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chr20:46,840,115-48,591,758

Best TWAS P=2.82e-17 · Best GWAS P=7.49e-14 conditioned to 0.846

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	YFS	Blood	CSE1L	0.06	0.05	enet	21	0.06	2.0e-19	-7.4	-8.5	2.8e-17	0.87	0.01	0.99	TRUE
7	GTEx	Artery Tibial	CSE1L	0.12	0.03	lasso	6	0.04	3.8e-04	-7.5	-7.9	3.4e-15	0.94	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CSE1L	0.08	0.07	bslmm	503	0.05	1.7e-06	-6.9	-7.8	8.1e-15	0.91	0.02	0.98	FALSE
24	METSIM	Adipose	CSE1L	0.05	0.05	lasso	4	0.04	5.3e-07	-7.4	-7.7	1.2e-14	0.98	0.02	0.98	FALSE
11	GTEx	Colon Transverse	ARFGEF2	0.11	0.07	enet	12	0.09	2.9e-05	-7.4	-7.6	3.3e-14	0.88	0.03	0.96	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CSE1L	0.05	0.07	blup	50	0.07	3.2e-08	6.9	-7.5	5.7e-14	0.70	0.32	0.68	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	CSE1L	0.15	0.06	lasso	3	0.07	4.4e-03	-7.3	-7.5	9.1e-14	0.97	0.01	0.64	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	CSE1L	0.12	0.20	lasso	2	0.19	7.1e-18	-7.5	-7.4	9.7e-14	0.99	0.01	0.99	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	CSE1L	0.17	0.07	lasso	5	0.07	1.6e-03	-7.4	-7.4	1.2e-13	0.90	0.02	0.94	FALSE
4	GTEx	Adipose Subcutaneous	ARFGEF2	0.10	0.07	lasso	3	0.06	1.1e-05	-7.5	-7.3	2.1e-13	0.97	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	CSE1L	0.05	0.06	lasso	3	0.05	1.0e-06	-7.3	-7.3	3.2e-13	0.98	0.01	0.99	FALSE
14	GTEx	Esophagus Mucosa	CSE1L	0.09	0.06	lasso	4	0.06	6.9e-05	6.5	-7.3	3.7e-13	0.70	0.15	0.81	FALSE
22	GTEx	Thyroid	CSE1L	0.20	0.21	enet	15	0.20	2.3e-15	-6.9	-7.2	4.2e-13	0.99	0.02	0.98	FALSE
5	GTEx	Adipose Subcutaneous	CSE1L	0.15	0.15	lasso	4	0.15	2.4e-12	-7.3	-7.2	5.7e-13	0.97	0.02	0.98	FALSE
20	GTEx	Skin Sun Exposed Lower leg	CSE1L	0.08	0.03	lasso	2	0.03	9.5e-04	6.6	-7.1	1.1e-12	0.66	0.12	0.78	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	CSE1L	0.05	0.05	lasso	3	0.06	8.1e-07	-6.9	-7.1	1.1e-12	0.98	0.01	0.99	FALSE
15	GTEx	Esophagus Muscularis	CSE1L	0.16	0.14	enet	22	0.12	5.1e-08	-7.5	-7.1	1.3e-12	0.91	0.01	0.99	FALSE
10	GTEx	Colon Sigmoid	CSE1L	0.18	0.12	lasso	11	0.09	4.4e-04	7.0	-7.0	3.1e-12	0.56	0.16	0.76	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	CSE1L	0.04	0.02	enet	16	0.02	2.8e-03	5.9	-7.0	3.2e-12	0.80	0.04	0.95	FALSE
17	GTEx	Lung	CSE1L	0.10	0.09	lasso	5	0.08	6.6e-07	6.2	-6.9	6.2e-12	0.61	0.30	0.69	FALSE
6	GTEx	Artery Aorta	CSE1L	0.12	0.18	lasso	4	0.16	2.9e-09	-6.9	-6.8	9.0e-12	0.95	0.02	0.98	FALSE
16	GTEx	Heart Atrial Appendage	CSE1L	0.09	0.07	lasso	5	0.06	9.1e-04	-7.4	-6.8	1.1e-11	0.97	0.02	0.97	FALSE
19	GTEx	Nerve Tibial	CSE1L	0.12	0.01	lasso	10	0.03	5.7e-03	-7.4	-6.8	1.3e-11	0.85	0.03	0.89	FALSE
18	GTEx	Muscle Skeletal	CSE1L	0.18	0.19	lasso	9	0.20	4.6e-19	-7.5	-6.7	1.8e-11	0.97	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	DDX27	0.08	0.05	lasso	3	0.05	1.9e-05	5.0	6.5	5.8e-11	-0.70	0.25	0.57	FALSE
8	GTEx	Cells Transformed fibroblasts	STAU1	0.08	0.03	lasso	6	0.02	2.3e-02	6.2	6.3	2.5e-10	-0.50	0.21	0.39	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CSE1L	0.03	0.05	lasso	1	0.03	9.3e-05	6.2	-6.2	6.6e-10	0.49	0.40	0.48	FALSE
12	GTEx	Colon Transverse	CSE1L	0.17	0.01	enet	19	0.03	1.2e-02	6.2	-6.1	8.1e-10	0.56	0.18	0.21	FALSE
21	GTEx	Testis	ARFGEF2	0.20	0.20	lasso	7	0.24	5.4e-11	6.2	-6.1	8.7e-10	0.49	0.68	0.32	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARFGEF2	0.05	0.04	lasso	5	0.05	3.2e-06	5.3	-6.1	1.1e-09	0.48	0.60	0.39	FALSE
9	GTEx	Colon Sigmoid	ARFGEF2	0.15	0.12	lasso	1	0.07	2.3e-03	5.9	-5.9	3.6e-09	0.69	0.08	0.42	FALSE
3	CommonMind	Brain Pre-frontal Cortex	STAU1	0.09	0.00	bslmm	500	0.01	8.7e-03	-6.5	-5.7	1.4e-08	0.51	0.05	0.82	FALSE
23	METSIM	Adipose	ARFGEF2	0.04	0.03	lasso	12	0.02	9.8e-05	5.5	-5.4	7.4e-08	0.44	0.69	0.21	FALSE
25	NTR	Blood	SNORD12B	0.03	0.05	lasso	8	0.05	1.9e-14	5.0	-5.4	8.0e-08	0.46	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DDX27	0.04	0.04	enet	11	0.07	7.3e-09	-6.7	5.3	9.4e-08	-0.82	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CSE1L	0.08	0.02	enet	28	0.03	1.7e-02	3.1	-5.2	1.8e-07	0.55	0.02	0.51	FALSE