TWAS hub - PAM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0600	0.0320	9.3e-03	0.027	NA	0.012	NA	0.021	1.3e-02	NA	6.7e-02	NA	2.4e-02
2	GTEx	Brain Cerebellar Hemisphere	0.2690	0.1030	8.6e-06	0.105	NA	0.112	NA	0.134	1.2e-03	NA	8.6e-04	NA	2.7e-04
3	GTEx	Brain Cerebellum	0.2640	0.0890	1.4e-05	0.167	NA	0.096	NA	0.149	1.2e-05	NA	8.9e-04	NA	3.5e-05
4	GTEx	Nerve Tibial	0.0568	0.0293	4.1e-03	0.038	NA	0.026	NA	0.046	1.0e-03	NA	5.6e-03	NA	3.1e-04
5	GTEx	Pancreas	0.7630	0.0570	2.8e-06	0.009	NA	0.136	NA	0.036	1.3e-01	NA	2.4e-06	NA	1.1e-02
6	GTEx	Skin Sun Exposed Lower leg	0.0360	0.0210	1.0e-02	-0.002	NA	-0.003	NA	0.041	5.6e-01	NA	8.4e-01	NA	2.3e-04
7	GTEx	Thyroid	0.0710	0.0300	4.9e-04	0.085	NA	0.063	NA	0.069	4.8e-07	NA	1.3e-05	NA	5.4e-06
8	GTEx	Whole Blood	0.2000	0.0430	0.0e+00	0.275	NA	0.267	NA	0.268	2.2e-25	NA	1.2e-24	NA	1.1e-24
9	METSIM	Adipose	0.0355	0.0231	1.7e-03	0.024	0.017	0.021	0.019	0.021	1.5e-04	1.1e-03	3.1e-04	5.3e-04	2.9e-04
10	NTR	Blood	0.2633	0.0432	0.0e+00	0.292	0.252	0.288	0.291	0.292	2.0e-95	1.6e-80	7.2e-94	6.2e-95	2.6e-95
11	YFS	Blood	0.6431	0.0333	0.0e+00	0.682	0.698	0.719	0.716	0.706	2.9e-316	0.0e+00	0.0e+00	0.0e+00	0.0e+00
12	TCGA	Pheochromocytoma and Paraganglioma	0.0880	0.0590	8.1e-03	0.033	0.024	0.006	NA	0.026	1.8e-02	3.7e-02	1.7e-01	NA	3.2e-02
13	TCGA	Thyroid Carcinoma	0.2280	0.0750	1.7e-06	0.068	0.054	0.104	NA	0.103	3.8e-07	5.7e-06	2.5e-10	NA	3.6e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	6	7	8	9	10	11	12	13
Rheumatoid Arthritis	9.2	12.7	35.7	-2.4	-6.0	-3.2	3.1	-4.3	3.2	-3.9	-3.7	-3.9	-3.6	-3.3	2.5
Waist Hip Ratio (WHR)	8.5	38.4	66.4	-7.2	-7.9	-6.6	3.7	-7.5	6.2	-6.4	-5.9	-6.4	-5.6	-8.2	4.3
Type 2 Diabetes (T2D) (2012)	7.0	8.1	11.6	2.8	2.2	3.3	-3.0	2.8	-3.3	3.2	3.2	3.4	3.3	2.5	-1.8
Diabetes diagnosed by doctor	6.8	11.2	16.8	2.8	3.3	2.8	-3.5	4.0	-3.8	4.0	3.2	3.8	3.6	4.1	-2.5
Suffer from ‘nerves’	6.6	10.3	19.4	-1.5	-3.7	-2.0	4.4	-3.3	3.4	-3.5	-3.8	-3.5	-2.9	-3.5	3.7
Type 2 Diabetes (T2D) (2018)	6.2	11.6	23.3	2.6	3.9	2.7	-3.2	4.2	-3.9	3.9	3.3	3.8	3.3	4.8	-2.0
Impedance of leg (left)	5.6	27.4	45.8	-4.2	-4.3	-4.4	5.9	-5.5	6.8	-6.0	-5.9	-5.6	-6.0	-4.8	5.4
Diabetes (self-reported)	5.4	8.3	12.7	3.0	2.8	2.9	-2.8	3.6	-3.1	3.3	2.8	3.2	3.1	3.3	-1.9
Worry (Nagel 2018)	5.3	11.1	21.9	-1.3	-4.4	-1.1	2.6	-3.7	2.6	-3.8	-4.1	-4.1	-3.2	-4.7	3.7
Impedance of leg (right)	5.3	25.5	43.2	-4.3	-4.3	-4.6	5.5	-5.3	6.6	-5.7	-5.6	-5.2	-5.5	-5.1	5.0
Hypothyroidism/myxoedema (self-reported)	5.2	10.2	36.2	-3.5	-6.0	-3.3	2.0	-3.3	2.7	-3.2	-2.8	-3.0	-2.7	-2.7	3.1
Mouth/teeth dental problems: Mouth ulcers	4.9	7.8	17.5	-1.9	-4.2	-2.8	1.2	-3.0	1.9	-3.2	-3.4	-3.3	-2.6	-3.6	2.5
Medication: Levothyroxine sodium	4.6	7.8	33.8	-3.1	-5.8	-3.1	1.6	-2.5	2.1	-2.5	-2.6	-2.3	-2.2	-2.5	2.3
Worrier / anxious feelings	4.5	8.6	21.3	-1.7	-4.6	-1.6	2.2	-3.6	2.5	-3.0	-3.3	-3.0	-2.5	-4.0	3.0
Medication: Metformin	4.3	6.0	9.8	1.9	2.9	2.0	-2.3	2.5	-2.9	2.9	2.4	2.7	2.5	3.1	-2.2
Hypothyroidism (self reported)	4.2	9.6	39.3	-2.6	-6.3	-2.7	1.7	-3.6	2.0	-3.1	-2.6	-3.0	-2.4	-3.1	3.2
Impedance of whole body	4.1	20.7	33.3	-3.7	-3.2	-3.5	5.0	-4.5	5.8	-5.5	-5.2	-5.1	-5.6	-3.7	5.1
Diabetes (father)	4.0	4.9	13.6	1.3	1.9	1.1	-1.3	3.7	-2.3	2.5	1.7	2.4	2.1	3.6	-2.1
Emphysema/chronic bronchitis	4.0	4.5	8.8	-1.4	-2.3	-1.7	2.6	-2.3	1.7	-2.4	-2.2	-2.6	-2.6	-1.0	3.0
Diastolic blood pressure, automated reading	3.9	12.0	18.1	3.7	2.9	3.9	-4.0	3.2	-4.3	3.8	3.2	3.5	3.7	3.2	-3.7
Medication for pain relief, constipation, heartburn	3.7	6.3	13.6	3.0	3.7	2.9	-2.1	2.9	-2.3	2.6	2.4	2.5	2.5	2.1	-1.9
Ever taken oral contraceptive pill	3.7	4.1	8.5	1.7	1.7	1.7	-1.3	2.9	-1.3	2.3	2.1	2.4	2.2	2.6	-2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.6	4.2	8.3	-2.7	-1.9	-2.9	2.2	-1.2	2.1	-2.3	-1.8	-2.0	-2.5	-1.0	2.4
Body mass index (BMI)	3.5	14.8	23.9	3.4	2.2	3.3	-3.9	4.0	-4.9	4.7	4.2	4.3	4.6	3.7	-4.1
Blood White Count	3.4	25.5	36.0	5.4	5.3	5.5	-4.7	5.4	-5.0	5.8	5.4	6.0	5.9	4.5	-3.7
BMI	3.4	19.6	34.3	3.7	3.0	3.9	-5.1	4.4	-5.9	5.3	4.5	4.8	5.1	4.9	-4.0
Financial situation satisfaction	3.4	4.2	7.2	-0.4	-2.5	-1.0	2.2	-1.5	1.9	-2.7	-2.6	-2.7	-2.7	-1.8	2.3
Hip circumference	3.3	14.2	23.2	3.4	2.6	3.9	-3.7	3.6	-4.8	4.5	4.2	4.2	4.4	3.6	-3.8
Nervous feelings	3.2	5.9	12.8	-0.2	-2.4	-0.0	2.5	-2.0	2.4	-3.0	-2.9	-3.2	-2.8	-2.5	3.6
