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chr6:85,466,286-87,086,122

Best TWAS P=1.49e-10 · Best GWAS P=1.15e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Artery Coronary	PKMP3	0.15	0.19	lasso	12	0.17	1.8e-06	6.6	-6.4	1.5e-10	-0.97	0.08	0.90	TRUE
12	GTEx	Brain Caudate basal ganglia	PKMP3	0.17	0.19	enet	15	0.22	7.6e-07	6.3	-6.4	2.1e-10	-0.81	0.41	0.55	FALSE
60	The Cancer Genome Atlas	Esophageal Carcinoma	SNX14	0.13	0.13	lasso	1	0.10	4.8e-04	6.3	-6.3	3.4e-10	-0.71	0.01	0.91	FALSE
6	GTEx	Artery Aorta	PKMP3	0.07	0.08	enet	6	0.03	6.0e-03	6.2	-6.3	4.0e-10	-0.73	0.14	0.55	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	PKMP3	0.10	0.09	blup	328	0.12	3.6e-15	6.2	-6.2	4.8e-10	-0.83	0.76	0.24	FALSE
16	GTEx	Brain Cerebellum	PKMP3	0.12	0.20	lasso	3	0.19	2.3e-06	6.2	-6.2	5.6e-10	-0.73	0.18	0.77	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	PKMP3	0.12	0.16	lasso	5	0.11	7.6e-04	6.3	-6.2	7.0e-10	-0.82	0.20	0.50	FALSE
45	GTEx	Stomach	SNHG5	0.49	0.54	enet	18	0.52	2.2e-28	5.4	-6.2	7.7e-10	-0.82	1.00	0.00	FALSE
31	GTEx	Heart Atrial Appendage	SNHG5	0.28	0.44	enet	31	0.41	5.5e-20	5.4	-6.1	8.0e-10	-0.87	0.88	0.12	FALSE
80	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SNHG5	0.58	0.58	enet	7	0.57	2.7e-19	5.4	-6.1	8.8e-10	-0.80	0.04	0.96	FALSE
13	GTEx	Brain Cerebellar Hemisphere	SNHG5	0.13	0.10	lasso	5	0.09	2.8e-03	6.2	-6.0	1.8e-09	-0.79	0.21	0.42	FALSE
70	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SNHG5	0.60	0.60	enet	6	0.60	5.8e-31	5.4	-6.0	1.9e-09	-0.82	0.55	0.45	FALSE
57	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SYNCRIP	0.07	0.04	blup	35	0.03	1.3e-02	5.6	6.0	2.5e-09	0.87	0.02	0.80	FALSE
14	GTEx	Brain Cerebellar Hemisphere	PKMP3	0.14	0.02	lasso	6	0.03	5.2e-02	6.2	-6.0	2.6e-09	-0.73	0.08	0.64	FALSE
5	GTEx	Artery Aorta	SNHG5	0.49	0.56	enet	22	0.52	5.4e-33	5.4	-5.9	3.2e-09	-0.78	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Esophageal Carcinoma	SNHG5	0.50	0.37	lasso	5	0.45	8.5e-16	5.4	-5.9	3.4e-09	-0.83	0.30	0.70	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNHG5	0.43	0.37	enet	11	0.44	6.9e-54	5.5	-5.9	4.3e-09	-0.77	0.68	0.32	FALSE
4	GTEx	Adrenal Gland	SNHG5	0.44	0.55	enet	30	0.50	3.6e-20	5.4	-5.9	4.5e-09	-0.77	0.99	0.01	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SNHG5	0.45	0.31	lasso	7	0.32	3.0e-13	5.5	-5.8	5.0e-09	-0.80	0.22	0.78	FALSE
26	GTEx	Colon Sigmoid	SNHG5	0.41	0.40	enet	23	0.44	4.6e-17	5.4	-5.8	5.4e-09	-0.78	0.74	0.26	FALSE
43	GTEx	Small Intestine Terminal Ileum	SNHG5	0.47	0.37	enet	23	0.25	2.6e-06	5.4	-5.8	5.7e-09	-0.80	0.64	0.33	FALSE
11	GTEx	Brain Caudate basal ganglia	SNHG5	0.51	0.48	lasso	13	0.40	2.1e-12	5.5	-5.8	5.9e-09	-0.74	0.90	0.10	FALSE
33	GTEx	Liver	SNHG5	0.47	0.42	enet	25	0.52	1.0e-16	5.4	-5.8	6.5e-09	-0.79	0.89	0.11	FALSE
49	GTEx	Vagina	SNHG5	0.45	0.31	lasso	7	0.30	1.1e-07	5.4	-5.8	6.5e-09	-0.79	0.42	0.54	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	SNHG5	0.51	0.64	enet	26	0.61	6.3e-25	5.4	-5.8	7.7e-09	-0.77	0.98	0.02	FALSE
