TWAS hub - UPP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2100	0.0850	6.5e-03	0.051	NA	0.041	NA	0.029	1.3e-02	NA	2.3e-02	NA	4.8e-02
2	GTEx	Brain Nucleus accumbens basal ganglia	0.3210	0.0990	1.6e-03	-0.008	NA	0.009	NA	-0.011	6.2e-01	NA	1.8e-01	NA	9.8e-01
3	GTEx	Cells Transformed fibroblasts	0.1940	0.0520	3.7e-07	0.146	NA	0.167	NA	0.161	4.3e-11	NA	1.5e-12	NA	3.8e-12
4	GTEx	Esophagus Gastroesophageal Junction	0.1880	0.0750	8.1e-03	0.041	NA	-0.005	NA	0.023	1.3e-02	NA	5.3e-01	NA	4.9e-02
5	GTEx	Esophagus Muscularis	0.1080	0.0510	6.7e-03	0.006	NA	0.028	NA	0.035	1.3e-01	NA	7.6e-03	NA	3.1e-03
6	GTEx	Muscle Skeletal	0.0961	0.0260	4.3e-07	0.137	NA	0.144	NA	0.136	2.5e-13	NA	5.9e-14	NA	3.2e-13
7	GTEx	Skin Sun Exposed Lower leg	0.0850	0.0360	4.0e-03	-0.003	NA	-0.003	NA	-0.003	8.1e-01	NA	6.8e-01	NA	7.8e-01
8	METSIM	Adipose	0.0870	0.0308	1.6e-05	0.030	0.041	0.044	0.041	0.046	2.4e-05	7.3e-07	3.1e-07	7.8e-07	1.9e-07
9	TCGA	Glioblastoma Multiforme	0.1570	0.0970	5.7e-03	0.068	0.056	0.113	NA	0.130	4.2e-03	8.5e-03	2.6e-04	NA	9.5e-05
10	TCGA	Soft Tissue Sarcoma	0.0550	0.0350	6.7e-03	0.000	0.023	0.006	NA	0.005	2.9e-01	1.5e-02	1.3e-01	NA	1.6e-01
11	TCGA	Thyroid Carcinoma	0.0600	0.0320	8.5e-04	0.025	0.034	0.024	NA	0.026	1.7e-03	2.7e-04	2.0e-03	NA	1.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	8	9	10	11
Medication: Bendroflumethiazide	6.6	10.0	20.1	2.5	1.7	4.3	0.9	4.3	4.3	4.2	2.5	4.5	0.7
Ever used hormone-replacement therapy (HRT)	3.6	4.6	10.8	1.3	2.1	2.6	0.7	3.3	2.7	2.9	1.8	2.7	0.9
Tinnitus: Yes, but not now, but have in the past	3.6	3.8	11.4	-1.7	-1.1	-2.1	0.5	-1.4	-1.5	-2.1	-3.4	-2.8	-2.4
Commuting to job workplace: Public transport	3.4	4.0	10.1	0.7	0.8	2.8	0.6	3.2	2.7	2.4	1.8	2.9	-0.1
Exposure to tobacco smoke outside home	3.2	4.3	10.2	1.5	1.4	2.7	1.0	1.7	2.0	2.3	2.9	3.2	2.2
Bipolar Disorder (2011)	3.0	2.9	7.7	-1.3	-0.3	-1.7	1.6	-1.1	-1.6	-1.9	-2.8	-2.1	-2.3
Depression (Nagel 2018)	2.9	4.3	9.5	2.8	0.1	2.1	1.3	1.8	2.1	1.7	3.1	2.6	2.5
Supplements: Vitamin C	2.9	3.4	6.2	2.2	0.8	1.6	-0.3	2.4	1.8	2.5	2.5	2.0	1.9
Breast cancer (self-reported)	2.9	3.4	12.3	-1.7	-0.5	-2.3	-1.1	-3.5	-2.0	-1.2	-1.7	-2.8	0.5
Ever had prostate specific antigen (PSA) test	2.6	3.0	8.8	1.6	0.4	2.4	-1.2	1.4	3.0	2.6	0.4	2.3	-0.7