Qualifications: College or University degree	3.2	10.1	25.2	2.4	5.0	2.8	-2.9	4.0	-3.2	3.2	3.7	2.8	2.6	3.2	-3.0
Angina (self-reported)	3.2	4.2	8.0	-2.4	-1.9	-1.8	0.6	-2.4	1.6	-2.5	-2.2	-2.4	-2.2	-2.8	1.9
Time employed in main current job	3.0	3.5	7.3	-2.2	-2.7	-2.4	1.4	-1.5	2.2	-2.1	-2.3	-1.6	-1.9	-1.0	1.5
Medication: Paracetamol	3.0	5.0	9.1	-1.7	-2.7	-1.8	2.2	-2.5	2.0	-2.6	-2.4	-2.4	-2.3	-2.1	3.0
Medication: Paracetamol	3.0	4.7	7.1	-1.8	-2.7	-1.5	2.2	-2.5	2.3	-2.5	-2.1	-2.5	-2.4	-1.7	2.5
Medication: Ibuprofen	2.9	3.5	7.0	-1.0	-1.7	-1.1	2.1	-2.2	1.9	-2.6	-1.6	-2.5	-2.6	-1.0	2.0
Qualifications: CSEs or equivalent	2.8	3.7	11.0	-1.2	-2.3	-1.2	0.9	-2.5	1.6	-2.0	-2.3	-1.7	-1.3	-3.3	2.2
Fluid intelligence score	2.8	5.8	14.1	1.0	3.8	1.0	-3.0	3.5	-2.7	2.4	1.8	2.4	1.9	3.1	-1.8
Pain type(s) experienced in last month: Hip pain	2.8	3.5	7.2	-1.4	-2.2	-2.0	2.7	-2.1	2.5	-2.0	-1.6	-2.0	-1.8	-1.6	0.9
Neuroticism	2.7	6.6	9.9	-0.4	-2.7	-0.1	2.8	-3.0	2.6	-3.0	-3.0	-3.2	-2.8	-3.1	2.9
Angina	2.7	3.6	7.0	-2.1	-1.8	-1.5	0.4	-2.2	1.3	-2.4	-2.0	-2.3	-2.0	-2.6	1.9
Hair/balding pattern: Pattern 4	2.7	6.7	14.5	-2.2	-2.6	-1.9	2.0	-3.8	2.4	-2.9	-2.8	-2.9	-2.6	-3.4	2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	7.0	1.1	1.3	1.2	-2.1	2.0	-2.1	2.0	1.4	1.8	2.2	1.6	-2.7
Relative age voice broke	2.6	3.9	9.1	0.8	0.9	1.2	-3.0	1.6	-2.1	2.6	2.1	2.3	2.5	0.6	-3.0
Neuroticism score	2.6	5.5	9.2	-0.2	-2.7	0.2	3.0	-2.7	2.5	-2.5	-2.4	-2.4	-2.3	-2.9	3.0
Verbal and Numeric Reasoning (VNR)	2.5	6.0	15.8	1.8	4.0	2.1	-2.5	3.6	-2.8	2.4	1.9	2.1	1.6	3.3	-1.0
LDL Cholesterol	2.5	4.0	7.1	-1.0	-1.8	-1.1	2.2	-2.6	2.2	-2.2	-2.0	-2.5	-2.4	-2.7	1.4
Overall health rating	2.5	5.3	11.4	-1.6	-3.4	-2.2	2.8	-1.3	2.5	-2.7	-3.0	-2.2	-2.2	-1.2	2.5
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	4.2	1.0	-1.3	0.4	1.6	-2.0	1.3	-2.1	-2.1	-2.0	-1.7	-1.9	1.9
Impedance of arm (right)	2.4	11.0	18.5	-2.5	-1.7	-2.4	4.0	-3.2	3.9	-4.1	-3.6	-3.8	-4.3	-2.6	4.0
Arm fat percentage (left)	2.4	9.5	14.6	2.8	1.6	2.9	-2.9	3.3	-3.8	3.7	3.4	3.4	3.6	3.2	-3.3
Tinnitus: Yes, now most or all of the time	2.4	2.8	5.5	-1.3	-2.3	-1.4	1.7	-2.2	1.1	-1.9	-1.5	-1.9	-1.8	-1.6	1.6
Arm fat percentage (right)	2.3	8.9	14.5	2.7	1.4	2.6	-2.8	3.2	-3.8	3.6	3.4	3.3	3.5	3.1	-3.1
Back pain experienced in last month	2.3	3.3	8.4	-0.5	-1.5	-0.8	2.9	-2.5	2.3	-2.1	-1.6	-2.1	-1.8	-2.3	0.7
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	5.0	0.6	1.4	0.7	-1.9	2.2	-2.0	1.8	1.6	1.7	1.6	2.1	-0.3
Severe depression (siblings)	2.2	2.5	4.6	-0.8	-2.0	-1.3	2.1	-1.5	2.1	-1.6	-1.1	-1.8	-1.6	-1.8	1.7
Arm fat mass (left)	2.2	9.0	16.9	2.4	1.3	2.6	-3.4	2.8	-4.1	3.7	3.3	3.3	3.7	2.6	-3.2
Ulcerative Colitis (UC)	2.1	3.9	8.4	-0.8	-2.0	-0.6	2.0	-2.0	2.5	-2.4	-2.9	-2.7	-2.5	-1.8	0.9
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.3	-0.6	-0.8	-0.5	2.0	-2.3	2.2	-1.9	-1.2	-1.7	-1.6	-1.7	1.9
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	9.1	-0.6	-3.0	-0.1	1.7	-2.1	1.2	-1.8	-1.9	-1.9	-1.6	-3.0	1.4
Impedance of arm (left)	2.1	9.6	17.3	-2.4	-1.4	-1.9	3.4	-3.0	3.8	-4.0	-3.4	-3.7	-4.2	-2.2	3.9
Arm fat mass (right)	2.1	8.6	15.8	2.3	1.2	2.3	-3.2	2.8	-4.0	3.6	3.2	3.3	3.7	2.4	-3.3
Qualifications: nursing, teaching	2.1	3.2	6.2	2.3	1.9	2.5	-1.3	2.2	-1.7	2.0	2.0	1.9	2.0	1.1	-0.6
Lung FEV1/FVC ratio	2.0	10.0	15.3	3.3	2.5	3.1	-3.1	3.8	-3.9	3.5	3.0	3.2	3.1	3.7	-3.0
Osteoarthritis (self-reported)	2.0	2.5	7.3	0.7	1.3	0.6	-0.6	2.7	-1.1	1.8	2.0	1.7	1.4	2.7	-1.4
Neuroticism (Nagel 2018)	1.9	4.4	6.9	-0.2	-2.5	-0.2	2.3	-2.2	1.8	-2.4	-2.6	-2.5	-2.3	-2.5	2.6
Fasting Glucose	1.9	2.3	5.3	-2.1	-2.2	-2.3	1.0	-1.4	0.8	-1.2	-1.0	-1.2	-1.1	-1.5	2.1
Diabetes (mother)	1.9	2.5	4.2	1.1	1.6	1.2	-1.7	1.6	-1.8	2.0	1.5	1.8	2.0	0.9	-2.0
Ever highly irritable/argumentative for 2 days	1.9	2.3	6.0	-1.2	-0.5	-0.6	2.2	-1.6	1.7	-1.9	-1.2	-1.7	-2.5	-0.2	1.7
Mouth/teeth dental problems: Loose teeth	1.9	2.2	5.8	2.3	1.6	2.2	-0.6	1.4	-1.3	1.1	1.3	1.1	0.7	2.4	-1.3
Myopia	1.9	2.8	5.2	-1.3	-1.8	-1.4	0.6	-1.9	1.4	-2.1	-2.3	-1.8	-1.7	-2.3	1.4
Age at last live birth	1.8	2.6	6.7	1.6	2.6	2.1	-2.0	1.5	-1.7	1.0	1.9	1.0	0.7	2.0	-1.0
Irritability	1.8	3.1	5.8	-0.7	-1.7	-0.6	1.6	-2.0	1.8	-2.4	-2.4	-2.3	-2.3	-1.3	1.7
Neuroticism (2016)	1.7	2.4	8.7	-1.4	-3.0	-1.5	2.1	-1.4	1.8	-1.2	-1.0	-1.4	-0.9	-1.9	0.8
Supplements: Glucosamine	1.7	2.3	5.5	1.6	0.9	1.1	-1.1	2.1	-1.4	1.8	1.8	1.5	1.3	1.2	-2.4
