TWAS hub - DLD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1650	0.0350	1.3e-13	0.138	0.148	0.153	0.156	0.153	1.7e-16	1.4e-17	3.5e-18	1.5e-18	3.1e-18
2	GTEx	Brain Cerebellar Hemisphere	0.2360	0.0930	2.8e-03	0.058	NA	0.054	NA	0.045	1.3e-02	NA	1.7e-02	NA	2.6e-02
3	GTEx	Brain Frontal Cortex BA9	0.2126	0.0787	3.0e-03	0.134	NA	0.052	NA	0.129	2.2e-04	NA	1.7e-02	NA	2.9e-04
4	GTEx	Brain Hypothalamus	0.3140	0.1080	1.1e-03	0.045	NA	0.038	NA	0.020	3.3e-02	NA	4.6e-02	NA	1.1e-01
5	GTEx	Cells Transformed fibroblasts	0.0790	0.0340	6.6e-03	-0.004	NA	-0.002	NA	-0.004	9.4e-01	NA	5.3e-01	NA	9.9e-01
6	GTEx	Testis	0.1130	0.0460	4.4e-03	0.115	NA	0.028	NA	0.061	8.7e-06	NA	2.0e-02	NA	1.1e-03
7	GTEx	Thyroid	0.1460	0.0460	1.2e-04	0.030	NA	0.072	NA	0.050	2.2e-03	NA	3.6e-06	NA	1.0e-04
8	NTR	Blood	0.0383	0.0118	4.8e-06	0.023	0.015	0.023	0.019	0.024	5.0e-08	7.8e-06	3.5e-08	6.1e-07	2.2e-08
9	ROSMAP	Brain Pre-frontal Cortex	0.1161	0.0261	1.5e-13	0.115	0.105	0.137	0.123	0.147	1.5e-14	2.3e-13	3.1e-17	1.6e-15	2.1e-18
10	YFS	Blood	0.0211	0.0084	1.1e-03	0.011	0.009	0.006	0.010	0.007	1.2e-04	3.2e-04	4.0e-03	2.3e-04	1.6e-03
11	TCGA	Bladder Urothelial Carcinoma	0.0480	0.0350	7.1e-04	0.041	0.041	0.038	NA	0.040	2.1e-04	2.0e-04	3.5e-04	NA	2.3e-04
12	TCGA	Brain Lower Grade Glioma	0.0899	0.0390	1.5e-11	0.116	0.109	0.099	NA	0.106	4.3e-13	2.5e-12	2.4e-11	NA	4.9e-12
13	TCGA	Thyroid Carcinoma	0.0660	0.0350	1.9e-04	0.014	0.027	0.011	NA	0.010	1.6e-02	1.1e-03	2.6e-02	NA	3.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Ulcerative Colitis (UC)	28.4	53.2	83.5	-7.9	-8.7	-8.1	-8.8	-3.2	-8.2	-2.0	-8.3	-9.1	7.6	-7.1	-7.7	-3.0
Ulcerative Colitis	27.5	39.9	64.5	-7.1	-7.6	-7.1	-7.5	-3.0	-6.9	-1.6	-7.3	-8.0	6.3	-6.1	-6.6	-2.6
Irritable Bowel Disease (IBD)	15.2	36.1	55.5	-6.4	-6.9	-6.4	-7.4	-3.4	-6.5	-2.1	-6.6	-7.4	6.1	-6.3	-6.7	-2.9
Unable to work because of sickness or disability	6.0	7.8	14.7	-3.8	-3.7	-3.0	-3.1	0.4	-3.6	0.2	-3.3	-3.8	2.7	-1.7	-2.3	0.1
Taking other prescription medications	5.4	8.3	12.6	-3.0	-3.4	-2.8	-3.5	-2.2	-2.9	-1.4	-2.5	-3.5	2.4	-3.2	-3.4	-2.4
Illnesses of siblings: Diabetes	3.8	4.7	8.7	-0.9	-2.2	-1.2	-2.9	-2.5	-1.3	-1.5	-1.3	-2.4	2.4	-2.9	-2.9	-2.3
Waist Hip Ratio (WHR)	3.7	16.7	28.0	-4.8	-4.0	-4.2	-5.0	-1.0	-4.7	-0.9	-4.7	-5.3	4.5	-3.7	-4.5	-2.8
Medication: Atorvastatin	3.6	4.4	8.8	-2.4	-3.0	-1.9	-2.4	-2.3	-1.5	-1.4	-1.7	-2.4	1.3	-2.4	-2.5	-1.6
Number of treatments/medications taken	3.3	5.9	11.4	-1.8	-2.9	-1.2	-3.4	-2.7	-1.2	-2.0	-1.1	-2.5	1.5	-3.4	-3.1	-3.0
Illnesses of mother	3.3	4.1	9.6	1.1	1.5	1.0	2.5	3.1	0.5	2.4	0.6	1.5	-0.9	2.8	2.7	2.9
Medication: Amlodipine	3.3	4.6	9.3	-2.5	-1.8	-1.0	-3.0	-2.4	-1.3	-1.8	-1.2	-2.4	1.1	-3.0	-2.7	-2.3
Mouth/teeth dental problems: Loose teeth	3.1	3.7	12.5	0.1	-1.0	0.6	-1.9	-3.4	0.6	-3.5	0.7	-0.8	-0.7	-2.5	-1.8	-2.7
Long-standing illness, disability or infirmity	3.0	4.6	7.9	-1.3	-2.4	-1.9	-2.8	-1.8	-1.4	-1.7	-1.9	-2.5	0.9	-2.8	-2.7	-2.6
Triglycerides	2.9	4.8	7.3	-2.3	-2.3	-2.6	-2.5	-0.5	-2.5	-0.6	-2.7	-2.7	2.7	-2.0	-2.3	-0.7
Happiness	2.9	3.6	6.8	-2.6	-1.6	-2.4	-1.9	-0.4	-2.4	-0.2	-2.5	-2.3	2.1	-1.6	-1.8	-0.1
Health satisfaction	2.9	3.8	7.8	-2.1	-1.3	-1.8	-2.4	-1.4	-1.5	-1.8	-1.7	-2.2	0.9	-2.5	-2.8	-2.0
Coronary Artery Disease (CAD)	2.7	3.2	6.8	-1.9	-1.7	0.1	-2.2	-2.2	-0.2	-2.2	-0.6	-1.5	0.6	-2.6	-2.3	-2.4
Hearing difficulty/problems: Yes	2.7	4.1	9.0	-1.5	-2.1	-0.7	-2.7	-2.3	-1.0	-1.6	-1.2	-2.3	0.8	-3.0	-2.9	-2.3
Supplements: Zinc	2.7	2.9	5.7	2.2	0.9	0.7	2.1	2.0	1.1	1.8	0.3	1.8	-0.5	2.4	2.3	2.3
Medication: Levothyroxine sodium	2.6	4.4	9.4	-2.6	-1.8	-2.3	-1.4	0.7	-2.8	1.2	-3.1	-2.6	3.1	-1.4	-1.4	0.9
Medication: Ramipril	2.6	3.3	6.8	-2.0	-2.1	-0.9	-1.9	-1.5	-1.8	-0.6	-1.8	-2.0	2.6	-2.3	-2.1	-0.7
Noisy workplace	2.6	3.2	6.6	1.5	0.4	2.5	0.0	-2.5	2.2	-2.1	2.6	1.2	-2.1	-1.1	-0.1	-1.9
Illnesses of siblings	2.5	3.5	6.6	1.9	1.8	0.8	2.4	2.1	1.4	1.3	1.1	1.9	-1.3	2.6	2.5	2.1
Commuting to job workplace: Car/motor vehicle	2.5	2.9	5.4	2.3	1.9	2.1	1.6	-0.6	2.1	-0.8	2.2	2.1	-2.0	1.0	1.2	-0.1
Loneliness, isolation	2.4	3.2	5.6	-1.9	-1.9	-1.7	-2.2	-1.7	-1.0	-0.8	-1.7	-2.1	1.2	-2.3	-2.4	-1.6
Fluid intelligence score	2.3	4.7	13.2	-2.6	-2.1	-3.6	-1.9	0.3	-2.6	-0.6	-3.2	-2.6	1.9	-1.1	-1.9	-0.3
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	9.5	-2.5	-1.4	-2.6	-1.2	1.0	-2.9	1.9	-3.1	-2.4	2.8	-1.0	-1.3	1.0
Wears glasses or contact lenses	2.2	2.5	8.1	0.4	0.8	0.5	-0.8	-2.9	1.0	-2.6	0.9	0.1	-0.8	-2.0	-1.6	-2.7
Diabetes diagnosed by doctor	2.1	3.5	8.6	-1.0	-1.4	0.3	-2.4	-2.5	-0.5	-2.7	-0.0	-1.2	0.3	-2.9	-2.2	-2.9
