TWAS hub - LTC4S

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0494	0.0188	0.00076	0.042	0.017	0.023	0.022	0.024	5.3e-07	0.0012	0.00016	0.00027	0.00015
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0355	0.0265	0.00710	0.001	0.019	0.013	NA	0.012	2.7e-01	0.0026	0.01200	NA	0.01500

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood White Count	5.8	42.8	80.6	2.2	-9.0
Eye problems/disorders: Diabetes related eye disease	5.3	5.8	9.1	3.0	-1.6
Impedance of leg (right)	4.1	19.7	37.5	-6.1	1.4
Illnesses of mother	3.7	4.6	7.2	-1.4	2.7
Alzheimer’s Disease (in mother)	3.3	3.8	4.2	1.8	-2.1
Pack years adult smoking proportion	3.2	4.9	7.2	1.6	-2.7
Type 2 Diabetes (T2D) (2012)	3.1	3.6	3.7	-1.9	1.9
Impedance of leg (left)	3.0	14.7	28.0	-5.3	1.2
Tinnitus: Yes, now most or all of the time	3.0	3.5	4.4	-2.1	1.6
Loneliness, isolation	2.9	4.0	4.2	-2.0	1.9
Hand grip strength (right)	2.8	7.6	11.7	-1.9	3.4
Pack years of smoking	2.8	4.1	5.2	1.7	-2.3
Angina	2.6	3.5	6.0	0.9	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.8	10.7	1.0	-3.3
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	5.6	2.4	-1.1
Angina (self-reported)	2.5	3.3	6.0	0.8	-2.4
Hypothyroidism/myxoedema (self-reported)	2.4	4.8	7.3	-1.5	2.7
Medication: Blood pressure	2.4	4.5	8.9	0.2	-3.0
Medication: Levothyroxine sodium	2.3	3.9	7.6	-0.4	2.8
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	5.1	-1.5	2.3
Heart attack	2.3	3.0	6.0	0.0	-2.4
Breast cancer (self-reported)	2.2	2.6	5.1	-2.3	0.4
Ever taken oral contraceptive pill	2.2	2.4	4.9	2.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.2	2.6	4.4	-2.1	0.9
Heart attack/myocardial infarction (self-reported)	2.2	2.9	5.6	0.4	-2.4
Ever had hysterectomy (womb removed)	2.1	2.4	3.9	-1.0	-2.0
Diabetes (father)	2.1	2.7	3.9	-1.2	2.0
Exposure to tobacco smoke outside home	2.1	2.8	4.2	-2.0	1.2
Suffer from ‘nerves’	2.1	3.2	4.2	-2.0	1.5
Miserableness	2.1	3.7	4.6	-2.1	1.7
Vascular/heart problems diagnosed by doctor	2.1	5.7	11.4	0.0	3.4
Cardiovascular Disease	2.0	6.6	13.0	0.6	-3.6
Hand grip strength (left)	2.0	5.2	8.9	-1.2	3.0
Mouth/teeth dental problems	2.0	3.1	5.0	-1.1	2.2
Mouth/teeth dental problems: Dentures	2.0	3.3	6.6	0.3	-2.6
Worry too long after embarrassment	2.0	3.4	4.8	-2.2	1.4
Medication for cholesterol	2.0	3.1	6.0	-0.4	2.4
Medication: Lisinopril	2.0	2.6	5.0	-0.4	-2.2
Hypothyroidism (self reported)	1.9	4.4	5.9	-1.7	2.4
Sensitivity / hurt feelings	1.9	3.2	3.5	-1.9	1.7
Arm fat percentage (right)	1.9	7.3	13.7	0.9	-3.7
Falls in the last year	1.9	2.6	5.1	0.4	2.2
Pulse wave Arterial Stiffness index	1.9	2.3	2.3	-1.5	1.5
Birth weight of first child	1.9	3.5	4.5	2.1	1.6
Illnesses of siblings: Diabetes	1.9	2.4	4.6	0.4	-2.2
Eye problems/disorders: Cataract	1.9	2.2	2.8	-1.2	1.7
Unable to work because of sickness or disability	1.9	2.5	3.3	1.3	-1.8
Body Mass Index (BMI) (2010)	1.8	2.5	2.8	1.7	-1.5
BMI	1.8	10.3	13.2	2.7	-3.6
