Best TWAS P=7.85e-10 · Best GWAS P=1.32e-08 conditioned to 0.174
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | UPP1 | 0.19 | 0.15 | enet | 14 | 0.17 | 1.5e-12 | -5.5 | 5.5 | 4.8e-08 | -0.89 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Muscularis | UPP1 | 0.11 | 0.01 | lasso | 5 | 0.04 | 3.1e-03 | -5.7 | 6.2 | 7.8e-10 | -0.79 | 0.02 | 0.94 | TRUE |
| 3 | GTEx | Muscle Skeletal | UPP1 | 0.10 | 0.14 | enet | 13 | 0.14 | 5.9e-14 | -5.6 | 5.7 | 1.5e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C7orf57 | 0.05 | 0.07 | blup | 48 | 0.07 | 2.1e-08 | 5.5 | 5.4 | 6.4e-08 | -0.67 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Soft Tissue Sarcoma | UPP1 | 0.06 | 0.00 | blup | 51 | 0.02 | 1.5e-02 | -4.5 | 5.3 | 1.3e-07 | -0.88 | 0.01 | 0.66 | FALSE |