Leg predicted mass (left)	1.7	8.9	17.8	1.7	2.2	2.4	-4.0	2.4	-4.2	3.5	3.4	3.1	3.8	1.7	-3.4
Number of live births	1.7	2.5	6.0	1.8	2.2	2.4	-1.3	0.8	-1.3	1.5	1.7	1.5	1.3	1.7	-1.5
Eye problems/disorders: Cataract	1.7	2.0	4.0	-0.6	-1.7	-1.2	1.2	-1.5	1.2	-1.8	-2.0	-2.0	-1.8	-0.7	1.4
Leg fat-free mass (left)	1.6	8.4	17.3	1.6	2.1	2.3	-3.9	2.3	-4.2	3.4	3.3	3.0	3.7	1.6	-3.3
Qualifications: None of the above	1.6	3.5	9.6	-1.3	-3.1	-1.7	2.3	-2.2	1.9	-1.8	-1.5	-1.9	-1.8	-2.0	0.8
Sensitivity / hurt feelings	1.5	2.6	8.2	-0.9	-1.8	-0.6	2.1	-1.4	2.1	-1.6	-0.9	-1.2	-1.4	-1.8	2.9
Chronic bronchitis/emphysema (father)	1.5	1.8	4.0	0.0	-0.2	0.0	1.8	-1.6	1.6	-1.7	-1.3	-2.0	-1.9	-1.1	0.9
Medication: Amlodipine	1.5	2.1	3.9	-1.2	-1.3	-1.1	0.9	-1.9	0.6	-1.9	-1.2	-2.0	-1.7	-1.5	1.8
Medication: Aspirin	1.5	2.0	6.5	-2.6	-2.4	-2.1	-0.4	-1.9	0.5	-0.8	-1.0	-0.7	-0.3	-1.7	0.4
Fractured/broken bones in last 5 years	1.5	2.0	3.7	-1.1	-1.7	-1.2	1.0	-1.4	1.8	-1.5	-1.6	-1.6	-1.6	-1.9	0.5
Irritable Bowel Disease (IBD)	1.4	3.4	6.2	-1.5	-2.3	-1.6	1.2	-1.8	2.1	-2.2	-2.5	-2.3	-2.1	-1.7	1.1
Primary Biliary Cirrhosis	1.4	2.0	12.2	-0.1	-3.5	-0.7	0.8	-1.6	1.0	-1.4	-2.0	-1.3	-0.8	0.0	0.8
Relative age of first facial hair	1.4	2.8	9.0	-0.5	0.9	0.2	-1.9	2.1	-0.8	2.1	1.9	2.1	1.8	1.4	-3.0
Hand grip strength (right)	1.4	3.7	10.4	-0.7	-1.5	-0.9	0.9	-3.2	1.5	-2.3	-2.5	-2.4	-1.7	-3.2	0.8
Age when periods started (menarche)	1.4	3.3	8.6	2.7	2.2	2.9	-2.4	0.9	-2.4	1.5	1.0	1.5	1.9	-0.0	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.5	-1.1	-1.2	-1.3	1.7	-1.1	1.9	-1.4	-1.6	-1.3	-1.3	-0.5	0.8
Comparative height size at age 10	1.4	7.9	23.5	-4.8	-2.4	-3.3	0.7	-4.0	1.8	-3.0	-2.2	-3.1	-2.9	-2.8	1.8
Chest pain or discomfort	1.4	2.0	5.2	-0.8	-2.3	-0.6	1.2	-1.6	1.1	-1.9	-1.6	-1.8	-1.7	-0.8	1.6
Leg fat-free mass (right)	1.4	7.6	16.2	1.6	2.2	2.2	-3.7	2.2	-4.0	3.2	3.1	2.8	3.4	1.8	-3.1
Leg predicted mass (right)	1.4	7.5	15.9	1.5	2.1	2.2	-3.7	2.2	-4.0	3.2	3.1	2.8	3.4	1.8	-3.1
Mother’s age at death	1.4	1.8	8.1	-0.3	0.9	0.0	-2.8	1.2	-1.3	1.1	1.1	0.8	0.8	1.4	-2.3
Leg fat mass (left)	1.4	5.4	9.4	1.9	1.0	2.0	-2.5	2.1	-3.1	2.9	2.4	2.6	2.9	1.9	-2.8
Intelligence (Savage-Jansen 2018)	1.3	4.1	16.4	1.3	4.1	1.3	-1.7	3.1	-1.6	1.8	1.5	1.7	1.2	2.6	-1.3
Height	1.3	24.8	68.0	-5.4	-5.5	-4.4	2.2	-6.8	3.2	-5.2	-5.3	-5.3	-4.2	-8.2	3.9
Weight	1.3	6.2	13.7	1.6	1.1	2.1	-3.3	1.8	-3.7	3.1	2.7	2.6	3.2	1.5	-3.0
Exposure to tobacco smoke at home	1.3	1.4	3.8	-1.8	-1.2	-1.9	0.9	-1.1	1.4	-1.0	-0.4	-1.3	-1.6	-0.6	-0.5
Loud music exposure frequency	1.3	1.5	4.9	-1.7	-0.3	-1.7	0.5	0.2	1.2	-1.5	-1.3	-1.4	-2.2	0.3	0.9
Wheeze or whistling in the chest in last year	1.3	2.3	6.2	-0.9	-1.8	-1.3	2.5	-0.5	1.5	-1.5	-1.8	-1.2	-1.5	0.2	2.4
Leg fat mass (right)	1.3	4.9	8.5	1.6	0.7	1.6	-2.5	2.1	-2.9	2.8	2.3	2.6	2.9	1.6	-2.7
Alcohol intake frequency.	1.3	2.9	5.8	-2.3	-2.3	-2.4	1.5	-1.3	1.5	-1.9	-1.2	-1.9	-2.0	-0.2	1.6
Illnesses of siblings: Diabetes	1.3	1.6	11.9	0.5	1.6	0.6	-0.2	1.0	-0.8	1.1	1.3	0.9	0.3	3.4	-0.7
Medication: Aspirin	1.3	1.7	5.7	-2.2	-2.4	-1.7	-0.1	-1.8	0.6	-1.0	-1.1	-0.9	-0.6	-1.3	0.5
Alcohol drinker status: Never	1.3	1.5	3.9	0.7	-0.1	0.3	-0.8	2.0	-1.3	1.5	1.3	1.4	1.5	1.9	-1.3
Bipolar Disorder (2018)	1.2	1.8	4.8	-1.7	-2.0	-1.3	0.1	-1.3	1.0	-1.4	-2.2	-1.4	-1.3	0.0	1.5
Stomach or abdominal pain in last month	1.2	1.5	7.9	-1.0	-2.8	-1.1	0.6	-1.5	0.8	-1.1	-1.2	-1.2	-1.4	0.1	0.7
Alcohol usually taken with meals	1.2	1.9	5.4	-0.9	-0.8	-1.5	0.2	-1.8	0.5	-1.5	-2.3	-1.3	-0.9	-2.3	1.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	5.9	-0.3	-0.4	-0.2	2.4	-0.0	2.0	-1.3	-0.9	-1.2	-1.7	0.3	1.6
Tense / ‘highly strung’	1.2	1.9	10.2	-0.6	-3.2	-0.3	1.1	-2.1	0.8	-1.3	-1.2	-1.2	-0.8	-1.6	0.5
Whole body fat mass	1.2	4.9	9.7	1.7	0.8	2.0	-2.7	1.8	-3.1	2.7	2.4	2.4	2.8	1.8	-2.6
Number of self-reported non-cancer illnesses	1.2	2.1	4.5	-0.9	-1.7	-0.9	1.1	-1.1	1.0	-2.0	-2.1	-1.9	-2.0	-0.5	1.5
Wears glasses or contact lenses	1.2	1.4	3.2	-0.9	-1.2	-0.5	1.0	-1.3	1.6	-1.4	-0.7	-1.6	-1.8	-0.9	1.0
Illnesses of father: High blood pressure	1.2	1.5	2.7	0.7	1.3	0.7	-1.2	1.6	-1.7	1.4	1.0	1.4	1.4	1.2	-1.4
HbA1C	1.1	1.2	3.2	1.5	1.8	1.4	-0.4	1.0	-0.7	0.8	1.5	0.5	0.3	1.7	-0.7
Lupus	1.1	1.7	5.2	-0.4	-2.3	-0.8	0.9	-1.3	0.4	-1.5	-1.4	-1.4	-1.0	-2.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	6.2	1.4	2.5	1.6	-2.2	1.6	-1.9	1.4	1.4	1.6	1.6	1.4	-0.9
