Best TWAS P=2.03e-09 · Best GWAS P=2.03e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | PAM | 0.06 | 0.03 | lasso | 6 | 0.02 | 2.5e-02 | 5.5 | 5.4 | 7.7e-08 | 0.52 | 0.07 | 0.69 | FALSE |
2 | GTEx | Artery Tibial | PPIP5K2 | 0.07 | 0.04 | enet | 22 | 0.05 | 1.4e-04 | 5.0 | -6.0 | 2.3e-09 | -0.75 | 0.36 | 0.62 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | PAM | 0.27 | 0.10 | lasso | 4 | 0.13 | 2.7e-04 | 3.5 | 5.3 | 1.0e-07 | 0.64 | 0.15 | 0.78 | FALSE |
4 | GTEx | Brain Cerebellum | PAM | 0.26 | 0.17 | lasso | 4 | 0.15 | 3.5e-05 | 5.4 | 5.5 | 4.6e-08 | 0.56 | 0.10 | 0.87 | FALSE |
5 | GTEx | Breast Mammary Tissue | PPIP5K2 | 0.11 | 0.10 | lasso | 5 | 0.04 | 2.7e-03 | 4.5 | -5.2 | 2.3e-07 | -0.83 | 0.14 | 0.80 | FALSE |
6 | GTEx | Breast Mammary Tissue (Female) | PPIP5K2 | 0.09 | 0.01 | lasso | 7 | 0.00 | 2.9e-01 | 4.0 | -5.2 | 1.8e-07 | -0.82 | 0.11 | 0.50 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | PAM | 0.04 | 0.00 | lasso | 4 | 0.04 | 2.3e-04 | 5.7 | 5.4 | 6.2e-08 | 0.86 | 0.08 | 0.59 | FALSE |
8 | GTEx | Whole Blood | PAM | 0.20 | 0.28 | lasso | 9 | 0.27 | 1.0e-24 | 5.6 | 5.8 | 5.3e-09 | 0.99 | 0.02 | 0.98 | FALSE |
9 | METSIM | Adipose | PAM | 0.04 | 0.02 | lasso | 2 | 0.02 | 2.9e-04 | 5.5 | 5.4 | 8.3e-08 | 0.92 | 0.03 | 0.96 | FALSE |
10 | METSIM | Adipose | PPIP5K2 | 0.05 | 0.07 | blup | 347 | 0.07 | 6.3e-11 | 4.2 | -5.2 | 2.0e-07 | -0.66 | 0.86 | 0.14 | FALSE |
11 | NTR | Blood | PAM | 0.26 | 0.29 | lasso | 1 | 0.29 | 2.6e-95 | 6.0 | 6.0 | 2.0e-09 | 1.00 | 0.00 | 1.00 | TRUE |
12 | YFS | Blood | GIN1 | 0.02 | 0.04 | lasso | 7 | 0.05 | 5.1e-17 | 4.7 | 5.2 | 2.3e-07 | 0.84 | 0.25 | 0.75 | FALSE |
13 | YFS | Blood | PAM | 0.64 | 0.68 | enet | 68 | 0.72 | 0.0e+00 | 6.0 | 5.9 | 4.6e-09 | 0.97 | 0.00 | 1.00 | FALSE |