Best TWAS P=2.62e-13 · Best GWAS P=1.73e-23 conditioned to 1.7e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SLC30A7 | 0.07 | 0.03 | lasso | 3 | 0.02 | 1.3e-02 | -6.4 | 6.0 | 2.4e-09 | 0.31 | 0.45 | 0.03 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP4-549L20.3 | 0.12 | 0.00 | lasso | 2 | 0.00 | 3.9e-01 | -4.7 | 7.3 | 2.6e-13 | 0.17 | 0.06 | 0.12 | TRUE |
| 3 | GTEx | Artery Tibial | RP11-421L21.3 | 0.13 | 0.03 | lasso | 3 | 0.02 | 1.3e-02 | -6.8 | 6.7 | 1.8e-11 | 0.67 | 0.63 | 0.12 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | RP4-549L20.3 | 0.11 | 0.08 | lasso | 2 | 0.07 | 9.6e-06 | 5.4 | -5.4 | 6.6e-08 | -0.24 | 0.54 | 0.03 | TRUE |
| 5 | GTEx | Muscle Skeletal | S1PR1 | 0.07 | 0.00 | enet | 22 | 0.01 | 4.1e-02 | -5.4 | 6.9 | 6.1e-12 | 0.55 | 0.08 | 0.53 | FALSE |
| 6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | VCAM1 | 0.10 | 0.05 | lasso | 3 | 0.05 | 4.2e-04 | -4.1 | 5.7 | 1.1e-08 | 0.09 | 0.07 | 0.05 | FALSE |