Past tobacco smoking	1.1	2.1	6.5	2.5	2.0	2.1	0.5	1.1	-0.5	1.3	1.6	1.4	1.5	1.0	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.5	-0.5	-0.8	-0.7	1.4	-1.2	1.1	-1.8	-1.2	-1.6	-1.9	-0.4	1.4
Pulse wave reflection index	1.1	1.3	3.9	1.1	0.8	1.3	-2.0	0.6	-1.4	1.1	0.8	1.3	1.5	0.4	-1.2
Exposure to tobacco smoke outside home	1.1	1.5	4.9	0.2	-1.9	-0.0	2.2	-1.2	1.5	-1.5	-1.1	-1.2	-1.5	-0.2	0.4
Health satisfaction	1.1	1.4	3.5	0.3	-0.5	0.2	1.7	-0.3	0.9	-1.7	-1.6	-1.5	-1.7	0.6	1.9
Family relationship satisfaction	1.1	1.3	7.1	1.2	2.7	1.6	-0.4	1.1	-0.4	0.2	0.4	0.1	-0.4	2.1	0.1
Medication: Bendroflumethiazide	1.1	1.6	4.0	1.5	2.0	1.9	-1.9	0.3	-1.8	0.9	0.5	0.6	0.9	0.1	-1.4
Alzheimer’s Disease (in father)	1.0	1.1	5.2	-1.6	-2.3	-1.6	0.1	-0.3	0.6	-0.7	-0.8	-0.8	-0.8	-0.8	-0.3
Hearing difficulty/problems with background noise	1.0	1.6	3.3	-1.5	-1.3	-1.7	1.2	-0.7	0.8	-1.5	-1.4	-1.7	-1.8	0.2	0.7
Hair/balding pattern: Pattern 3	1.0	1.5	3.7	-1.6	-0.7	-1.9	1.7	-0.3	0.8	-1.3	-1.3	-1.2	-1.5	-0.9	1.1
Basal metabolic rate	1.0	5.5	12.5	1.1	1.0	1.7	-3.4	1.5	-3.5	2.8	2.6	2.4	3.2	0.8	-3.0
Ulcerative Colitis	0.9	1.2	4.1	-1.0	-0.9	-0.7	0.5	-0.9	1.1	-1.4	-2.0	-1.7	-1.7	0.0	-0.2
Blood Red Count	0.9	9.0	27.2	-2.7	-5.2	-2.6	2.7	-3.9	2.4	-3.0	-3.1	-2.9	-2.1	-3.3	2.3
Allergy or Eczema	0.9	2.3	10.2	-1.5	-3.2	-1.2	0.5	-1.6	0.9	-1.7	-1.7	-1.5	-1.3	-1.5	0.6
Multivitamins +/- minerals	0.9	1.2	3.8	0.1	0.6	0.2	1.8	-0.1	1.9	-0.7	-0.1	-0.6	-1.2	1.3	1.9
Supplements: Vitamin C	0.9	1.1	2.4	-0.9	-1.6	-0.7	0.4	-0.8	1.4	-1.0	-0.5	-0.9	-0.9	-1.5	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.6	0.0	-1.3	-0.4	1.6	-0.9	0.9	-1.4	-0.9	-1.1	-0.8	-1.2	1.2
Smoking status: Previous	0.9	1.4	3.5	-1.9	-1.9	-1.7	-0.3	-1.2	0.2	-1.0	-1.4	-1.1	-1.0	-1.1	0.7
Whole body fat-free mass	0.9	5.1	11.6	0.8	1.1	1.4	-3.4	1.4	-3.3	2.7	2.5	2.3	3.1	0.6	-3.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.3	-0.1	0.5	-0.6	0.3	2.1	0.3	1.2	0.7	1.6	1.1	1.1	-1.7
Friendships satisfaction	0.9	1.1	5.6	0.6	2.4	0.9	0.4	1.5	-0.0	-0.0	0.3	-0.1	-0.6	1.8	1.3
Whole body water mass	0.9	5.2	11.5	1.0	1.2	1.6	-3.3	1.4	-3.4	2.7	2.6	2.3	3.1	0.6	-3.0
Number of operations (self-reported)	0.9	1.4	5.8	0.9	-1.0	0.5	0.4	-1.3	0.0	-1.5	-1.8	-1.4	-0.6	-2.4	0.4
Age started oral contraceptive pill	0.9	1.1	4.5	-0.4	-0.7	-0.3	-0.0	-2.1	0.4	-1.1	-1.1	-1.4	-0.7	-1.9	1.0
Chronotype (morning person)	0.8	1.8	9.7	3.1	0.6	2.3	0.2	0.5	-1.6	0.9	0.7	1.1	1.5	0.9	0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.7	-1.1	-1.5	-0.7	0.6	-0.4	0.7	-1.2	-1.6	-1.2	-1.2	-1.0	1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.3	1.8	0.3	2.1	-0.6	-0.5	-1.6	-0.1	-0.5	-0.2	0.2	-0.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.4	1.6	2.3	1.4	-1.6	1.6	-1.3	1.1	1.0	1.2	1.3	1.3	-1.1
Medication: Simvastatin	0.8	1.1	3.5	0.3	-1.1	0.4	-0.0	-1.9	0.3	-1.4	-1.6	-1.1	-0.9	-1.4	1.0
Medication: Cholesterol lowering	0.8	1.2	3.0	-0.5	-0.4	-0.4	0.5	-1.7	0.7	-1.3	-1.7	-1.2	-1.2	-0.9	1.7
Standing height	0.8	7.7	18.8	-3.6	-2.2	-2.2	0.9	-4.3	1.9	-3.0	-2.7	-3.2	-2.5	-4.3	2.1
Body fat percentage	0.8	3.3	5.5	1.6	0.7	1.7	-1.9	1.6	-2.3	2.2	1.9	2.0	2.2	1.9	-2.1
Arm fat-free mass (right)	0.8	3.9	9.9	0.5	0.6	1.0	-3.1	1.0	-2.9	2.4	2.0	2.0	2.8	0.4	-2.8
Hearing aid user	0.8	0.9	2.1	-1.1	-1.2	-1.2	1.4	0.2	1.3	-0.7	-0.3	-0.6	-0.8	1.0	0.6
Commuting to job workplace: Public transport	0.8	0.9	4.9	-2.2	-0.2	-1.7	0.7	-0.2	0.8	-0.1	0.5	0.1	-0.4	0.6	1.3
Medication: Lisinopril	0.8	1.0	3.9	-0.3	2.0	0.4	-0.4	-0.3	-0.9	1.3	1.4	0.8	0.7	0.6	-1.7
Leg fat percentage (left)	0.8	2.8	5.2	1.6	0.3	1.4	-1.3	1.7	-1.8	2.1	1.9	1.9	2.0	1.6	-2.3
Respiratory disease	0.7	1.7	3.7	-1.8	-1.9	-1.5	0.5	-0.9	1.0	-1.1	-1.7	-1.2	-1.3	-1.1	1.2
Tanning	0.7	8.4	13.3	3.4	3.2	3.4	-1.9	2.9	-2.3	3.4	3.2	3.6	3.5	2.5	-2.5
Medication: Co-codamol	0.7	0.8	2.3	1.2	1.5	1.3	1.1	0.2	0.7	-0.5	-0.4	-0.7	-0.8	0.7	0.9
Trunk fat mass	0.7	3.1	7.3	1.2	0.7	1.7	-2.3	1.2	-2.7	2.1	1.8	1.8	2.2	1.4	-2.1
Gout (self-reported)	0.7	0.9	2.9	-0.7	-0.6	-1.0	1.2	-0.1	1.7	-1.2	-0.8	-1.1	-1.3	-0.7	0.4
Leg fat percentage (right)	0.7	2.6	5.3	1.3	0.0	1.0	-1.4	1.7	-1.7	2.1	1.8	2.0	2.2	1.2	-2.3
Arm predicted mass (right)	0.7	3.5	8.1	0.4	0.5	1.0	-2.8	0.9	-2.7	2.3	2.0	2.0	2.7	0.4	-2.7
Mood swings	0.7	1.3	6.2	0.7	-1.5	0.5	2.5	-1.2	1.1	-0.9	-0.8	-0.8	-0.8	-1.0	1.4