Neuroticism	1.8	4.3	5.2	-2.3	1.9
Body mass index (BMI)	1.8	7.7	11.5	2.0	-3.4
Body fat percentage	1.8	7.0	14.0	0.2	-3.7
Pulse wave peak to peak time	1.8	2.1	2.1	1.4	-1.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.1	1.0	-1.8
Neuroticism (Nagel 2018)	1.7	4.0	6.2	-2.5	1.3
Neuroticism (2016)	1.7	2.5	4.0	-2.0	1.0
Frequency of depressed mood in last 2 weeks	1.7	2.4	4.7	0.1	2.2
Diabetes (mother)	1.7	2.1	3.7	0.8	-1.9
Chronic bronchitis/emphysema (father)	1.7	2.0	4.1	0.0	-2.0
Arm fat percentage (left)	1.7	7.0	13.1	0.9	-3.6
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.3	-1.0	1.8
Depressed Affect (Nagel 2018)	1.6	3.4	5.8	-2.4	1.1
Prostate Cancer	1.6	2.3	2.4	-1.5	1.6
Lung FVC	1.6	8.4	16.4	0.5	4.1
Trunk fat percentage	1.6	6.5	12.7	0.4	-3.6
Depression (self-reported)	1.6	1.9	2.6	1.6	-1.1
Number of full sisters	1.6	2.0	3.8	-0.4	-2.0
Mineral and other dietary supplements	1.6	2.1	3.5	0.9	-1.9
Impedance of whole body	1.6	8.0	15.8	-4.0	0.4
Bipolar Disorder or Schizophrenia	1.5	3.6	7.2	0.1	2.7
Worry (Nagel 2018)	1.5	3.1	5.7	-2.4	0.7
Coronary Artery Disease (CAD)	1.5	1.8	2.9	-0.8	1.7
Average weekly spirits intake	1.5	1.9	3.7	-1.9	0.1
Medication: Metformin	1.5	2.1	4.1	-0.3	-2.0
Leg fat percentage (right)	1.5	5.5	9.4	-1.3	-3.1
Emphysema/chronic bronchitis	1.5	1.6	2.5	-0.9	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.5	-0.3	1.9
Arm fat mass (left)	1.5	6.2	10.6	1.3	-3.3
Medication: Atorvastatin	1.5	1.9	3.3	0.6	-1.8
Leg fat percentage (left)	1.5	5.3	10.2	-0.5	-3.2
Cholesterol lowering medication	1.5	2.2	4.4	0.1	-2.1
High blood pressure	1.4	4.0	8.1	-0.1	-2.8
Hair/balding pattern: Pattern 2	1.4	1.7	2.6	-0.9	-1.6
Medication: Simvastatin	1.4	2.1	3.9	0.6	-2.0
Arm fat mass (right)	1.4	5.6	9.8	1.2	-3.1
Number of full brothers	1.4	1.8	3.5	-1.9	0.2
Hypertension (Self-reported)	1.4	3.9	7.8	-0.1	-2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.2	1.0	-1.5
Lupus	1.3	2.0	3.1	1.8	-0.9
Maternal smoking around birth	1.3	1.8	3.6	0.3	-1.9
Waist circumference	1.3	4.8	7.7	1.3	-2.8
Past tobacco smoking	1.3	2.3	4.6	-2.2	-0.1
Medication: Cholesterol lowering	1.3	2.0	3.9	0.2	-2.0
Tense / ‘highly strung’	1.3	2.2	4.4	-2.1	0.3
Headache pain in last month	1.3	2.2	3.4	-1.8	-1.0
Number of children fathered	1.3	1.5	2.0	-1.0	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	1.8	1.2	-1.3
Osteoporosis (self-reported)	1.3	1.7	2.2	1.1	-1.5
Guilty feelings	1.3	1.9	3.7	-0.2	1.9
Basal cell carcinoma (self-reported)	1.3	1.6	3.0	0.5	1.7
Leg fat mass (left)	1.3	5.2	9.9	0.6	-3.1
HDL Cholesterol	1.2	2.0	4.0	-0.0	2.0
Schizophrenia (2014)	1.2	2.7	5.3	0.1	2.3
Average weekly fortified wine intake	1.2	1.4	1.5	-1.2	-1.1
Trunk fat mass	1.2	5.0	9.5	0.7	-3.1
Forced vital capacity (FVC)	1.2	4.6	8.1	-1.0	2.8
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.5	0.3	-2.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	1.7	-1.3	1.1
