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chr7:43,924,401-45,801,046

Best TWAS P=8.12e-36 · Best GWAS P=1.98e-47 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	H2AFV	0.14	0.08	lasso	8	0.08	1.8e-10	-6.78	8.1	7.0e-16	-0.19	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	NACAD	0.05	0.01	blup	436	0.01	7.8e-03	-3.59	-6.1	1.0e-09	0.45	0.26	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TBRG4	0.23	0.21	enet	27	0.22	5.6e-27	-8.35	-9.0	2.4e-19	0.56	1.00	0.00	TRUE
4	GTEx	Adipose Subcutaneous	TBRG4	0.13	0.08	lasso	2	0.04	2.5e-04	-5.25	-5.3	1.1e-07	0.44	0.78	0.10	FALSE
5	GTEx	Adipose Visceral Omentum	SNORA5C	0.25	-0.01	lasso	8	0.00	3.2e-01	-0.67	-5.1	2.8e-07	0.32	0.06	0.06	FALSE
6	GTEx	Artery Aorta	H2AFV	0.10	0.08	lasso	2	0.06	1.9e-04	5.24	5.2	1.6e-07	-0.21	0.43	0.05	FALSE
7	GTEx	Artery Aorta	TBRG4	0.19	0.01	enet	21	0.03	1.1e-02	-6.42	-7.4	1.4e-13	0.52	0.05	0.48	FALSE
8	GTEx	Artery Tibial	TBRG4	0.11	0.06	enet	12	0.08	1.6e-06	-5.25	-7.8	4.8e-15	0.58	0.40	0.58	FALSE
9	GTEx	Brain Hypothalamus	TMED4	0.37	-0.01	enet	36	-0.01	6.3e-01	-8.01	6.1	1.2e-09	-0.15	0.04	0.05	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	TBRG4	0.42	0.26	lasso	9	0.30	2.1e-10	-8.35	-7.8	7.3e-15	0.56	0.63	0.27	FALSE
11	GTEx	Cells Transformed fibroblasts	ZMIZ2	0.12	0.09	lasso	4	0.06	2.3e-05	-5.28	-5.7	1.0e-08	0.02	0.84	0.02	FALSE
12	GTEx	Cells Transformed fibroblasts	TBRG4	0.13	0.13	lasso	1	0.12	5.7e-09	-8.35	-8.3	7.1e-17	0.59	0.99	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	NACAD	0.13	0.11	lasso	9	0.11	1.2e-08	-6.77	7.2	8.2e-13	-0.56	0.69	0.31	TRUE
14	GTEx	Esophagus Mucosa	TBRG4	0.12	0.07	lasso	9	0.08	3.6e-06	-8.35	-10.2	3.1e-24	0.72	0.08	0.92	FALSE
15	GTEx	Lung	TBRG4	0.11	0.08	lasso	4	0.08	6.4e-07	-5.33	-5.6	1.8e-08	0.47	0.93	0.06	FALSE
16	GTEx	Lung	NACAD	0.07	0.02	lasso	4	0.02	1.1e-02	-6.42	7.8	7.6e-15	-0.59	0.10	0.28	FALSE
17	GTEx	Lung	CCM2	0.10	0.06	lasso	6	0.04	3.6e-04	-6.77	-5.2	1.5e-07	0.43	0.72	0.05	TRUE
18	GTEx	Muscle Skeletal	CCM2	0.09	0.09	lasso	2	0.06	7.3e-07	-6.60	-6.5	9.1e-11	0.51	1.00	0.00	FALSE
19	GTEx	Nerve Tibial	TBRG4	0.13	0.14	lasso	1	0.12	5.6e-09	-5.25	-5.2	1.5e-07	0.44	1.00	0.00	FALSE
20	GTEx	Spleen	TBRG4	0.35	0.00	enet	37	0.01	2.1e-01	-8.35	-5.6	1.7e-08	0.51	0.05	0.31	FALSE
21	GTEx	Testis	H2AFV	0.22	0.06	lasso	4	0.05	3.2e-03	-6.78	-7.3	2.3e-13	0.18	0.35	0.03	FALSE
22	GTEx	Testis	TBRG4	0.32	0.27	enet	13	0.21	8.7e-10	-5.25	-5.2	2.5e-07	0.39	1.00	0.00	FALSE
23	GTEx	Testis	SNHG15	0.26	0.13	enet	17	0.18	2.0e-08	-12.06	11.0	6.1e-28	-0.71	0.04	0.96	FALSE
24	GTEx	Thyroid	H2AFV	0.15	0.04	lasso	6	0.08	1.8e-06	5.24	6.1	1.2e-09	-0.18	0.43	0.02	FALSE
25	GTEx	Thyroid	TBRG4	0.15	0.06	enet	14	0.08	9.1e-07	-5.33	-9.4	6.7e-21	0.72	0.86	0.14	FALSE
26	METSIM	Adipose	OGDH	0.04	0.00	blup	443	0.01	8.2e-03	-1.10	5.4	7.1e-08	-0.44	0.17	0.33	FALSE
27	METSIM	Adipose	TBRG4	0.05	0.04	lasso	2	0.04	3.1e-06	-8.35	-8.3	7.1e-17	0.59	0.83	0.15	FALSE
28	NTR	Blood	ZMIZ2	0.08	0.06	enet	17	0.06	1.5e-18	8.19	-7.3	2.5e-13	0.17	1.00	0.00	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	TBRG4	0.18	0.19	lasso	6	0.22	3.8e-27	-5.25	-7.9	3.6e-15	0.58	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	NACAD	0.02	0.02	blup	56	0.00	1.1e-01	-5.36	6.7	1.6e-11	-0.52	0.08	0.21	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	TBRG4	0.03	0.03	lasso	3	0.02	1.2e-05	-8.35	-8.2	3.1e-16	0.59	0.15	0.81	TRUE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C7orf40	0.03	0.02	enet	4	0.02	2.4e-03	-13.26	12.5	8.1e-36	-0.89	0.02	0.41	TRUE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TBRG4	0.05	0.01	blup	61	0.03	6.8e-04	-3.59	-8.5	1.6e-17	0.63	0.10	0.71	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPIA	0.05	0.02	enet	5	0.03	7.7e-05	-6.37	-5.5	4.9e-08	-0.05	0.02	0.72	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	C7orf40	0.04	0.03	blup	29	0.02	1.9e-03	2.75	7.7	2.1e-14	-0.43	0.14	0.07	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C7orf40	0.07	0.00	blup	29	0.01	9.0e-03	2.75	8.1	6.6e-16	-0.52	0.03	0.18	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TBRG4	0.08	0.03	blup	61	0.03	7.5e-05	-8.35	-8.3	9.2e-17	0.57	0.03	0.82	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	C7orf40	0.15	0.05	blup	29	0.08	1.6e-08	2.85	7.1	1.1e-12	-0.41	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	TBRG4	0.08	0.09	lasso	6	0.10	1.5e-10	-8.35	-7.4	1.3e-13	0.56	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	H2AFV	0.15	0.14	lasso	3	0.14	1.3e-13	5.24	5.8	6.7e-09	-0.21	0.89	0.11	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	TBRG4	0.09	0.09	blup	61	0.09	3.2e-09	-8.35	-10.2	3.0e-24	0.75	0.23	0.77	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	ZMIZ2	0.06	0.03	blup	35	0.03	3.8e-04	5.13	7.4	1.5e-13	-0.16	0.02	0.97	FALSE