TWAS
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Models
Genes
Traits
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Traits
:
Blood White Count
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chr7:47,429,054-48,843,814
Best TWAS P=7.85e-10 · Best GWAS P=1.32e-08 conditioned to 0.174
47.4M
47.6M
47.8M
48M
48.2M
48.4M
48.6M
48.8M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Esophagus Muscularis
UPP1
0.11
0.01
lasso
5
0.04
3.1e-03
-5.7
6.2
7.8e-10
-0.79
0.02
0.94
TRUE
3
GTEx
Muscle Skeletal
UPP1
0.10
0.14
enet
13
0.14
5.9e-14
-5.6
5.7
1.5e-08
-0.95
0.01
0.99
FALSE
1
GTEx
Cells Transformed fibroblasts
UPP1
0.19
0.15
enet
14
0.17
1.5e-12
-5.5
5.5
4.8e-08
-0.89
0.02
0.98
FALSE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
C7orf57
0.05
0.07
blup
48
0.07
2.1e-08
5.5
5.4
6.4e-08
-0.67
0.02
0.98
FALSE
5
The Cancer Genome Atlas
Soft Tissue Sarcoma
UPP1
0.06
0.00
blup
51
0.02
1.5e-02
-4.5
5.3
1.3e-07
-0.88
0.01
0.66
FALSE