Neuroticism score	1.2	2.5	3.5	-1.9	1.2
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	8.0	-0.4	2.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	7.7	-0.1	2.8
Comparative body size at age 10	1.2	3.4	4.8	2.2	-1.4
Whole body fat mass	1.2	5.2	9.9	0.7	-3.2
Leg fat mass (right)	1.2	4.6	9.1	0.3	-3.0
Smoking status: Previous	1.2	1.8	3.6	1.9	0.0
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.0	-1.7	-0.4
Alcohol drinker status: Never	1.2	1.4	2.7	-1.6	0.3
Alzheimer’s Disease (in father)	1.1	1.2	2.2	-1.5	0.5
Noisy workplace	1.1	1.4	2.6	-1.6	0.5
Medication: Paracetamol	1.1	1.8	1.9	1.3	-1.4
Medication: Omeprazole	1.1	1.4	2.4	-1.5	0.6
Medication: Aspirin	1.1	1.5	1.6	-1.3	-1.2
Medication: Gliclazide	1.1	1.2	1.4	1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	3.8	0.9	1.9
Illnesses of father: High blood pressure	1.1	1.4	2.2	-1.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	1.8	1.0	1.3
Bipolar Disorder (2018)	1.0	1.6	3.1	0.2	1.8
Schizophrenia (2018)	1.0	2.1	4.2	-0.1	2.0
Multivitamins +/- minerals	1.0	1.2	1.7	-0.9	1.3
Blood clot in the leg (DVT)	1.0	1.3	1.9	0.8	1.4
High blood pressure (siblings)	1.0	1.5	2.9	-1.7	-0.2
Forced vital capacity (FVC), Best measure	1.0	3.8	7.4	-0.5	2.7
Shortness of breath walking on level ground	1.0	1.1	1.9	-1.4	-0.6
Age at last live birth	1.0	1.5	2.3	-0.8	1.5
Leg fat-free mass (right)	1.0	5.4	8.6	2.9	-1.5
Leg predicted mass (right)	1.0	5.5	8.7	3.0	-1.5
Average weekly champagne plus white wine intake	1.0	1.3	1.8	1.0	1.3
Alzheimer’s Disease (including proxy)	0.9	1.3	2.6	0.3	-1.6
Heel T-Score	0.9	7.3	14.1	0.7	-3.8
Systolic Blood Pressure	0.9	4.3	6.9	-2.6	-1.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.2	-0.4	-1.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	1.5	-1.2	-0.8
Stomach or abdominal pain in last month	0.9	1.1	2.3	0.1	-1.5
Medication: Atenolol	0.9	1.2	2.4	0.1	-1.5
Number of incorrect matches in round	0.9	1.5	1.8	1.1	-1.3
Medication: Ramipril	0.9	1.1	1.5	0.9	-1.2
Father’s age at death	0.9	1.2	2.3	-1.5	0.4
Worrier / anxious feelings	0.9	1.8	3.5	-1.9	0.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.6	-0.7	1.6
Leg pain on walking	0.9	1.1	1.3	-1.1	-1.0
Supplements: Vitamin C	0.9	1.1	1.9	1.4	-0.5
Back pain experienced in last month	0.9	1.2	2.5	0.2	-1.6
Osteoarthritis (self-reported)	0.9	1.2	2.0	1.4	0.7
Illnesses of father: None of the above (group 1)	0.9	1.1	1.4	-0.9	1.2
Mother’s age at death	0.9	1.1	2.2	-0.2	1.5
Leg predicted mass (left)	0.8	4.2	5.7	2.4	-1.7
Pulse rate	0.8	1.4	2.2	-0.8	1.5
Happiness	0.8	0.9	1.0	-1.0	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.0	-1.0	1.0
Medication: Lansoprazole	0.8	0.9	1.6	-1.2	0.5
Impedance of arm (left)	0.8	3.7	7.3	-2.7	0.1
Mean time to correctly identify matches	0.8	1.5	2.9	1.7	-0.1
Medication: Aspirin	0.8	1.0	1.2	-1.1	-0.9
Average weekly beer plus cider intake	0.8	1.2	1.6	-0.9	1.3
Heart disease (siblings)	0.8	1.0	2.0	1.4	-0.3
