Hub : Genes

LTC4S

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0494 0.0188 0.00076 0.042 0.017 0.023 0.022 0.024 5.3e-07 0.0012 0.00016 0.00027 0.00015
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0355 0.0265 0.00710 0.001 0.019 0.013 NA 0.012 2.7e-01 0.0026 0.01200 NA 0.01500

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.0 1.6 3.1 0.2 1.8
Bipolar Disorder or Schizophrenia 1.5 3.6 7.2 0.1 2.7
Depressed Affect (Nagel 2018) 1.6 3.4 5.8 -2.4 1.1
Depression (Nagel 2018) 0.1 0.2 0.4 0.0 0.6
Intelligence (Savage-Jansen 2018) 0.4 1.4 1.5 1.2 -1.1
Neuroticism (Nagel 2018) 1.7 4.0 6.2 -2.5 1.3
Schizophrenia (2018) 1.0 2.1 4.2 -0.1 2.0
Schizophrenia vs Biploar Disorder 0.2 0.2 0.4 0.1 -0.7
Worry (Nagel 2018) 1.5 3.1 5.7 -2.4 0.7
Alzheimer’s Disease (in mother) 3.3 3.8 4.2 1.8 -2.1
Alzheimer’s Disease (in father) 1.1 1.2 2.2 -1.5 0.5
Alzheimer’s Disease (including proxy) 0.9 1.3 2.6 0.3 -1.6
Crohns Disease (2017) 0.7 1.6 2.1 -1.1 -1.4
Irritable Bowel Disease (IBD) 0.5 1.1 2.1 -1.4 -0.3
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.6 0.3
Major Depression (MDD) 0.1 0.1 0.2 -0.5 0.1
Reaction Time 0.5 0.9 1.8 1.3 0.0
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.1 -0.0 -1.4
Breast Cancer 0.2 0.4 0.5 -0.7 -0.6
Ovarian Cancer 0.3 0.4 0.7 0.8 -0.4
Prostate Cancer 1.6 2.3 2.4 -1.5 1.6
Age at First Birth 0.7 1.0 1.6 0.7 -1.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.8 2.5 2.8 1.7 -1.5
Coronary Artery Disease (CAD) 1.5 1.8 2.9 -0.8 1.7
Crohns Disease (2012) 0.5 0.8 1.1 0.8 -1.0
Mean Putamen Volume 0.5 0.5 0.7 -0.9 0.6
Fasting Glucose 0.1 0.1 0.2 0.5 -0.2
HbA1C 0.0 0.0 0.0 0.1 0.0
HDL Cholesterol 1.2 2.0 4.0 -0.0 2.0
LDL Cholesterol 0.6 1.0 2.0 -0.2 1.4
Lupus 1.3 2.0 3.1 1.8 -0.9
Neuroticism (2016) 1.7 2.5 4.0 -2.0 1.0
Primary Biliary Cirrhosis 0.1 0.1 0.2 0.1 -0.4
Rheumatoid Arthritis 0.5 0.7 1.1 -0.5 1.0
Schizophrenia (2014) 1.2 2.7 5.3 0.1 2.3
Triglycerides 0.0 0.0 0.1 -0.0 -0.3
Type 2 Diabetes (T2D) (2012) 3.1 3.6 3.7 -1.9 1.9
Ulcerative Colitis 0.5 0.8 0.8 -0.8 0.9
Blood Eosinophil Count 0.7 5.0 6.2 2.0 -2.5
Blood Platelet Count 0.2 2.8 5.4 -2.3 -0.3
Blood Red Count 0.1 1.3 2.7 -0.0 -1.6
Blood White Count 5.8 42.8 80.6 2.2 -9.0
Heel T-Score 0.9 7.3 14.1 0.7 -3.8
BMI 1.8 10.3 13.2 2.7 -3.6
Height 0.3 6.0 10.1 -1.4 3.2
Waist Hip Ratio (WHR) 0.0 0.1 0.3 -0.0 -0.5
Systolic Blood Pressure 0.9 4.3 6.9 -2.6 -1.3
Smoking Status 0.1 0.2 0.3 0.6 0.2
Allergy or Eczema 0.4 1.2 2.1 1.4 -0.5
Cardiovascular Disease 2.0 6.6 13.0 0.6 -3.6
Hypothyroidism (self reported) 1.9 4.4 5.9 -1.7 2.4
Respiratory disease 0.3 0.6 0.8 0.5 -0.9
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.2 -0.4 -1.8
Lung FEV1/FVC ratio 0.2 1.1 1.4 1.2 0.9
Lung FVC 1.6 8.4 16.4 0.5 4.1
Neuroticism 1.8 4.3 5.2 -2.3 1.9
Chronotype (morning person) 0.3 0.7 0.9 1.0 -0.7
Hair Pigment 0.1 2.3 2.4 -1.6 1.5
Tanning 0.6 7.5 14.1 -1.0 3.8