Mineral and other dietary supplements	2.1	2.8	6.6	-2.1	-0.5	-1.9	0.8	2.6	-2.2	1.7	-1.9	-0.9	0.8	1.3	0.7	2.4
Medication: Blood pressure	2.0	3.8	10.5	-0.9	-1.3	-0.1	-2.3	-2.8	-0.1	-2.4	-0.6	-1.5	0.3	-3.2	-2.6	-2.6
Illnesses of father: High blood pressure	2.0	2.4	8.1	-1.0	-1.7	-0.3	-1.6	-2.0	-0.9	-2.9	-0.6	-1.3	1.3	-2.0	-1.6	-1.2
Bipolar Disorder (2011)	1.9	1.8	6.0	-0.5	-0.3	0.6	-1.1	-2.3	-0.3	-2.5	0.1	-0.6	-0.1	-2.0	-1.6	-1.9
Diabetes (self-reported)	1.9	2.9	7.3	-0.9	-1.5	0.3	-2.1	-2.3	-0.5	-2.5	0.1	-1.1	0.3	-2.5	-1.9	-2.7
Overall health rating	1.9	4.2	7.3	-2.1	-2.3	-2.0	-2.7	-1.5	-1.7	-1.2	-1.6	-2.3	0.5	-2.5	-2.7	-2.2
Commuting to job workplace: Public transport	1.9	2.3	5.4	-1.7	-1.0	-1.8	-0.0	1.7	-1.8	2.0	-1.6	-1.0	2.3	0.8	0.3	1.4
Heart disease (siblings)	1.9	2.3	4.4	-1.3	-2.1	-1.5	-2.0	-1.5	-1.1	-1.1	-1.3	-1.8	0.1	-1.8	-1.8	-1.3
Body Mass Index (BMI) (2010)	1.8	2.4	3.5	1.6	1.8	1.6	1.9	1.1	1.9	0.7	1.7	1.8	-1.3	1.7	1.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	5.7	-1.6	-1.5	-0.4	-2.4	-0.9	-1.1	-1.5	-0.8	-2.0	0.4	-2.2	-1.9	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	6.0	0.7	1.6	2.4	0.6	-1.1	1.7	-0.9	2.1	1.3	-2.4	0.1	0.8	-0.6
Basal cell carcinoma (self-reported)	1.8	2.2	4.6	0.2	1.1	0.9	1.9	1.7	0.4	2.1	0.5	1.3	-0.8	2.0	1.9	2.1
Hearing aid user	1.7	1.9	4.6	1.5	0.3	2.1	0.3	-1.6	1.7	-1.8	1.5	1.1	-1.7	-0.8	-0.2	-1.4
Supplements: Fish oil (including cod liver oil)	1.7	2.2	5.6	1.5	0.3	1.6	-1.2	-2.3	1.8	-1.6	1.6	0.3	-0.6	-1.4	-0.9	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	5.2	-1.3	-1.7	-0.4	-2.0	-2.0	-0.5	-1.6	-0.6	-1.5	-0.3	-2.3	-2.2	-1.9
Chronic bronchitis/emphysema (mother)	1.6	1.8	4.6	1.7	0.6	1.9	0.8	-1.1	2.1	-0.8	1.7	1.7	-1.8	-0.1	0.5	-0.5
Average weekly beer plus cider intake	1.6	2.3	6.2	1.3	1.3	0.4	2.1	1.7	0.6	1.5	0.6	1.7	-0.6	2.5	1.9	1.5
Fractured/broken bones in last 5 years	1.6	2.0	4.6	-0.4	-1.1	-0.3	-2.0	-2.0	-0.6	-0.8	-0.6	-1.6	0.8	-2.1	-2.0	-1.8
Crohns Disease (2012)	1.5	2.5	4.5	-1.2	-1.1	-1.8	-2.1	-1.3	-1.3	-1.3	-1.6	-1.9	1.2	-1.9	-2.0	-1.4
Hypothyroidism (self reported)	1.5	3.5	7.3	-2.3	-1.4	-2.5	-0.8	1.2	-2.7	1.9	-2.7	-1.9	2.6	-0.6	-0.8	1.1
Pain all over the body in last month	1.5	1.6	4.3	-2.1	-0.6	-1.4	-1.1	0.4	-1.8	-0.6	-1.6	-1.5	1.3	-0.8	-1.4	-0.2
Worrier / anxious feelings	1.5	2.9	5.7	-1.0	-1.8	-0.7	-2.0	-2.2	0.1	-2.4	-0.4	-1.4	0.4	-2.4	-2.1	-2.4
Number of live births	1.5	2.1	8.0	1.5	1.5	1.4	1.3	0.1	1.8	-0.5	1.5	1.8	-2.8	0.9	1.2	-0.2
High blood pressure (siblings)	1.5	2.2	4.8	-1.5	-1.0	-0.3	-1.8	-2.2	-0.9	-1.6	-0.5	-1.1	0.6	-2.1	-1.9	-2.0
Alcohol intake frequency.	1.5	3.5	6.7	-1.4	-1.2	-0.8	-2.4	-2.6	-1.2	-1.6	-1.1	-2.0	1.4	-2.6	-2.5	-2.2
Commuting to job workplace: Walk	1.5	1.6	3.0	-1.6	-1.3	-1.1	-1.7	-0.9	-1.6	0.2	-1.2	-1.5	0.6	-1.5	-1.5	-0.6
Medication: Metformin	1.4	1.9	4.3	-1.5	-1.1	-0.3	-1.7	-1.4	-1.2	-1.4	-0.8	-1.2	1.6	-2.1	-1.6	-1.3
Current tobacco smoking	1.4	2.4	4.8	-1.5	-1.8	-1.0	-2.0	-1.4	-0.9	-0.8	-0.9	-1.5	1.0	-2.0	-2.0	-2.2
High blood pressure	1.4	3.9	8.8	-1.3	-2.2	-0.2	-2.4	-2.6	0.5	-2.6	-0.3	-1.4	0.8	-2.9	-2.3	-3.0
Number of incorrect matches in round	1.4	2.3	7.5	-1.0	-2.7	-0.6	-2.0	-1.2	-1.1	-0.7	-1.2	-1.8	1.4	-2.0	-1.6	-1.0
Alcohol usually taken with meals	1.4	2.3	4.3	-1.2	-0.2	-0.5	-1.6	-2.0	-1.5	-1.6	-0.7	-1.5	1.8	-2.1	-2.1	-1.4
Hair/balding pattern: Pattern 3	1.4	2.0	6.1	0.3	-1.0	0.6	-1.5	-2.0	0.7	-2.5	0.7	-0.2	-0.6	-1.7	-1.4	-2.5
Qualifications: A levels/AS levels or equivalent	1.4	3.0	6.7	-1.8	-1.3	-2.6	-0.9	1.5	-2.6	1.1	-2.4	-1.9	2.5	-0.4	-0.9	0.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	5.4	0.8	2.3	0.4	2.1	1.9	0.1	1.8	0.2	1.3	-0.7	2.0	1.8	1.9
Heart disease (mother)	1.4	1.7	3.6	1.4	0.6	1.4	0.0	-1.9	1.4	-1.8	1.8	0.9	-1.0	-0.8	-0.4	-1.5
Leg pain on walking	1.4	1.7	5.5	-0.8	-0.0	0.2	-1.5	-2.2	-0.1	-1.2	0.2	-1.0	0.5	-1.9	-1.7	-2.4
Medication: Aspirin	1.4	1.8	3.2	-1.6	-1.3	-0.8	-1.8	-1.1	-0.9	-1.0	-1.0	-1.5	0.9	-1.7	-1.7	-1.7
Hypertension (Self-reported)	1.4	3.8	8.2	-1.3	-2.1	-0.3	-2.4	-2.6	0.2	-2.4	-0.4	-1.5	1.0	-2.8	-2.3	-2.9
Ever had bowel cancer screening	1.4	1.7	5.8	-1.5	-1.0	-0.4	-1.3	0.0	-1.8	0.5	-1.4	-1.8	2.4	-0.9	-1.0	0.2
Medication for cholesterol	1.4	2.1	5.4	0.8	1.2	-0.2	1.7	2.2	-0.2	2.1	0.3	1.0	0.4	2.3	1.8	2.0
Pack years of smoking	1.4	2.1	4.7	-1.5	-2.2	-0.5	-1.6	-1.2	-1.4	-1.4	-1.2	-1.5	0.8	-2.0	-1.6	-1.3
Relative age of first facial hair	1.3	2.6	5.2	-2.1	-2.3	-1.9	-1.3	0.1	-2.1	1.1	-2.3	-1.7	1.9	-0.7	-1.2	0.4
Serious illness, injury or assault to yourself	1.3	1.6	3.8	-1.2	-1.9	-1.9	-1.3	-0.6	-0.7	-0.4	-1.2	-1.3	1.2	-1.1	-1.3	-1.2