Risk taking	0.7	1.0	2.2	-0.4	1.4	-0.4	-0.6	1.5	-0.4	1.2	1.3	1.1	0.6	1.4	-1.5
Pain experienced in last month	0.7	1.2	4.3	1.9	1.3	2.1	-1.0	0.7	-0.6	0.9	1.1	0.9	0.9	0.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.4	-1.5	-1.1	-1.1	-0.3	-0.4	0.8	-1.1	-0.6	-0.9	-1.0	-0.3	1.5
Arm predicted mass (left)	0.7	3.4	7.8	0.4	0.0	0.7	-2.7	0.8	-2.8	2.4	2.0	2.0	2.8	0.1	-2.5
Coronary Artery Disease (CAD)	0.6	0.7	2.8	1.2	-1.7	-0.1	1.2	-0.7	-0.1	0.1	-0.6	0.4	0.8	-1.2	-0.3
Blood Platelet Count	0.6	7.3	16.7	-1.9	-4.1	-2.3	2.5	-2.8	3.3	-2.9	-2.6	-2.8	-2.5	-3.2	2.1
Number of treatments/medications taken	0.6	1.0	5.2	-0.5	-2.3	-0.4	0.5	-1.7	0.3	-1.1	-0.9	-1.2	-0.7	-0.6	0.6
Ever had hysterectomy (womb removed)	0.6	0.7	2.1	-1.0	-0.7	-0.9	0.8	-1.4	0.6	-0.7	-0.8	-1.0	-1.1	-0.3	0.7
Pack years adult smoking proportion	0.6	1.0	1.9	-1.4	-1.2	-1.2	1.0	-0.7	1.3	-0.9	-0.7	-0.8	-1.1	-0.6	0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.4	1.9	0.5	1.4	1.2	-0.5	-0.1	0.2	-0.7	0.3	0.5	-1.1	-0.2
Waist circumference	0.6	2.1	5.0	0.1	-1.1	0.5	-2.2	0.3	-2.0	1.8	1.4	1.5	2.1	0.2	-2.2
Had other major operations	0.6	0.7	3.6	1.9	-0.3	1.6	-0.1	-0.5	-0.5	-0.4	-0.9	-0.5	0.1	-0.9	-0.5
Illnesses of siblings	0.6	0.8	4.1	-0.1	2.0	0.2	-1.2	1.1	-0.5	0.9	0.4	1.1	1.1	-0.4	-0.4
Happiness	0.6	0.8	2.4	0.4	0.3	0.8	1.1	0.1	1.1	-1.1	-0.6	-1.1	-1.5	0.7	1.2
Medication: Lansoprazole	0.6	0.7	2.4	-0.3	-1.4	-0.6	0.5	-1.0	0.3	-0.7	-0.8	-0.7	-0.6	-1.5	1.1
Trunk predicted mass	0.6	3.2	7.8	0.4	0.5	1.0	-2.8	0.6	-2.7	2.1	2.1	1.7	2.5	-0.2	-2.5
Medication: Seretide 50 evohaler	0.6	0.7	2.7	-1.3	-1.6	-1.5	0.1	-0.4	0.6	-0.4	0.0	-0.6	-0.6	-0.0	-0.7
Mean time to correctly identify matches	0.6	1.1	5.2	0.9	1.0	1.4	-1.4	1.0	-0.6	0.6	0.5	0.7	0.2	2.3	-0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.6	0.3	-1.6	-0.1	0.2	-0.8	0.3	-0.8	-1.4	-0.9	-0.4	-1.3	-0.6
Medication for cholesterol	0.6	1.0	4.1	-1.1	2.0	-0.9	0.3	0.5	1.5	-0.1	0.4	-0.2	-1.1	1.4	0.8
Asthma (self-reported)	0.6	1.3	3.1	-1.8	-0.7	-1.6	1.4	-0.7	1.5	-1.0	-1.1	-0.9	-1.4	0.0	0.9
Illnesses of father: None of the above (group 1)	0.6	0.8	2.0	-1.4	-1.4	-1.0	-0.3	-1.2	0.2	-0.7	-0.2	-0.8	-0.8	-0.5	1.0
High cholesterol (Self-reported)	0.6	1.1	4.8	-0.3	-2.2	-0.5	1.0	-1.2	1.1	-1.1	-1.6	-0.6	-0.5	-0.8	0.4
Medication: Atorvastatin	0.6	0.7	2.4	-0.3	-1.3	-0.8	1.6	-1.0	1.1	-0.5	-1.1	-0.4	-0.1	-0.9	0.4
Ever smoked	0.6	1.1	5.6	-2.4	-1.2	-1.8	-1.5	-0.5	-0.2	-0.4	-0.9	-0.4	-0.6	-0.7	-0.0
Arm fat-free mass (left)	0.6	3.2	7.6	0.5	0.2	0.8	-2.6	0.6	-2.7	2.3	1.9	1.8	2.8	-0.1	-2.5
Ever depressed for a whole week	0.6	0.8	1.9	0.6	-0.0	0.7	1.3	-0.2	1.4	-1.0	-1.0	-0.9	-1.0	-0.7	1.0
Supplements: Calcium	0.6	0.7	3.3	-1.3	-1.8	-1.5	0.4	0.5	0.6	-0.6	-0.4	-0.5	-0.7	-0.1	0.1
Heart disease (siblings)	0.6	0.7	3.9	0.4	-0.2	0.5	1.1	-1.0	1.3	-0.9	-0.2	-0.7	-0.7	0.1	2.0
Alcohol drinker status: Previous	0.6	0.7	3.2	-1.8	-0.1	-1.1	-1.0	0.1	0.6	-0.7	-0.7	-0.6	-1.0	0.7	0.6
Blood Eosinophil Count	0.5	3.9	7.9	-2.8	-2.7	-2.8	1.9	-2.0	2.2	-1.6	-1.0	-1.8	-1.9	-0.7	2.0
Hand grip strength (left)	0.5	1.3	7.1	-0.2	-0.3	-0.1	-1.0	-2.1	-0.2	-0.8	-1.5	-0.9	0.1	-2.7	0.1
Medication for hormone replacement therapy	0.5	0.5	3.1	1.5	0.7	1.8	0.4	0.0	-0.3	0.1	0.1	0.2	0.1	0.4	0.8
Trunk fat percentage	0.5	2.0	4.6	1.0	0.4	1.4	-1.7	1.1	-2.1	1.6	1.3	1.5	1.6	1.5	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.7	0.7	0.4	1.2	-1.1	1.4	-0.7	0.5	0.3	0.5	-0.0	1.6	0.1
Taking other prescription medications	0.5	0.8	4.0	-1.3	-2.0	-1.0	0.1	-0.9	0.6	-0.7	-0.8	-0.6	-0.6	-0.2	-0.3
Trunk fat-free mass	0.5	3.2	7.9	0.4	0.5	1.0	-2.8	0.7	-2.7	2.1	2.0	1.7	2.5	-0.1	-2.5
Mouth/teeth dental problems: Dentures	0.5	0.8	2.7	1.1	0.5	1.6	-1.3	-0.1	-1.4	0.5	0.7	0.4	0.5	1.0	-0.8
Asthma	0.5	1.0	2.9	-1.7	-0.7	-1.5	1.4	-0.5	1.2	-0.8	-0.9	-0.7	-1.3	0.3	0.8
Birth weight of first child	0.5	0.9	2.0	0.6	1.4	0.7	-1.3	0.2	-1.0	1.0	0.6	0.9	1.1	0.6	-1.4
Peak expiratory flow (PEF)	0.5	1.3	3.3	-1.7	-0.1	-1.2	-0.3	-0.7	0.4	-1.1	-1.8	-1.1	-0.9	-1.8	1.1
Blood clot in the leg (DVT)	0.5	0.7	2.3	1.1	1.1	1.5	-1.3	-0.1	-1.1	0.3	0.5	0.1	0.4	0.6	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	4.4	0.4	0.6	0.8	-0.4	1.4	-0.4	0.1	0.6	0.2	-0.4	2.1	0.2
Neck or shoulder pain in last month	0.5	0.7	4.5	-0.9	-2.1	-0.9	0.3	-1.0	0.5	-0.6	-0.2	-0.7	-0.5	-0.4	0.1
