Hub : Genes

HMGB3P22

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0950 0.0380 0.00540 0.003 NA 0.009 NA 0.010 1.6e-01 NA 5.8e-02 NA 4.9e-02
2 ROSMAP Brain Pre-frontal Cortex 0.0823 0.0254 0.00004 0.045 0.029 0.043 0.029 0.044 1.8e-06 0.00012 3.0e-06 9.7e-05 2.4e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.7 1.2 2.4 1.5 0.0
Bipolar Disorder or Schizophrenia 1.7 4.1 8.2 2.9 0.0
Depressed Affect (Nagel 2018) 0.8 1.8 1.9 -1.3 -1.4
Depression (Nagel 2018) 0.7 1.1 1.8 -1.3 0.6
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.0 1.0 1.0
Neuroticism (Nagel 2018) 0.6 1.4 2.1 -0.8 -1.5
Schizophrenia (2018) 1.4 3.0 6.0 2.4 0.0
Schizophrenia vs Biploar Disorder 1.7 2.3 4.5 2.1 0.0
Worry (Nagel 2018) 0.3 0.7 0.7 -0.8 -0.9
Alzheimer’s Disease (in mother) 4.2 4.9 5.7 -2.0 2.4
Alzheimer’s Disease (in father) 1.5 1.6 2.8 0.6 -1.7
Alzheimer’s Disease (including proxy) 0.8 1.1 1.2 -1.1 1.0
Crohns Disease (2017) 0.0 0.0 0.0 -0.1 0.2
Irritable Bowel Disease (IBD) 0.1 0.3 0.6 -0.0 -0.8
Ulcerative Colitis (UC) 0.3 0.5 0.9 -0.4 -1.0
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.1 0.2 0.3 0.5 0.3
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.6 -0.7 0.1
Breast Cancer 0.3 0.7 1.2 -1.1 0.3
Ovarian Cancer 1.2 1.6 1.7 1.3 1.3
Prostate Cancer 0.9 1.2 2.3 0.3 -1.5
Age at First Birth 1.1 1.6 3.2 1.8 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 0.9 1.7 0.4 1.3
Coronary Artery Disease (CAD) 0.3 0.4 0.8 -0.9 0.0
Crohns Disease (2012) 0.1 0.1 0.2 -0.4 0.0
Mean Putamen Volume 0.3 0.3 0.6 -0.8 -0.3
Fasting Glucose 0.3 0.4 0.7 -0.9 0.1
HbA1C 1.9 2.1 3.8 1.9 -0.6
HDL Cholesterol 0.8 1.3 1.8 -0.8 -1.4
LDL Cholesterol 0.6 0.9 1.3 0.7 -1.2
Lupus 0.7 1.1 1.5 -1.2 0.8
Neuroticism (2016) 2.5 3.5 4.9 -1.5 -2.2
Primary Biliary Cirrhosis 0.1 0.1 0.2 0.4 0.2
Rheumatoid Arthritis 1.6 2.2 3.6 0.9 -1.9
Schizophrenia (2014) 2.3 5.1 10.1 3.2 0.0
Triglycerides 0.7 1.1 2.0 -1.4 0.5
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.1 1.8 0.0
Ulcerative Colitis 0.0 0.0 0.1 -0.3 0.0
Blood Eosinophil Count 0.3 2.4 4.7 0.5 2.2
Blood Platelet Count 0.2 2.5 3.9 1.0 -2.0
Blood Red Count 0.1 1.1 1.6 1.3 0.8
Blood White Count 3.4 24.9 49.7 0.3 7.0
Heel T-Score 0.6 4.9 6.8 1.8 2.6
BMI 1.4 8.1 15.9 0.5 4.0
Height 0.1 2.5 2.7 -1.5 -1.6
Waist Hip Ratio (WHR) 0.2 0.7 1.4 -1.2 -0.1
Systolic Blood Pressure 0.1 0.6 1.1 -1.1 -0.0
Smoking Status 0.3 0.7 0.8 0.8 -0.9
Allergy or Eczema 1.3 3.5 6.3 -2.5 0.9
Cardiovascular Disease 1.1 3.5 5.2 -1.4 2.3
Hypothyroidism (self reported) 1.5 3.5 5.6 -1.2 -2.4
Respiratory disease 0.8 1.8 2.3 1.1 1.5
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 -0.3 -0.3
Lung FEV1/FVC ratio 0.0 0.0 0.0 -0.2 -0.2
Lung FVC 0.7 3.5 7.0 -0.0 -2.6
Neuroticism 0.8 2.0 3.8 -0.3 -2.0
Chronotype (morning person) 0.1 0.1 0.3 0.5 0.1
Hair Pigment 0.0 1.4 1.7 -1.0 -1.3
Tanning 0.5 6.6 13.0 0.6 -3.6
Hand grip strength (left) 1.5 3.9 7.0 -0.9 -2.7
