TWAS hub - GIN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1460	0.0670	9.6e-03	0.050	NA	0.039	NA	0.045	9.3e-04	NA	3.1e-03	NA	1.6e-03
2	GTEx	Muscle Skeletal	0.0418	0.0241	6.3e-03	0.010	NA	-0.003	NA	0.003	3.5e-02	NA	8.1e-01	NA	1.5e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0173	0.0106	1.3e-02	0.006	0.009	-0.002	0.008	-0.002	5.2e-02	2.3e-02	9.6e-01	2.8e-02	7.6e-01
4	YFS	Blood	0.0216	0.0069	1.8e-15	0.045	0.046	0.053	0.046	0.054	2.2e-14	6.0e-15	9.5e-17	1.1e-14	5.1e-17
5	TCGA	Breast Invasive Carcinoma	0.0085	0.0061	3.3e-03	0.010	0.011	0.006	NA	0.008	3.5e-03	1.7e-03	1.4e-02	NA	7.8e-03
6	TCGA	Cervical Squamous Cell Carcinoma	0.1140	0.0750	1.0e-03	0.025	0.050	0.048	NA	0.050	2.0e-02	1.7e-03	2.2e-03	NA	1.7e-03
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.1303	0.0924	3.2e-03	0.006	0.003	0.015	NA	0.014	5.5e-02	1.3e-01	7.0e-03	NA	9.8e-03
8	TCGA	Brain Lower Grade Glioma	0.0846	0.0454	5.5e-09	0.083	0.081	0.076	NA	0.088	1.1e-09	1.7e-09	5.7e-09	NA	3.1e-10
9	TCGA	Prostate Adenocarcinoma	0.0267	0.0168	2.8e-04	0.033	0.028	0.014	NA	0.026	1.9e-04	5.5e-04	1.2e-02	NA	9.2e-04
10	TCGA	Soft Tissue Sarcoma	0.0330	0.0240	8.6e-03	0.024	0.029	0.013	NA	0.027	1.3e-02	7.9e-03	5.6e-02	NA	9.0e-03
11	TCGA	Thyroid Carcinoma	0.0560	0.0360	3.2e-06	0.066	0.058	0.053	NA	0.060	5.3e-07	2.4e-06	6.1e-06	NA	1.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Waist Hip Ratio (WHR)	9.9	44.6	53.6	3.4	-6.9	-7.2	-7.1	-7.3	-7.3	-5.1	-6.6	-7.0	-7.3	-7.2
Type 2 Diabetes (T2D) (2018)	9.8	18.3	27.2	-1.6	5.2	4.5	4.0	4.7	4.5	3.4	4.4	4.5	4.6	4.6
Diabetes diagnosed by doctor	9.2	15.1	20.7	-1.1	4.6	4.1	4.1	4.2	4.0	3.2	4.1	4.0	4.1	4.1
Worry (Nagel 2018)	9.1	19.2	24.8	3.8	-3.9	-4.7	-5.0	-4.7	-5.0	-2.9	-4.0	-4.5	-4.7	-4.6
Suffer from ‘nerves’	8.7	13.7	19.8	2.5	-2.9	-4.5	-4.3	-3.8	-4.0	-2.7	-3.7	-4.0	-3.9	-3.9
Rheumatoid Arthritis	8.2	11.3	17.4	1.4	-3.8	-4.1	-4.2	-3.7	-3.7	-2.6	-3.6	-3.6	-3.7	0.0
Worrier / anxious feelings	8.1	15.4	20.5	3.0	-4.0	-4.3	-4.0	-4.3	-4.5	-2.9	-3.6	-3.9	-4.2	-4.2
Mouth/teeth dental problems: Mouth ulcers	7.4	11.7	15.5	0.0	-2.8	-3.5	-3.8	-3.8	-3.9	-2.7	-3.5	-3.9	-3.9	-3.9
Diabetes (father)	7.0	8.7	16.2	0.5	4.0	2.7	2.8	3.3	3.3	2.2	2.9	3.0	3.2	3.2
Hypothyroidism (self reported)	6.9	15.9	23.2	2.4	-3.8	-4.4	-4.0	-4.5	-4.8	-1.6	-4.1	-4.3	-4.4	-4.4
Diabetes (self-reported)	6.5	10.0	13.9	-1.3	3.7	3.6	3.3	3.2	2.9	3.1	3.4	3.1	3.2	3.3
Qualifications: CSEs or equivalent	6.2	8.2	11.4	0.2	-2.9	-2.4	-3.1	-3.4	-3.4	-1.7	-3.0	-3.2	-3.3	-3.1
Hypothyroidism/myxoedema (self-reported)	6.0	11.6	15.9	2.7	-3.4	-4.0	-3.7	-3.7	-4.0	-0.8	-3.4	-3.5	-3.6	-3.6
Medication: Metformin	5.7	8.1	12.2	-0.2	3.5	3.2	3.1	3.0	2.9	1.8	3.1	3.0	2.9	3.0
Illnesses of siblings: Diabetes	5.7	7.0	10.1	0.7	2.3	2.2	2.4	2.9	3.1	2.6	2.7	3.0	3.1	3.2
Hair/balding pattern: Pattern 4	5.4	13.1	18.0	0.8	-3.4	-3.6	-3.6	-3.9	-3.9	-3.4	-4.2	-3.8	-3.8	-4.0
Verbal and Numeric Reasoning (VNR)	5.3	12.8	17.1	-0.1	3.8	4.1	3.3	4.0	3.9	2.4	3.8	3.9	3.9	3.9
Fluid intelligence score	5.3	11.0	16.5	-0.3	3.3	4.1	3.3	3.6	3.5	2.7	3.5	3.5	3.5	3.6
Medication: Levothyroxine sodium	4.6	7.7	12.5	2.7	-2.7	-3.5	-3.0	-2.9	-3.1	-0.8	-2.7	-2.7	-2.8	-2.8
Ever taken oral contraceptive pill	4.6	5.2	7.7	0.1	2.5	2.3	2.8	2.5	2.3	1.7	2.3	2.4	2.5	2.4
Family relationship satisfaction	4.5	5.6	6.9	-1.8	2.5	2.3	1.8	2.6	2.6	2.2	2.3	2.5	2.6	2.6
Number of operations (self-reported)	4.5	6.7	9.3	-1.5	-2.2	-1.9	-2.2	-2.8	-3.0	-3.0	-2.5	-2.8	-2.9	-2.9
Chronic bronchitis/emphysema (mother)	4.2	4.9	8.2	1.9	2.1	1.5	1.9	2.5	2.1	1.8	2.9	2.6	2.4	2.3
Osteoarthritis (self-reported)	4.2	5.4	7.5	-1.9	2.7	1.9	2.5	2.4	2.1	1.8	2.7	2.5	2.4	2.4
Diverticular disease/diverticulitis (self-reported)	4.1	4.9	7.0	0.9	-2.2	-2.6	-2.4	-2.5	-2.4	-1.3	-2.4	-2.3	-2.4	-2.2
Mouth/teeth dental problems: Loose teeth	4.0	4.8	7.5	-1.3	1.6	2.1	2.2	2.5	2.7	2.1	2.0	2.2	2.5	2.5
Hand grip strength (right)	3.9	10.6	14.1	0.2	-3.4	-2.5	-3.0	-3.7	-3.5	-3.2	-3.5	-3.7	-3.8	-3.7
Alcohol usually taken with meals	3.9	6.3	10.4	1.9	-2.4	-2.5	-2.5	-2.4	-2.4	-3.2	-2.5	-2.5	-2.5	-2.6