Medication: Atenolol	1.3	1.6	4.6	1.3	0.5	2.0	1.2	0.2	2.1	-0.4	1.6	1.5	-1.3	0.6	1.4	0.2
Birth weight of first child	1.3	2.4	3.6	1.9	1.4	1.6	1.6	1.1	1.5	1.1	1.8	1.8	-1.6	1.5	1.7	1.0
Glaucoma (self-reported)	1.3	1.6	7.0	-0.6	0.9	-0.8	0.8	1.5	-0.9	2.6	-1.0	0.0	1.0	1.3	0.6	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	5.5	0.6	-0.6	1.2	-0.5	-2.4	0.8	-1.7	1.4	0.1	-0.8	-1.4	-0.8	-1.9
Mother’s age at death	1.3	1.6	3.5	-1.7	-1.9	-0.7	-1.3	0.4	-1.8	-0.4	-1.6	-1.7	1.5	-0.9	-0.9	0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.3	-1.7	-1.5	-1.3	-1.3	0.0	-2.3	-0.0	-1.4	-1.4	1.3	-0.6	-1.1	-0.4
Blood White Count	1.2	8.6	17.4	-1.6	-3.2	-1.3	-3.9	-3.5	-1.1	-2.6	-1.3	-3.2	2.4	-4.2	-3.8	-3.5
Medication: Cholesterol lowering	1.2	1.9	6.3	-0.8	-2.5	-1.0	-2.0	-1.3	-0.7	-1.3	-0.5	-1.4	0.2	-1.4	-1.5	-1.7
Tense / ‘highly strung’	1.2	2.0	5.4	-0.3	-0.7	0.1	-1.4	-2.1	-0.3	-2.3	-0.2	-1.0	-0.4	-1.9	-2.0	-1.9
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.9	2.2	1.1	0.4	1.3	0.8	1.3	0.9	1.0	1.7	-0.8	1.6	1.5	0.6
Medication: Aspirin	1.2	1.6	2.7	-1.6	-1.1	-1.0	-1.5	-0.8	-1.0	-0.9	-1.1	-1.4	0.9	-1.5	-1.6	-1.5
Cholesterol lowering medication	1.2	1.8	4.4	-1.0	-0.4	0.7	-1.2	-1.9	0.7	-2.0	-0.0	-0.9	-0.6	-2.1	-1.6	-1.9
Depression (Nagel 2018)	1.1	1.7	3.8	-1.5	-0.5	-0.7	-1.4	-1.0	-0.9	-0.3	-0.9	-1.9	1.4	-1.6	-1.9	-1.4
Alzheimer’s Disease (in mother)	1.1	1.3	2.4	-1.3	-1.1	-1.0	-1.1	-0.5	-0.8	-1.5	-1.0	-1.4	0.8	-1.2	-1.5	-0.8
HDL Cholesterol	1.1	1.9	3.5	1.1	1.7	1.9	1.3	0.7	1.3	0.9	1.8	1.5	-1.5	1.3	1.7	0.5
LDL Cholesterol	1.1	1.8	3.3	0.5	1.1	0.9	1.4	1.6	1.3	1.7	0.4	1.0	-1.4	1.5	1.7	1.8
Lupus	1.1	1.7	4.8	-2.2	-0.8	-1.0	-0.6	1.3	-2.1	0.9	-1.4	-1.2	1.4	0.2	-0.3	1.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.0	-0.2	-0.2	1.0	-0.9	-1.7	0.2	-2.0	0.7	-0.3	-0.7	-1.7	-1.0	-1.3
Fed-up feelings	1.1	2.0	4.7	-0.9	-1.2	-0.4	-1.9	-1.8	-0.1	-1.3	-0.3	-1.3	0.4	-2.2	-2.1	-2.1
Gout (self-reported)	1.1	1.5	4.2	-2.0	-1.1	-1.2	-1.3	-0.9	-1.1	-0.8	-0.9	-1.6	0.8	-1.3	-1.4	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.8	1.7	1.1	1.0	1.3	0.6	1.1	0.4	1.2	1.4	-1.4	1.0	1.2	0.3
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.9	1.2	1.3	0.9	0.9	-0.9	1.4	-1.4	1.7	1.4	-1.4	0.5	0.7	-0.2
Breast cancer (self-reported)	1.1	1.3	3.9	1.4	0.7	1.2	-0.8	-1.3	0.2	-1.5	1.3	-0.4	-1.1	-1.0	-0.7	-2.0
Number of self-reported non-cancer illnesses	1.1	2.0	3.4	-1.6	-1.5	-0.9	-1.6	-1.6	-0.5	-1.6	-0.9	-1.3	0.9	-1.8	-1.7	-1.6
Medication: Lisinopril	1.1	1.5	2.8	-1.0	-1.7	-0.1	-1.5	-1.1	-1.1	-1.4	-0.5	-1.4	1.0	-1.6	-1.3	-1.0
Commuting to job workplace: Cycle	1.1	1.3	3.9	-0.7	-0.2	-1.2	0.6	1.5	-1.0	2.0	-1.1	-0.3	1.2	1.0	0.6	1.7
Vascular/heart problems diagnosed by doctor	1.1	2.9	7.6	1.0	1.8	-0.2	2.0	2.3	-0.7	2.4	0.0	1.0	-0.4	2.5	1.9	2.8
Pain experienced in last month	1.1	1.8	3.9	0.4	1.7	0.1	1.8	1.6	0.5	1.9	0.6	1.3	-0.5	2.0	1.5	1.6
Crohns Disease (2017)	1.0	2.2	3.6	-1.5	-1.3	-1.6	-1.8	-1.4	-1.3	-0.9	-1.6	-1.7	1.2	-1.8	-1.9	-0.9
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.7	-2.4	-1.3	-2.4	-1.2	0.6	-1.9	-0.1	-2.3	-1.9	1.1	-0.5	-1.1	-0.0
Hand grip strength (left)	1.0	2.7	5.7	1.5	1.3	0.3	2.4	1.5	1.0	1.0	1.0	2.0	-1.0	2.3	2.2	2.2
Vitamin and mineral supplements	1.0	1.4	3.1	1.0	1.4	1.0	1.6	0.9	1.1	0.3	1.2	1.1	-1.8	1.2	1.2	0.7
Diabetes (mother)	1.0	1.3	4.0	0.1	-0.1	0.0	-1.1	-2.0	0.8	-1.5	0.4	-0.2	-0.2	-1.6	-1.2	-1.9
Pack years adult smoking proportion	1.0	1.6	4.8	-1.4	-2.2	-0.6	-1.3	-0.7	-1.5	-0.9	-1.3	-1.4	0.8	-1.4	-1.2	-0.7
Supplements: Glucosamine	1.0	1.3	4.5	2.1	1.5	0.9	1.2	0.2	1.6	0.5	1.1	1.6	-0.3	0.8	1.0	0.4
Medication: Simvastatin	1.0	1.5	3.4	-1.1	-1.3	0.2	-1.7	-1.1	0.1	-1.3	-0.1	-1.2	-0.3	-1.8	-1.5	-1.8
Pulse wave reflection index	1.0	1.2	3.3	1.1	0.7	1.8	1.1	-0.4	1.6	-0.4	1.8	1.4	-0.6	0.6	1.1	0.2
Illnesses of father: None of the above (group 1)	1.0	1.2	2.5	1.2	1.4	0.6	1.5	1.6	1.0	1.1	0.4	1.2	-0.7	1.3	1.0	0.8
Medication: Bendroflumethiazide	1.0	1.5	4.1	0.5	-0.4	1.3	-0.7	-2.0	1.2	-2.0	0.7	0.2	-0.8	-1.5	-1.1	-1.6
Schizophrenia vs Biploar Disorder	0.9	1.1	2.2	1.3	0.6	1.3	1.5	0.2	1.4	0.5	1.0	1.1	0.4	1.1	1.3	1.0
Neuroticism (2016)	0.9	1.2	4.0	1.0	2.0	1.1	1.1	0.6	0.8	0.6	1.5	1.4	-1.0	1.1	1.1	0.2
Primary Biliary Cirrhosis	0.9	1.3	3.8	0.6	0.4	0.9	1.2	1.5	0.3	1.4	0.4	0.9	0.4	1.6	1.6	1.9
Systolic Blood Pressure	0.9	4.6	8.2	-2.9	-2.4	-2.2	-2.0	-0.8	-2.5	-0.7	-2.6	-2.5	2.9	-2.0	-2.2	-0.1