Number of treatments/medications taken 0.7 1.3 1.9 -0.9 1.4
Average weekly spirits intake 0.9 1.1 1.2 1.1 -1.0
Sensitivity / hurt feelings 2.1 3.7 5.2 2.3 -1.5
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.2 -1.5 -0.5
Hearing difficulty/problems: Yes 1.7 2.6 5.0 -2.2 0.4
Relative age of first facial hair 0.5 1.1 2.1 1.5 0.1
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 -0.2 0.2
Ever used hormone-replacement therapy (HRT) 1.7 2.1 4.0 -2.0 0.5
Ever had hysterectomy (womb removed) 1.6 1.8 2.3 -1.1 1.5
Systolic blood pressure, automated reading 0.6 1.6 2.2 -1.5 1.0
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 2.4 -0.8 1.6
Angina 4.4 5.8 10.8 -0.8 3.3
Medication for hormone replacement therapy 0.3 0.3 0.5 -0.7 0.3
Vitamin and mineral supplements 0.2 0.3 0.4 -0.6 -0.5
Supplements: Zinc 2.5 2.8 4.8 -2.2 0.8
Medication: Co-codamol 0.4 0.5 1.0 0.1 1.0
Medication: Metformin 0.4 0.6 0.8 0.9 0.6
Diabetes (father) 1.9 2.4 4.5 0.5 -2.1
Diabetes (mother) 0.7 0.9 1.4 -0.7 1.2
Severe depression (siblings) 0.2 0.2 0.2 -0.5 -0.4
Pack years adult smoking proportion 2.3 3.6 6.8 -0.5 2.6
Impedance of leg (right) 1.4 7.0 13.2 0.8 -3.6
Leg fat-free mass (left) 0.5 2.7 5.1 -0.6 2.2
Trunk fat percentage 1.1 4.6 9.0 -0.4 3.0
Hand grip strength (right) 3.7 10.0 16.8 -1.8 -4.1
Townsend deprivation index at recruitment 1.5 2.1 2.3 1.5 1.4
Current tobacco smoking 0.3 0.4 0.5 0.7 -0.6
Average weekly fortified wine intake 0.5 0.6 1.2 1.1 -0.2
Maternal smoking around birth 0.3 0.4 0.8 -0.1 0.9
Fed-up feelings 0.5 0.9 1.7 -1.3 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 2.3 -1.5 -0.5
Relative age voice broke 0.3 0.4 0.8 0.1 -0.9
Taking other prescription medications 0.4 0.6 1.1 -1.0 0.4
Age when periods started (menarche) 0.3 0.6 1.1 -1.1 0.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 0.7 -0.9 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 3.3 -0.2 1.8
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 0.1 0.5
Qualifications: CSEs or equivalent 0.3 0.4 0.5 0.7 0.6
Serious illness, injury or assault to yourself 0.8 0.9 1.7 -1.3 0.4
High blood pressure 1.0 2.9 4.0 -1.4 2.0
Hayfever, allergic rhinitis or eczema 1.0 2.3 4.4 -2.1 0.4
Multivitamins +/- minerals 0.1 0.2 0.3 -0.2 -0.6
Stomach or abdominal pain in last month 0.4 0.5 0.7 -0.8 0.6
Supplements: Glucosamine 1.5 1.9 3.3 -1.8 -0.7
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.7 1.3 0.3
Medication: Atenolol 0.2 0.3 0.3 0.6 0.5
Medication: Levothyroxine sodium 1.2 2.1 4.1 0.0 -2.0
Sitting height 0.2 1.3 1.7 -0.9 -1.3
Chronic bronchitis/emphysema (father) 2.3 2.7 4.2 -1.1 2.0
High blood pressure (mother) 0.4 0.6 1.2 -1.1 0.1
Body mass index (BMI) 1.3 5.7 11.4 -0.1 3.4
Impedance of leg (left) 1.1 5.6 10.6 0.7 -3.3
Leg predicted mass (left) 0.6 3.0 5.7 -0.6 2.4
Trunk fat mass 0.9 4.0 7.6 -0.6 2.8
Waist circumference 0.9 3.2 6.3 -0.3 2.5
Number of incorrect matches in round 1.0 1.7 2.3 -1.5 1.1