Hand grip strength (left) 2.0 5.2 8.9 -1.2 3.0
Number of treatments/medications taken 0.3 0.5 0.6 -0.6 -0.7
Average weekly spirits intake 1.5 1.9 3.7 -1.9 0.1
Sensitivity / hurt feelings 1.9 3.2 3.5 -1.9 1.7
Frequency of depressed mood in last 2 weeks 1.7 2.4 4.7 0.1 2.2
Hearing difficulty/problems: Yes 0.0 0.1 0.1 -0.0 -0.3
Relative age of first facial hair 0.6 1.2 1.3 1.0 1.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.1 0.3 0.2
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.7 -0.6 -0.8
Ever had hysterectomy (womb removed) 2.1 2.4 3.9 -1.0 -2.0
Systolic blood pressure, automated reading 0.4 1.1 1.2 -1.1 -1.1
Eye problems/disorders: Diabetes related eye disease 5.3 5.8 9.1 3.0 -1.6
Angina 2.6 3.5 6.0 0.9 -2.5
Medication for hormone replacement therapy 0.0 0.1 0.1 -0.0 -0.3
Vitamin and mineral supplements 0.3 0.4 0.4 -0.6 -0.7
Supplements: Zinc 0.4 0.4 0.8 0.9 0.3
Medication: Co-codamol 0.0 0.0 0.0 -0.2 -0.1
Medication: Metformin 1.5 2.1 4.1 -0.3 -2.0
Diabetes (father) 2.1 2.7 3.9 -1.2 2.0
Diabetes (mother) 1.7 2.1 3.7 0.8 -1.9
Severe depression (siblings) 0.2 0.2 0.2 -0.5 0.4
Pack years adult smoking proportion 3.2 4.9 7.2 1.6 -2.7
Impedance of leg (right) 4.1 19.7 37.5 -6.1 1.4
Leg fat-free mass (left) 0.7 3.9 5.3 2.3 -1.6
Trunk fat percentage 1.6 6.5 12.7 0.4 -3.6
Hand grip strength (right) 2.8 7.6 11.7 -1.9 3.4
Townsend deprivation index at recruitment 0.6 0.8 1.5 1.2 -0.3
Current tobacco smoking 0.1 0.2 0.3 -0.6 0.0
Average weekly fortified wine intake 1.2 1.4 1.5 -1.2 -1.1
Maternal smoking around birth 1.3 1.8 3.6 0.3 -1.9
Fed-up feelings 0.3 0.6 1.1 -1.1 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.0 -0.1 1.0
Relative age voice broke 0.6 0.9 1.3 -1.1 0.7
Taking other prescription medications 0.5 0.7 1.2 -1.1 -0.4
Age when periods started (menarche) 0.2 0.5 0.8 0.9 -0.3
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 1.5 -1.2 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 2.6 5.8 10.7 1.0 -3.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.4 -0.3
Qualifications: CSEs or equivalent 0.1 0.1 0.1 0.3 -0.3
Serious illness, injury or assault to yourself 0.5 0.7 1.3 -1.1 -0.2
High blood pressure 1.4 4.0 8.1 -0.1 -2.8
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.1 1.1 -0.6
Multivitamins +/- minerals 1.0 1.2 1.7 -0.9 1.3
Stomach or abdominal pain in last month 0.9 1.1 2.3 0.1 -1.5
Supplements: Glucosamine 0.4 0.6 1.0 -0.3 1.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.1 -0.7
Medication: Atenolol 0.9 1.2 2.4 0.1 -1.5
Medication: Levothyroxine sodium 2.3 3.9 7.6 -0.4 2.8
Sitting height 0.2 1.4 2.3 -0.6 1.5
Chronic bronchitis/emphysema (father) 1.7 2.0 4.1 0.0 -2.0
High blood pressure (mother) 0.2 0.3 0.5 -0.2 -0.7
Body mass index (BMI) 1.8 7.7 11.5 2.0 -3.4
Impedance of leg (left) 3.0 14.7 28.0 -5.3 1.2
Leg predicted mass (left) 0.8 4.2 5.7 2.4 -1.7
Trunk fat mass 1.2 5.0 9.5 0.7 -3.1
Waist circumference 1.3 4.8 7.7 1.3 -2.8