Cardiovascular Disease	0.9	3.1	5.9	-1.8	-2.4	-0.7	-2.1	-2.0	-0.3	-2.3	-0.8	-1.5	0.5	-2.3	-2.0	-2.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.6	-0.7	-0.6	0.3	-1.6	-1.7	-0.3	-1.9	-0.0	-0.8	-0.1	-2.1	-1.5	-2.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.4	-1.2	-0.8	-1.0	-1.2	-0.4	-1.4	0.2	-1.4	-1.3	1.8	-1.0	-1.2	-0.1
Hand grip strength (right)	0.9	2.4	5.4	0.9	0.9	-0.0	2.2	1.8	0.4	1.5	0.4	1.7	-1.0	2.3	2.1	2.3
High blood pressure (mother)	0.9	1.2	3.7	-0.2	-0.1	-0.7	-1.2	-1.9	0.2	-1.9	-0.1	-0.6	0.1	-1.4	-1.3	-1.7
Impedance of leg (left)	0.9	4.1	8.9	-3.0	-2.5	-2.5	-1.8	0.9	-2.7	1.9	-2.8	-2.2	1.8	-0.6	-1.1	0.3
Father’s age at death	0.9	1.2	3.4	0.6	1.3	0.1	1.3	1.8	-0.3	1.2	-0.0	0.5	0.3	1.6	1.4	1.4
Asthma	0.9	1.7	5.2	-0.8	-0.8	-0.2	-1.6	-2.3	-0.4	-1.6	0.1	-0.8	-0.1	-1.9	-1.6	-1.9
Hair/balding pattern: Pattern 4	0.9	2.2	5.2	2.0	2.3	1.5	1.5	0.5	1.6	0.5	2.0	1.6	-1.5	1.1	1.3	0.1
Blood clot in the leg (DVT)	0.9	1.1	3.7	-0.0	1.1	-0.1	1.1	1.9	0.6	0.7	0.2	1.0	-0.8	1.6	1.5	1.0
Wheeze or whistling in the chest in last year	0.9	1.6	5.6	-1.6	-2.4	-0.9	-1.4	-0.4	-1.0	0.6	-1.3	-1.3	1.3	-1.1	-1.1	-0.6
Medication: Blood pressure	0.9	1.6	3.6	-0.8	-1.5	0.1	-1.5	-1.9	0.2	-1.7	-0.0	-0.7	0.9	-1.8	-1.4	-1.7
Migraine (self-reported)	0.9	1.2	2.6	-1.4	-0.9	-1.0	-1.1	0.2	-1.0	-0.3	-1.4	-1.4	1.6	-0.6	-1.1	-0.9
Medication: Ibuprofen	0.9	1.1	2.8	0.7	-0.1	1.3	-0.6	-1.4	0.7	-1.7	1.2	0.4	-0.8	-1.0	-0.5	-1.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	1.2	1.1	1.6	0.8	-0.5	1.3	0.1	1.7	1.2	-1.0	0.6	1.0	0.2
Smoking status: Previous	0.9	1.4	2.6	0.5	1.4	0.9	1.6	0.8	1.4	0.4	0.9	1.4	-0.8	1.5	1.4	1.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.8	0.8	-0.8	1.0	-1.2	-1.9	0.2	-1.7	0.7	-0.4	0.1	-1.2	-0.8	-1.2
Ever depressed for a whole week	0.9	1.2	2.7	1.6	1.4	1.2	1.0	-0.7	1.3	-0.7	1.5	1.0	-1.2	0.2	0.5	-0.1
Depressed Affect (Nagel 2018)	0.8	1.7	3.8	-0.7	-1.1	-0.7	-1.6	-2.0	-0.1	-0.8	-0.5	-1.3	0.8	-1.9	-1.9	-1.8
Worry (Nagel 2018)	0.8	1.6	3.7	-0.6	-0.6	-1.2	-1.5	-1.6	-0.4	-1.3	-0.8	-1.2	0.1	-1.7	-1.9	-1.9
Alzheimer’s Disease (including proxy)	0.8	1.2	2.3	-0.9	-0.7	-0.6	-0.8	-1.2	-1.0	-1.3	-1.2	-1.1	1.1	-1.5	-1.5	-0.5
Breast Cancer	0.8	1.9	5.0	1.5	1.3	2.2	1.4	1.0	1.3	0.9	1.7	1.4	-1.1	1.3	1.5	0.6
Rheumatoid Arthritis	0.8	1.0	2.6	0.8	0.4	1.6	1.3	0.8	1.1	0.8	0.9	1.3	-0.7	1.0	1.1	1.0
Waist circumference	0.8	3.1	5.6	-1.6	-1.7	-1.2	-2.2	-1.4	-1.4	-1.3	-1.1	-2.1	2.4	-2.0	-2.1	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.1	-0.9	-1.2	-1.0	-1.4	-0.9	-1.0	-1.1	-0.6	-1.3	0.4	-1.3	-1.5	-1.4
Medication: Lansoprazole	0.8	0.9	2.9	-0.2	-1.5	-0.4	-0.9	-1.7	-0.1	-1.2	0.1	-0.4	0.4	-1.2	-1.0	-1.2
Breastfed as a baby	0.8	1.0	2.1	1.1	0.6	1.2	0.5	-1.2	1.4	-1.3	1.4	1.0	-0.4	-0.2	-0.1	-1.0
Medication: Allopurinol	0.8	1.1	2.9	-1.2	-0.1	-0.6	-1.2	-1.5	-0.3	-1.7	0.0	-0.8	0.1	-1.2	-1.3	-1.4
Knee pain experienced in last month	0.8	1.3	4.5	0.8	0.2	0.9	-0.9	-1.5	0.9	-2.1	1.1	0.0	-0.5	-1.2	-0.7	-1.8
Qualifications: nursing, teaching	0.8	1.3	3.2	-1.0	-0.9	-1.8	-1.0	0.1	-1.1	0.4	-1.6	-1.2	1.7	-0.7	-1.2	-0.5
Asthma (self-reported)	0.8	1.6	4.9	-0.8	-0.7	-0.0	-1.5	-2.2	-0.3	-1.5	0.2	-0.8	-0.0	-1.8	-1.6	-2.0
Number of operations (self-reported)	0.8	1.1	3.1	1.7	-0.2	1.4	0.3	-1.0	1.8	-1.2	1.1	0.9	-0.6	-0.3	-0.1	-1.3
Myopia	0.8	1.2	4.6	-0.0	1.2	-0.7	0.6	1.6	-1.0	2.1	-0.9	-0.2	0.7	1.2	0.8	1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.7	-0.2	1.0	-0.4	1.0	1.9	0.4	0.8	-0.1	0.8	-0.5	1.6	1.3	1.0
HbA1C	0.7	0.8	2.1	0.6	1.2	0.6	1.4	0.8	0.7	0.9	0.5	0.9	-0.1	1.0	1.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	-1.1	-0.7	-0.1	-1.0	-1.1	-1.0	-1.3	-0.3	-0.9	-0.0	-1.3	-1.1	-0.4
Nervous feelings	0.7	1.4	3.0	-0.6	-0.7	-1.1	-1.7	-0.7	-1.1	-1.0	-0.8	-1.6	0.3	-1.5	-1.7	-1.5
Had other major operations	0.7	0.8	4.1	2.0	0.2	0.8	0.5	-0.4	1.6	-0.9	0.9	0.6	-0.5	0.2	0.3	-0.7
Qualifications: None of the above	0.7	1.6	4.7	1.1	-0.1	2.2	0.0	-0.5	2.0	-0.5	1.8	0.9	-2.0	-0.2	0.4	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.8	1.1	-0.2	1.4	-0.2	-1.1	0.8	-1.2	1.2	0.7	-1.1	-0.6	-0.1	-1.2
Medication for pain relief, constipation, heartburn	0.7	1.1	2.7	1.0	1.7	0.4	1.6	0.2	1.2	-0.0	0.9	1.4	-0.7	1.2	1.0	0.9
Medication: Omeprazole	0.7	0.9	2.5	-1.3	-0.9	-0.9	-1.0	0.1	-1.6	-0.2	-1.1	-1.1	0.9	-0.6	-0.9	-0.2
Supplements: Vitamin C	0.7	0.8	2.1	1.5	0.2	1.4	0.9	-0.6	1.0	0.4	1.3	1.2	-0.3	0.7	0.9	0.5
Osteoarthritis (self-reported)	0.7	1.0	2.5	0.7	0.6	0.9	-0.5	-1.5	0.9	-1.6	1.0	-0.0	-0.7	-0.9	-0.6	-1.6
Medication: Gliclazide	0.7	0.8	2.0	-1.2	-0.6	-0.7	-0.8	-0.2	-1.4	-0.2	-1.1	-0.9	1.4	-0.5	-0.8	-0.1
Smoking status: Current	0.7	1.1	3.0	-0.9	-1.2	-0.5	-1.4	-1.0	-0.4	-0.5	-0.5	-0.9	0.6	-1.5	-1.4	-1.7