Impedance of leg (right)	3.8	18.2	32.3	0.5	-4.9	-5.0	-5.7	-4.4	-4.4	-2.5	-4.1	-4.3	-4.4	-4.2
Age started oral contraceptive pill	3.6	4.6	5.6	1.9	-2.1	-1.5	-2.1	-2.3	-2.2	-2.1	-2.1	-2.3	-2.4	-2.3
Hand grip strength (left)	3.4	9.0	12.3	0.6	-3.0	-2.1	-2.1	-3.4	-3.3	-3.4	-3.4	-3.4	-3.5	-3.5
Impedance of leg (left)	3.4	16.5	32.7	0.8	-4.7	-5.1	-5.7	-4.1	-4.0	-2.4	-3.8	-4.0	-4.1	-3.9
Qualifications: College or University degree	3.3	10.3	19.8	-1.1	3.3	4.4	3.6	3.3	3.5	1.5	3.2	3.2	3.2	3.3
Neuroticism	3.2	7.6	11.6	2.7	-2.5	-3.4	-3.3	-2.9	-2.9	-1.6	-2.6	-2.6	-2.8	-2.7
Relative age of first facial hair	3.2	6.6	10.9	-0.7	2.4	2.6	2.7	2.6	2.3	3.3	2.9	2.6	2.6	2.8
Angina (self-reported)	3.1	4.0	7.0	0.3	-2.2	-2.6	-2.3	-1.9	-2.0	-2.2	-1.6	-1.9	-2.0	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	4.0	8.2	-1.0	2.5	1.6	1.4	1.9	1.8	2.9	2.2	2.1	2.0	2.1
Neuroticism score	3.0	6.2	10.3	2.2	-2.3	-3.2	-3.0	-2.6	-2.7	-1.4	-2.3	-2.4	-2.5	-2.4
Pain type(s) experienced in last month: Hip pain	3.0	3.8	5.8	-1.4	-2.2	-2.4	-2.2	-2.0	-1.8	-1.3	-1.8	-2.1	-2.1	-1.9
Intelligence (Savage-Jansen 2018)	2.9	8.8	11.9	0.6	3.0	3.4	2.9	3.3	3.3	1.8	3.3	3.2	3.2	3.2
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	7.2	0.5	-2.0	-2.5	-2.7	-2.4	-2.7	-0.7	-1.8	-2.2	-2.4	-2.2
Friendships satisfaction	2.9	3.7	5.9	-0.6	2.4	1.1	1.2	2.2	2.2	1.3	2.4	2.2	2.1	2.3
Lupus	2.8	4.3	6.1	-0.3	-1.8	-2.1	-2.0	-2.3	-2.3	-1.6	-2.5	-2.4	-2.3	-2.4
Angina	2.8	3.7	6.5	0.5	-2.2	-2.5	-2.2	-1.8	-1.8	-2.1	-1.6	-1.8	-1.9	-1.9
Eye problems/disorders: Diabetes related eye disease	2.7	2.9	6.2	0.0	2.5	1.2	2.1	1.8	1.8	1.6	1.5	1.7	1.9	1.7
Supplements: Glucosamine	2.7	3.5	5.6	-1.9	1.0	2.0	2.0	1.9	1.5	1.6	2.4	2.1	1.9	1.9
Height	2.6	50.0	59.4	3.5	-7.3	-6.9	-6.7	-7.6	-7.4	-7.4	-7.0	-7.4	-7.7	-7.7
Primary Biliary Cirrhosis	2.5	3.5	6.3	2.1	-2.0	-2.5	-1.9	-2.0	-2.1	-0.8	-1.7	-2.0	-2.0	0.0
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	4.7	1.0	-2.2	-1.9	-1.9	-1.6	-1.6	-0.9	-1.5	-1.6	-1.6	-1.6
Tense / ‘highly strung’	2.4	4.0	6.3	2.2	-2.0	-2.5	-2.0	-2.1	-2.1	-0.0	-2.0	-2.1	-2.1	-1.9
Commuting to job workplace: Walk	2.4	2.6	3.5	0.3	1.8	1.6	1.2	1.8	1.7	1.5	1.8	1.9	1.8	1.8
Back pain experienced in last month	2.4	3.5	8.1	0.5	-1.7	-2.8	-2.1	-1.7	-1.6	-2.2	-1.6	-1.8	-1.8	-1.8
Smoking status: Current	2.4	3.7	5.3	0.5	2.3	1.5	1.7	2.2	2.2	1.5	2.0	2.2	2.2	2.1
Blood White Count	2.3	17.4	26.7	0.3	4.5	5.0	5.2	4.2	4.0	4.5	3.8	4.1	4.3	4.1
Loud music exposure frequency	2.3	2.5	4.9	0.4	1.9	0.7	0.5	1.9	1.8	0.8	2.2	2.0	1.8	1.9
Tinnitus: Yes, now most or all of the time	2.3	2.7	4.8	0.3	-1.3	-2.2	-2.2	-1.6	-1.5	-1.7	-1.7	-1.6	-1.6	-1.7
Diastolic blood pressure, automated reading	2.3	7.0	15.6	-1.0	2.8	3.9	3.5	2.5	2.6	1.5	2.5	2.5	2.5	2.6
Coronary Artery Disease (CAD)	2.2	2.6	5.7	-0.1	-0.9	-1.9	-1.7	-1.9	-1.6	-1.1	-2.4	-2.2	-1.9	0.0
Neuroticism (2016)	2.2	3.2	4.7	1.7	-1.4	-2.1	-2.0	-2.1	-2.2	-1.4	-1.6	-2.1	-2.1	0.0
BMI	2.2	12.5	20.5	-2.9	4.1	4.2	4.5	3.5	3.5	2.2	3.0	3.4	3.6	3.3
Shortness of breath walking on level ground	2.2	2.7	3.9	-1.6	1.3	1.1	1.2	2.0	1.9	1.1	1.9	1.8	1.9	1.8
Mean time to correctly identify matches	2.2	4.2	5.6	0.5	2.1	2.0	1.7	2.1	2.1	2.4	2.2	2.4	2.3	2.2
Medication: Aspirin	2.2	2.9	5.5	1.2	-2.4	-1.8	-1.5	-1.7	-1.5	-1.7	-1.6	-1.7	-1.7	-1.6
HbA1C	2.1	2.3	3.2	-1.3	0.5	1.8	1.5	1.7	1.8	1.3	1.5	1.6	1.6	1.7
Nervous feelings	2.1	4.0	9.5	3.1	-1.5	-2.3	-2.8	-1.8	-2.1	-0.7	-1.1	-1.7	-1.9	-1.7
Comparative height size at age 10	2.1	11.8	17.0	2.1	-3.5	-3.0	-3.6	-3.5	-3.1	-4.1	-3.8	-3.5	-3.5	-3.6
Age at last live birth	2.1	3.1	6.7	-0.9	1.9	2.1	1.7	1.6	1.5	2.6	1.5	1.6	1.7	1.7
Myopia	2.1	3.0	5.7	2.4	-1.8	-1.6	-2.0	-1.6	-1.4	-2.1	-1.1	-1.5	-1.7	-1.5
Impedance of whole body	2.1	10.5	24.0	0.4	-3.8	-4.1	-4.9	-3.2	-3.1	-1.9	-3.0	-3.1	-3.2	-3.0
Blood Red Count	2.0	19.6	28.6	0.7	-4.0	-4.0	-4.5	-5.0	-4.7	-3.5	-5.1	-5.3	-5.1	-4.9
Body mass index (BMI)	2.0	8.4	17.1	-2.7	3.5	3.6	4.1	2.7	2.6	1.9	2.4	2.6	2.7	2.5
Eye problems/disorders: Glaucoma	2.0	2.3	7.6	-2.8	-0.6	-1.1	-1.2	-1.5	-1.6	-0.4	-1.6	-1.6	-1.5	-1.5
Neuroticism (Nagel 2018)	1.9	4.6	9.2	3.0	-1.4	-2.7	-2.7	-2.1	-2.2	-1.2	-1.6	-1.8	-2.1	-2.0