Past tobacco smoking 0.5 0.9 1.7 -1.3 0.3
Alcohol usually taken with meals 1.7 2.7 4.1 -1.1 2.0
Nervous feelings 1.1 2.1 4.1 0.0 -2.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.2 -0.7 -1.1
Hearing difficulty/problems with background noise 0.7 1.1 2.1 -1.4 0.3
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 -0.1 0.1
Had menopause 0.0 0.0 0.0 0.1 0.2
Had other major operations 0.6 0.8 1.1 -0.7 -1.1
Forced vital capacity (FVC) 0.5 2.1 4.2 0.2 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 1.3 -0.6 1.1
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.1 0.0 -0.3
Qualifications: None of the above 0.2 0.4 0.7 0.8 0.5
Financial difficulties in last 2 years 0.1 0.2 0.2 -0.4 0.4
Mouth/teeth dental problems 1.9 3.0 4.2 2.0 -1.3
Heart attack 1.7 2.2 4.4 -0.0 2.1
Allergy 0.1 0.3 0.4 0.5 -0.6
Pain all over the body in last month 0.5 0.6 1.1 1.0 0.2
Diabetes (self-reported) 1.2 1.8 2.2 -1.5 -1.2
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.7 0.4 1.3
Medication: Ramipril 2.0 2.5 3.1 1.4 1.8
Medication: Simvastatin 1.9 2.8 5.5 -0.3 2.4
Fluid intelligence score 0.2 0.4 0.7 -0.9 -0.1
Illnesses of siblings 0.2 0.2 0.4 0.1 -0.7
Neuroticism score 0.9 1.9 3.7 -0.1 -1.9
Weight 0.6 3.0 5.8 -0.6 2.4
Impedance of arm (right) 0.1 0.4 0.7 -0.4 -0.8
Arm fat percentage (right) 1.3 5.2 10.2 -0.3 3.2
Trunk fat-free mass 0.1 0.9 1.1 -1.0 0.8
Hip circumference 0.3 1.2 2.4 -0.1 1.6
Time employed in main current job 0.5 0.6 1.1 0.3 -1.1
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.0 0.5
Father’s age at death 1.6 2.2 4.0 2.0 -0.5
Worrier / anxious feelings 0.7 1.4 1.9 -1.4 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.8 -0.2 0.9
Falls in the last year 0.7 0.9 0.9 -1.0 -0.9
Hair/balding pattern: Pattern 3 0.5 0.7 1.5 -1.2 0.1
Number of live births 0.1 0.2 0.3 0.3 -0.6
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 4.3 -0.2 -2.1
Pulse rate 1.2 2.1 3.5 1.9 -0.8
Happiness 0.9 1.1 2.2 0.2 -1.5
Noisy workplace 0.3 0.4 0.5 -0.6 -0.7
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.6 -1.6 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.6 -0.8 -0.3
Mouth/teeth dental problems: Dentures 1.0 1.6 3.3 -0.1 1.8
Asthma 0.9 1.8 3.2 1.8 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 0.6 -0.7 -0.8
Medication: Cholesterol lowering 0.9 1.4 2.7 0.3 1.6
Depression (self-reported) 1.7 2.0 2.2 -1.3 1.5
Medication: Lansoprazole 1.2 1.4 2.4 -0.7 -1.5
Prospective memory result 0.1 0.1 0.2 -0.0 0.5
Lung cancer (father) 1.1 1.3 2.6 -1.6 -0.3
Illnesses of mother 4.6 5.7 8.0 1.9 -2.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 2.5 -0.7 -1.6
Pulse wave Arterial Stiffness index 2.6 3.1 4.9 1.1 -2.2
Impedance of arm (left) 0.1 0.7 1.2 0.3 -1.1
Arm fat mass (right) 1.1 4.5 8.8 -0.5 3.0
Trunk predicted mass 0.2 0.9 1.1 -1.1 0.8
Standing height 0.2 2.0 3.3 -0.9 -1.8
Length of working week for main job 0.5 0.6 1.2 -0.1 -1.1