Crohns Disease (2017)	0.7	1.6	2.1	-1.1	-1.4
Age at First Birth	0.7	1.0	1.6	0.7	-1.3
Blood Eosinophil Count	0.7	5.0	6.2	2.0	-2.5
Leg fat-free mass (left)	0.7	3.9	5.3	2.3	-1.6
Allergy	0.7	1.7	3.0	-1.7	0.7
Weight	0.7	3.3	4.9	1.3	-2.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.9	1.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.5	-1.2	0.9
Alcohol intake frequency.	0.7	1.6	2.1	-1.0	-1.4
Knee pain experienced in last month	0.7	1.0	2.0	1.4	-0.3
Illnesses of father: Heart disease	0.7	1.0	1.9	1.4	0.0
Mood swings	0.7	1.2	1.8	-0.8	1.3
Diabetes diagnosed by doctor	0.7	1.1	1.8	-0.6	-1.4
Asthma (self-reported)	0.7	1.5	2.5	1.6	-0.7
High cholesterol (Self-reported)	0.7	1.2	2.4	-0.2	-1.5
Medication: Paracetamol	0.7	1.1	1.8	1.3	-0.7
Number of operations (self-reported)	0.7	1.0	2.0	-1.4	0.1
LDL Cholesterol	0.6	1.0	2.0	-0.2	1.4
Tanning	0.6	7.5	14.1	-1.0	3.8
Relative age of first facial hair	0.6	1.2	1.3	1.0	1.1
Townsend deprivation index at recruitment	0.6	0.8	1.5	1.2	-0.3
Relative age voice broke	0.6	0.9	1.3	-1.1	0.7
Alcohol usually taken with meals	0.6	1.0	1.9	1.4	-0.3
Nervous feelings	0.6	1.2	1.4	-1.2	1.0
Breastfed as a baby	0.6	0.8	1.4	0.3	1.2
Peak expiratory flow (PEF)	0.6	1.3	2.6	-0.0	1.6
Pulse rate, automated reading	0.6	2.0	2.7	1.1	1.6
Long-standing illness, disability or infirmity	0.6	0.9	1.7	-0.3	-1.3
Ever had bowel cancer screening	0.6	0.7	1.2	1.1	-0.4
Friendships satisfaction	0.6	0.8	1.5	-1.2	-0.1
Qualifications: nursing, teaching	0.6	1.0	2.0	1.4	-0.2
Number of self-reported non-cancer illnesses	0.6	1.0	2.1	-0.1	-1.4
Myopia	0.6	0.9	1.8	-0.2	-1.3
Alcohol drinker status: Previous	0.6	0.7	1.3	0.1	-1.2
Irritable Bowel Disease (IBD)	0.5	1.1	2.1	-1.4	-0.3
Reaction Time	0.5	0.9	1.8	1.3	0.0
Crohns Disease (2012)	0.5	0.8	1.1	0.8	-1.0
Mean Putamen Volume	0.5	0.5	0.7	-0.9	0.6
Rheumatoid Arthritis	0.5	0.7	1.1	-0.5	1.0
Ulcerative Colitis	0.5	0.8	0.8	-0.8	0.9
Taking other prescription medications	0.5	0.7	1.2	-1.1	-0.4
Serious illness, injury or assault to yourself	0.5	0.7	1.3	-1.1	-0.2
Impedance of arm (right)	0.5	2.4	4.8	-2.2	-0.3
Hip circumference	0.5	2.1	4.2	0.2	-2.0
Hair/balding pattern: Pattern 3	0.5	0.8	0.8	0.9	0.9
Asthma	0.5	1.0	1.8	1.3	-0.4
Lung cancer (father)	0.5	0.6	1.0	-1.0	0.4
Glaucoma (self-reported)	0.5	0.6	0.9	-0.6	-0.9
Medication: Amlodipine	0.5	0.6	1.2	-0.3	-1.1
Birth weight	0.5	1.2	2.4	-0.0	1.5
Neck or shoulder pain in last month	0.5	0.7	1.1	-0.5	-1.1
Migraine (self-reported)	0.5	0.6	0.7	0.6	-0.9
Heart disease (mother)	0.5	0.6	1.1	0.1	-1.0
Overall health rating	0.5	1.1	1.3	-1.1	-1.0
Financial situation satisfaction	0.5	0.6	0.9	-0.4	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.9	-0.5	0.9
Ever depressed for a whole week	0.5	0.6	1.1	-1.1	0.2
Supplements: Calcium	0.5	0.5	1.0	-0.2	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.4	1.5	1.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	-0.0	-1.4