Medication for pain relief, constipation, heartburn	1.9	3.2	6.0	0.2	2.4	2.4	2.1	1.8	1.9	1.1	1.4	1.7	1.8	1.7
Fasting Glucose	1.8	2.1	4.7	1.4	0.2	-2.2	-1.8	-1.5	-1.4	-1.3	-1.4	-1.4	-1.5	-1.4
Lung FEV1/FVC ratio	1.8	9.0	13.2	-0.4	3.6	2.7	3.4	3.2	3.1	3.2	2.6	2.9	3.2	3.1
Diabetes (mother)	1.8	2.3	3.9	0.0	1.9	2.0	1.7	1.5	1.4	1.4	1.5	1.4	1.4	1.4
Current tobacco smoking	1.8	2.9	4.2	0.7	2.1	1.2	1.5	2.0	1.9	1.1	1.8	2.0	2.0	1.9
Standing height	1.8	17.8	23.4	3.0	-4.3	-3.5	-4.3	-4.5	-4.0	-4.8	-4.5	-4.4	-4.5	-4.5
Medication: Paracetamol	1.8	3.0	5.7	0.9	-2.1	-2.3	-2.4	-1.9	-2.0	-0.3	-1.2	-1.6	-1.8	-1.5
Financial situation satisfaction	1.8	2.3	6.7	-1.6	-0.9	-1.9	-2.6	-1.4	-1.3	-0.9	-0.7	-1.5	-1.6	-1.2
Alcohol intake versus 10 years previously	1.7	2.5	4.2	-0.6	1.4	0.7	1.1	1.9	2.0	1.6	1.9	1.6	1.7	1.9
Supplements: Vitamin C	1.7	2.0	4.0	-0.4	-1.5	-1.6	-1.1	-1.7	-2.0	-0.4	-1.4	-1.4	-1.5	-1.7
Risk taking	1.7	2.5	7.1	-2.7	1.9	1.3	1.7	1.5	1.5	0.6	1.2	1.4	1.5	1.2
Commuting to job workplace: Cycle	1.7	2.1	4.5	0.2	1.1	1.1	1.0	1.5	1.7	2.1	1.4	1.6	1.6	1.7
Allergy or Eczema	1.6	4.1	6.4	0.4	-1.5	-2.4	-1.8	-2.2	-2.5	-1.3	-2.5	-2.1	-2.1	-2.5
Severe depression (siblings)	1.6	1.8	3.8	0.5	-1.5	-2.0	-1.6	-1.2	-1.4	-1.2	-0.9	-1.4	-1.4	-1.2
Hip circumference	1.6	6.9	13.2	-2.6	3.0	3.6	3.6	2.4	2.5	1.6	1.9	2.2	2.5	2.3
Medication: Omeprazole	1.6	1.9	2.9	0.6	-1.3	-1.3	-1.0	-1.7	-1.7	-0.5	-1.3	-1.7	-1.7	-1.6
Arm fat percentage (left)	1.6	6.3	10.9	-2.6	3.1	3.2	3.3	2.3	2.2	1.6	2.0	2.2	2.3	2.1
Medication for cholesterol	1.6	2.4	6.6	-2.6	0.5	1.1	0.8	1.7	1.9	1.0	1.5	1.7	1.6	1.7
Medication: Paracetamol	1.6	2.5	4.2	0.9	-2.0	-2.1	-2.0	-1.7	-1.8	-0.4	-1.2	-1.3	-1.5	-1.4
Arm fat percentage (right)	1.5	5.9	10.0	-2.8	3.1	3.0	3.2	2.3	2.1	1.4	2.0	2.1	2.2	2.0
Medication: Ibuprofen	1.5	1.7	3.1	-1.5	-1.8	-1.3	-1.6	-1.3	-1.4	-0.1	-1.3	-1.2	-1.2	-1.2
Eye problems/disorders: Cataract	1.5	1.7	4.0	-2.0	-0.9	-1.4	-1.4	-1.2	-1.2	-0.8	-1.3	-1.2	-1.2	-1.4
Alcohol drinker status: Never	1.5	1.8	2.9	-0.4	1.7	1.1	1.4	1.4	1.6	1.1	1.4	1.3	1.4	1.6
Bipolar Disorder (2018)	1.4	2.2	3.3	0.0	-1.7	-1.8	-1.8	-1.6	-1.5	-1.3	-1.8	-1.6	-1.5	0.0
Depression (Nagel 2018)	1.4	2.0	3.8	0.2	2.0	1.1	0.9	1.3	1.0	1.9	1.9	1.7	1.4	1.5
LDL Cholesterol	1.4	2.2	5.8	-0.8	-1.5	-1.8	-2.4	-1.8	0.0	-0.3	-1.2	-1.4	-1.6	-1.7
Type 2 Diabetes (T2D) (2012)	1.4	1.6	8.5	0.4	1.2	2.9	2.6	0.0	0.0	0.7	0.0	0.0	0.0	0.0
Sensitivity / hurt feelings	1.4	2.4	5.4	1.7	-1.0	-2.3	-1.9	-1.6	-1.7	-0.9	-1.2	-1.2	-1.5	-1.5
Qualifications: None of the above	1.4	2.9	7.6	0.2	-1.9	-2.8	-1.9	-1.7	-1.8	-0.5	-1.6	-1.6	-1.7	-1.8
Pulse rate	1.4	2.3	6.1	-2.5	1.0	1.3	1.2	1.3	1.3	2.0	1.4	1.4	1.4	1.4
Medication: Amlodipine	1.4	2.0	3.0	1.6	-0.7	-1.7	-1.7	-1.3	-1.3	-1.7	-1.2	-1.3	-1.3	-1.5
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.2	0.1	2.1	1.0	1.1	1.2	1.1	1.9	1.2	1.1	1.1	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.1	-0.6	-1.0	-1.8	-1.4	-1.3	-1.5	-1.1	-0.6	-1.2	-1.4	-1.4
Medication: Aspirin	1.3	1.7	3.8	0.9	-2.0	-1.5	-1.2	-1.2	-1.1	-1.4	-1.1	-1.2	-1.2	-1.1
Mother’s age at death	1.3	1.6	2.8	0.1	0.4	1.6	1.7	1.3	1.2	1.1	1.5	1.5	1.3	1.3
Smoking Status	1.2	2.8	4.5	-0.1	1.8	1.6	1.0	1.8	1.6	2.1	1.8	1.9	1.9	1.7
Hearing difficulty/problems: Yes	1.2	1.8	3.2	0.7	1.4	0.7	0.8	1.5	1.6	1.2	1.8	1.5	1.4	1.5
Chronic bronchitis/emphysema (father)	1.2	1.4	2.2	0.6	-0.5	-1.4	-1.5	-1.3	-1.3	-0.8	-1.4	-1.2	-1.2	-1.3
Time employed in main current job	1.2	1.4	3.0	0.7	-0.8	-1.3	-1.7	-1.2	-1.0	-1.2	-1.2	-1.3	-1.2	-1.2
Fractured/broken bones in last 5 years	1.2	1.5	5.2	2.3	-1.5	-1.4	-1.4	-1.0	-1.3	-0.4	-0.4	-0.8	-1.0	-1.0
Had other major operations	1.1	1.3	2.8	-0.7	-0.6	-0.6	-0.9	-1.2	-1.1	-1.7	-1.2	-1.4	-1.3	-1.2
Impedance of arm (right)	1.1	5.1	13.6	0.7	-2.3	-2.9	-3.7	-2.1	-1.9	-2.0	-1.9	-2.1	-2.1	-2.0
Number of live births	1.1	1.5	3.5	-0.7	1.1	1.9	1.6	1.2	1.2	1.2	0.6	1.1	1.3	1.2
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.4	-0.9	-1.2	-0.8	-0.9	-1.0	-0.9	-1.9	-0.8	-1.1	-1.2	-1.1
Cholesterol lowering medication	1.1	1.6	3.0	1.7	-1.3	-1.3	-0.7	-1.2	-1.5	-1.0	-1.2	-1.2	-1.2	-1.3
