Best TWAS P=9.87e-16 · Best GWAS P=1.69e-15 conditioned to 0.00924
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DLD | 0.17 | 0.14 | bslmm | 510 | 0.16 | 1.5e-18 | -7.2 | -7.1 | 1.5e-12 | 0.78 | 0.48 | 0.52 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | DLD | 0.24 | 0.06 | enet | 16 | 0.05 | 1.7e-02 | 6.4 | -7.6 | 3.3e-14 | 0.78 | 0.03 | 0.91 | FALSE |
3 | GTEx | Brain Frontal Cortex BA9 | DLD | 0.21 | 0.13 | lasso | 4 | 0.13 | 2.8e-04 | -6.6 | -7.1 | 1.2e-12 | 0.76 | 0.05 | 0.79 | FALSE |
4 | GTEx | Brain Hypothalamus | DLD | 0.31 | 0.04 | enet | 10 | 0.04 | 4.6e-02 | 7.1 | -7.5 | 6.7e-14 | 0.61 | 0.12 | 0.60 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | CTB-13F3.1 | 0.10 | 0.04 | enet | 14 | 0.04 | 3.2e-04 | -7.0 | -5.3 | 1.0e-07 | 0.66 | 0.06 | 0.88 | FALSE |
6 | GTEx | Testis | DLD | 0.11 | 0.12 | lasso | 2 | 0.06 | 1.1e-03 | -7.3 | -6.9 | 4.2e-12 | 0.82 | 0.08 | 0.69 | FALSE |
7 | NTR | Blood | DLD | 0.04 | 0.02 | lasso | 2 | 0.02 | 2.2e-08 | -7.2 | -7.3 | 2.5e-13 | 0.86 | 0.32 | 0.68 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | LAMB1 | 0.06 | 0.05 | enet | 14 | 0.05 | 3.3e-07 | -7.0 | 5.6 | 2.3e-08 | -0.77 | 0.53 | 0.47 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | DLD | 0.12 | 0.12 | lasso | 8 | 0.15 | 2.1e-18 | 7.0 | -8.0 | 9.9e-16 | 0.80 | 0.65 | 0.35 | TRUE |
10 | YFS | Blood | DLD | 0.02 | 0.01 | bslmm | 508 | 0.01 | 2.3e-04 | -7.2 | 6.3 | 2.9e-10 | -0.82 | 0.09 | 0.91 | FALSE |
11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DLD | 0.05 | 0.04 | blup | 64 | 0.04 | 2.0e-04 | 7.6 | -6.1 | 1.4e-09 | 0.42 | 0.08 | 0.79 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DLD | 0.09 | 0.12 | blup | 64 | 0.11 | 2.5e-12 | 6.9 | -6.6 | 3.3e-11 | 0.50 | 0.67 | 0.33 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LAMB1 | 0.03 | 0.01 | blup | 92 | 0.02 | 7.7e-03 | 1.2 | -5.2 | 2.0e-07 | 0.50 | 0.04 | 0.26 | FALSE |