Eye problems/disorders: Glaucoma	2.5	2.9	8.8	-3.0	-0.4	-2.1	-0.8	-0.9	-1.5	-2.1	-1.7	-2.3	-1.5
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	8.5	-1.1	-0.7	-2.9	1.0	-2.9	-2.9	-2.2	-1.1	-2.8	0.8
Glaucoma (self-reported)	2.3	2.7	6.7	-2.6	-0.4	-2.2	-0.2	-0.7	-2.1	-2.3	-1.3	-2.3	-1.1
Commuting to job workplace: Car/motor vehicle	2.3	2.6	6.7	-1.3	-1.8	-2.3	-0.3	-2.6	-1.9	-1.4	-1.3	-2.1	-0.2
Medication: Omeprazole	2.2	2.6	5.2	-2.1	-2.3	-1.7	1.0	-0.9	-1.6	-1.2	-1.9	-2.2	-1.3
Handedness (chirality/laterality): Left-handed	2.2	2.7	6.4	2.2	0.4	2.2	0.4	2.5	2.4	1.8	0.4	1.9	-0.1
Medication: Blood pressure	2.1	3.7	8.8	0.5	1.0	2.7	-1.2	2.4	2.6	2.2	2.2	3.0	0.4
Supplements: Calcium	2.1	2.3	7.0	1.9	-0.7	0.9	1.0	0.8	0.9	1.5	2.2	1.9	2.6
Blood White Count	2.0	15.1	37.8	2.9	1.5	5.5	0.4	6.2	5.7	4.5	2.3	5.3	-1.2
Qualifications: None of the above	2.0	4.3	12.0	0.3	2.2	2.7	0.1	3.5	2.5	2.3	2.0	2.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	5.3	1.3	-0.0	2.0	2.3	2.3	1.6	2.1	0.5	1.6	0.5
Medication: Ventolin 100micrograms inhaler	1.9	2.5	7.1	0.8	0.2	2.1	2.6	1.4	2.0	2.7	-0.7	1.4	-0.4
Prostate Cancer	1.8	2.6	6.3	-2.5	0.4	-2.1	0.5	-1.4	-2.3	-2.0	-0.9	-2.2	-0.1
Frequency of depressed mood in last 2 weeks	1.8	2.5	9.0	1.3	0.2	1.1	2.3	0.7	1.2	0.7	3.0	1.9	2.2
Reaction Time	1.7	3.3	6.9	2.6	0.0	2.3	-0.4	2.2	2.0	2.3	1.8	2.2	1.3
Had other major operations	1.7	2.1	5.6	-0.7	-1.5	-2.1	0.7	-1.4	-2.1	-1.4	-1.1	-2.4	0.3
Medication for pain relief, constipation, heartburn	1.7	3.0	9.4	-0.6	-0.6	-2.0	-2.5	-3.1	-2.1	-2.0	-1.1	-1.7	-0.5
Mean time to correctly identify matches	1.7	3.3	6.6	2.5	0.2	2.6	0.5	2.0	2.4	2.5	1.4	2.2	0.9
Illnesses of father: Heart disease	1.7	2.3	4.9	-1.0	-1.3	-1.8	-1.6	-1.3	-0.8	-1.9	-1.7	-1.8	-2.2
Noisy workplace	1.6	2.0	4.4	-1.9	-1.2	-2.0	0.6	-2.1	-1.9	-1.1	1.1	-1.1	1.3
Eye problems/disorders: None of the above	1.6	1.9	4.6	1.2	0.7	2.2	-1.1	1.3	1.7	1.9	0.9	1.7	0.5
Hypertension (Self-reported)	1.6	4.4	8.1	1.8	2.1	2.8	0.9	2.5	2.6	2.6	1.7	2.7	0.7
Medication: Gliclazide	1.6	1.8	4.4	1.1	0.1	1.9	0.7	2.1	2.0	1.4	0.2	1.4	-1.3
Tinnitus: Yes, now most or all of the time	1.6	1.9	9.7	1.4	1.1	0.2	-0.3	-0.6	-0.6	0.7	2.4	1.0	3.1
Medication: Lisinopril	1.6	2.1	5.2	1.4	0.2	2.2	0.4	1.3	2.1	1.2	1.9	2.3	0.5
High blood pressure	1.5	4.2	7.1	2.0	2.3	2.7	0.9	2.6	2.5	2.4	1.6	2.6	0.6