Crohns Disease (2012)	1.0	1.6	2.4	-0.0	1.0	1.1	1.1	1.4	1.3	1.6	1.4	1.5	1.4	1.4
HDL Cholesterol	1.0	1.7	3.5	0.2	-1.8	-0.9	-0.9	-1.4	0.0	-1.2	-1.9	-1.6	-1.4	-1.4
Frequency of depressed mood in last 2 weeks	1.0	1.3	6.4	0.4	1.5	0.7	0.3	0.7	0.4	2.5	1.4	1.0	0.8	1.0
Medication: Co-codamol	1.0	1.1	1.8	-1.3	0.3	0.4	0.7	1.1	1.0	1.3	1.3	1.2	1.1	1.2
Relative age voice broke	1.0	1.5	3.5	0.1	1.1	1.8	1.9	1.1	0.8	1.4	1.1	1.1	1.1	1.1
Medication: Ramipril	1.0	1.2	4.3	0.7	2.1	0.4	0.5	1.1	1.1	1.2	0.9	1.0	1.1	1.2
Medication: Simvastatin	1.0	1.5	2.4	0.5	-1.3	-1.0	-1.1	-1.4	-1.6	-1.1	-1.2	-1.1	-1.3	-1.5
Noisy workplace	1.0	1.2	2.9	-0.7	-1.7	-0.9	-0.8	-1.0	-1.0	-1.3	-0.8	-1.1	-1.1	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	-0.9	1.0	1.8	1.5	1.0	1.0	0.6	1.1	0.7	0.9	0.9
Chest pain or discomfort	1.0	1.4	4.2	2.0	-1.2	-1.5	-1.2	-1.0	-1.0	-0.6	-0.9	-0.9	-0.9	-1.0
Schizophrenia vs Biploar Disorder	0.9	1.1	2.2	0.1	0.7	1.0	0.7	1.4	1.5	1.2	1.2	1.2	1.4	0.0
Ulcerative Colitis (UC)	0.9	1.7	4.3	0.9	-1.2	-1.2	-2.1	-1.4	-1.4	-0.8	-1.1	-1.2	-1.4	-1.3
Blood Platelet Count	0.9	10.9	14.8	1.8	-3.1	-3.0	-3.4	-3.6	-3.9	-2.2	-3.5	-3.8	-3.7	-3.6
Number of treatments/medications taken	0.9	1.7	2.9	0.7	-1.7	-1.3	-1.0	-1.5	-1.7	-0.8	-1.2	-1.3	-1.4	-1.4
Maternal smoking around birth	0.9	1.3	2.1	-0.5	1.5	0.4	0.5	1.3	1.1	1.4	1.2	1.2	1.3	1.2
Multivitamins +/- minerals	0.9	1.2	2.2	0.5	1.2	0.1	0.6	1.3	1.4	0.8	1.2	1.5	1.3	1.2
Impedance of arm (left)	0.9	4.1	11.6	0.4	-2.3	-2.4	-3.4	-2.0	-1.7	-1.4	-1.8	-1.9	-2.0	-1.8
Overall health rating	0.9	1.9	5.9	0.1	-0.3	-2.4	-2.2	-1.2	-1.2	-0.8	-0.9	-1.5	-1.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.5	-1.2	-1.0	-0.5	-0.9	-0.9	-0.8	-1.2	-1.1	-1.2	-1.1	-1.0
Medication: Atorvastatin	0.9	1.1	2.8	1.7	-0.8	-1.4	-1.0	-0.9	-0.9	-0.2	-1.1	-1.1	-0.9	-0.9
Unable to work because of sickness or disability	0.9	1.1	2.8	0.2	1.1	0.6	0.7	1.2	1.3	0.3	1.7	1.3	1.1	1.2
Basal cell carcinoma (self-reported)	0.9	1.1	1.6	0.8	0.8	1.2	1.1	1.1	1.0	0.5	1.3	1.1	1.1	1.1
Irritable Bowel Disease (IBD)	0.8	1.8	3.8	1.1	-1.7	-1.3	-1.9	-1.4	-1.5	-0.6	-0.9	-1.1	-1.4	-1.3
Lung FVC	0.8	3.9	6.8	-0.7	2.6	1.5	1.6	2.1	2.2	2.1	1.9	2.0	2.1	2.2
Townsend deprivation index at recruitment	0.8	1.1	1.9	0.7	1.3	0.6	0.5	1.1	1.3	1.4	1.2	1.1	1.1	1.1
Serious illness, injury or assault to yourself	0.8	0.9	1.3	-0.9	1.0	0.7	0.9	1.0	1.0	0.9	1.1	1.1	1.0	1.0
Stomach or abdominal pain in last month	0.8	1.0	6.3	2.5	-1.1	-1.4	-0.8	-0.3	-0.4	0.8	-0.1	-0.1	-0.2	-0.2
Arm fat mass (right)	0.8	3.1	7.6	-2.1	2.4	2.4	2.8	1.4	1.4	0.6	1.1	1.3	1.4	1.2
Glaucoma (self-reported)	0.8	0.9	2.1	-1.3	-0.3	-0.7	-0.7	-1.0	-0.9	-0.2	-1.4	-1.2	-1.0	-1.0
Emphysema/chronic bronchitis	0.8	0.9	3.0	0.7	-1.3	-1.5	-1.7	-0.7	-0.5	0.0	-0.4	-0.7	-0.7	-0.5
Qualifications: nursing, teaching	0.8	1.2	4.1	-1.3	1.4	2.0	1.4	0.9	0.8	0.4	0.5	0.8	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	4.7	-2.2	1.4	0.8	0.6	1.3	1.5	0.1	1.2	1.2	1.2	1.2
Arm fat mass (left)	0.8	3.4	8.2	-2.1	2.3	2.6	2.9	1.5	1.5	0.8	1.2	1.4	1.5	1.3
Illnesses of father: High blood pressure	0.8	1.0	1.9	0.6	0.7	1.4	1.4	1.2	1.2	-0.1	0.9	1.0	1.1	1.0
Alcohol drinker status: Previous	0.8	0.9	1.7	-0.1	1.2	0.2	0.6	1.0	1.0	1.1	1.3	1.2	1.0	1.0
Alzheimer’s Disease (including proxy)	0.7	1.1	2.8	-0.8	0.5	0.7	0.2	1.1	1.2	1.1	1.7	1.2	1.0	1.2
Reaction Time	0.7	1.3	2.7	0.2	1.3	1.2	0.5	1.1	1.1	1.6	1.2	1.3	1.2	1.2
Prostate Cancer	0.7	0.9	1.4	1.0	0.5	0.6	1.1	1.0	1.0	1.2	1.2	1.0	0.9	1.0
Lung cancer (father)	0.7	0.9	1.6	-1.3	0.2	0.5	0.9	1.0	0.9	1.0	1.0	1.0	1.0	0.9
Peak expiratory flow (PEF)	0.7	1.7	2.4	-0.2	-1.0	-1.5	-1.2	-1.4	-1.4	-1.1	-1.5	-1.4	-1.4	-1.5
Number of children fathered	0.7	0.8	1.7	0.3	0.6	0.9	1.2	0.9	0.5	0.9	1.3	1.1	0.9	0.9
Eye problems/disorders: None of the above	0.7	0.8	6.2	2.5	-0.3	0.7	0.1	0.3	0.4	0.5	0.7	0.5	0.4	0.5
Number of full sisters	0.7	0.8	1.3	0.6	0.8	0.8	1.1	0.9	1.1	0.8	0.6	0.9	1.0	1.0
Osteoporosis (self-reported)	0.7	0.9	1.5	1.2	-1.2	-1.2	-0.8	-0.8	-1.0	-1.1	-0.3	-0.6	-0.8	-0.7
Miserableness	0.7	1.2	2.4	1.4	1.3	0.5	0.7	1.0	1.0	1.5	1.1	1.1	1.0	1.1