Number of incorrect matches in round 0.9 1.5 1.8 1.1 -1.3
Past tobacco smoking 1.3 2.3 4.6 -2.2 -0.1
Alcohol usually taken with meals 0.6 1.0 1.9 1.4 -0.3
Nervous feelings 0.6 1.2 1.4 -1.2 1.0
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 5.1 -1.5 2.3
Hearing difficulty/problems with background noise 0.0 0.0 0.0 0.2 0.1
Hair/balding pattern: Pattern 2 1.4 1.7 2.6 -0.9 -1.6
Had menopause 0.2 0.3 0.4 -0.3 -0.6
Had other major operations 0.0 0.1 0.1 -0.2 0.2
Forced vital capacity (FVC) 1.2 4.6 8.1 -1.0 2.8
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 5.5 0.3 -2.3
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 1.7 -1.3 1.1
Qualifications: None of the above 0.4 0.8 1.7 -0.0 -1.3
Financial difficulties in last 2 years 0.2 0.3 0.6 0.2 0.7
Mouth/teeth dental problems 2.0 3.1 5.0 -1.1 2.2
Heart attack 2.3 3.0 6.0 0.0 -2.4
Allergy 0.7 1.7 3.0 -1.7 0.7
Pain all over the body in last month 0.1 0.1 0.1 -0.3 0.1
Diabetes (self-reported) 0.4 0.6 1.1 -1.0 -0.2
Hayfever/allergic rhinitis (self-reported) 2.6 3.4 5.6 2.4 -1.1
Medication: Ramipril 0.9 1.1 1.5 0.9 -1.2
Medication: Simvastatin 1.4 2.1 3.9 0.6 -2.0
Fluid intelligence score 0.2 0.4 0.4 0.6 -0.6
Illnesses of siblings 0.4 0.6 1.1 -0.2 1.1
Neuroticism score 1.2 2.5 3.5 -1.9 1.2
Weight 0.7 3.3 4.9 1.3 -2.2
Impedance of arm (right) 0.5 2.4 4.8 -2.2 -0.3
Arm fat percentage (right) 1.9 7.3 13.7 0.9 -3.7
Trunk fat-free mass 0.1 0.6 1.2 1.1 -0.1
Hip circumference 0.5 2.1 4.2 0.2 -2.0
Time employed in main current job 0.2 0.2 0.5 -0.7 0.1
Alcohol intake versus 10 years previously 0.2 0.2 0.3 -0.4 -0.6
Father’s age at death 0.9 1.2 2.3 -1.5 0.4
Worrier / anxious feelings 0.9 1.8 3.5 -1.9 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.3 -0.5 0.2
Falls in the last year 1.9 2.6 5.1 0.4 2.2
Hair/balding pattern: Pattern 3 0.5 0.8 0.8 0.9 0.9
Number of live births 0.1 0.1 0.1 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 8.0 -0.4 2.8
Pulse rate 0.8 1.4 2.2 -0.8 1.5
Happiness 0.8 0.9 1.0 -1.0 0.9
Noisy workplace 1.1 1.4 2.6 -1.6 0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.9 1.7 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 0.4 0.1
Mouth/teeth dental problems: Dentures 2.0 3.3 6.6 0.3 -2.6
Asthma 0.5 1.0 1.8 1.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.0 -1.0 1.0
Medication: Cholesterol lowering 1.3 2.0 3.9 0.2 -2.0
Depression (self-reported) 1.6 1.9 2.6 1.6 -1.1
Medication: Lansoprazole 0.8 0.9 1.6 -1.2 0.5
Prospective memory result 0.3 0.3 0.5 0.4 -0.7
Lung cancer (father) 0.5 0.6 1.0 -1.0 0.4
Illnesses of mother 3.7 4.6 7.2 -1.4 2.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 7.7 -0.1 2.8
Pulse wave Arterial Stiffness index 1.9 2.3 2.3 -1.5 1.5
Impedance of arm (left) 0.8 3.7 7.3 -2.7 0.1
Arm fat mass (right) 1.4 5.6 9.8 1.2 -3.1
Trunk predicted mass 0.1 0.6 1.2 1.1 -0.0
Standing height 0.4 4.3 5.4 -1.8 2.3