Had menopause	1.5	1.9	4.9	1.4	1.3	1.8	0.1	0.9	1.9	2.2	0.6	1.6	1.0
Headache pain in last month	1.5	2.5	9.4	0.9	-0.3	1.6	3.1	2.3	1.4	1.8	-0.4	1.3	-1.6
Medication: Aspirin	1.5	1.9	5.3	0.7	-0.6	1.7	-0.9	2.3	2.1	1.7	1.1	1.7	-0.0
Pack years of smoking	1.5	2.1	5.6	1.3	0.9	2.2	0.0	1.6	1.7	1.3	1.7	2.4	0.6
Medication: Cholesterol lowering	1.4	2.2	4.9	0.7	-0.2	2.0	-1.0	2.2	2.2	1.3	-0.0	2.0	-1.8
Number of treatments/medications taken	1.3	2.4	6.1	1.3	0.2	1.8	1.8	2.5	2.1	1.9	-0.7	1.5	-1.1
Medication: Ramipril	1.3	1.6	4.2	0.6	1.7	1.3	-0.6	1.7	1.8	0.7	1.4	2.1	0.0
Number of children fathered	1.3	1.5	4.1	0.9	2.0	1.6	-0.0	1.6	1.4	1.4	0.7	1.2	0.7
Medication: Ibuprofen	1.3	1.6	4.0	1.0	-1.4	1.4	1.7	2.0	1.1	1.9	0.2	1.0	0.3
Commuting to job workplace: Walk	1.3	1.4	4.4	1.9	2.1	0.2	0.6	0.9	-0.1	-0.1	1.8	0.5	1.4
Medication for cholesterol	1.3	2.0	5.2	-1.7	-2.3	-0.6	-1.2	-1.7	-1.2	-1.3	-1.7	-1.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	8.8	-1.0	0.2	-0.3	1.2	-0.2	0.5	-0.3	-2.1	-0.9	-3.0
Mineral and other dietary supplements	1.3	1.8	3.1	-1.4	-0.9	-1.2	-1.5	-1.4	-1.1	-1.2	-1.8	-1.7	-1.7
Supplements: Fish oil (including cod liver oil)	1.3	1.7	5.1	0.4	1.5	1.1	0.4	0.8	0.8	1.2	2.2	1.4	2.3
Ever depressed for a whole week	1.3	1.6	4.6	-2.1	0.1	-1.4	-0.5	-1.3	-1.6	-2.0	-1.2	-1.2	-0.4
Myopia	1.3	1.9	4.9	1.6	-0.1	1.7	-2.1	2.2	1.0	1.4	0.7	1.3	0.5
Primary Biliary Cirrhosis	1.2	1.8	6.6	-0.8	-0.8	-2.6	-0.1	-1.7	-1.6	-0.9	-0.5	-2.1	0.6
Taking other prescription medications	1.2	1.8	10.3	-1.6	0.1	-0.0	1.3	0.7	0.1	-0.6	-3.2	-0.9	-2.0
Happiness	1.2	1.4	7.6	1.0	0.2	0.5	-1.3	0.8	0.4	0.5	2.8	1.0	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	5.2	0.5	-2.3	-1.2	1.2	-1.3	-0.5	-0.9	-1.3	-1.2	-1.6
Medication: Atorvastatin	1.2	1.5	3.0	-1.7	0.8	-1.2	-0.8	-1.0	-1.0	-1.6	-1.4	-1.0	-1.7
Alcohol drinker status: Never	1.2	1.5	4.1	-0.5	0.4	1.5	0.3	0.8	1.7	2.0	1.4	1.5	1.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.6	-1.3	-1.6	-0.9	1.2	-0.0	-1.0	-1.0	-1.9	-1.5	-1.5
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.5	-2.5	-0.5	-0.4	-0.8	-0.8	-0.4	-1.1	-2.5	-1.1	-2.5
Serious illness, injury or assault to yourself	1.1	1.3	4.2	-0.8	0.5	-0.8	0.0	-0.5	-0.7	-1.7	-2.1	-1.3	-1.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	4.0	1.0	-2.0	1.2	0.9	1.7	1.1	1.7	0.0	1.1	-0.2
