Best TWAS P=2.82e-14 · Best GWAS P=7.37e-15 conditioned to 9.3e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | GTEx | Muscle Skeletal | RP11-483I13.5 | 0.06 | 0.01 | enet | 12 | 0.03 | 5.2e-04 | 4.1 | -7.6 | 2.8e-14 | -0.08 | 0.00 | 0.95 | TRUE |
| 4 | GTEx | Colon Transverse | STXBP3 | 0.26 | 0.09 | enet | 26 | 0.07 | 3.7e-04 | 5.3 | 6.6 | 4.9e-11 | -0.01 | 0.03 | 0.97 | TRUE |
| 1 | GTEx | Brain Caudate basal ganglia | RP4-735C1.4 | 0.59 | 0.46 | enet | 15 | 0.53 | 8.4e-18 | 4.1 | 5.2 | 2.4e-07 | -0.04 | 1.00 | 0.00 | TRUE |
| 8 | NTR | Blood | SLC25A24 | 0.03 | 0.02 | enet | 3 | 0.02 | 4.2e-06 | -6.2 | 6.6 | 4.3e-11 | 0.13 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC25A24 | 0.04 | 0.00 | enet | 12 | 0.02 | 7.0e-05 | 2.7 | 6.4 | 1.4e-10 | 0.09 | 0.01 | 0.94 | FALSE |
| 5 | GTEx | Muscle Skeletal | SLC25A24 | 0.08 | 0.03 | lasso | 4 | 0.02 | 2.7e-03 | -6.2 | -6.4 | 1.7e-10 | -0.13 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Testis | SLC25A24 | 0.29 | 0.22 | lasso | 5 | 0.34 | 6.6e-16 | 4.1 | -6.2 | 6.8e-10 | -0.08 | 0.25 | 0.75 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC25A24 | 0.04 | 0.02 | blup | 84 | 0.02 | 2.9e-03 | -6.2 | 6.1 | 8.3e-10 | 0.12 | 0.00 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC25A24 | 0.09 | 0.04 | blup | 84 | 0.05 | 8.8e-07 | -4.9 | 6.0 | 1.9e-09 | 0.11 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | STXBP3 | 0.13 | 0.00 | lasso | 3 | -0.01 | 8.8e-01 | 5.6 | 5.4 | 7.2e-08 | -0.01 | 0.02 | 0.52 | FALSE |
| 2 | GTEx | Brain Cortex | GSTM3 | 0.68 | 0.35 | lasso | 12 | 0.38 | 1.2e-11 | 4.1 | 5.1 | 2.9e-07 | -0.02 | 0.90 | 0.00 | FALSE |