Ever had bowel cancer screening	0.5	0.5	2.5	-0.6	-1.6	-0.6	-0.9	-0.8	-0.1	-0.6	-0.6	-0.7	-0.4	-0.8	-0.3
Osteoporosis (self-reported)	0.5	0.7	1.5	-0.4	-1.2	-0.4	0.1	-1.1	0.7	-1.0	-1.2	-1.1	-1.0	-0.5	0.7
Eye problems/disorders: Glaucoma	0.5	0.6	4.1	-0.8	-2.0	-0.8	-0.0	0.1	0.5	-0.3	-1.0	-0.3	-0.1	-0.8	0.6
Cholesterol lowering medication	0.5	0.7	6.0	-0.3	-2.4	-0.3	-0.2	-0.9	-0.4	-0.1	-0.4	-0.2	0.3	-0.9	-1.1
Basal cell carcinoma (self-reported)	0.5	0.5	1.8	0.2	1.4	0.3	-1.2	1.3	-0.4	0.3	0.1	0.3	0.1	1.2	-0.4
Pack years of smoking	0.5	0.8	2.0	-1.4	-1.0	-1.1	0.7	-0.8	1.1	-0.9	-0.7	-0.9	-1.1	-0.5	0.7
Bipolar Disorder or Schizophrenia	0.4	1.1	4.9	-2.2	-1.4	-1.8	-0.0	-0.0	1.1	-0.6	-0.4	-0.7	-1.1	0.0	0.7
Breast Cancer	0.4	1.0	4.0	2.0	1.2	1.5	0.1	1.4	-0.4	0.7	1.1	0.8	0.5	1.2	0.2
Crohns Disease (2012)	0.4	0.7	1.8	0.8	0.3	0.3	-0.7	1.0	-1.0	1.0	1.3	0.9	0.7	1.3	-0.6
Schizophrenia (2014)	0.4	0.8	3.7	-1.9	-0.8	-1.3	-0.4	0.8	1.1	-0.6	0.2	-0.4	-1.2	0.0	0.4
Heel T-Score	0.4	2.9	8.0	2.8	2.6	2.3	-0.9	2.0	-1.6	1.4	1.0	1.5	1.6	1.6	-0.4
Cardiovascular Disease	0.4	1.2	5.3	0.4	-0.9	0.4	-1.7	0.1	-2.3	1.2	0.8	1.0	1.6	0.6	-0.9
Lung FVC	0.4	2.3	15.6	0.7	4.0	1.0	-1.1	2.2	0.2	0.9	1.4	1.1	0.6	1.4	-0.4
Average weekly fortified wine intake	0.4	0.4	1.0	-1.0	-0.9	-1.0	-0.4	-0.6	-0.3	-0.6	-0.8	-0.7	-0.6	-0.2	-0.4
Mouth/teeth dental problems	0.4	0.6	2.8	0.4	1.7	0.3	0.7	1.2	0.2	0.7	0.9	0.7	0.6	0.2	0.1
Heart attack	0.4	0.6	2.0	-1.3	-0.7	-0.8	-0.4	-0.2	0.6	-0.8	-0.4	-0.6	-0.7	-0.2	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.7	-0.2	-1.0	-0.4	1.3	-0.9	0.7	-0.9	-1.0	-0.8	-0.8	-0.5	-0.1
Alcohol intake versus 10 years previously	0.4	0.6	3.4	-0.6	-0.8	-0.9	0.1	0.9	0.0	0.6	1.1	0.4	0.0	1.9	-0.2
Father’s age at death	0.4	0.6	3.4	-0.6	0.8	-0.5	-1.9	-0.1	-1.1	0.1	-0.4	-0.1	-0.1	-0.4	-1.0
Breastfed as a baby	0.4	0.5	2.0	0.2	0.1	0.1	-0.9	0.5	-1.2	0.7	0.1	0.7	0.9	0.5	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.9	-0.6	-1.7	0.0	0.3	-0.6	0.8	-0.8	-0.6	-0.6	-0.8	-1.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.7	-0.8	-1.0	-0.8	0.3	0.1	1.0	-0.8	-0.7	-0.5	-0.6	-0.9	1.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	0.6	0.0	0.2	0.2	1.4	0.0	0.9	0.9	1.2	1.1	-0.1	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	-0.8	-0.7	-0.3	0.6	-0.9	0.2	-0.8	-0.4	-0.5	-1.0	0.5	1.3
Number of full brothers	0.4	0.4	1.4	0.1	0.7	0.6	-0.3	0.8	-0.0	0.8	0.8	1.0	0.7	1.2	-0.1
Number of children fathered	0.4	0.4	1.3	0.3	1.1	0.5	-1.0	0.6	-0.9	0.6	0.6	0.3	0.3	0.5	-0.5
Shortness of breath walking on level ground	0.4	0.4	2.4	0.5	0.4	0.9	0.2	0.7	0.2	-0.4	-0.8	-0.4	-0.8	1.5	0.3
Eye problems/disorders: None of the above	0.4	0.5	2.7	0.7	1.6	1.0	0.1	-0.0	-0.7	0.4	0.7	0.4	0.4	-0.7	-0.4
Medication: Allopurinol	0.4	0.6	1.9	0.5	-0.3	0.2	1.4	-0.4	1.1	-1.0	-0.8	-0.7	-0.8	-0.5	0.8
Number of full sisters	0.4	0.5	1.3	-0.1	0.9	0.2	-0.9	0.9	-0.7	1.0	0.6	1.1	0.8	0.3	-0.6
Leg pain on walking	0.4	0.5	2.1	0.6	-0.1	0.4	0.7	-0.7	-0.7	-0.7	-0.6	-0.8	-0.7	0.0	1.4
Hypertension (Self-reported)	0.4	1.1	6.0	0.4	-0.4	0.6	-1.6	0.2	-2.4	0.9	0.7	0.7	1.4	-0.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.2	-1.5	-0.3	-1.0	-1.3	0.2	0.0	0.3	0.4	0.5	0.2	0.7	-0.5
Mineral and other dietary supplements	0.4	0.6	1.2	-0.8	-0.6	-0.4	0.5	-0.9	0.0	-1.0	-0.8	-1.1	-1.0	-0.8	0.8
Breast cancer (self-reported)	0.4	0.5	1.5	1.2	0.5	0.8	0.3	0.0	-0.8	0.6	0.9	0.8	1.2	-0.3	-0.5
Medication: Gliclazide	0.4	0.5	1.2	0.1	-0.3	-0.4	-0.4	0.8	-0.8	0.8	0.5	0.9	1.0	0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	6.1	0.9	2.5	0.7	-0.1	1.0	-0.3	-0.1	0.2	-0.0	-0.4	0.8	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.0	1.2	1.4	1.1	-0.3	0.8	-0.1	0.5	0.1	0.6	0.3	0.9	0.2
Commuting to job workplace: Cycle	0.4	0.5	2.7	-0.1	1.0	0.6	-1.3	0.5	-0.4	-0.3	-0.0	-0.1	-0.6	1.7	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	0.8	0.8	1.2	-1.2	-0.2	-1.0	0.3	0.4	0.1	0.4	0.3	0.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	0.8	-0.6	0.7	1.3	-1.1	0.6	-0.8	-0.7	-0.8	-1.0	-1.0	0.9
Triglycerides	0.3	0.5	2.7	0.4	-0.6	0.4	1.0	0.6	0.4	-0.6	0.1	-0.4	-0.8	0.2	1.7
Systolic blood pressure, automated reading	0.3	1.0	2.8	1.7	-0.0	1.6	-1.0	0.3	-1.5	0.8	0.6	0.8	1.1	-0.1	-1.3
Vitamin and mineral supplements	0.3	0.5	2.6	-0.3	-0.1	-0.4	-0.9	0.2	-1.4	0.3	-0.1	0.2	0.4	-0.3	-1.6
Maternal smoking around birth	0.3	0.5	1.6	-0.7	-0.7	-0.7	1.0	-0.0	0.8	-0.5	0.1	-0.4	-0.9	0.5	1.3