Length of working week for main job 0.3 0.3 0.4 -0.7 0.5
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.5 -0.1
Breastfed as a baby 0.6 0.8 1.4 0.3 1.2
Tense / ‘highly strung’ 1.3 2.2 4.4 -2.1 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.5 -1.2 0.9
Hair/balding pattern: Pattern 4 0.2 0.5 0.5 0.7 0.7
Birth weight of first child 1.9 3.5 4.5 2.1 1.6
Peak expiratory flow (PEF) 0.6 1.3 2.6 -0.0 1.6
Pulse wave reflection index 0.2 0.2 0.4 -0.6 -0.2
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.1 -0.3
Loud music exposure frequency 0.0 0.0 0.1 0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 0.4 -0.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.4 0.4 -0.6
Blood clot in the leg (DVT) 1.0 1.3 1.9 0.8 1.4
Medication: Paracetamol 1.1 1.8 1.9 1.3 -1.4
Headache pain in last month 1.3 2.2 3.4 -1.8 -1.0
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 2.6 -0.7 1.6
Glaucoma (self-reported) 0.5 0.6 0.9 -0.6 -0.9
Gout (self-reported) 0.4 0.6 0.7 -0.8 0.6
Hypothyroidism/myxoedema (self-reported) 2.4 4.8 7.3 -1.5 2.7
Medication: Amlodipine 0.5 0.6 1.2 -0.3 -1.1
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.4 0.7 0.1
Birth weight 0.5 1.2 2.4 -0.0 1.5
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.6 -0.8 -0.7
High blood pressure (siblings) 1.0 1.5 2.9 -1.7 -0.2
Forced vital capacity (FVC), Best measure 1.0 3.8 7.4 -0.5 2.7
Body fat percentage 1.8 7.0 14.0 0.2 -3.7
Leg fat percentage (right) 1.5 5.5 9.4 -1.3 -3.1
Arm fat-free mass (right) 0.2 1.2 2.0 1.4 -0.7
Exposure to tobacco smoke outside home 2.1 2.8 4.2 -2.0 1.2
Comparative body size at age 10 1.2 3.4 4.8 2.2 -1.4
Number of full brothers 1.4 1.8 3.5 -1.9 0.2
Worry too long after embarrassment 2.0 3.4 4.8 -2.2 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.0 0.8
Wheeze or whistling in the chest in last year 0.3 0.5 0.9 1.0 -0.4
Number of children fathered 1.3 1.5 2.0 -1.0 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 -0.4 0.0
Age at first live birth 0.2 0.4 0.6 0.7 0.6
Pulse wave peak to peak time 1.8 2.1 2.1 1.4 -1.4
Health satisfaction 0.2 0.3 0.3 -0.6 -0.5
Shortness of breath walking on level ground 1.0 1.1 1.9 -1.4 -0.6
Qualifications: College or University degree 0.4 1.3 1.8 0.9 1.3
Eye problems/disorders: None of the above 0.1 0.2 0.3 0.1 -0.5
Mouth/teeth dental problems: Loose teeth 1.8 2.1 3.1 1.0 -1.8
Emphysema/chronic bronchitis 1.5 1.6 2.5 -0.9 1.6
Medication for pain relief, constipation, heartburn 0.3 0.5 0.7 0.4 0.9
Neck or shoulder pain in last month 0.5 0.7 1.1 -0.5 -1.1
Medication: Blood pressure 0.4 0.8 1.3 0.5 -1.1
Angina (self-reported) 2.5 3.3 6.0 0.8 -2.4
Migraine (self-reported) 0.5 0.6 0.7 0.6 -0.9
Medication: Ibuprofen 0.1 0.1 0.2 -0.3 0.5
Medication: Allopurinol 0.2 0.2 0.4 -0.0 0.6
Medication: Omeprazole 1.1 1.4 2.4 -1.5 0.6
Medication: Seretide 50 evohaler 0.4 0.4 0.8 0.9 0.2
Mean time to correctly identify matches 0.8 1.5 2.9 1.7 -0.1