36	GTEx	Nerve Tibial	NT5E	0.07	0.03	enet	9	0.04	1.2e-03	5.9	5.8	7.7e-09	0.78	0.59	0.36	FALSE
29	GTEx	Esophagus Mucosa	SNHG5	0.53	0.70	enet	27	0.68	8.1e-62	5.4	-5.8	7.8e-09	-0.75	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SNHG5	0.55	0.62	lasso	6	0.61	6.7e-27	5.4	-5.8	7.8e-09	-0.77	0.58	0.42	FALSE
25	GTEx	Cells Transformed fibroblasts	SNHG5	0.44	0.66	enet	21	0.65	2.2e-63	5.4	-5.8	8.0e-09	-0.77	1.00	0.00	FALSE
27	GTEx	Colon Transverse	SNHG5	0.56	0.62	lasso	8	0.60	2.5e-35	5.4	-5.8	8.7e-09	-0.76	0.99	0.01	FALSE
10	GTEx	Artery Tibial	PKMP3	0.05	0.02	lasso	4	0.01	3.9e-02	5.9	-5.7	1.1e-08	-0.68	0.24	0.47	FALSE
40	GTEx	Prostate	SNHG5	0.44	0.46	lasso	5	0.48	8.9e-14	5.4	-5.7	1.1e-08	-0.79	0.67	0.33	FALSE
7	GTEx	Artery Coronary	SNHG5	0.63	0.71	enet	24	0.70	1.7e-32	5.5	-5.7	1.2e-08	-0.77	0.99	0.01	FALSE
17	GTEx	Brain Cortex	SNHG5	0.51	0.57	lasso	3	0.54	1.8e-17	5.4	-5.7	1.3e-08	-0.74	0.97	0.03	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	SNHG5	0.37	0.56	enet	12	0.48	3.8e-29	5.4	-5.7	1.4e-08	-0.76	1.00	0.00	FALSE
51	METSIM	Adipose	SNHG5	0.30	0.46	enet	30	0.43	1.9e-71	5.4	-5.7	1.4e-08	-0.77	1.00	0.00	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	SNHG5	0.49	0.71	lasso	8	0.71	5.1e-132	5.4	-5.6	1.6e-08	-0.77	1.00	0.00	FALSE
18	GTEx	Brain Hippocampus	SNHG5	0.33	0.38	enet	32	0.34	6.0e-09	5.5	-5.6	1.9e-08	-0.83	0.64	0.35	FALSE
42	GTEx	Skin Sun Exposed Lower leg	SNHG5	0.53	0.68	lasso	3	0.68	5.3e-77	5.4	-5.6	2.1e-08	-0.76	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	SNHG5	0.54	0.54	lasso	4	0.54	2.4e-36	5.5	-5.6	2.1e-08	-0.77	0.91	0.09	FALSE
35	GTEx	Muscle Skeletal	SNHG5	0.60	0.56	lasso	10	0.57	1.9e-67	5.4	-5.6	2.2e-08	-0.75	1.00	0.00	FALSE
15	GTEx	Brain Cerebellum	SNHG5	0.16	0.21	enet	13	0.20	1.1e-06	5.4	-5.6	2.5e-08	-0.74	0.37	0.55	FALSE
9	GTEx	Artery Tibial	SNHG5	0.40	0.56	lasso	5	0.56	1.2e-52	5.4	-5.6	2.6e-08	-0.75	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SNHG5	0.55	0.62	lasso	4	0.62	1.2e-52	5.4	-5.6	2.6e-08	-0.74	0.91	0.09	FALSE
44	GTEx	Spleen	SNHG5	0.56	0.58	lasso	3	0.57	1.1e-17	5.4	-5.6	2.8e-08	-0.73	0.97	0.03	FALSE
2	GTEx	Adipose Subcutaneous	SNHG5	0.48	0.71	lasso	4	0.72	4.9e-83	5.4	-5.5	3.0e-08	-0.75	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SNHG5	0.48	0.52	lasso	3	0.52	2.0e-29	5.5	-5.5	3.2e-08	-0.75	0.82	0.18	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNHG5	0.49	0.55	enet	8	0.56	4.3e-77	5.4	-5.5	3.2e-08	-0.74	0.92	0.08	FALSE
48	GTEx	Uterus	SNHG5	0.29	0.29	enet	8	0.17	2.2e-04	5.4	-5.5	3.3e-08	-0.71	0.26	0.26	FALSE
46	GTEx	Testis	SNHG5	0.47	0.64	lasso	5	0.64	5.8e-36	5.4	-5.5	3.7e-08	-0.74	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNHG5	0.62	0.60	lasso	4	0.61	1.8e-55	5.4	-5.5	3.7e-08	-0.75	0.92	0.08	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNHG5	0.75	0.64	enet	8	0.63	1.4e-171	5.4	-5.5	4.0e-08	-0.73	0.92	0.08	FALSE
3	GTEx	Adipose Visceral Omentum	SNHG5	0.44	0.54	lasso	3	0.49	2.1e-28	5.4	-5.5	4.2e-08	-0.73	1.00	0.00	FALSE
21	GTEx	Breast Mammary Tissue	SNHG5	0.43	0.53	enet	26	0.50	1.5e-29	5.4	-5.5	4.2e-08	-0.76	1.00	0.00	FALSE