Neuroticism (Nagel 2018)	0.6	1.5	3.5	-0.6	-0.8	-0.8	-1.4	-1.7	-0.1	-1.0	-0.6	-1.2	0.1	-1.7	-1.9	-1.8
Major Depression (MDD)	0.6	0.8	2.5	-0.4	0.0	-0.9	-0.1	0.8	-1.5	0.7	-1.1	-0.9	1.6	0.1	-0.2	1.0
Prostate Cancer	0.6	0.8	1.8	-1.0	-0.5	-1.0	-0.3	1.2	-1.2	0.8	-1.3	-0.9	0.9	0.2	0.3	1.3
Blood Platelet Count	0.6	7.3	13.5	-2.9	-2.9	-2.2	-3.7	-2.5	-2.8	-1.7	-1.9	-3.1	2.0	-3.2	-3.2	-2.4
Allergy or Eczema	0.6	1.6	4.4	-0.4	-0.4	-0.4	-1.3	-2.1	-0.2	-2.1	0.0	-0.8	-0.2	-1.7	-1.6	-1.9
Respiratory disease	0.6	1.4	3.5	-0.9	-0.0	-0.4	-1.2	-1.9	-0.9	-1.2	-0.2	-1.0	0.0	-1.6	-1.6	-1.8
Lung FEV1/FVC ratio	0.6	3.3	6.5	-1.2	-1.5	-0.3	-2.5	-1.9	-1.0	-2.3	-0.6	-2.3	0.8	-2.5	-2.2	-2.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	-0.4	-0.2	1.1	-0.7	-1.2	-0.7	-1.2	0.0	-0.6	-0.1	-1.4	-1.0	-0.8
Severe depression (siblings)	0.6	0.7	1.7	-0.3	-1.3	-0.8	-1.2	-0.7	-1.0	-0.0	-0.7	-0.9	1.1	-0.7	-0.7	-0.3
Impedance of leg (right)	0.6	3.1	6.4	-2.5	-2.2	-2.0	-1.5	0.9	-2.4	2.1	-2.4	-1.8	1.2	-0.4	-0.8	0.6
Age when periods started (menarche)	0.6	1.5	4.4	1.1	0.4	1.4	1.1	0.3	1.6	1.0	1.2	1.5	-2.1	1.2	1.3	0.3
Qualifications: CSEs or equivalent	0.6	0.8	2.7	0.4	0.4	1.1	0.8	-0.8	1.0	-0.7	1.6	1.3	-0.7	0.5	0.7	0.1
Hearing difficulty/problems with background noise	0.6	1.0	3.0	-1.1	-1.7	-0.9	-1.1	-0.8	-0.7	0.0	-1.1	-1.0	0.5	-1.1	-1.2	-0.5
Heart attack	0.6	0.7	2.2	-1.3	-1.3	0.2	-0.7	-0.3	-0.4	-1.0	-0.7	-0.8	1.5	-0.8	-0.8	-0.3
Neuroticism score	0.6	1.2	2.7	-0.6	-0.9	-1.1	-1.4	-1.0	-0.5	-1.1	-0.6	-1.2	0.3	-1.4	-1.6	-1.5
Ever highly irritable/argumentative for 2 days	0.6	0.8	3.0	1.1	0.6	1.2	0.2	-0.8	0.8	-1.7	1.0	0.5	-0.6	-0.4	-0.2	-1.0
Birth weight	0.6	1.2	3.8	0.7	-0.7	-0.2	0.7	2.0	0.7	0.9	0.1	0.6	-1.8	1.4	1.4	1.1
Emphysema/chronic bronchitis	0.6	0.7	1.2	-1.1	-0.5	-0.8	-0.9	-0.4	-1.1	-0.5	-0.9	-0.9	0.9	-0.7	-1.1	-0.8
Family relationship satisfaction	0.6	0.8	2.4	-1.4	-1.0	-0.8	-0.7	-0.2	-1.5	-0.5	-1.1	-0.9	0.7	-0.4	-0.6	0.5
Friendships satisfaction	0.6	0.7	2.6	-1.6	-0.8	-0.6	-0.4	-0.1	-0.9	-0.4	-1.3	-0.9	0.4	-0.8	-0.6	0.8
Eye problems/disorders: Cataract	0.6	0.7	2.7	-1.7	-0.6	-0.7	-0.3	1.1	-0.9	0.9	-0.8	-0.9	0.9	0.1	-0.1	0.4
Mean Putamen Volume	0.5	0.6	1.8	0.9	0.3	0.5	0.5	-1.0	0.9	-1.3	0.9	0.6	-1.0	0.2	0.1	-0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	0.4	1.5	1.4	0.4	0.4	0.7	-0.2	1.1	0.7	-0.7	0.1	0.2	-0.6
Maternal smoking around birth	0.5	0.8	2.0	-0.8	-1.2	0.0	-1.0	-1.3	-0.6	-0.6	-0.7	-1.0	0.4	-1.4	-1.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	-0.7	-0.4	0.0	-0.8	-0.9	-0.3	-1.0	-0.1	-0.8	-0.2	-1.1	-1.2	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	0.3	-1.0	-0.5	-0.9	-0.4	0.1	-1.2	-0.4	-0.7	0.3	-0.8	-0.8	-1.0
Mouth/teeth dental problems	0.5	0.7	2.6	-1.6	-0.8	-0.9	-0.2	0.7	-1.1	0.8	-1.1	-0.9	0.8	-0.1	-0.4	0.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-0.3	-0.4	1.1	-0.7	-1.2	0.1	-1.1	0.8	-0.4	0.3	-1.1	-0.8	-1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.2	-0.6	-0.3	-1.8	-0.5	0.7	-1.2	-0.2	-1.5	-0.7	0.8	-0.2	-0.7	0.1
Forced vital capacity (FVC), Best measure	0.5	1.6	3.5	0.6	1.1	1.2	1.6	0.6	1.5	0.2	1.6	1.8	-1.9	1.3	1.5	0.6
Comparative body size at age 10	0.5	1.4	3.8	1.9	1.4	1.5	1.1	0.2	1.7	-0.2	1.5	1.4	-0.5	0.8	1.1	-0.1
Pulse wave peak to peak time	0.5	0.5	1.6	0.1	0.3	-1.2	0.6	1.1	-0.1	1.0	-0.8	0.3	-0.3	0.9	0.6	0.8
Shortness of breath walking on level ground	0.5	0.5	2.4	0.7	-0.6	0.4	-0.9	-0.8	0.5	-0.9	0.5	-0.3	-0.5	-0.6	-0.5	-1.5
Age at last live birth	0.5	0.7	1.7	0.4	-0.3	0.1	1.2	1.3	0.3	0.6	0.3	0.8	-0.8	1.2	1.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.8	-0.8	-1.1	-1.1	0.1	0.6	-1.3	0.4	-0.7	-0.5	0.6	0.6	0.1	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	-0.0	-0.5	-0.0	-1.0	-1.2	-0.1	-1.1	0.5	-0.3	0.3	-1.0	-0.9	-1.4
High cholesterol (Self-reported)	0.5	1.0	2.2	-0.9	-1.5	-0.6	-1.4	-0.7	-0.4	-1.1	-0.7	-1.1	-0.3	-1.4	-1.0	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.1	-1.4	-1.2	0.2	-0.6	-0.2	-0.4	-0.8	-0.7	-0.8	1.4	-0.7	-0.7	-0.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	4.6	-1.2	-0.5	-2.1	-0.1	0.9	-1.5	-0.0	-1.7	-1.2	0.7	0.5	-0.4	0.5
Fasting Glucose	0.4	0.5	1.1	-0.8	-0.4	-0.7	-0.4	-0.9	-0.8	0.0	-1.1	-0.5	0.3	-1.1	-0.9	0.0
Blood Eosinophil Count	0.4	3.4	6.0	-1.8	-2.5	-2.0	-1.9	-0.9	-1.4	-0.9	-1.9	-2.2	2.0	-2.0	-2.2	-1.3
Average weekly spirits intake	0.4	0.5	1.6	-0.6	-0.5	-0.8	-0.3	1.0	-1.0	0.7	-1.2	-0.7	0.5	-0.1	-0.1	0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	0.1	-0.6	0.6	-0.5	-1.2	0.5	-1.0	0.6	0.1	-0.1	-0.7	-0.5	-1.1
Systolic blood pressure, automated reading	0.4	1.0	3.4	-1.2	-0.8	-0.7	-0.9	-0.4	-1.2	0.1	-1.1	-1.2	1.8	-1.0	-1.2	-0.2