Exposure to tobacco smoke at home 1.7 1.9 3.3 1.8 0.7
Breastfed as a baby 2.4 3.0 3.8 1.5 -1.9
Tense / ‘highly strung’ 0.4 0.6 0.8 0.7 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 3.2 -0.3 -1.8
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 0.4 -0.5
Birth weight of first child 0.2 0.5 0.6 -0.7 0.6
Peak expiratory flow (PEF) 0.6 1.3 2.6 -0.2 -1.6
Pulse wave reflection index 0.4 0.5 0.9 -0.4 -1.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.4 -1.2 -0.4
Loud music exposure frequency 0.3 0.3 0.6 0.3 -0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.6 -0.8 0.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.0 -1.0 -0.4
Blood clot in the leg (DVT) 0.1 0.2 0.3 -0.1 -0.5
Medication: Paracetamol 2.1 3.4 5.1 -1.3 2.3
Headache pain in last month 1.1 2.0 2.9 -1.7 1.0
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 3.6 0.7 -1.9
Glaucoma (self-reported) 0.7 0.9 1.7 1.3 0.0
Gout (self-reported) 0.3 0.4 0.5 0.7 -0.5
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 5.3 -0.3 -2.3
Medication: Amlodipine 0.1 0.1 0.2 0.5 0.1
Medication: Ventolin 100micrograms inhaler 2.2 2.8 3.9 2.0 1.3
Birth weight 0.8 1.7 3.2 -0.3 -1.8
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 0.4 0.8
High blood pressure (siblings) 0.9 1.2 1.6 -1.3 -0.9
Forced vital capacity (FVC), Best measure 0.2 0.9 1.7 -0.2 -1.3
Body fat percentage 1.1 4.4 8.8 -0.0 3.0
Leg fat percentage (right) 0.6 2.0 3.4 0.8 1.9
Arm fat-free mass (right) 0.2 0.8 1.4 -0.4 1.2
Exposure to tobacco smoke outside home 0.6 0.8 1.6 0.3 -1.3
Comparative body size at age 10 0.6 1.7 3.2 -0.4 1.8
Number of full brothers 1.7 2.2 3.1 1.8 -1.1
Worry too long after embarrassment 1.8 3.0 5.8 0.5 -2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.8 -0.2 -1.4
Wheeze or whistling in the chest in last year 0.6 1.0 1.9 0.2 1.4
Number of children fathered 1.1 1.3 1.6 -1.3 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.8 -0.2 -0.9
Age at first live birth 0.0 0.0 0.0 0.0 0.1
Pulse wave peak to peak time 2.6 3.1 4.8 -1.1 2.2
Health satisfaction 0.3 0.4 0.8 -0.9 -0.1
Shortness of breath walking on level ground 0.0 0.0 0.0 0.1 -0.2
Qualifications: College or University degree 0.2 0.5 0.7 0.5 -0.9
Eye problems/disorders: None of the above 1.0 1.1 1.6 0.8 1.3
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.6 0.5 1.3
Emphysema/chronic bronchitis 1.5 1.7 3.4 -0.3 -1.8
Medication for pain relief, constipation, heartburn 0.7 1.1 2.2 0.3 -1.5
Neck or shoulder pain in last month 0.7 1.0 1.8 0.5 1.3
Medication: Blood pressure 0.9 1.5 2.9 0.3 1.7
Angina (self-reported) 3.9 5.1 9.3 -1.0 3.0
Migraine (self-reported) 0.9 1.1 1.6 0.8 1.3
Medication: Ibuprofen 0.1 0.1 0.2 -0.4 0.0
Medication: Allopurinol 0.2 0.2 0.3 0.6 -0.4
Medication: Omeprazole 0.6 0.7 0.9 -0.7 -0.9
Medication: Seretide 50 evohaler 0.2 0.2 0.2 0.5 0.5
Mean time to correctly identify matches 0.1 0.1 0.1 -0.4 0.2