Allergy or Eczema	0.4	1.2	2.1	1.4	-0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.7	-0.6	-0.8
Systolic blood pressure, automated reading	0.4	1.1	1.2	-1.1	-1.1
Supplements: Zinc	0.4	0.4	0.8	0.9	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.0	-0.1	1.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.1	1.1	-0.6
Supplements: Glucosamine	0.4	0.6	1.0	-0.3	1.0
Qualifications: None of the above	0.4	0.8	1.7	-0.0	-1.3
Diabetes (self-reported)	0.4	0.6	1.1	-1.0	-0.2
Illnesses of siblings	0.4	0.6	1.1	-0.2	1.1
Standing height	0.4	4.3	5.4	-1.8	2.3
Gout (self-reported)	0.4	0.6	0.7	-0.8	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.6	-0.8	-0.7
Qualifications: College or University degree	0.4	1.3	1.8	0.9	1.3
Medication: Blood pressure	0.4	0.8	1.3	0.5	-1.1
Medication: Seretide 50 evohaler	0.4	0.4	0.8	0.9	0.2
Whole body fat-free mass	0.4	2.1	3.4	1.9	-0.9
Whole body water mass	0.4	2.1	3.6	1.9	-0.8
Commuting to job workplace: Public transport	0.4	0.4	0.7	0.8	0.5
Ever smoked	0.4	0.7	1.4	1.2	-0.0
Basal metabolic rate	0.4	2.2	2.7	1.6	-1.3
Ovarian Cancer	0.3	0.4	0.7	0.8	-0.4
Height	0.3	6.0	10.1	-1.4	3.2
Respiratory disease	0.3	0.6	0.8	0.5	-0.9
Chronotype (morning person)	0.3	0.7	0.9	1.0	-0.7
Number of treatments/medications taken	0.3	0.5	0.6	-0.6	-0.7
Vitamin and mineral supplements	0.3	0.4	0.4	-0.6	-0.7
Fed-up feelings	0.3	0.6	1.1	-1.1	0.0
Prospective memory result	0.3	0.3	0.5	0.4	-0.7
Length of working week for main job	0.3	0.3	0.4	-0.7	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	1.0	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	0.7	0.4	0.9
Family relationship satisfaction	0.3	0.3	0.7	-0.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	-0.8	0.4
Average weekly red wine intake	0.3	0.4	0.5	0.7	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.7	0.8	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	-0.8	-0.4
Medication: Bendroflumethiazide	0.3	0.4	0.8	0.1	-0.9
Arm fat-free mass (left)	0.3	1.6	2.2	1.5	-1.1
Arm predicted mass (left)	0.3	1.6	2.1	1.4	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.1	-0.7
Breast Cancer	0.2	0.4	0.5	-0.7	-0.6
Blood Platelet Count	0.2	2.8	5.4	-2.3	-0.3
Lung FEV1/FVC ratio	0.2	1.1	1.4	1.2	0.9
Severe depression (siblings)	0.2	0.2	0.2	-0.5	0.4
Age when periods started (menarche)	0.2	0.5	0.8	0.9	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.1	-0.7
Sitting height	0.2	1.4	2.3	-0.6	1.5
High blood pressure (mother)	0.2	0.3	0.5	-0.2	-0.7
Had menopause	0.2	0.3	0.4	-0.3	-0.6
Financial difficulties in last 2 years	0.2	0.3	0.6	0.2	0.7
Fluid intelligence score	0.2	0.4	0.4	0.6	-0.6
Time employed in main current job	0.2	0.2	0.5	-0.7	0.1
Alcohol intake versus 10 years previously	0.2	0.2	0.3	-0.4	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	0.5	0.7	0.7