Heart disease (mother) 0.5 0.6 1.1 0.1 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 3.5 -0.3 1.9
Whole body fat mass 1.2 5.2 9.9 0.7 -3.2
Leg fat mass (right) 1.2 4.6 9.1 0.3 -3.0
Arm predicted mass (right) 0.2 1.0 1.7 1.3 -0.6
Pulse rate, automated reading 0.6 2.0 2.7 1.1 1.6
Alcohol intake frequency. 0.7 1.6 2.1 -1.0 -1.4
Comparative height size at age 10 0.0 0.3 0.4 0.7 0.3
Number of full sisters 1.6 2.0 3.8 -0.4 -2.0
Suffer from ‘nerves’ 2.1 3.2 4.2 -2.0 1.5
Overall health rating 0.5 1.1 1.3 -1.1 -1.0
Chest pain or discomfort 0.0 0.0 0.0 -0.2 -0.1
Had major operations 0.0 0.1 0.1 -0.2 0.3
Age at last live birth 1.0 1.5 2.3 -0.8 1.5
Family relationship satisfaction 0.3 0.3 0.7 -0.1 0.8
Leg pain on walking 0.9 1.1 1.3 -1.1 -1.0
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 1.8 1.2 -1.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 0.1 -0.6
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.2 0.4
Medication: Aspirin 0.8 1.0 1.2 -1.1 -0.9
Supplements: Vitamin C 0.9 1.1 1.9 1.4 -0.5
Knee pain experienced in last month 0.7 1.0 2.0 1.4 -0.3
Hypertension (Self-reported) 1.4 3.9 7.8 -0.1 -2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.6 -0.8 0.4
Illnesses of father: Heart disease 0.7 1.0 1.9 1.4 0.0
Illnesses of siblings: Diabetes 1.9 2.4 4.6 0.4 -2.2
Smoking status: Previous 1.2 1.8 3.6 1.9 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.7 -0.4 0.9
Whole body fat-free mass 0.4 2.1 3.4 1.9 -0.9
Leg fat-free mass (right) 1.0 5.4 8.6 2.9 -1.5
Arm fat percentage (left) 1.7 7.0 13.1 0.9 -3.6
Average weekly red wine intake 0.3 0.4 0.5 0.7 0.5
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.1 -0.4
Mood swings 0.7 1.2 1.8 -0.8 1.3
Loneliness, isolation 2.9 4.0 4.2 -2.0 1.9
Long-standing illness, disability or infirmity 0.6 0.9 1.7 -0.3 -1.3
Ever had bowel cancer screening 0.6 0.7 1.2 1.1 -0.4
Diabetes diagnosed by doctor 0.7 1.1 1.8 -0.6 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.7 0.8 0.3
Friendships satisfaction 0.6 0.8 1.5 -1.2 -0.1
Qualifications: nursing, teaching 0.6 1.0 2.0 1.4 -0.2
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.5 0.0
Eye problems/disorders: Cataract 1.9 2.2 2.8 -1.2 1.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.7 0.8 0.3
Medication for cholesterol 2.0 3.1 6.0 -0.4 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 2.2 1.0 -1.5
Back pain experienced in last month 0.9 1.2 2.5 0.2 -1.6
Mineral and other dietary supplements 1.6 2.1 3.5 0.9 -1.9
Breast cancer (self-reported) 2.2 2.6 5.1 -2.3 0.4
Asthma (self-reported) 0.7 1.5 2.5 1.6 -0.7
Osteoporosis (self-reported) 1.3 1.7 2.2 1.1 -1.5
Osteoarthritis (self-reported) 0.9 1.2 2.0 1.4 0.7
Medication: Aspirin 1.1 1.5 1.6 -1.3 -1.2
Medication: Gliclazide 1.1 1.2 1.4 1.2 -1.0
Illnesses of father: None of the above (group 1) 0.9 1.1 1.4 -0.9 1.2
Smoking status: Current 0.1 0.2 0.3 -0.5 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 3.8 0.9 1.9
