Best TWAS P=5.49e-12 · Best GWAS P=1.26e-12 conditioned to 0.0621
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CTB-36H16.2 | 0.09 | 0.06 | enet | 30 | 0.07 | 3.5e-06 | 6.5 | -6.0 | 2.2e-09 | -0.76 | 0.04 | 0.96 | FALSE |
2 | GTEx | Artery Aorta | CTB-36H16.2 | 0.12 | 0.15 | lasso | 3 | 0.12 | 2.6e-07 | 6.6 | -6.9 | 5.5e-12 | -0.93 | 0.02 | 0.98 | TRUE |
3 | GTEx | Artery Coronary | RN7SL689P | 0.17 | 0.16 | lasso | 13 | 0.14 | 1.8e-05 | -5.8 | 5.8 | 8.9e-09 | 0.61 | 0.81 | 0.08 | FALSE |
4 | GTEx | Artery Tibial | CTB-36H16.2 | 0.15 | 0.12 | lasso | 6 | 0.09 | 8.1e-08 | 6.5 | -6.5 | 7.2e-11 | -0.85 | 0.04 | 0.96 | FALSE |
5 | GTEx | Breast Mammary Tissue | PPIC | 0.06 | 0.06 | lasso | 2 | 0.06 | 8.4e-04 | -5.3 | 5.6 | 1.8e-08 | 0.53 | 0.43 | 0.12 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | PPIC | 0.06 | -0.01 | lasso | 1 | 0.00 | 2.6e-01 | -5.3 | 5.3 | 1.3e-07 | 0.49 | 0.05 | 0.10 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SNX24 | 0.07 | 0.04 | lasso | 3 | 0.04 | 3.0e-04 | -6.0 | 6.1 | 1.1e-09 | 0.62 | 0.72 | 0.16 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | PPIC | 0.11 | 0.08 | enet | 13 | 0.10 | 1.4e-07 | -5.3 | 5.7 | 1.4e-08 | 0.54 | 0.92 | 0.08 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | RP11-359P5.1 | 0.05 | 0.04 | lasso | 4 | 0.02 | 5.9e-03 | -5.3 | 5.3 | 1.2e-07 | 0.50 | 0.46 | 0.05 | FALSE |
10 | GTEx | Colon Transverse | RN7SL689P | 0.12 | 0.03 | lasso | 7 | 0.05 | 3.1e-03 | -5.5 | 5.3 | 1.0e-07 | 0.47 | 0.45 | 0.10 | FALSE |
11 | GTEx | Esophagus Mucosa | PPIC | 0.15 | 0.06 | enet | 35 | 0.07 | 2.3e-05 | -5.3 | 6.0 | 2.0e-09 | 0.54 | 0.81 | 0.08 | FALSE |
12 | GTEx | Esophagus Muscularis | CTB-36H16.2 | 0.08 | 0.08 | lasso | 2 | 0.04 | 1.5e-03 | 6.7 | -6.7 | 2.5e-11 | -0.88 | 0.05 | 0.88 | FALSE |
13 | GTEx | Muscle Skeletal | PPIC | 0.15 | 0.15 | lasso | 3 | 0.16 | 4.6e-15 | -5.3 | 5.5 | 5.0e-08 | 0.49 | 0.99 | 0.01 | FALSE |
14 | GTEx | Nerve Tibial | SNX24 | 0.14 | 0.17 | enet | 20 | 0.17 | 3.6e-12 | -6.2 | 6.6 | 4.8e-11 | 0.67 | 0.58 | 0.42 | FALSE |
15 | GTEx | Ovary | PPIC | 0.28 | 0.07 | lasso | 7 | 0.04 | 3.6e-02 | -5.7 | 6.4 | 1.3e-10 | 0.58 | 0.11 | 0.20 | FALSE |
16 | GTEx | Pancreas | PPIC | 0.25 | 0.12 | lasso | 13 | 0.10 | 4.0e-05 | -5.7 | 5.8 | 4.9e-09 | 0.53 | 0.88 | 0.11 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | PPIC | 0.10 | 0.08 | lasso | 3 | 0.05 | 5.9e-05 | -5.3 | 5.3 | 1.2e-07 | 0.23 | 0.79 | 0.04 | FALSE |
18 | NTR | Blood | PPIC | 0.01 | 0.00 | blup | 443 | 0.00 | 8.7e-03 | -5.2 | -5.9 | 4.6e-09 | -0.70 | 0.15 | 0.47 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPIC | 0.03 | 0.03 | lasso | 2 | 0.02 | 9.1e-04 | -5.3 | 5.5 | 4.2e-08 | 0.49 | 0.11 | 0.24 | FALSE |