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chr1:92,277,843-95,009,145

Best TWAS P=1.21e-10 · Best GWAS P=2.5e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Heart Left Ventricle	EVI5	0.07	0.11	lasso	5	0.08	7.7e-05	6.3	6.4	1.2e-10	0.99	0.01	0.98	TRUE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	BCAR3	0.36	0.30	lasso	2	0.30	3.0e-32	5.7	5.7	1.4e-08	0.00	0.00	1.00	TRUE
24	ROSMAP	Brain Pre-frontal Cortex	BCAR3	0.04	0.02	enet	13	0.02	1.7e-03	-5.3	5.2	1.8e-07	0.05	0.05	0.90	TRUE
12	GTEx	Cells Transformed fibroblasts	EVI5	0.18	0.11	enet	28	0.20	5.9e-15	4.6	6.4	1.5e-10	0.83	0.11	0.89	FALSE
17	GTEx	Heart Atrial Appendage	EVI5	0.09	0.06	lasso	7	0.05	4.2e-03	6.2	6.3	3.0e-10	1.00	0.02	0.95	FALSE
13	GTEx	Colon Sigmoid	EVI5	0.13	0.16	lasso	3	0.12	7.0e-05	6.3	6.3	3.6e-10	1.00	0.01	0.98	FALSE
10	GTEx	Breast Mammary Tissue	EVI5	0.07	0.06	lasso	4	0.07	2.3e-04	6.3	6.2	4.4e-10	0.99	0.02	0.98	FALSE
5	GTEx	Artery Tibial	EVI5	0.08	0.08	lasso	10	0.12	9.5e-10	5.7	6.2	5.7e-10	0.88	0.11	0.89	FALSE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EVI5	0.10	0.06	blup	94	0.08	2.9e-04	6.3	6.2	6.5e-10	0.92	0.01	0.96	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.15	2.4e-19	5.2	6.2	6.7e-10	0.70	0.84	0.16	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI5	0.18	0.16	lasso	7	0.15	2.0e-16	6.2	6.2	6.8e-10	0.98	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI5	0.06	0.10	blup	94	0.10	1.7e-10	6.3	6.1	8.4e-10	0.92	0.01	0.99	FALSE
23	GTEx	Whole Blood	EVI5	0.03	0.01	lasso	2	0.01	6.8e-02	6.3	6.1	8.6e-10	0.96	0.02	0.97	FALSE
9	GTEx	Brain Hypothalamus	EVI5	0.16	0.12	lasso	13	0.05	2.1e-02	6.2	6.1	9.5e-10	1.00	0.02	0.87	FALSE
22	GTEx	Uterus	EVI5	0.23	0.12	enet	27	0.16	4.3e-04	6.2	6.0	1.4e-09	0.90	0.04	0.88	FALSE
8	GTEx	Brain Cortex	EVI5	0.25	0.33	lasso	13	0.30	4.1e-09	6.2	6.0	1.6e-09	0.99	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EVI5	0.08	0.04	blup	96	0.06	8.6e-08	4.1	6.0	1.9e-09	0.88	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EVI5	0.03	0.01	blup	335	0.02	1.3e-03	6.2	6.0	2.1e-09	0.92	0.02	0.96	FALSE
14	GTEx	Colon Transverse	EVI5	0.21	0.08	lasso	9	0.14	4.2e-07	4.5	5.9	3.0e-09	0.77	0.03	0.97	FALSE
26	YFS	Blood	FAM69A	0.28	0.09	enet	29	0.13	4.9e-40	-2.3	-5.9	3.7e-09	-0.42	1.00	0.00	FALSE
19	GTEx	Lung	EVI5	0.11	0.08	lasso	11	0.13	7.0e-10	4.5	5.9	4.2e-09	0.86	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EVI5	0.05	0.02	blup	96	0.03	2.3e-03	5.3	5.8	5.4e-09	0.83	0.09	0.71	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM69A	0.10	0.13	lasso	4	0.14	1.2e-16	5.2	5.8	6.8e-09	0.76	0.75	0.25	FALSE
11	GTEx	Breast Mammary Tissue (Male)	EVI5	0.17	0.03	lasso	10	0.08	5.9e-03	5.7	5.8	7.4e-09	0.82	0.04	0.57	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	EVI5	0.14	0.04	blup	93	0.06	8.9e-03	4.5	5.8	8.0e-09	0.88	0.03	0.75	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI5	0.03	0.03	lasso	4	0.04	3.6e-09	4.3	5.7	1.0e-08	0.89	0.04	0.96	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EVI5	0.04	0.02	blup	96	0.04	1.4e-03	4.6	5.6	1.7e-08	0.85	0.03	0.67	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI5	0.04	0.04	blup	93	0.03	4.8e-04	4.2	5.6	2.1e-08	0.85	0.10	0.87	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	EVI5	0.07	0.04	blup	93	0.03	4.7e-03	5.3	5.5	3.1e-08	0.79	0.10	0.51	FALSE
7	GTEx	Brain Caudate basal ganglia	EVI5	0.10	0.00	enet	19	0.01	1.7e-01	6.2	5.4	5.8e-08	0.82	0.04	0.69	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	EVI5	0.07	0.05	lasso	6	0.08	2.2e-05	4.2	5.4	7.4e-08	0.72	0.06	0.93	FALSE
4	GTEx	Artery Coronary	EVI5	0.09	0.10	lasso	2	0.07	3.1e-03	5.4	5.4	8.1e-08	0.64	0.09	0.60	FALSE
20	GTEx	Nerve Tibial	FAM69A	0.17	0.03	enet	19	0.05	1.4e-04	4.0	-5.3	9.0e-08	-0.64	0.50	0.44	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	EVI5	0.22	0.10	lasso	7	0.06	2.3e-03	4.2	5.3	9.4e-08	0.84	0.04	0.96	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI5	0.07	0.05	blup	96	0.06	2.5e-07	4.3	5.3	1.3e-07	0.80	0.15	0.85	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI5	0.05	0.07	lasso	5	0.07	5.6e-09	4.3	5.2	2.0e-07	0.80	0.13	0.87	FALSE
6	GTEx	Artery Tibial	BCAR3	0.11	0.12	lasso	3	0.12	1.1e-09	5.4	-5.2	2.6e-07	0.00	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	EVI5	0.09	0.07	lasso	3	0.09	1.2e-07	5.3	5.1	2.9e-07	0.66	0.44	0.56	FALSE
16	GTEx	Esophagus Mucosa	EVI5	0.12	0.19	lasso	4	0.19	6.0e-13	4.2	5.1	2.9e-07	0.83	0.04	0.96	FALSE