Worry too long after embarrassment	1.1	1.9	5.1	-2.2	0.2	-1.1	1.3	-0.6	-1.3	-2.3	-1.6	-1.3	-1.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.5	0.1	-0.7	1.5	-0.5	1.1	1.9	1.8	0.6	1.6	-0.7
Heart disease (siblings)	1.1	1.4	3.3	1.2	1.8	0.9	1.0	0.0	0.7	0.7	1.8	1.4	1.4
Crohns Disease (2012)	1.0	1.7	3.7	-1.6	1.9	-0.7	0.1	-1.8	-1.8	-0.0	-1.1	-1.5	1.3
Supplements: Zinc	1.0	1.1	2.8	1.1	1.3	1.3	1.7	0.7	0.7	1.0	0.7	0.7	1.5
Medication: Co-codamol	1.0	1.2	7.9	-0.3	1.4	0.4	-2.8	-0.7	0.3	-0.0	1.0	1.0	0.6
Medication: Metformin	1.0	1.4	6.1	-2.5	0.5	-0.1	-2.5	-0.5	-0.7	-0.9	-1.0	-0.3	-0.1
Diabetes (mother)	1.0	1.3	2.5	-1.0	0.6	-1.5	-1.6	-1.3	-1.4	-1.2	-0.1	-1.5	0.8
Illnesses of siblings	1.0	1.5	4.1	-1.2	-1.7	-0.3	-1.8	-0.3	-0.3	-0.8	-2.0	-0.8	-1.7
Depression (self-reported)	1.0	1.1	3.9	-1.0	-0.5	-0.6	1.5	0.0	-0.6	-1.3	-1.6	-0.5	-2.0
Illnesses of mother	1.0	1.3	3.9	-1.4	-1.9	0.2	-1.5	0.5	0.1	-0.1	-1.3	-0.5	-2.0
Length of working week for main job	1.0	1.1	3.4	-1.9	0.5	-0.3	0.4	-0.6	-0.3	-1.0	-1.7	-1.3	-1.6
Blood clot in the leg (DVT)	1.0	1.3	3.1	0.1	-1.5	1.5	-0.8	1.8	1.5	0.9	0.1	1.6	-0.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.1	1.5	-0.1	1.1	-1.8	0.6	1.1	1.6	0.2	1.6	-0.0
Guilty feelings	1.0	1.6	7.9	-0.3	-0.3	-0.4	2.8	-0.1	-0.4	-1.3	-2.0	-1.1	-1.4
Hearing aid user	1.0	1.2	4.0	0.2	2.0	1.1	0.2	-0.6	0.2	0.7	1.9	1.1	1.3
Vascular/heart problems diagnosed by doctor	1.0	2.8	4.9	-1.5	-2.0	-2.1	-0.7	-2.2	-2.2	-1.9	-1.2	-2.0	-0.3
Major Depression (MDD)	0.9	1.1	2.8	0.0	-0.5	1.5	0.7	1.5	1.7	1.4	0.4	1.5	-0.2
Blood Eosinophil Count	0.9	6.6	16.4	1.1	0.8	4.0	-1.0	3.5	3.9	3.0	1.6	3.9	-0.3
Systolic Blood Pressure	0.9	4.5	12.2	3.5	2.1	2.3	0.1	2.1	2.5	2.5	2.1	2.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.4	1.2	-0.3	1.4	-0.5	1.3	1.8	1.4	0.2	0.9	-0.1
Alcohol usually taken with meals	0.9	1.5	3.8	-0.6	-0.9	-1.9	0.5	-1.0	-2.0	-1.2	-1.6	-1.6	-0.4
Falls in the last year	0.9	1.2	2.4	-1.4	0.5	-1.6	0.5	-1.2	-1.6	-1.2	-0.3	-1.3	0.9
Exposure to tobacco smoke at home	0.9	1.0	5.2	-0.1	2.3	0.5	-1.5	0.2	0.6	0.3	1.4	0.7	0.5
Knee pain experienced in last month	0.9	1.3	3.6	-1.9	-1.7	-1.0	1.0	-1.5	-1.1	-1.0	-0.2	-0.8	1.1
Pain experienced in last month	0.9	1.4	6.0	2.4	-2.3	-0.1	-1.3	0.3	0.9	0.2	-0.4	0.1	-1.4
Bipolar Disorder (2018)	0.8	1.3	6.8	-1.2	-0.3	-0.5	0.1	-1.4	-0.5	-0.1	-2.6	-1.0	-1.5