Angina	0.4	0.5	2.4	-0.3	0.2	0.1	-0.2	-0.9	0.6	-1.1	0.4	0.2	-0.9	-0.5	-0.5	-1.5
Medication: Co-codamol	0.4	0.5	1.3	-0.1	-0.9	-1.0	-0.6	0.3	-0.6	1.0	-0.7	-0.6	1.1	0.1	0.1	0.6
Relative age voice broke	0.4	0.6	2.1	-0.9	-0.9	-1.1	-0.5	-0.3	-1.5	0.1	-0.9	-0.6	0.5	-0.1	-0.7	-0.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.5	-0.4	-0.7	-0.2	0.6	0.7	0.1	1.2	-0.4	0.2	-0.1	1.0	0.9	1.2
Had menopause	0.4	0.5	2.1	-0.5	0.5	0.6	-0.5	-1.4	-0.2	-0.7	0.2	-0.2	0.1	-1.1	-0.9	-0.8
Falls in the last year	0.4	0.5	1.0	-0.5	-1.0	0.6	-0.9	-1.0	0.3	-0.5	0.2	-0.6	0.2	-1.0	-0.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.4	-1.2	-0.2	-0.8	-0.5	0.1	-0.9	-0.6	-0.7	-0.6	0.8	-0.3	-0.5	-0.1
Exposure to tobacco smoke at home	0.4	0.4	1.0	-1.0	-0.4	-0.8	-0.8	0.1	-0.6	0.6	-0.7	-0.8	0.7	-0.3	-0.7	-0.2
Headache pain in last month	0.4	0.7	2.0	-0.2	-0.9	-1.1	-0.6	1.1	-1.2	0.8	-1.4	-0.9	0.8	0.0	-0.0	0.7
Number of children fathered	0.4	0.4	1.6	0.5	1.3	0.3	1.0	0.4	0.3	0.2	0.2	0.9	-0.1	0.8	0.7	0.5
Angina (self-reported)	0.4	0.5	2.3	-0.1	0.4	0.4	-0.1	-1.0	0.8	-1.0	0.6	0.3	-1.0	-0.5	-0.4	-1.5
Mean time to correctly identify matches	0.4	0.7	1.8	-0.7	-0.7	0.0	-1.1	-0.7	-0.4	-1.0	-0.2	-1.2	0.7	-1.3	-0.9	-0.9
Illnesses of father: Heart disease	0.4	0.5	2.0	-1.4	-0.6	-0.7	-0.3	0.3	-1.1	1.1	-0.6	-0.5	0.4	0.4	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.1	-1.8	-0.9	-1.1	-1.0	-0.0	-0.8	-0.6	-1.0	-1.1	0.8	-0.8	-0.9	-0.1
Mood swings	0.4	0.8	2.1	-0.2	-0.6	0.1	-1.1	-1.1	0.2	-1.0	0.1	-0.8	0.5	-1.4	-1.2	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	1.0	-0.3	1.3	-0.4	0.0	1.0	-0.5	0.9	0.3	-0.6	-0.3	0.0	-0.7
Back pain experienced in last month	0.4	0.6	1.6	0.1	-1.1	0.8	-0.7	-1.3	0.3	-1.3	0.3	-0.7	-0.1	-1.0	-0.6	-0.8
Financial situation satisfaction	0.4	0.5	1.4	0.6	1.2	0.6	0.9	-0.4	1.0	-0.4	0.8	1.0	-0.6	0.0	0.1	-0.1
Risk taking	0.4	0.6	1.7	0.5	0.1	-0.6	0.6	1.3	-0.4	1.2	-0.3	0.4	0.5	1.1	0.9	0.9
Schizophrenia (2018)	0.3	0.5	2.9	-1.1	-1.7	-0.6	-0.3	0.4	-0.5	-0.3	-0.6	-0.6	1.0	-0.0	-0.4	0.1
Alzheimer’s Disease (in father)	0.3	0.3	1.9	0.3	0.3	0.2	-0.3	-1.4	-0.5	-0.3	-0.1	-0.1	0.5	-0.7	-0.6	-0.2
Neuroticism	0.3	0.8	1.4	-0.7	-0.8	-1.1	-1.1	-0.7	-0.4	0.0	-0.8	-1.1	0.7	-1.1	-1.2	-0.9
Chronotype (morning person)	0.3	0.7	1.8	0.9	0.5	1.3	0.9	0.9	0.2	0.2	0.6	0.8	-0.2	1.0	1.0	1.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	0.2	0.3	1.2	0.0	-0.6	0.8	-0.8	1.0	0.2	-0.8	-0.4	-0.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.3	0.1	-0.2	0.6	-0.7	-0.6	0.6	-0.3	0.4	-0.5	-0.0	-0.8	-0.7	-1.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.4	-0.1	0.5	0.0	0.0	-1.2	0.5	-0.6	0.7	0.3	-0.1	-0.3	-0.3	-1.1
Alcohol intake versus 10 years previously	0.3	0.5	1.9	0.1	0.8	0.5	-0.1	-1.4	0.6	-0.4	0.9	0.5	-0.5	-0.4	-0.2	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.2	-1.0	-1.1	0.2	-0.8	-0.3	-0.4	0.0	-0.3	-0.9	0.8	-0.7	-0.6	-0.2
Prospective memory result	0.3	0.4	1.3	0.5	-0.7	1.1	0.2	0.4	0.5	0.6	0.9	0.2	-0.3	0.4	0.8	0.2
Impedance of arm (left)	0.3	1.2	2.3	-1.4	-0.4	-1.5	-1.3	-0.2	-1.4	0.6	-1.4	-1.3	-0.3	-0.8	-1.2	-0.8
Length of working week for main job	0.3	0.4	0.9	0.3	-0.5	0.5	0.8	0.2	0.2	0.7	0.3	0.7	0.3	0.7	0.9	1.0
Loud music exposure frequency	0.3	0.3	0.8	0.7	0.2	0.7	0.4	0.6	0.2	0.4	0.8	0.6	-0.9	0.7	0.6	0.0
Number of full brothers	0.3	0.4	1.7	-0.1	-0.7	-0.7	-0.0	1.3	-0.3	0.8	-0.6	-0.3	0.4	0.8	0.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.4	-0.2	-0.7	-1.2	-0.1	0.3	-0.7	0.6	-0.7	-0.2	0.5	0.3	0.2	0.3
Osteoporosis (self-reported)	0.3	0.4	1.4	-1.1	-0.2	-0.3	-0.3	0.4	-1.2	0.6	-0.9	-0.8	0.0	-0.1	-0.1	0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.2	0.4	0.0	0.4	0.6	0.8	0.0	0.9	0.4	0.2	0.6	0.8	0.9	1.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.4	-0.9	0.4	-0.7	-0.3	-0.1	-0.8	1.2	-0.7	-0.5	0.5	-0.1	-0.5	0.4
Alcohol drinker status: Never	0.3	0.4	1.1	-0.2	-0.4	-0.4	-0.5	-0.9	-0.8	0.1	-0.6	-0.7	1.1	-0.7	-0.5	0.0
Supplements: Calcium	0.3	0.4	1.2	0.5	0.1	1.1	0.9	0.4	0.7	-0.5	0.5	0.6	-0.5	0.4	0.6	0.5
Impedance of whole body	0.3	1.6	3.8	-1.9	-1.1	-1.7	-1.3	0.4	-1.9	1.3	-1.7	-1.4	0.2	-0.4	-0.9	-0.2
Bipolar Disorder (2018)	0.2	0.2	1.0	-0.2	-0.3	0.0	-0.4	-0.4	-0.9	-1.0	0.2	-0.5	-0.3	-0.4	-0.4	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	2.2	-1.0	-1.5	-0.5	-0.5	0.0	-0.9	-0.9	-0.4	-0.8	0.6	-0.3	-0.6	-0.1
Ovarian Cancer	0.2	0.3	1.2	0.9	-0.1	0.2	0.2	-0.4	1.1	0.2	0.7	0.5	-0.8	0.1	0.3	-0.5
Lung FVC	0.2	1.1	2.4	0.8	0.4	1.5	1.3	0.7	1.2	0.6	1.4	1.3	-0.9	0.8	1.4	0.4