22	GTEx	Breast Mammary Tissue (Male)	SNHG5	0.38	0.38	lasso	5	0.38	6.3e-10	5.4	-5.5	4.4e-08	-0.74	0.75	0.20	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	SNHG5	0.49	0.58	lasso	2	0.58	4.7e-83	5.4	-5.5	4.5e-08	-0.74	0.92	0.08	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	SNHG5	0.61	0.60	lasso	2	0.60	1.8e-73	5.4	-5.5	4.5e-08	-0.73	0.92	0.08	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SNHG5	0.14	0.21	lasso	5	0.21	1.2e-24	5.5	-5.5	4.6e-08	-0.75	1.00	0.00	FALSE
50	GTEx	Whole Blood	SNHG5	0.25	0.32	lasso	7	0.31	1.8e-29	5.4	-5.5	4.8e-08	-0.72	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Glioblastoma Multiforme	SNHG5	0.54	0.57	lasso	2	0.58	2.6e-21	5.4	-5.5	4.8e-08	-0.73	0.78	0.22	FALSE
73	The Cancer Genome Atlas	Rectum Adenocarcinoma	NT5E	0.22	0.17	lasso	2	0.12	8.3e-04	5.5	-5.5	4.8e-08	-0.74	0.02	0.39	FALSE
75	The Cancer Genome Atlas	Soft Tissue Sarcoma	SNHG5	0.45	0.54	lasso	2	0.53	1.7e-36	5.4	-5.5	4.8e-08	-0.73	0.91	0.09	FALSE
30	GTEx	Esophagus Muscularis	SNHG5	0.40	0.53	enet	23	0.52	5.4e-36	5.4	-5.5	4.9e-08	-0.77	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNHG5	0.56	0.64	lasso	4	0.63	2.1e-92	5.4	-5.5	5.0e-08	-0.73	0.92	0.08	FALSE
34	GTEx	Lung	SNHG5	0.45	0.59	lasso	4	0.59	2.3e-55	5.4	-5.4	5.1e-08	-0.72	1.00	0.00	FALSE
37	GTEx	Nerve Tibial	SNHG5	0.59	0.68	lasso	3	0.68	2.9e-65	5.4	-5.4	5.4e-08	-0.72	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue (Female)	SNHG5	0.38	0.55	lasso	1	0.54	9.0e-19	5.4	-5.4	5.5e-08	-0.72	0.98	0.02	FALSE
32	GTEx	Heart Left Ventricle	SNHG5	0.39	0.52	lasso	2	0.52	8.7e-32	5.4	-5.4	5.5e-08	-0.72	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNHG5	0.61	0.60	lasso	2	0.60	4.5e-42	5.4	-5.4	5.5e-08	-0.72	0.92	0.08	FALSE
68	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNHG5	0.69	0.67	lasso	1	0.67	7.1e-102	5.4	-5.4	5.5e-08	-0.72	0.92	0.08	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNHG5	0.66	0.63	lasso	1	0.63	6.7e-85	5.4	-5.4	5.5e-08	-0.72	0.92	0.08	FALSE
76	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SNHG5	0.48	0.40	lasso	1	0.41	2.7e-12	5.4	-5.4	5.5e-08	-0.72	0.50	0.50	FALSE
39	GTEx	Pancreas	SNHG5	0.25	0.36	lasso	2	0.36	5.3e-16	5.4	-5.4	5.9e-08	-0.72	0.98	0.02	FALSE
66	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SNHG5	0.53	0.49	enet	9	0.49	3.6e-26	5.4	-5.4	7.0e-08	-0.72	0.91	0.09	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SNHG5	0.60	0.56	lasso	3	0.56	5.2e-57	5.4	-5.4	8.6e-08	-0.71	0.92	0.08	FALSE
47	GTEx	Thyroid	SNHG5	0.34	0.45	enet	21	0.44	4.8e-37	5.4	-5.3	1.2e-07	-0.73	1.00	0.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	SNHG5	0.29	0.34	lasso	3	0.34	7.3e-13	5.4	-5.3	1.5e-07	-0.72	0.85	0.15	FALSE
74	The Cancer Genome Atlas	Rectum Adenocarcinoma	SNHG5	0.73	0.47	enet	5	0.47	1.9e-12	5.4	-5.2	1.8e-07	-0.68	0.68	0.31	FALSE
19	GTEx	Brain Hypothalamus	SNHG5	0.32	0.29	enet	21	0.17	9.8e-05	5.5	-5.2	2.0e-07	-0.66	0.54	0.15	FALSE
38	GTEx	Ovary	SNHG5	0.24	0.19	enet	11	0.26	4.5e-07	6.2	-5.2	2.4e-07	-0.64	0.38	0.30	FALSE