Heart disease (mother) 2.7 3.3 5.3 -2.3 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.8 0.3 -1.4
Whole body fat mass 0.9 3.8 7.6 -0.2 2.8
Leg fat mass (right) 0.8 3.0 6.0 0.2 2.4
Arm predicted mass (right) 0.1 0.7 1.2 -0.4 1.1
Pulse rate, automated reading 0.2 0.6 1.2 0.1 -1.1
Alcohol intake frequency. 0.7 1.6 1.7 1.2 1.3
Comparative height size at age 10 0.5 2.6 4.5 -2.1 0.9
Number of full sisters 1.2 1.5 2.3 1.5 0.8
Suffer from ‘nerves’ 0.7 1.0 1.9 -0.3 -1.4
Overall health rating 0.2 0.4 0.7 -0.3 0.8
Chest pain or discomfort 0.6 0.8 1.7 -1.3 -0.0
Had major operations 0.1 0.2 0.2 0.5 0.3
Age at last live birth 1.6 2.3 2.6 1.6 -1.4
Family relationship satisfaction 0.4 0.5 0.8 0.5 -0.9
Leg pain on walking 0.3 0.4 0.4 0.6 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.7 0.3 1.3
Commuting to job workplace: Car/motor vehicle 1.6 1.9 3.5 -1.9 0.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 0.9 0.9 -0.9
Medication: Aspirin 0.5 0.6 1.1 -0.3 1.1
Supplements: Vitamin C 0.0 0.1 0.1 0.1 0.3
Knee pain experienced in last month 0.5 0.8 1.3 -1.1 0.5
Hypertension (Self-reported) 1.0 2.8 3.3 -1.5 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.4 0.8 -1.5
Illnesses of father: Heart disease 0.0 0.0 0.1 0.0 0.3
Illnesses of siblings: Diabetes 1.0 1.3 2.2 0.6 1.5
Smoking status: Previous 0.3 0.4 0.8 0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 0.8 -0.4 -0.9
Whole body fat-free mass 0.3 1.9 2.7 -1.0 1.6
Leg fat-free mass (right) 0.6 3.2 5.8 -0.9 2.4
Arm fat percentage (left) 1.2 4.8 9.6 0.2 3.1
Average weekly red wine intake 0.1 0.1 0.2 0.4 0.2
Handedness (chirality/laterality): Left-handed 5.6 6.8 12.0 3.5 1.2
Mood swings 0.6 1.1 1.8 -1.3 -0.6
Loneliness, isolation 1.2 1.7 3.4 -0.2 -1.8
Long-standing illness, disability or infirmity 0.3 0.5 0.6 -0.6 0.8
Ever had bowel cancer screening 1.1 1.3 2.5 -1.6 0.3
Diabetes diagnosed by doctor 0.1 0.1 0.2 -0.4 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.4 0.3
Friendships satisfaction 0.8 1.0 1.0 1.0 -1.0
Qualifications: nursing, teaching 0.4 0.6 0.9 0.9 0.5
Commuting to job workplace: Walk 0.1 0.1 0.2 0.4 -0.3
Eye problems/disorders: Cataract 2.7 3.2 6.3 -0.2 -2.5
Mouth/teeth dental problems: Mouth ulcers 3.1 4.9 9.2 -3.0 0.8
Medication for cholesterol 1.0 1.6 2.5 0.8 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 2.9 1.0 1.7
Back pain experienced in last month 1.3 2.0 3.3 -0.8 1.8
Mineral and other dietary supplements 1.1 1.4 2.9 -0.1 1.7
Breast cancer (self-reported) 1.1 1.3 1.9 -0.8 -1.4
Asthma (self-reported) 0.8 1.6 2.3 1.5 1.0
Osteoporosis (self-reported) 2.4 3.0 4.1 -1.4 2.0
Osteoarthritis (self-reported) 0.0 0.1 0.1 0.0 0.3
Medication: Aspirin 0.5 0.6 1.1 -0.4 1.1
Medication: Gliclazide 1.0 1.2 2.3 0.3 1.5
Illnesses of father: None of the above (group 1) 1.1 1.4 1.5 1.1 -1.2
Smoking status: Current 0.4 0.7 0.7 0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 3.3 -1.8 -0.5