Breast Cancer	0.6	1.4	3.3	-1.6	0.8	1.8	0.8	1.0	1.1	1.4	0.9	1.0	1.0	1.1
Body Mass Index (BMI) (2010)	0.6	0.9	1.9	-0.3	1.4	0.7	0.7	1.1	0.0	1.3	0.7	0.9	1.1	1.2
Mean Putamen Volume	0.6	0.6	1.4	-0.9	0.5	1.2	0.8	0.9	1.0	0.3	0.8	0.8	0.9	0.0
Systolic Blood Pressure	0.6	3.0	5.0	0.4	-1.5	-1.3	-1.2	-2.0	-2.2	-1.7	-1.7	-2.0	-2.1	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.5	2.5	1.1	0.8	1.2	1.6	1.2	1.3	1.4	0.8	1.2	1.3	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.4	1.3	0.8	1.0	1.5	1.1	1.1	1.6	0.8	1.1	1.2	1.1
Pain all over the body in last month	0.6	0.7	1.7	-0.6	0.9	0.7	0.4	0.9	0.6	0.8	1.3	1.0	0.8	0.8
Happiness	0.6	0.7	2.8	-1.1	1.3	0.2	-0.1	0.6	0.6	1.7	0.6	0.6	0.6	0.8
Medication: Lansoprazole	0.6	0.7	1.4	-0.5	-1.1	-1.2	-0.9	-0.9	-1.0	0.1	-0.6	-0.6	-0.8	-0.8
Body fat percentage	0.6	2.2	6.5	-2.6	1.7	1.7	2.0	1.2	1.1	0.8	1.0	1.1	1.2	1.1
Comparative body size at age 10	0.6	1.6	2.9	-0.8	1.5	0.8	1.1	1.5	1.7	-0.7	1.4	1.3	1.3	1.4
Mood swings	0.6	1.0	3.0	1.3	-0.5	-1.7	-1.3	-0.9	-0.8	-0.1	-0.9	-0.9	-0.9	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	-0.3	-1.3	-0.9	-1.0	-1.0	-0.8	-0.6	-0.7	-0.9	-1.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.4	-0.6	0.5	0.7	0.9	0.9	0.9	1.0	1.0	1.2	1.0	0.9
High cholesterol (Self-reported)	0.6	1.0	1.8	0.8	-1.3	-1.4	-0.9	-1.0	-1.2	-0.5	-0.9	-0.9	-1.0	-1.1
Leg fat percentage (left)	0.6	2.2	5.9	-2.4	1.6	1.5	2.0	1.2	1.0	1.3	1.1	1.2	1.3	1.1
Irritability	0.6	1.0	2.6	0.5	-1.4	-1.2	-1.6	-1.0	-0.8	-0.8	-0.5	-0.9	-1.0	-0.7
Leg fat mass (left)	0.6	2.3	5.6	-2.1	1.9	1.9	2.4	1.2	1.1	0.6	0.9	1.1	1.2	1.0
Tanning	0.5	5.5	8.0	0.6	2.5	2.3	2.8	2.8	2.7	1.1	2.3	2.6	2.7	2.4
Taking other prescription medications	0.5	0.8	4.5	2.1	-0.6	-1.3	-0.3	-0.6	-0.9	0.4	-0.5	-0.4	-0.5	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.0	-0.2	-0.7	-0.5	-0.3	-0.9	-1.0	-0.8	-0.9	-0.8	-0.8	-1.0
Forced vital capacity (FVC)	0.5	1.8	3.2	-0.4	-0.8	-0.8	-1.4	-1.5	-1.2	-1.5	-1.8	-1.6	-1.5	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.4	0.9	1.8	0.1	0.3	0.9	0.8	1.1	0.7	0.7	0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	3.1	-1.8	-1.1	-0.4	-0.8	-0.5	-0.6	0.7	-0.5	-0.5	-0.4	-0.4
Pulse wave reflection index	0.5	0.6	4.7	2.2	-0.2	0.9	0.8	-0.0	0.1	-0.1	0.1	0.1	-0.0	0.1
Birth weight	0.5	1.1	6.8	2.6	-0.5	-0.6	-0.3	-0.7	-0.4	-1.2	-1.2	-0.7	-0.6	-0.8
Number of full brothers	0.5	0.6	2.8	-0.2	0.8	0.2	0.6	0.5	1.0	1.7	0.2	0.6	0.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.8	1.3	0.7	0.3	0.5	0.7	0.5	0.6	1.1	1.0	0.8	0.7
Neck or shoulder pain in last month	0.5	0.7	1.5	0.5	-1.0	-1.2	-0.8	-0.8	-0.8	0.7	-0.7	-0.8	-0.8	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	1.4	-0.4	-1.2	-0.9	-0.7	-0.6	0.2	-0.8	-0.7	-0.6	-0.6
Leg fat mass (right)	0.5	1.9	4.9	-2.2	1.7	1.8	2.2	1.1	0.9	0.5	0.8	0.9	1.1	0.8
Pulse rate, automated reading	0.5	1.7	2.2	-1.5	1.3	1.3	1.5	1.2	1.1	1.3	1.3	1.4	1.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	5.8	2.4	-0.1	0.0	0.1	-0.3	-0.1	-0.3	-0.4	-0.3	-0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.4	0.7	-0.4	-1.5	-1.5	-0.4	-0.3	-0.7	-0.1	-0.5	-0.5	-0.4
Medication: Bendroflumethiazide	0.5	0.7	2.4	0.7	0.9	1.5	1.1	0.7	0.5	0.6	0.8	0.8	0.7	0.6
Respiratory disease	0.4	1.0	3.3	1.8	-0.8	-1.5	-0.8	-0.9	-0.9	0.3	-0.9	-0.7	-0.7	-0.8
Chronotype (morning person)	0.4	0.9	7.3	2.7	0.2	0.0	0.2	0.2	0.4	-1.5	-0.0	0.0	0.1	-0.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.0	-0.5	-0.7	-0.8	-0.4	-1.1	-1.4	-0.4	-1.3	-0.9	-0.9	-1.2
High blood pressure (mother)	0.4	0.5	1.6	1.3	-0.4	0.1	-0.7	-0.8	-0.8	0.8	-0.4	-0.7	-0.7	-0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-1.2	0.8	-0.8	-0.5	0.5	0.6	1.1	0.5	0.3	0.5	0.6
Mouth/teeth dental problems	0.4	0.7	1.4	-0.4	0.8	1.2	0.7	0.7	0.6	0.7	1.1	0.9	0.7	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	-0.5	-0.7	-0.8	-0.8	-0.8	-0.9	-0.2	-0.9	-0.7	-0.7	-0.8
Asthma	0.4	0.8	3.6	1.5	0.6	-0.4	0.0	0.6	0.7	1.9	0.0	0.6	0.8	0.7
Depression (self-reported)	0.4	0.5	2.3	1.5	0.7	0.0	0.2	0.4	0.5	1.3	0.3	0.6	0.6	0.5
Illnesses of mother	0.4	0.5	2.1	-1.4	-0.8	-0.4	-0.1	-0.1	-0.0	-1.3	-0.3	-0.2	-0.2	-0.3