Fed-up feelings	0.3	0.5	2.4	1.5	-0.2	1.5	1.0	-0.7	-0.1	-0.2	0.2	-0.0	-0.3	0.1	0.5
Serious illness, injury or assault to yourself	0.3	0.3	1.5	0.6	-0.0	0.3	-0.7	0.8	-0.1	-0.1	-0.3	-0.3	-0.3	0.9	-1.2
High blood pressure	0.3	0.8	4.8	0.0	-0.5	0.2	-1.5	-0.1	-2.2	0.7	0.4	0.4	1.1	-0.4	-0.6
Number of incorrect matches in round	0.3	0.5	1.2	-0.8	-1.0	-0.8	-0.2	0.2	0.7	0.8	0.6	0.7	0.4	0.5	-1.1
Had menopause	0.3	0.4	1.7	-1.3	-0.6	-1.0	0.1	-0.8	-0.1	-0.3	-0.2	-0.6	-0.5	-0.1	0.4
Forced vital capacity (FVC)	0.3	1.0	2.9	-1.2	1.7	-0.3	0.2	-0.9	0.7	-1.0	-0.8	-1.0	-0.8	-1.5	1.3
Allergy	0.3	0.7	2.6	1.3	1.6	0.7	-0.4	0.8	-0.6	0.9	0.6	0.9	1.1	0.3	0.0
Pain all over the body in last month	0.3	0.3	1.3	-1.1	0.1	-1.2	0.2	0.7	0.6	-0.2	-0.4	-0.2	-0.4	-0.0	0.3
Medication: Ramipril	0.3	0.4	2.1	0.3	0.1	0.4	-0.7	0.7	-1.4	-0.0	-0.1	-0.3	-0.3	0.9	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.8	-0.3	0.5	0.4	-0.2	0.7	-0.8	-0.4	-0.6	-0.5	-0.7	0.7
Prospective memory result	0.3	0.4	1.3	0.2	-0.8	-0.1	-0.0	-0.0	-0.8	0.8	0.8	0.4	0.8	-0.1	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.6	0.5	2.1	1.2	-1.1	0.2	-1.4	0.7	0.7	0.6	0.9	-0.5	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	-0.2	-0.9	0.4	-0.9	-0.6	-0.5	-0.5	-0.7	-0.5	-0.3	0.1	1.0
High blood pressure (siblings)	0.3	0.5	4.4	0.6	-2.1	0.2	0.5	-0.2	0.1	-0.5	-0.1	-0.6	-0.4	0.1	-0.1
Comparative body size at age 10	0.3	0.8	2.4	1.1	1.2	0.6	0.7	1.5	0.1	0.6	1.3	0.7	0.5	1.2	-0.4
Worry too long after embarrassment	0.3	0.5	2.8	1.1	0.6	1.7	0.2	0.1	0.4	-0.1	-0.1	-0.3	-0.4	0.5	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.1	0.6	0.9	0.5	-0.1	0.8	-0.7	0.1	-0.8	-1.0	0.0	0.7
Pulse wave peak to peak time	0.3	0.3	1.2	-0.0	0.7	-0.6	1.1	0.3	0.7	0.3	0.5	0.2	0.1	-0.5	-0.8
Medication: Omeprazole	0.3	0.4	1.5	0.5	-1.2	-0.0	0.3	-0.5	-0.3	-0.0	0.0	0.0	0.8	-1.1	-0.9
Heart disease (mother)	0.3	0.3	0.8	-0.2	-0.5	-0.6	0.8	-0.3	0.5	-0.7	-0.5	-0.9	-0.7	-0.5	0.1
Had major operations	0.3	0.4	0.7	0.6	0.6	0.4	-0.8	0.9	-0.8	0.4	0.7	0.5	0.7	0.5	-0.6
Knee pain experienced in last month	0.3	0.5	2.6	-0.4	-1.6	-1.2	0.1	0.5	-0.8	0.3	0.4	0.3	0.4	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.8	0.8	1.0	1.3	-0.4	1.1	-0.9	0.8	0.4	0.7	0.9	0.3	-0.4
Long-standing illness, disability or infirmity	0.3	0.5	1.3	-0.8	-1.0	-0.4	-0.2	0.0	0.6	-0.8	-1.1	-0.9	-0.9	0.7	0.5
Commuting to job workplace: Walk	0.3	0.4	1.6	-0.2	0.9	-0.0	-0.5	1.2	-0.2	0.3	0.9	0.3	-0.3	1.1	-0.1
Smoking status: Current	0.3	0.4	2.7	-0.3	0.5	-0.1	-0.4	1.3	0.1	0.2	0.7	0.3	-0.4	1.7	0.0
Average weekly champagne plus white wine intake	0.3	0.4	1.3	-0.5	0.8	-0.1	-1.1	0.2	-0.2	0.7	0.2	1.1	0.8	-0.5	-0.5
Miserableness	0.3	0.5	2.2	1.5	0.4	1.4	1.0	0.4	0.2	0.5	0.4	0.8	0.4	0.3	-0.3
Medication: Blood pressure	0.3	0.5	2.1	0.1	-1.3	-0.1	-0.8	0.3	-1.4	0.2	-0.5	0.2	0.8	-0.7	-0.9
Average weekly beer plus cider intake	0.3	0.5	1.3	-0.6	-0.6	-0.1	-0.3	1.0	-0.4	0.8	1.1	1.1	0.7	-0.0	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	0.6	-0.2	0.4	-0.9	-0.2	-0.7	-0.6	-1.0	-0.5	-0.2	-0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.6	0.7	-0.2	0.4	-0.1	0.4	-0.6	0.7	0.5	0.7	1.2	-0.1	-1.3
Depression (Nagel 2018)	0.2	0.3	1.8	-0.1	0.1	0.5	-1.3	1.0	-0.4	0.2	0.0	0.2	-0.2	0.3	-0.0
Schizophrenia (2018)	0.2	0.5	2.2	-1.5	-0.2	-1.2	-0.1	1.0	0.6	0.3	1.2	0.3	-0.4	0.0	-0.1
Alzheimer’s Disease (in mother)	0.2	0.2	1.7	0.3	0.1	0.3	0.3	0.3	0.2	-0.5	-0.2	-0.4	-0.6	0.3	1.3
Crohns Disease (2017)	0.2	0.3	1.2	-0.9	-1.1	-0.9	-0.5	-0.5	0.3	-0.4	-0.4	-0.5	-0.3	-0.4	0.1
Major Depression (MDD)	0.2	0.2	1.0	0.3	1.0	0.4	-0.2	-0.4	-0.2	-0.4	-0.3	-0.7	-0.7	0.0	-0.4
Reaction Time	0.2	0.5	3.9	0.4	0.2	0.7	-0.8	0.4	-0.4	0.3	-0.3	0.3	-0.1	2.0	-0.1
Prostate Cancer	0.2	0.3	0.8	0.6	0.6	0.3	-0.1	0.7	0.3	0.3	0.7	0.1	0.3	0.9	-0.8
Age at First Birth	0.2	0.3	1.9	0.4	1.4	-0.0	-0.3	0.5	-0.6	0.6	0.0	0.2	0.4	0.3	-0.8
Body Mass Index (BMI) (2010)	0.2	0.3	2.6	-0.5	-0.3	-0.9	0.4	0.6	0.1	0.4	0.2	0.2	0.2	1.6	-0.1
Mean Putamen Volume	0.2	0.3	0.7	-0.0	0.4	0.1	-0.2	0.8	-0.0	0.8	0.6	0.7	0.5	0.6	-0.6
HDL Cholesterol	0.2	0.3	1.0	0.8	0.1	0.4	0.8	-1.0	0.5	-0.1	-0.7	0.2	0.5	-1.0	-0.3
Smoking Status	0.2	0.5	1.9	-0.9	0.1	-0.1	-1.4	0.7	-0.5	-0.1	0.3	-0.0	-0.6	1.4	0.4
Average weekly spirits intake	0.2	0.2	0.9	-1.0	-0.3	-0.8	-0.0	-0.4	-0.2	-0.3	-0.2	-0.5	-0.5	0.6	0.4