Pulse wave reflection index	0.2	0.2	0.4	-0.6	-0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.4	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.7	0.1
Arm fat-free mass (right)	0.2	1.2	2.0	1.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.0	0.8
Age at first live birth	0.2	0.4	0.6	0.7	0.6
Health satisfaction	0.2	0.3	0.3	-0.6	-0.5
Medication: Allopurinol	0.2	0.2	0.4	-0.0	0.6
Arm predicted mass (right)	0.2	1.0	1.7	1.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.4	0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	0.8	0.3
Wears glasses or contact lenses	0.2	0.2	0.2	0.5	0.4
Risk taking	0.2	0.3	0.6	0.2	0.7
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.7	0.0
Pain experienced in last month	0.2	0.3	0.5	0.7	0.2
Depression (Nagel 2018)	0.1	0.2	0.4	0.0	0.6
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.6	0.3
Major Depression (MDD)	0.1	0.1	0.2	-0.5	0.1
Fasting Glucose	0.1	0.1	0.2	0.5	-0.2
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.1	-0.4
Blood Red Count	0.1	1.3	2.7	-0.0	-1.6
Smoking Status	0.1	0.2	0.3	0.6	0.2
Hair Pigment	0.1	2.3	2.4	-1.6	1.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.3	0.2
Current tobacco smoking	0.1	0.2	0.3	-0.6	0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.4	-0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.3	-0.3
Pain all over the body in last month	0.1	0.1	0.1	-0.3	0.1
Trunk fat-free mass	0.1	0.6	1.2	1.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.5	0.2
Number of live births	0.1	0.1	0.1	-0.3	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.4	0.1
Trunk predicted mass	0.1	0.6	1.2	1.1	-0.0
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	0.0
Eye problems/disorders: None of the above	0.1	0.2	0.3	0.1	-0.5
Medication: Ibuprofen	0.1	0.1	0.2	-0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.2	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.5	0.0
Smoking status: Current	0.1	0.2	0.3	-0.5	0.4
Hearing aid user	0.1	0.2	0.2	-0.4	0.4
Irritability	0.1	0.1	0.2	-0.4	-0.1
Fractured/broken bones in last 5 years	0.1	0.2	0.2	0.4	0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.4	0.4	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	0.1	0.0
Triglycerides	0.0	0.0	0.1	-0.0	-0.3
Waist Hip Ratio (WHR)	0.0	0.1	0.3	-0.0	-0.5
Hearing difficulty/problems: Yes	0.0	0.1	0.1	-0.0	-0.3
Medication for hormone replacement therapy	0.0	0.1	0.1	-0.0	-0.3
Medication: Co-codamol	0.0	0.0	0.0	-0.2	-0.1
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.2	0.1
Had other major operations	0.0	0.1	0.1	-0.2	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.1	-0.3
Loud music exposure frequency	0.0	0.0	0.1	0.3	-0.1
Comparative height size at age 10	0.0	0.3	0.4	0.7	0.3
Chest pain or discomfort	0.0	0.0	0.0	-0.2	-0.1
Had major operations	0.0	0.1	0.1	-0.2	0.3
Age started oral contraceptive pill	0.0	0.0	0.1	0.0	0.3

Hub : Genes

LTC4S

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Trait associations