Whole body water mass 0.4 2.1 3.6 1.9 -0.8
Leg predicted mass (right) 1.0 5.5 8.7 3.0 -1.5
Arm fat mass (left) 1.5 6.2 10.6 1.3 -3.3
Number of self-reported non-cancer illnesses 0.6 1.0 2.1 -0.1 -1.4
Average weekly champagne plus white wine intake 1.0 1.3 1.8 1.0 1.3
Miserableness 2.1 3.7 4.6 -2.1 1.7
Guilty feelings 1.3 1.9 3.7 -0.2 1.9
Wears glasses or contact lenses 0.2 0.2 0.2 0.5 0.4
Ever taken oral contraceptive pill 2.2 2.4 4.9 2.2 -0.1
Hearing aid user 0.1 0.2 0.2 -0.4 0.4
Mother’s age at death 0.9 1.1 2.2 -0.2 1.5
Financial situation satisfaction 0.5 0.6 0.9 -0.4 -1.0
Tinnitus: Yes, now most or all of the time 3.0 3.5 4.4 -2.1 1.6
Commuting to job workplace: Public transport 0.4 0.4 0.7 0.8 0.5
Eye problems/disorders: Glaucoma 0.3 0.4 0.6 -0.8 -0.4
Medication: Blood pressure 2.4 4.5 8.9 0.2 -3.0
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.0 -1.7 -0.4
Supplements: Fish oil (including cod liver oil) 1.7 2.2 3.3 -1.0 1.8
High cholesterol (Self-reported) 0.7 1.2 2.4 -0.2 -1.5
Medication: Bendroflumethiazide 0.3 0.4 0.8 0.1 -0.9
Medication: Paracetamol 0.7 1.1 1.8 1.3 -0.7
Medication: Lisinopril 2.0 2.6 5.0 -0.4 -2.2
Medication: Atorvastatin 1.5 1.9 3.3 0.6 -1.8
Illnesses of father: High blood pressure 1.1 1.4 2.2 -1.5 -0.7
Alcohol drinker status: Never 1.2 1.4 2.7 -1.6 0.3
Ever smoked 0.4 0.7 1.4 1.2 -0.0
Basal metabolic rate 0.4 2.2 2.7 1.6 -1.3
Leg fat percentage (left) 1.5 5.3 10.2 -0.5 -3.2
Arm fat-free mass (left) 0.3 1.6 2.2 1.5 -1.1
Number of operations (self-reported) 0.7 1.0 2.0 -1.4 0.1
Average weekly beer plus cider intake 0.8 1.2 1.6 -0.9 1.3
Irritability 0.1 0.1 0.2 -0.4 -0.1
Risk taking 0.2 0.3 0.6 0.2 0.7
Ever had prostate specific antigen (PSA) test 0.5 0.6 0.9 -0.5 0.9
Fractured/broken bones in last 5 years 0.1 0.2 0.2 0.4 0.4
Age started oral contraceptive pill 0.0 0.0 0.1 0.0 0.3
Diastolic blood pressure, automated reading 0.1 0.3 0.4 0.4 -0.6
Ever depressed for a whole week 0.5 0.6 1.1 -1.1 0.2
Unable to work because of sickness or disability 1.9 2.5 3.3 1.3 -1.8
Commuting to job workplace: Cycle 0.2 0.3 0.5 0.7 0.0
Myopia 0.6 0.9 1.8 -0.2 -1.3
Vascular/heart problems diagnosed by doctor 2.1 5.7 11.4 0.0 3.4
Cholesterol lowering medication 1.5 2.2 4.4 0.1 -2.1
Medication: Omeprazole (e.g. Zanprol) 2.2 2.6 4.4 -2.1 0.9
Pain experienced in last month 0.2 0.3 0.5 0.7 0.2
Supplements: Calcium 0.5 0.5 1.0 -0.2 1.0
Basal cell carcinoma (self-reported) 1.3 1.6 3.0 0.5 1.7
Heart attack/myocardial infarction (self-reported) 2.2 2.9 5.6 0.4 -2.4
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 1.8 1.0 1.3
Heart disease (siblings) 0.8 1.0 2.0 1.4 -0.3
Alcohol drinker status: Previous 0.6 0.7 1.3 0.1 -1.2
Pack years of smoking 2.8 4.1 5.2 1.7 -2.3
Impedance of whole body 1.6 8.0 15.8 -4.0 0.4
Leg fat mass (left) 1.3 5.2 9.9 0.6 -3.1
Arm predicted mass (left) 0.3 1.6 2.1 1.4 -1.1