Pulse wave Arterial Stiffness index	0.4	0.5	3.8	2.0	-1.0	-0.0	-0.4	-0.4	-0.2	-0.2	0.1	-0.2	-0.4	-0.2
Length of working week for main job	0.4	0.5	4.1	-2.0	-0.2	0.6	0.2	0.1	0.1	-0.9	-0.2	-0.1	0.0	0.0
Exposure to tobacco smoke at home	0.4	0.4	3.1	-1.8	0.1	-0.1	-0.0	0.4	0.3	0.6	0.8	0.5	0.4	0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-1.1	0.4	-0.6	-0.5	0.7	0.6	0.8	0.6	0.9	0.8	0.6
Forced vital capacity (FVC), Best measure	0.4	1.5	3.2	-0.3	-1.0	-0.7	-1.1	-1.3	-0.9	-1.6	-1.8	-1.4	-1.3	-1.4
Leg fat percentage (right)	0.4	1.6	6.2	-2.5	1.3	1.4	1.8	0.9	0.6	1.1	0.8	0.8	0.9	0.7
Health satisfaction	0.4	0.6	3.6	-1.9	0.7	-0.3	-0.7	0.4	0.6	0.6	0.4	0.2	0.3	0.5
Medication: Blood pressure	0.4	0.7	1.6	1.3	0.8	0.2	0.6	0.9	0.9	0.1	1.0	1.0	1.0	0.9
Migraine (self-reported)	0.4	0.5	1.6	0.8	-0.8	-0.8	-0.4	-0.4	-0.6	-1.2	-0.6	-0.4	-0.4	-0.7
Whole body fat mass	0.4	1.7	4.4	-1.9	1.7	1.8	2.1	1.0	0.9	0.4	0.7	0.9	1.0	0.8
Ever had bowel cancer screening	0.4	0.5	1.2	1.0	-0.6	-0.3	-0.6	-0.9	-1.1	0.2	-0.4	-0.6	-0.8	-0.7
Breast cancer (self-reported)	0.4	0.5	1.3	0.1	-0.4	-0.5	-0.4	-0.6	-0.3	-1.1	-0.9	-0.9	-0.7	-0.7
Asthma (self-reported)	0.4	0.7	4.1	1.4	0.4	-0.4	-0.1	0.4	0.5	2.0	-0.0	0.5	0.6	0.6
Number of self-reported non-cancer illnesses	0.4	0.6	1.7	0.3	-0.2	-1.2	-1.1	-0.6	-0.8	-1.3	-0.4	-0.6	-0.7	-0.7
Commuting to job workplace: Public transport	0.4	0.5	2.3	1.5	0.6	-0.2	0.1	0.7	0.9	0.6	0.3	0.5	0.7	0.7
Average weekly beer plus cider intake	0.4	0.6	3.0	-1.7	0.8	0.9	0.5	0.4	0.3	0.8	0.2	0.4	0.4	0.3
Heart disease (siblings)	0.4	0.5	2.0	1.4	-0.8	-1.0	-0.8	-0.5	-0.2	0.2	-0.7	-0.5	-0.4	-0.3
Schizophrenia (2018)	0.3	0.6	1.2	-1.1	0.5	0.6	0.8	1.0	1.1	-0.0	0.9	0.8	0.9	0.0
Major Depression (MDD)	0.3	0.4	0.7	-0.3	0.9	0.4	0.6	0.7	0.7	-0.3	0.6	0.7	0.7	0.6
Ovarian Cancer	0.3	0.4	1.5	-1.2	1.2	0.3	0.5	0.3	0.4	0.7	0.0	0.4	0.5	0.5
Triglycerides	0.3	0.5	1.0	-0.1	0.7	0.5	0.2	0.8	0.0	1.0	1.0	0.9	0.8	0.8
Blood Eosinophil Count	0.3	2.1	4.9	0.5	-1.2	-2.2	-1.8	-1.4	-1.3	-0.5	-1.9	-1.6	-1.4	-1.4
Average weekly spirits intake	0.3	0.3	2.4	-1.5	0.3	0.1	0.1	0.4	0.5	0.0	0.2	0.3	0.4	0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	0.4	-0.2	-0.9	-1.0	-0.6	-0.9	-0.7	0.1	-0.4	-0.7	-0.6
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	0.7	-0.9	-0.7	-0.5	-0.3	-0.2	-0.7	-0.5	-0.3	-0.3	-0.4
Leg fat-free mass (left)	0.3	1.3	5.4	-0.3	1.6	2.1	2.3	0.7	0.7	-0.7	0.3	0.5	0.6	0.4
Trunk fat percentage	0.3	1.2	5.3	-2.3	1.1	1.2	1.4	0.8	0.8	0.4	0.6	0.7	0.8	0.7
Age when periods started (menarche)	0.3	0.6	3.0	-0.2	0.2	1.7	1.0	0.2	-0.1	1.4	0.4	0.4	0.3	0.3
Sitting height	0.3	2.5	7.3	2.7	-0.7	-0.6	-0.6	-1.4	-1.2	-2.5	-1.6	-1.4	-1.4	-1.6
Leg predicted mass (left)	0.3	1.5	5.9	-0.4	1.7	2.2	2.4	0.7	0.8	-0.6	0.4	0.6	0.7	0.5
Number of incorrect matches in round	0.3	0.5	2.3	1.1	-0.2	-0.8	0.6	0.5	0.5	1.5	0.2	0.5	0.6	0.6
Financial difficulties in last 2 years	0.3	0.3	2.9	-1.7	0.1	0.5	0.3	0.2	0.0	0.3	0.3	0.4	0.3	0.2
Illnesses of siblings	0.3	0.4	1.6	-0.9	0.3	0.9	0.7	-0.2	-0.3	-1.3	-0.2	-0.2	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.6	-0.6	-0.2	-0.3	-0.5	-1.0	-0.8	-1.6	-1.4	-1.2	-1.1	-1.2
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	0.4	0.2	0.4	0.8	0.8	0.9	0.6	0.6	0.6	0.8	0.8
Medication: Cholesterol lowering	0.3	0.4	0.9	-0.3	-0.7	-0.8	-0.9	-0.7	-0.7	0.0	-0.6	-0.5	-0.6	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.8	1.7	-0.3	-0.8	-0.3	-0.3	-0.5	0.4	0.2	0.0	-0.2	-0.2
Blood clot in the leg (DVT)	0.3	0.4	2.2	-1.5	0.5	0.7	0.1	-0.3	-0.3	-0.5	-0.4	-0.1	-0.2	-0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.8	1.7	0.1	-0.5	-0.3	0.2	0.5	0.5	-0.3	0.2	0.3	0.3
High blood pressure (siblings)	0.3	0.5	3.8	2.0	-0.2	-0.9	-0.6	-0.1	-0.1	0.4	0.2	-0.1	-0.1	0.2
Exposure to tobacco smoke outside home	0.3	0.3	1.5	0.2	-0.1	-1.2	-1.1	-0.3	0.0	-0.2	-0.6	-0.5	-0.3	-0.3
Alcohol intake frequency.	0.3	0.7	3.1	-0.2	-0.5	-1.8	-1.4	-0.6	-0.7	-0.4	-0.2	-0.6	-0.7	-0.5
Illnesses of father: Heart disease	0.3	0.4	1.1	1.0	0.7	0.2	0.3	0.7	0.9	0.4	0.3	0.6	0.7	0.8
Smoking status: Previous	0.3	0.4	0.8	-0.1	-0.8	-0.7	-0.9	-0.7	-0.8	0.2	-0.4	-0.6	-0.6	-0.6