Medication for hormone replacement therapy	0.2	0.2	1.5	-0.1	-1.2	-0.7	-0.5	-0.3	-0.3	-0.0	-0.4	-0.3	0.6	-0.1	-0.2	-0.1
Diabetes (father)	0.2	0.2	0.8	-0.1	0.7	0.2	0.3	0.9	-0.5	0.2	0.2	-0.0	0.3	0.5	0.5	0.4
Leg fat-free mass (left)	0.2	1.1	2.1	1.4	1.4	1.0	1.1	-0.3	1.4	-1.1	1.3	1.3	-0.8	0.5	0.6	0.1
Average weekly fortified wine intake	0.2	0.2	1.3	1.1	0.1	-0.2	-0.2	0.7	-0.1	-0.3	-0.1	-0.1	-0.6	0.3	0.1	-0.1
Multivitamins +/- minerals	0.2	0.2	0.9	0.3	-0.3	0.1	-0.7	-0.7	0.3	-0.3	-0.1	-0.1	0.2	-0.6	-0.5	-0.9
Stomach or abdominal pain in last month	0.2	0.3	1.8	-0.7	-1.4	-0.4	-0.0	0.5	-0.1	-0.4	-0.0	0.3	-0.4	0.3	0.4	-0.2
Sitting height	0.2	1.2	3.1	0.5	0.6	-0.3	1.6	1.4	0.2	0.9	-0.1	1.2	0.6	1.6	1.3	1.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.9	0.5	-0.4	0.3	-0.5	-0.5	0.7	-0.6	0.0	-0.3	0.3	-0.9	-0.5	-0.7
Leg predicted mass (left)	0.2	1.2	2.3	1.5	1.4	1.0	1.1	-0.4	1.5	-1.2	1.4	1.4	-0.9	0.5	0.6	0.0
Forced vital capacity (FVC)	0.2	0.9	1.9	0.3	0.8	0.7	1.4	0.8	0.8	0.4	0.8	1.3	-1.4	1.0	1.2	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	1.1	-0.1	0.4	0.8	0.1	1.0	0.3	0.3	0.9	-0.6	0.5	0.7	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.9	0.6	0.9	0.2	0.4	-0.8	0.3	-0.1	0.4	0.2	-0.5	-0.4	-0.1	-0.2
Allergy	0.2	0.4	1.5	0.2	0.3	-0.0	0.4	1.0	-0.5	1.2	-0.2	0.1	0.1	0.8	0.5	1.1
Impedance of arm (right)	0.2	0.7	1.5	-1.1	-0.1	-1.2	-0.9	0.1	-1.2	0.9	-1.2	-1.0	-0.5	-0.4	-0.9	-0.5
Pulse rate	0.2	0.3	1.1	-0.2	-0.1	-0.1	-0.4	0.9	-1.0	0.4	-1.1	-0.6	0.6	-0.3	-0.2	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	0.5	0.3	0.8	-0.3	-1.0	0.6	-0.7	0.8	0.4	-0.5	-0.3	-0.0	-0.6
Depression (self-reported)	0.2	0.2	0.6	-0.8	0.1	-0.1	-0.3	-0.8	0.0	-0.4	-0.0	-0.3	-0.6	-0.4	-0.6	-0.5
Medication: Paracetamol	0.2	0.3	0.8	0.8	-0.4	0.5	0.2	0.9	-0.0	0.9	-0.1	0.0	-0.3	0.5	0.6	0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.0	-0.4	-0.2	-0.9	0.2	0.7	-1.0	0.0	-0.6	-0.3	0.4	0.4	0.0	0.4
Leg fat percentage (right)	0.2	0.6	1.6	-0.5	-1.3	0.3	-1.0	-0.9	-0.3	-0.1	0.3	-0.6	1.3	-0.9	-0.6	-0.4
Exposure to tobacco smoke outside home	0.2	0.2	0.6	0.8	-0.5	0.5	0.1	0.1	0.3	-0.1	0.6	0.4	-0.7	0.3	0.5	0.3
Qualifications: College or University degree	0.2	0.8	2.4	-1.0	0.0	-1.1	-0.2	0.7	-1.2	0.3	-1.5	-0.7	1.6	0.0	-0.3	0.7
Comparative height size at age 10	0.2	1.3	2.3	-1.0	-0.8	-1.1	-1.4	-0.9	-1.0	-1.2	-1.1	-1.0	1.2	-1.5	-1.5	-1.1
Number of full sisters	0.2	0.3	0.9	-0.7	-0.9	0.2	-0.3	-0.2	-0.5	-0.7	-0.2	-0.4	0.6	-0.6	-0.2	0.4
Chest pain or discomfort	0.2	0.3	1.5	-0.4	-0.1	0.2	-0.0	0.5	-0.8	1.2	-0.2	-0.3	0.8	-0.1	0.1	0.7
Had major operations	0.2	0.2	0.6	0.6	-0.5	0.4	-0.2	-0.5	0.2	-0.1	0.3	-0.2	0.8	-0.5	-0.4	-0.6
Leg fat-free mass (right)	0.2	1.0	1.9	1.4	1.4	0.8	1.0	-0.4	1.4	-1.4	1.3	1.2	-0.7	0.4	0.5	-0.1
Average weekly red wine intake	0.2	0.2	1.2	-0.2	-0.5	0.9	-0.3	-0.2	0.1	-1.1	0.5	0.1	-0.3	-0.4	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.2	0.2	0.7	1.0	0.1	-0.2	0.6	-0.2	1.0	0.3	-1.1	0.1	0.5	-0.2
Leg predicted mass (right)	0.2	1.1	2.1	1.4	1.3	0.9	0.9	-0.5	1.4	-1.4	1.4	1.2	-0.8	0.3	0.5	-0.2
Miserableness	0.2	0.4	0.8	0.3	-0.9	-0.3	-0.9	-0.6	0.1	-0.7	0.1	-0.5	0.7	-0.7	-0.6	-0.8
Guilty feelings	0.2	0.2	0.8	-0.3	-0.4	-0.3	-0.6	-0.7	0.5	-0.0	-0.1	-0.3	-0.0	-0.7	-0.6	-0.9
Ever taken oral contraceptive pill	0.2	0.2	1.0	-1.0	-0.4	-0.5	-0.1	0.5	-0.3	0.0	-0.3	-0.2	0.8	-0.1	-0.1	-0.3
Leg fat percentage (left)	0.2	0.7	1.9	-0.6	-1.2	0.2	-1.1	-1.0	-0.3	-0.4	0.3	-0.7	1.4	-1.0	-0.7	-0.7
Irritability	0.2	0.3	1.5	-0.2	-0.6	0.3	-0.1	-0.8	0.1	-1.1	0.4	0.1	-1.2	-0.5	-0.4	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.8	0.8	0.2	0.4	0.2	-0.9	0.2	-0.2	0.6	0.3	-0.0	-0.2	0.0	0.2
Age started oral contraceptive pill	0.2	0.3	2.7	-0.5	-0.1	0.1	-0.4	-0.1	-0.3	0.2	-0.5	-0.6	1.6	-0.2	-0.4	0.0
Reaction Time	0.1	0.1	0.6	-0.4	-0.5	0.1	-0.3	0.8	-0.2	-0.4	0.1	-0.4	0.2	0.1	0.2	0.2
Age at First Birth	0.1	0.1	0.6	-0.1	0.4	-0.1	0.5	-0.0	-0.4	0.8	0.0	0.4	0.6	0.5	0.3	0.2
Schizophrenia (2014)	0.1	0.2	1.3	-0.5	-1.1	-0.3	0.1	0.3	-0.1	-0.4	-0.1	-0.2	0.6	0.0	-0.1	0.0
Heel T-Score	0.1	1.1	4.2	2.0	0.9	0.6	0.8	-1.5	1.5	-0.8	1.1	1.1	-0.4	-0.1	-0.0	-0.8
BMI	0.1	0.4	0.9	1.0	0.5	0.4	0.8	0.4	0.6	0.1	0.8	0.6	0.5	0.7	0.9	0.9
Height	0.1	1.3	4.2	0.6	0.2	0.6	0.1	-1.7	1.4	-1.5	0.9	0.8	-2.0	-0.8	-0.6	-1.7
Smoking Status	0.1	0.2	1.1	-1.1	-0.5	-0.2	-0.2	-0.3	0.5	-0.1	-0.2	-0.3	0.3	-0.3	-0.5	-0.7
Tanning	0.1	0.9	3.0	-0.5	-0.4	-0.2	0.9	1.3	-0.8	1.7	-0.6	0.3	-0.1	1.2	0.9	1.6
Trunk fat percentage	0.1	0.4	1.3	0.1	-0.3	0.1	-0.8	-1.2	0.1	-0.6	0.7	-0.4	0.4	-0.7	-0.7	-1.1