Whole body water mass 0.3 1.8 2.7 -1.0 1.6
Leg predicted mass (right) 0.6 3.4 6.0 -0.9 2.4
Arm fat mass (left) 1.1 4.7 9.4 -0.0 3.1
Number of self-reported non-cancer illnesses 1.0 1.7 2.3 -1.1 1.5
Average weekly champagne plus white wine intake 0.7 1.0 1.1 1.0 -1.0
Miserableness 1.9 3.2 3.5 -1.9 -1.7
Guilty feelings 0.7 1.1 2.1 -0.3 -1.4
Wears glasses or contact lenses 1.4 1.6 3.1 -1.8 0.3
Ever taken oral contraceptive pill 0.2 0.3 0.5 0.7 -0.1
Hearing aid user 3.7 4.1 8.3 -2.9 -0.0
Mother’s age at death 0.8 1.0 1.8 -0.5 -1.3
Financial situation satisfaction 0.9 1.1 1.6 -1.3 0.8
Tinnitus: Yes, now most or all of the time 2.7 3.1 4.7 -2.2 -1.2
Commuting to job workplace: Public transport 1.1 1.3 2.0 -1.4 -0.8
Eye problems/disorders: Glaucoma 0.5 0.6 1.0 1.0 -0.3
Medication: Blood pressure 0.7 1.3 2.5 -0.4 1.6
Pain type(s) experienced in last month: Hip pain 1.4 1.8 3.5 -1.9 -0.2
Supplements: Fish oil (including cod liver oil) 2.8 3.6 5.7 1.2 -2.4
High cholesterol (Self-reported) 0.8 1.5 2.6 0.6 1.6
Medication: Bendroflumethiazide 0.5 0.8 1.2 -0.6 1.1
Medication: Paracetamol 1.6 2.5 4.0 -1.1 2.0
Medication: Lisinopril 1.8 2.4 3.1 -1.3 1.8
Medication: Atorvastatin 1.3 1.6 2.0 1.4 1.1
Illnesses of father: High blood pressure 0.3 0.4 0.7 -0.8 -0.4
Alcohol drinker status: Never 0.4 0.5 0.8 0.5 -0.9
Ever smoked 0.2 0.3 0.5 0.4 -0.7
Basal metabolic rate 0.4 2.0 3.5 -0.7 1.9
Leg fat percentage (left) 0.6 2.4 4.5 0.5 2.1
Arm fat-free mass (left) 0.3 1.6 2.5 -0.8 1.6
Number of operations (self-reported) 0.5 0.8 1.6 -1.3 -0.2
Average weekly beer plus cider intake 1.1 1.6 2.0 1.1 -1.4
Irritability 0.2 0.3 0.5 0.7 -0.3
Risk taking 0.8 1.1 1.5 -1.2 -0.9
Ever had prostate specific antigen (PSA) test 0.6 0.7 0.8 -0.7 -0.9
Fractured/broken bones in last 5 years 1.2 1.6 2.3 -1.5 0.9
Age started oral contraceptive pill 0.1 0.1 0.2 -0.5 -0.1
Diastolic blood pressure, automated reading 0.4 1.4 1.5 -1.1 1.2
Ever depressed for a whole week 0.5 0.6 1.2 -1.1 -0.3
Unable to work because of sickness or disability 1.8 2.4 4.8 0.1 2.2
Commuting to job workplace: Cycle 1.5 1.8 3.4 1.8 0.4
Myopia 0.2 0.3 0.5 0.7 0.3
Vascular/heart problems diagnosed by doctor 1.4 3.7 5.8 1.3 -2.4
Cholesterol lowering medication 1.0 1.5 2.4 -0.8 1.5
Medication: Omeprazole (e.g. Zanprol) 2.1 2.5 3.1 -1.8 -1.4
Pain experienced in last month 1.5 2.5 4.8 2.2 -0.5
Supplements: Calcium 0.3 0.3 0.3 0.6 -0.5
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.4 -0.3
Heart attack/myocardial infarction (self-reported) 2.1 2.7 5.4 -0.3 2.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.1 0.0 -0.4
Heart disease (siblings) 2.0 2.4 3.3 -1.8 1.2
Alcohol drinker status: Previous 1.8 2.0 4.0 0.2 2.0
Pack years of smoking 2.0 3.0 5.6 -0.6 2.4
Impedance of whole body 0.4 2.0 3.7 0.5 -1.9
Leg fat mass (left) 0.9 3.4 6.7 0.1 2.6
Arm predicted mass (left) 0.3 1.8 2.3 -1.1 1.5