems/disorders: Cataract	0.8	0.9	1.5	-1.2	-0.6
Number of self-reported non-cancer illnesses	0.8	1.5	1.6	-1.3	1.1
Vascular/heart problems diagnosed by doctor	0.8	2.3	3.8	0.9	-1.9
Alcohol drinker status: Previous	0.8	0.9	1.8	1.3	-0.2
Ulcerative Colitis	0.7	0.9	1.8	1.4	-0.2
Cardiovascular Disease	0.7	2.4	3.9	-1.0	2.0
Illnesses of siblings	0.7	1.0	1.5	1.2	-0.7
Time employed in main current job	0.7	0.8	1.3	1.2	0.5
Noisy workplace	0.7	0.9	1.2	0.8	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	-0.5	1.2
Asthma	0.7	1.4	2.1	1.4	-0.8
Worry too long after embarrassment	0.7	1.1	1.6	0.8	1.3
Had major operations	0.7	0.8	1.1	-0.7	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	0.4	-1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.5	1.2	0.6
Triglycerides	0.6	1.0	1.9	-1.4	0.3
Lung FVC	0.6	3.0	3.6	1.9	-1.6
Sensitivity / hurt feelings	0.6	1.0	2.0	1.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	-0.4	-1.1
Current tobacco smoking	0.6	1.0	1.3	-0.9	1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	0.3	-1.1
Hair/balding pattern: Pattern 2	0.6	0.7	1.4	0.2	-1.2
Trunk fat-free mass	0.6	3.4	5.6	2.4	1.1
Trunk predicted mass	0.6	3.6	5.8	2.4	1.2
Medication: Amlodipine	0.6	0.8	1.4	-0.5	1.2
Shortness of breath walking on level ground	0.6	0.7	1.2	1.1	-0.5
Neck or shoulder pain in last month	0.6	0.8	1.2	0.7	-1.1
Mood swings	0.6	1.2	2.2	1.5	0.4
Back pain experienced in last month	0.6	0.9	1.4	0.6	1.2
Asthma (self-reported)	0.6	1.2	1.8	1.3	-0.8
Guilty feelings	0.6	0.8	1.1	0.8	1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	-1.1	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.5	-1.2	0.1
Multivitamins +/- minerals	0.5	0.7	1.2	0.4	1.1
Medication: Atenolol	0.5	0.6	0.9	-1.0	-0.6
High blood pressure (siblings)	0.5	0.7	0.8	0.9	0.8
Medication: Omeprazole	0.5	0.6	1.2	-1.1	-0.0
Ever had bowel cancer screening	0.5	0.6	0.9	0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.8	-1.3	-0.4
Financial situation satisfaction	0.5	0.6	0.9	0.5	-1.0
Illnesses of father: High blood pressure	0.5	0.6	1.2	1.1	-0.1
Age started oral contraceptive pill	0.5	0.6	1.0	-1.0	0.5
Ever depressed for a whole week	0.5	0.6	0.7	0.8	-0.7
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	1.2	0.4
Age at First Birth	0.4	0.6	0.9	0.9	-0.6
Crohns Disease (2012)	0.4	0.7	0.8	0.8	0.9
LDL Cholesterol	0.4	0.7	1.3	-1.1	-0.4
Blood Platelet Count	0.4	4.1	7.8	-2.8	0.6
Blood Red Count	0.4	3.6	7.1	2.7	0.4
Smoking Status	0.4	0.9	1.8	-1.4	0.1
Respiratory disease	0.4	0.8	1.6	1.3	0.0
Vitamin and mineral supplements	0.4	0.5	0.8	0.9	-0.4
Qualifications: CSEs or equivalent	0.4	0.6	1.0	1.0	-0.4
Hearing difficulty/problems with background noise	0.4	0.7	1.3	-0.4	-1.1
Had other major operations	0.4	0.5	1.0	-1.0	0.1
Neuroticism score	0.4	0.8	1.1	1.0	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	1.3	0.1
Standing height	0.4	4.2	5.9	-2.4	1.6
Length of working week for main job	0.4	0.4	0.8	-0.9	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	1.0	-0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	0.3	-1.0
Chest pain or discomfort	0.4	0.5	0.7	-0.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.6	0.6	0.8
Commuting to job workplace: Walk	0.4	0.4	0.8	0.9	0.1
Bipolar Disorder (2018)	0.3	0.5	1.0	1.0	0.0
Worry (Nagel 2018)	0.3	0.7	0.7	0.9	-0.8
Ulcerative Colitis (UC)	0.3	0.6	0.6	0.7	0.8
Major Depression (MDD)	0.3	0.4	0.5	-0.5	0.7
Reaction Time	0.3	0.5	1.1	0.1	-1.0
Lupus	0.3	0.4	0.9	0.9	-0.0
Height	0.3	5.7	9.2	-3.0	1.5
Hand grip strength (left)	0.3	0.8	1.6	1.2	0.3
Medication: Co-codamol	0.3	0.3	0.5	0.3	-0.7
High blood pressure (mother)	0.3	0.4	0.5	-0.7	0.6
Number of incorrect matches in round	0.3	0.4	0.8	0.2	-0.9
Past tobacco smoking	0.3	0.5	1.0	0.2	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.6	0.7	0.8
Pulse rate	0.3	0.6	0.6	-0.7	-0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.9	0.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	-0.6	-0.6
Tense / ‘highly strung’	0.3	0.4	0.8	-0.9	-0.3
Loud music exposure frequency	0.3	0.4	0.5	0.5	-0.7
Exposure to tobacco smoke outside home	0.3	0.4	0.6	0.6	0.8
Pulse wave peak to peak time	0.3	0.3	0.5	0.2	0.7
Suffer from ‘nerves’	0.3	0.5	0.9	-0.4	-0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.5	-0.7	0.5
Knee pain experienced in last month	0.3	0.4	0.7	0.4	0.8