Leg fat-free mass (right)	0.3	1.5	5.3	-0.1	1.8	2.1	2.3	0.9	1.0	-0.6	0.6	0.7	0.8	0.7
Loneliness, isolation	0.3	0.5	2.4	0.2	0.9	-0.0	0.4	0.5	0.1	1.5	0.6	0.7	0.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.1	1.0	0.2	0.5	0.7	0.4	0.4	-0.2	0.5	0.4	0.4	0.3
Medication: Gliclazide	0.3	0.3	1.1	1.0	1.0	0.3	0.4	0.3	0.2	0.6	0.3	0.2	0.2	0.4
Leg predicted mass (right)	0.3	1.5	5.2	-0.1	1.7	2.1	2.3	0.8	1.0	-0.7	0.5	0.7	0.8	0.6
Wears glasses or contact lenses	0.3	0.4	1.5	0.8	-0.5	-1.2	-0.8	-0.4	-0.4	0.7	-0.4	0.0	-0.1	-0.2
Hearing aid user	0.3	0.3	1.7	-0.7	1.3	-0.2	-0.1	0.6	0.7	-0.0	0.4	0.3	0.4	0.3
Medication: Lisinopril	0.3	0.4	1.1	0.4	0.8	0.6	1.1	0.6	0.4	0.6	0.2	0.7	0.7	0.5
Ever depressed for a whole week	0.3	0.3	2.2	-0.3	0.0	-0.7	-0.6	-0.4	-0.5	1.5	-0.3	-0.3	-0.3	-0.2
Pain experienced in last month	0.3	0.5	2.3	0.8	0.1	1.1	0.7	0.2	0.1	1.5	0.1	0.4	0.4	0.4
Depressed Affect (Nagel 2018)	0.2	0.4	2.7	1.6	0.2	-1.1	-0.8	-0.2	-0.2	0.5	-0.0	-0.1	-0.2	-0.0
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.2	-0.2	-0.3	-0.5	0.1	-0.0	1.0	0.9	0.2	0.0	0.3
Crohns Disease (2017)	0.2	0.4	1.2	0.8	-1.1	-0.7	-0.6	-0.6	-0.8	-0.2	-0.2	-0.5	-0.6	-0.7
Age at First Birth	0.2	0.3	0.6	0.5	0.4	0.8	0.3	0.6	0.6	-0.5	0.6	0.6	0.5	0.4
Bipolar Disorder (2011)	0.2	0.2	1.8	1.4	-0.1	0.2	0.1	0.2	0.4	-0.4	0.1	0.0	0.1	0.0
Schizophrenia (2014)	0.2	0.5	1.0	-0.4	0.7	0.3	0.4	1.0	1.0	-0.1	0.9	0.9	0.9	0.0
Supplements: Zinc	0.2	0.2	0.3	0.5	-0.2	-0.2	-0.2	-0.5	-0.3	-0.6	-0.5	-0.3	-0.4	-0.5
Average weekly fortified wine intake	0.2	0.2	1.6	0.9	-0.2	-0.1	-0.3	0.0	-0.1	-1.3	0.3	-0.0	-0.1	-0.1
Fed-up feelings	0.2	0.4	2.0	1.1	0.7	-0.4	-0.0	0.3	0.4	1.4	0.4	0.4	0.4	0.6
Trunk fat mass	0.2	0.9	2.5	-1.6	1.1	1.4	1.5	0.6	0.6	0.0	0.4	0.6	0.6	0.5
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.7	0.3	-0.2	-0.4	0.7	0.9	-0.5	0.9	0.5	0.5	0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	-0.9	-0.8	-0.4	-0.5	-0.6	-0.4	0.3	-0.5	-0.6	-0.5	-0.3
Allergy	0.2	0.4	0.8	-0.3	0.3	0.7	0.4	0.7	0.9	-0.9	0.9	0.4	0.4	0.7
Weight	0.2	1.1	3.9	-1.2	1.3	1.8	2.0	0.6	0.6	-0.3	0.2	0.5	0.6	0.4
Trunk fat-free mass	0.2	0.9	2.8	0.8	-0.2	0.7	0.7	-0.9	-0.8	-1.7	-1.1	-1.0	-0.9	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.1	-0.2	-0.4	-0.6	-0.4	-0.5	-0.6	-0.1	-0.4	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.9	-0.6	-0.4	-0.3	-0.3	-0.8	-0.6	-1.4	-1.4	-1.0	-0.9	-1.0
Trunk predicted mass	0.2	1.0	2.9	0.7	-0.3	0.6	0.6	-1.0	-0.9	-1.7	-1.2	-1.1	-1.0	-1.2
Breastfed as a baby	0.2	0.3	2.4	0.3	-0.3	0.1	0.4	0.0	0.1	-1.6	-0.5	-0.2	-0.1	-0.3
Birth weight of first child	0.2	0.3	1.7	0.8	-0.1	0.6	0.6	0.1	0.3	-1.3	-0.2	0.1	0.1	0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.7	-0.2	0.1	-0.8	-0.6	-0.7	0.4	-0.4	-0.6	-0.6	-0.4
Headache pain in last month	0.2	0.3	0.7	-0.2	-0.1	0.4	0.5	0.6	0.7	-0.0	0.9	0.7	0.6	0.7
Worry too long after embarrassment	0.2	0.3	2.0	1.4	0.8	0.2	0.1	0.2	0.3	0.1	0.3	0.5	0.3	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	1.8	0.1	0.3	-1.0	-1.0	-0.1	0.2	1.4	-0.3	-0.3	-0.1	0.1
Pulse wave peak to peak time	0.2	0.3	2.2	-1.5	0.8	-0.2	0.1	0.1	-0.1	-0.1	-0.3	-0.1	0.1	-0.1
Medication: Allopurinol	0.2	0.3	2.7	-1.6	0.3	-0.2	-0.3	-0.1	-0.1	0.3	0.1	0.0	-0.0	-0.0
Medication: Seretide 50 evohaler	0.2	0.2	1.2	1.1	-0.1	-0.6	0.3	0.2	0.0	0.8	0.1	0.4	0.3	0.2
Heart disease (mother)	0.2	0.3	0.8	-0.9	0.1	-0.4	-0.5	-0.5	-0.6	-0.3	-0.5	-0.6	-0.6	-0.5
Mineral and other dietary supplements	0.2	0.3	1.1	0.3	-0.2	-0.4	-1.0	-0.5	-0.3	-0.2	-0.7	-0.7	-0.5	-0.4
Guilty feelings	0.2	0.3	2.4	1.6	0.4	0.2	0.0	0.4	0.2	0.3	0.4	0.6	0.5	0.4
Medication: Blood pressure	0.2	0.4	1.8	1.4	0.5	-0.4	-0.2	-0.6	-0.7	-0.1	-0.4	-0.7	-0.6	-0.5
Arm fat-free mass (left)	0.2	1.0	2.6	-0.3	-0.3	0.4	0.7	-1.0	-1.0	-1.6	-1.4	-1.2	-1.0	-1.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.4	-0.4	-0.2	-0.6	-0.4	-0.6	-0.4	-0.4	-0.5	-0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.6	-0.3	-0.2	0.1	-0.5	-0.7	0.1	-0.1	-0.5	-0.6	-0.5