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.4	-0.6	0.8	-0.4	-0.5	-0.0	-0.0	0.6	-0.4	0.2	-0.4	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	0.2	-0.7	0.1	0.2	-0.5	0.0	-0.1	-0.4	-0.1	0.6	-0.3	-0.1	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	1.1	0.0	-0.1	-0.5	-0.2	-0.7	0.3	-1.0	0.1	-0.2	-0.2	-0.5	-0.4	-0.8
Body mass index (BMI)	0.1	0.6	1.8	1.1	0.1	1.1	0.0	-0.9	1.0	-1.1	1.3	0.4	0.3	-0.3	0.1	-0.4
Trunk fat mass	0.1	0.4	1.0	0.3	-0.2	0.3	-0.7	-1.0	0.2	-0.8	0.7	-0.2	0.4	-0.6	-0.5	-1.0
Past tobacco smoking	0.1	0.2	0.5	0.2	-0.4	-0.0	-0.6	-0.4	-0.7	0.1	-0.3	-0.5	0.3	-0.7	-0.5	-0.5
Financial difficulties in last 2 years	0.1	0.1	0.5	0.2	0.1	-0.1	0.3	0.7	-0.3	0.3	0.1	0.3	-0.4	0.4	0.4	0.4
Arm fat percentage (right)	0.1	0.4	1.0	0.3	-0.3	0.5	-0.7	-1.0	0.1	-0.8	0.8	-0.4	0.6	-0.7	-0.5	-0.7
Trunk fat-free mass	0.1	0.3	0.9	0.4	0.5	0.6	0.7	-0.0	0.5	-0.9	0.5	0.7	0.3	0.2	0.4	0.5
Hip circumference	0.1	0.6	1.6	0.9	1.0	0.8	0.5	-0.7	1.1	-0.7	1.2	0.7	-0.1	0.0	0.2	-0.3
Time employed in main current job	0.1	0.1	0.6	0.1	0.6	-0.3	0.1	0.1	0.6	-0.0	0.2	0.2	-0.7	0.1	0.3	-0.2
Lung cancer (father)	0.1	0.1	0.4	-0.1	-0.6	-0.4	-0.0	0.3	0.5	0.5	-0.3	0.3	0.2	0.2	0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.4	-0.2	0.5	0.7	0.3	-0.3	0.8	-0.7	0.9	0.5	-1.2	0.0	0.3	-0.2
Arm fat mass (right)	0.1	0.4	1.3	0.7	0.0	0.9	-0.3	-1.0	0.6	-1.1	1.1	0.1	0.4	-0.5	-0.2	-0.6
Peak expiratory flow (PEF)	0.1	0.2	0.6	-0.5	-0.2	-0.8	-0.2	-0.6	-0.3	-0.5	-0.1	-0.3	-0.3	-0.2	-0.2	-0.4
Body fat percentage	0.1	0.4	1.0	-0.1	-0.6	0.2	-0.9	-1.0	-0.1	-0.3	0.6	-0.5	0.8	-0.7	-0.6	-0.8
Worry too long after embarrassment	0.1	0.2	0.7	0.8	0.7	-0.4	0.5	0.5	0.1	0.1	0.1	0.3	-0.1	0.7	0.3	0.1
Neck or shoulder pain in last month	0.1	0.2	1.3	0.8	1.1	0.7	-0.1	-0.2	0.1	0.0	0.3	0.1	0.2	-0.1	-0.1	0.1
Medication: Seretide 50 evohaler	0.1	0.2	1.0	0.4	1.0	-0.4	0.3	0.1	0.5	-0.3	0.1	0.1	0.1	-0.1	-0.0	-0.4
Whole body fat mass	0.1	0.3	0.8	0.5	-0.1	0.6	-0.3	-0.9	0.4	-0.6	0.9	0.1	0.5	-0.4	-0.2	-0.6
Suffer from ‘nerves’	0.1	0.2	0.9	0.3	0.6	-0.7	-0.3	-0.0	-0.5	-0.4	-0.1	-0.2	-1.0	0.0	-0.5	-0.6
Whole body fat-free mass	0.1	0.6	1.2	0.8	0.9	0.8	0.9	-0.1	0.9	-1.1	0.9	1.0	-0.1	0.3	0.5	0.4
Arm fat percentage (left)	0.1	0.4	1.2	0.3	-0.3	0.4	-0.8	-1.1	0.1	-0.8	0.8	-0.4	0.6	-0.7	-0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.4	-0.3	-0.4	-0.4	0.5	-0.6	-0.3	-0.5	-0.6	0.3	0.3	-0.3	-0.1
Whole body water mass	0.1	0.6	1.0	0.9	0.8	0.8	0.9	-0.1	0.9	-1.0	0.9	1.0	-0.1	0.3	0.5	0.4
Arm fat mass (left)	0.1	0.4	1.0	0.4	-0.2	0.5	-0.5	-1.0	0.2	-1.0	0.8	-0.2	0.6	-0.6	-0.4	-0.7
Medication: Paracetamol	0.1	0.2	0.6	0.0	-0.7	-0.1	-0.2	0.7	-0.5	0.3	-0.7	-0.5	0.4	0.2	0.1	0.7
Basal metabolic rate	0.1	0.4	1.0	0.8	0.7	0.7	0.7	-0.2	0.8	-1.0	0.9	0.9	0.0	0.3	0.4	0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.4	-0.2	0.1	0.4	0.9	-0.3	0.7	-0.1	-0.1	0.9	0.5	0.3	0.8
Alcohol drinker status: Previous	0.1	0.2	1.1	-0.3	1.1	0.5	-0.0	-0.3	-0.3	-0.2	-0.0	0.0	-0.2	-0.3	-0.3	-0.3
Leg fat mass (left)	0.1	0.2	0.8	0.0	-0.6	0.2	-0.5	-0.7	0.0	-0.6	0.5	-0.2	0.9	-0.5	-0.3	-0.4
Blood Red Count	0.0	0.4	2.0	0.5	-1.1	0.1	-0.6	-0.1	-0.2	0.5	-0.4	-0.9	1.4	-0.6	-0.5	0.0
Hair Pigment	0.0	0.7	1.4	0.8	0.3	1.2	0.8	-0.3	0.8	-1.2	1.2	1.1	-0.6	0.3	0.7	0.1
Sensitivity / hurt feelings	0.0	0.1	0.4	0.3	-0.1	0.1	-0.3	-0.0	0.3	-0.0	-0.0	-0.0	-0.5	-0.2	-0.3	-0.6
Weight	0.0	0.2	0.9	0.5	0.1	0.6	-0.0	-0.7	0.5	-0.9	0.7	0.2	0.5	-0.3	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.5	-0.4	-0.0	0.3	0.0	-0.1	0.0	-0.7	0.3	0.1	-0.7	-0.2	0.1	-0.3
Trunk predicted mass	0.0	0.3	1.0	0.3	0.5	0.7	0.6	-0.1	0.5	-1.0	0.5	0.7	0.4	0.1	0.3	0.5
Standing height	0.0	0.3	1.1	-1.0	-0.1	-1.0	-0.1	0.2	-0.9	-0.1	-1.0	-0.2	0.2	-0.1	-0.3	0.3
Arm fat-free mass (right)	0.0	0.2	0.8	0.3	0.1	0.3	0.4	-0.3	0.6	-0.9	0.4	0.6	0.5	-0.0	0.2	0.3
Age at first live birth	0.0	0.1	0.4	-0.0	-0.5	-0.3	0.2	0.1	-0.0	-0.2	0.0	-0.1	0.7	-0.1	-0.0	0.3
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.4	-0.3	-0.2	-0.2	0.0	0.3	-0.1	0.1	0.0	0.3	0.3	0.1	-0.2
Leg fat mass (right)	0.0	0.2	0.5	0.1	-0.6	0.3	-0.4	-0.6	0.1	-0.3	0.6	-0.1	0.7	-0.3	-0.1	-0.1
Arm predicted mass (right)	0.0	0.2	0.6	0.1	0.1	0.2	0.5	-0.0	0.5	-0.8	0.2	0.6	0.7	0.1	0.3	0.5
Pulse rate, automated reading	0.0	0.1	0.2	-0.2	0.3	0.2	-0.2	0.4	-0.4	-0.4	-0.3	-0.3	-0.5	-0.2	-0.1	-0.1
Ever smoked	0.0	0.1	0.3	-0.5	-0.6	-0.3	0.0	0.4	0.2	-0.3	0.2	0.1	0.1	0.2	0.2	0.0
Arm fat-free mass (left)	0.0	0.2	0.9	0.0	-0.2	0.4	0.2	-0.3	0.1	-1.0	0.4	0.2	0.7	-0.2	0.1	0.4
Arm predicted mass (left)	0.0	0.2	0.9	0.1	-0.0	0.6	0.2	-0.3	0.3	-0.9	0.5	0.4	0.7	-0.1	0.2	0.4

Hub : Genes

DLD

Models

Trait associations