Average weekly red wine intake	0.3	0.5	0.6	-0.8	-0.6
Mineral and other dietary supplements	0.3	0.5	0.6	-0.6	-0.8
Alcohol drinker status: Never	0.3	0.3	0.5	0.7	0.4
Irritability	0.3	0.6	1.1	0.0	1.1
Unable to work because of sickness or disability	0.3	0.4	0.4	0.6	0.6
Neuroticism (Nagel 2018)	0.2	0.5	1.0	1.0	0.0
Neuroticism (2016)	0.2	0.3	0.5	0.7	0.2
Schizophrenia (2014)	0.2	0.3	0.7	0.8	-0.0
Blood Eosinophil Count	0.2	1.5	3.0	0.2	-1.7
Blood White Count	0.2	1.3	2.5	-0.4	1.6
Average weekly spirits intake	0.2	0.2	0.3	-0.4	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.8	-0.2
Pack years adult smoking proportion	0.2	0.3	0.4	0.3	-0.7
Average weekly fortified wine intake	0.2	0.2	0.3	0.4	0.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	-0.7	-0.2
Nervous feelings	0.2	0.4	0.6	-0.4	0.8
Forced vital capacity (FVC)	0.2	0.7	1.4	0.2	-1.2
Mouth/teeth dental problems	0.2	0.3	0.5	-0.2	-0.7
Pain all over the body in last month	0.2	0.2	0.3	0.3	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.6	-0.3
Gout (self-reported)	0.2	0.3	0.5	0.0	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	-0.2
Medication: Ibuprofen	0.2	0.2	0.3	-0.5	-0.3
Mean time to correctly identify matches	0.2	0.5	0.9	0.0	-1.0
Comparative height size at age 10	0.2	0.9	1.5	-1.2	0.5
Family relationship satisfaction	0.2	0.3	0.5	0.0	0.7
Leg pain on walking	0.2	0.2	0.4	0.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.2	-0.4	-0.4
Loneliness, isolation	0.2	0.3	0.4	0.4	-0.6
Wears glasses or contact lenses	0.2	0.2	0.4	-0.6	-0.2
Medication: Paracetamol	0.2	0.3	0.5	0.7	0.2
Pack years of smoking	0.2	0.3	0.5	0.3	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	0.6	-0.3
Depression (Nagel 2018)	0.1	0.1	0.1	-0.4	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	-0.3	0.8
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	-0.3	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.6	0.3
Prostate Cancer	0.1	0.2	0.3	-0.3	0.5
HDL Cholesterol	0.1	0.1	0.2	-0.3	-0.4
Neuroticism	0.1	0.2	0.3	0.5	0.4
Hair Pigment	0.1	3.6	5.6	1.3	2.4
Maternal smoking around birth	0.1	0.1	0.2	-0.2	0.5
Relative age voice broke	0.1	0.1	0.2	-0.4	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.2	0.4	0.4
Happiness	0.1	0.1	0.1	0.3	0.2
Medication: Lansoprazole	0.1	0.1	0.1	0.4	0.0
Lung cancer (father)	0.1	0.1	0.2	0.0	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.4	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.5	0.7	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.2	0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.2	0.4
Health satisfaction	0.1	0.1	0.3	0.0	-0.5
Qualifications: College or University degree	0.1	0.5	0.6	0.8	0.6
Medication: Allopurinol	0.1	0.1	0.2	0.0	0.4
Heart disease (mother)	0.1	0.1	0.2	0.2	0.5
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.1	-0.6
Smoking status: Previous	0.1	0.1	0.1	-0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.1	0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	-0.5	-0.0
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.1	0.4
Hearing aid user	0.1	0.2	0.3	0.5	0.2
Mother’s age at death	0.1	0.2	0.2	0.4	-0.5
Ever smoked	0.1	0.1	0.2	-0.4	0.3
Number of operations (self-reported)	0.1	0.1	0.2	-0.1	0.4
Average weekly beer plus cider intake	0.1	0.1	0.1	0.2	0.3
Risk taking	0.1	0.2	0.3	-0.6	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.4	-0.0
Heart disease (siblings)	0.1	0.2	0.4	-0.1	-0.6
Schizophrenia (2018)	0.0	0.1	0.2	-0.0	-0.4
Crohns Disease (2017)	0.0	0.0	0.1	0.1	0.2
Tanning	0.0	0.1	0.2	0.2	0.5
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.3	0.1
Severe depression (siblings)	0.0	0.0	0.0	-0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.2	-0.1
Sitting height	0.0	0.1	0.2	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	-0.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	-0.2
Depression (self-reported)	0.0	0.0	0.1	0.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	-0.4	0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	0.2	-0.5
Number of children fathered	0.0	0.1	0.1	-0.3	0.1
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.1	-0.0
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.1	0.1
Supplements: Calcium	0.0	0.0	0.0	0.1	0.2

Hub : Genes

TCF7L2

Models

Trait associations