Supplements: Calcium	0.2	0.2	1.1	1.0	0.9	-0.6	-0.2	-0.1	-0.2	0.2	0.1	-0.1	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.1	-1.1	0.2	0.4	0.0	-0.4	-0.5	-0.9	-0.5	-0.2	-0.3	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.8	-0.6	-0.7	-0.5	-0.2	-0.1	-0.8	-0.3	-0.4	-0.3	0.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.5	0.6	0.3	-0.1	0.3	0.5	-0.1	0.4	0.3	0.2	0.2
Ulcerative Colitis	0.1	0.1	0.7	0.5	-0.3	0.0	-0.5	-0.1	-0.3	0.8	0.4	0.3	0.1	0.0
Heel T-Score	0.1	1.2	1.7	0.4	1.2	1.3	1.2	1.1	1.3	1.3	0.5	0.9	1.1	1.1
Cardiovascular Disease	0.1	0.2	1.6	1.3	-0.0	-0.2	0.4	-0.2	-0.4	-0.7	-0.1	-0.3	-0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	-0.4	-0.5	-0.1	-0.3	-0.5	-0.6	0.2	-0.3	-0.3	-0.4	-0.4
Vitamin and mineral supplements	0.1	0.1	1.0	-1.0	0.0	0.5	-0.2	0.1	0.1	0.0	0.1	-0.2	-0.1	0.1
Pack years adult smoking proportion	0.1	0.2	0.7	0.1	0.6	-0.9	-0.4	-0.3	-0.3	-0.5	-0.2	-0.1	-0.2	-0.4
High blood pressure	0.1	0.4	1.1	1.1	0.2	-0.5	-0.2	-0.6	-0.8	-0.4	-0.5	-0.7	-0.7	-0.6
Medication: Atenolol	0.1	0.2	0.8	0.9	-0.2	0.2	-0.1	0.3	0.3	-0.9	0.2	0.1	0.2	0.1
Waist circumference	0.1	0.3	0.5	-0.5	0.1	0.4	0.7	-0.6	-0.7	-0.1	-0.7	-0.6	-0.5	-0.7
Past tobacco smoking	0.1	0.1	0.4	0.3	0.6	0.5	0.7	0.2	0.3	-0.4	-0.0	0.2	0.2	0.2
Had menopause	0.1	0.2	0.6	0.8	-0.3	-0.5	-0.3	0.0	0.2	-0.8	-0.3	-0.1	0.0	-0.0
Father’s age at death	0.1	0.1	0.3	-0.4	-0.1	0.5	0.3	0.0	-0.2	-0.3	0.4	0.3	0.1	-0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.3	-0.3	-0.7	-0.8	0.0	-0.1	0.4	0.6	0.2	-0.0	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.0	-0.9	0.7	1.0	0.0	0.1	0.2	-0.7	0.1	-0.1	-0.0	0.1
Prospective memory result	0.1	0.1	0.9	-0.1	0.0	-0.9	-0.1	-0.3	-0.4	0.2	-0.3	-0.3	-0.3	-0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.7	-0.8	0.2	0.5	0.2	-0.1	-0.0	0.1	-0.1	-0.3	-0.2	-0.1
Gout (self-reported)	0.1	0.2	1.0	-0.4	0.6	-0.4	-0.4	-0.0	-0.2	1.0	0.3	0.1	0.0	0.1
Arm fat-free mass (right)	0.1	0.4	1.2	-0.0	0.2	1.0	1.1	-0.5	-0.4	-0.8	-0.7	-0.6	-0.5	-0.6
Age at first live birth	0.1	0.1	0.5	0.2	0.7	0.6	0.1	-0.1	-0.3	-0.2	0.0	-0.1	-0.1	-0.2
Arm predicted mass (right)	0.1	0.5	1.1	-0.0	0.1	1.0	1.0	-0.5	-0.5	-1.0	-0.8	-0.7	-0.6	-0.7
Had major operations	0.1	0.1	0.3	-0.3	0.6	0.3	0.3	0.1	-0.0	0.6	0.2	0.2	0.2	0.1
Leg pain on walking	0.1	0.2	1.0	-1.0	-0.4	-0.2	-0.5	0.1	0.2	-0.7	0.1	0.0	0.0	0.1
Knee pain experienced in last month	0.1	0.1	0.3	-0.6	0.3	-0.6	-0.0	-0.0	-0.1	0.3	0.3	0.1	-0.1	0.0
Hypertension (Self-reported)	0.1	0.2	0.9	0.9	0.5	-0.2	0.0	-0.4	-0.6	-0.4	-0.2	-0.5	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	1.0	-0.2	0.3	0.5	0.1	-0.2	0.3	-1.0	-0.6	-0.5	-0.3	-0.2
Whole body fat-free mass	0.1	0.6	1.9	0.2	0.6	1.3	1.4	-0.2	-0.2	-1.3	-0.5	-0.4	-0.3	-0.5
Average weekly red wine intake	0.1	0.1	0.3	-0.2	0.1	0.1	0.2	0.3	0.5	-0.4	0.1	0.2	0.3	0.3
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.3	0.5	-0.1	0.2	0.4	0.3	0.1	0.7	0.6	0.4	0.5
Whole body water mass	0.1	0.6	1.9	0.3	0.6	1.3	1.4	-0.2	-0.2	-1.3	-0.5	-0.4	-0.3	-0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.8	0.6	-0.9	0.1	0.1	-0.1	-0.3	-0.4	-0.1	0.0	-0.1	-0.1
Basal metabolic rate	0.1	0.6	2.1	-0.1	0.7	1.4	1.5	-0.2	-0.1	-1.1	-0.4	-0.3	-0.2	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.1	-1.1	0.0	0.5	0.3	0.6	0.8	0.1	0.4	0.6	0.6	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.3	-0.2	-0.5	-0.4	-0.2	-0.2	0.1	0.1	-0.1	-0.2	-0.1
Pack years of smoking	0.1	0.1	0.5	-0.0	0.7	-0.7	-0.3	-0.3	-0.3	-0.2	-0.2	-0.1	-0.2	-0.4
Arm predicted mass (left)	0.1	0.7	2.0	-0.2	-0.2	0.6	0.8	-0.8	-0.8	-1.4	-1.1	-1.0	-0.8	-1.0
Hair Pigment	0.0	0.1	0.4	-0.5	-0.1	-0.7	0.3	0.2	0.1	-0.0	0.3	0.4	0.3	0.3
Systolic blood pressure, automated reading	0.0	0.1	0.4	0.3	0.4	0.7	0.3	-0.1	-0.3	0.4	0.3	0.1	-0.1	0.0
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.1	0.3	0.2	0.1	-0.1	-0.1	0.1	-0.3	0.1	0.0	-0.1
Heart attack	0.0	0.0	0.1	-0.4	-0.1	-0.3	-0.2	-0.1	-0.1	-0.0	0.2	0.0	-0.1	-0.0
Falls in the last year	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.1	-0.2	-0.1	-0.1	-0.0	-0.1	-0.2	-0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.2	0.3	-0.4	0.0	0.2	0.3	0.2
Ever smoked	0.0	0.0	0.3	0.6	-0.1	-0.0	0.0	0.1	-0.0	0.2	0.2	0.2	0.1	0.0

Hub : Genes

GIN1

Models

Trait associations