Hearing difficulty/problems: Yes	0.2	0.2	1.2	-0.3	-0.5	-0.3	0.7	0.9	-0.2	0.1	0.1	0.1	-0.3	1.1	-0.3
Supplements: Zinc	0.2	0.2	0.8	-0.6	-0.9	-0.4	-0.0	-0.3	0.5	-0.5	-0.0	-0.5	-0.5	0.4	0.7
Townsend deprivation index at recruitment	0.2	0.3	1.7	-0.4	-0.6	0.0	0.5	0.1	0.5	-0.3	-0.0	-0.2	-0.7	1.3	0.4
Current tobacco smoking	0.2	0.3	1.8	-0.5	0.3	-0.3	-0.2	1.0	0.4	0.0	0.5	0.1	-0.5	1.3	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.9	-0.6	-1.7	-0.3	-0.1	-0.4	-0.1	-0.5	-0.4	-0.5	-0.3	-0.3	-0.9
Hair/balding pattern: Pattern 2	0.2	0.3	1.9	-0.4	-1.4	-0.6	-0.8	-0.6	-0.5	0.0	-0.1	-0.1	0.1	-0.2	0.1
Falls in the last year	0.2	0.2	0.7	0.5	0.3	0.6	-0.1	0.2	-0.7	0.1	-0.3	0.4	0.7	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	6.5	0.2	2.6	0.8	-0.9	0.1	-0.6	0.1	-0.0	0.1	0.4	-0.8	0.1
Noisy workplace	0.2	0.3	0.9	-0.2	-0.7	-0.0	-0.4	-1.0	-0.4	-0.5	-0.8	-0.6	-0.1	-0.8	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.8	-0.2	1.3	-0.4	-1.0	0.9	-0.7	0.0	0.1	-0.2	0.0	0.3	0.2
Depression (self-reported)	0.2	0.2	1.0	0.1	-0.2	0.5	0.8	-0.2	1.0	-0.4	-0.2	-0.3	-0.7	0.3	0.3
Lung cancer (father)	0.2	0.3	1.5	-0.2	0.0	0.2	-0.7	-0.1	-0.1	0.5	0.6	0.5	0.2	0.6	-1.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.8	-0.8	-0.4	-0.4	-0.3	-0.7	0.1	-0.4	-0.9	-0.2	-0.6	0.5	0.2
Headache pain in last month	0.2	0.3	1.4	-0.2	-0.6	-0.1	-0.6	0.0	-1.0	0.2	-0.6	-0.1	-0.1	1.2	0.5
Glaucoma (self-reported)	0.2	0.3	2.5	-0.0	-1.6	-0.1	0.6	0.2	0.5	0.2	-0.2	0.2	0.3	-0.1	0.3
Age at first live birth	0.2	0.4	2.0	0.4	1.2	0.6	-1.4	0.4	-0.6	0.1	0.5	-0.1	0.0	-0.3	-0.5
Medication: Blood pressure	0.2	0.4	1.2	-0.2	0.8	0.4	-0.7	-0.5	-1.1	-0.3	0.2	-0.7	-0.6	1.0	0.3
Migraine (self-reported)	0.2	0.2	0.9	0.6	-0.7	0.4	0.3	-0.1	0.4	-0.4	-1.0	0.1	0.0	-0.4	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.2	-1.1	-0.8	-1.1	0.3	-0.7	0.4	-0.2	0.2	-0.1	0.1	-0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.0	-0.2	0.8	-0.1	-0.4	0.5	-0.7	0.7	0.3	0.9	1.0	-0.2	0.0
Illnesses of father: Heart disease	0.2	0.3	1.3	0.5	1.1	0.3	0.7	0.6	0.3	-0.2	0.2	0.1	-0.2	0.3	0.8
Guilty feelings	0.2	0.3	1.2	-0.3	-0.9	-0.0	1.1	-0.2	0.8	-0.3	-0.5	-0.2	-0.6	0.5	0.3
Unable to work because of sickness or disability	0.2	0.3	0.9	-0.2	-0.3	-0.0	1.0	0.4	0.8	-0.6	-0.5	-0.5	-0.8	0.8	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	4.1	0.0	0.6	-0.2	1.5	0.3	2.0	-0.4	-0.4	-0.0	-0.8	0.6	0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.8	-0.3	0.9	0.0	0.2	0.5	-0.0	0.0	0.7	0.1	-0.3	0.0	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	-0.8	-0.4	-0.4	-0.3	0.5	-0.1	-0.1	0.1	-0.1	-0.4	0.8	0.3
Ovarian Cancer	0.1	0.1	0.5	0.1	-0.2	0.3	-0.0	0.4	-0.0	0.4	0.7	0.2	0.0	0.5	0.1
Bipolar Disorder (2011)	0.1	0.1	0.4	0.1	-0.1	0.4	-0.6	0.3	-0.2	0.0	-0.5	0.2	0.3	0.0	-0.1
Systolic Blood Pressure	0.1	0.6	2.1	0.8	-1.3	0.5	0.4	-1.2	-0.6	-0.2	-0.3	-0.1	0.4	-1.4	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.8	0.3	-0.9	0.9	-0.1	0.4	0.0	0.1	0.2	0.1	-0.1	-0.4	-0.5
Medication: Atenolol	0.1	0.1	0.6	-0.1	0.8	0.4	-0.2	-0.5	-0.4	-0.5	0.1	-0.4	-0.4	-0.3	-0.1
Sitting height	0.1	0.5	1.5	-0.1	1.0	0.8	-0.8	-0.4	-0.9	0.5	0.3	0.5	0.8	-1.2	-0.0
High blood pressure (mother)	0.1	0.2	1.1	0.6	-0.0	0.8	-0.2	-0.2	-0.5	-0.2	-0.3	-0.3	0.2	-1.0	-0.1
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.5	-0.3	0.0	-0.4	-0.6	0.3	-0.0	0.4	-0.0	-0.3	0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.9	0.3	-0.7	0.3	-0.0	0.7	-0.5	-0.0	-0.6	-0.2	-0.3	0.9	-0.0
Pulse rate	0.1	0.2	1.0	0.6	0.0	0.8	-0.2	1.0	0.1	0.3	0.4	0.2	0.0	0.9	-0.0
Illnesses of mother	0.1	0.1	0.5	-0.1	0.0	-0.2	0.6	-0.4	0.6	-0.3	-0.7	-0.1	-0.3	0.2	0.2
Length of working week for main job	0.1	0.1	1.1	1.1	-0.0	0.2	0.4	0.3	-0.1	0.0	-0.2	0.1	0.1	0.1	-0.7
Birth weight	0.1	0.2	0.5	0.2	0.1	0.3	0.1	-0.7	0.7	-0.5	0.3	-0.4	-0.3	-0.5	0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	2.4	-0.7	1.6	0.4	-0.5	-0.9	-0.3	-0.3	-0.1	-0.4	-0.2	-1.2	0.7
Pulse rate, automated reading	0.1	0.2	0.6	0.3	-0.2	0.4	-0.8	0.5	-0.0	0.7	0.3	0.5	0.4	0.7	-0.5
Average weekly red wine intake	0.1	0.1	0.8	-0.1	0.9	0.1	0.5	-0.2	0.3	-0.2	0.2	-0.4	-0.3	0.4	-0.1
Loneliness, isolation	0.1	0.2	0.8	-0.6	-0.5	-0.3	0.3	-0.1	-0.5	0.4	0.9	0.3	-0.0	-0.3	0.1
Hair Pigment	0.0	0.3	2.5	-0.5	-1.6	-0.4	0.1	-0.3	-0.3	-0.1	0.1	-0.1	-0.3	-0.1	0.6

Hub : Genes

PAM

Models

Trait associations