Depressed Affect (Nagel 2018)	0.8	1.6	5.0	2.1	0.0	0.6	2.2	1.5	1.3	0.5	1.3	1.3	0.3
Schizophrenia (2018)	0.8	1.6	5.7	2.4	-1.4	0.4	2.3	0.6	0.7	0.6	-0.1	0.5	-1.7
HDL Cholesterol	0.8	1.3	2.8	1.5	1.7	1.2	0.3	1.3	1.6	0.5	1.0	1.7	0.2
Smoking Status	0.8	1.9	4.4	-1.5	-2.1	-1.5	-1.9	0.9	-0.7	-1.4	-1.0	-1.4	-1.4
Medication for hormone replacement therapy	0.8	0.9	3.6	0.7	1.9	0.5	0.0	1.1	0.4	1.0	1.3	0.9	1.1
Diabetes (father)	0.8	1.0	2.7	-0.8	-1.5	-1.4	0.8	-0.8	-1.6	-1.0	0.3	-1.1	0.5
Townsend deprivation index at recruitment	0.8	1.1	4.7	1.3	0.0	1.1	0.8	2.2	1.1	0.5	0.9	1.2	-0.3
Average weekly fortified wine intake	0.8	0.9	3.1	0.7	-0.2	1.1	-1.8	1.0	1.2	1.3	0.3	1.0	0.3
Maternal smoking around birth	0.8	1.2	3.5	-1.9	-0.6	-0.9	-1.7	-1.2	-1.1	-1.0	0.8	-0.5	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.8	1.3	-0.5	0.5	1.3	1.1	0.8	0.3	1.7	0.9	1.3
Hair/balding pattern: Pattern 2	0.8	1.0	3.3	-0.5	1.0	0.8	-0.8	-0.1	-0.0	0.9	1.8	1.1	1.8
Asthma	0.8	1.5	3.5	-0.8	1.4	1.6	1.9	0.3	1.4	1.6	-0.3	1.3	1.4
Pulse wave Arterial Stiffness index	0.8	0.9	3.5	-0.8	-1.9	-1.3	0.7	-0.5	-1.4	-0.7	0.7	-0.5	0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.1	0.4	0.8	-1.1	-0.7	-0.5	-1.1	-1.4	-1.5	-0.9	-2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.9	-0.0	0.2	0.9	0.4	-0.5	0.1	1.2	1.7	0.9	2.2
Medication: Amlodipine	0.8	1.2	4.5	0.9	1.2	1.3	-0.5	2.1	0.7	1.2	0.3	1.3	0.9
Number of full brothers	0.8	1.0	3.0	-1.0	0.1	-1.4	0.9	-0.8	-0.2	-1.7	-0.9	-1.1	-1.2
Pulse wave peak to peak time	0.8	0.9	3.7	0.8	1.9	1.3	-0.6	0.7	1.4	0.6	-0.6	0.5	-0.6
Medication: Aspirin	0.8	1.0	3.2	-0.2	-0.6	1.1	-0.7	1.8	1.6	1.1	0.7	1.1	-0.5
Long-standing illness, disability or infirmity	0.8	1.1	3.3	-0.7	0.6	1.5	0.8	1.2	1.8	1.1	-0.8	1.1	-1.1
Osteoporosis (self-reported)	0.8	1.0	2.4	1.5	-0.6	1.0	1.3	0.8	1.1	0.9	0.6	1.5	-0.0
Medication: Blood pressure	0.8	1.6	4.6	1.3	2.1	0.7	1.4	1.5	1.1	1.1	1.4	1.0	1.0
Basal cell carcinoma (self-reported)	0.8	1.0	3.2	-1.8	0.0	-1.3	0.1	-0.2	-1.2	-1.1	-0.8	-1.2	-0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	3.5	1.8	-1.9	-0.2	0.2	0.4	0.3	0.0	1.5	0.6	-0.3
Coronary Artery Disease (CAD)	0.7	0.9	4.8	-1.0	0.9	0.0	2.2	-0.1	0.4	-0.2	1.2	0.9	0.9
Cardiovascular Disease	0.7	2.4	4.7	0.8	2.0	2.1	0.6	1.7	2.0	2.0	1.4	2.2	-0.1
Respiratory disease	0.7	1.6	3.4	0.6	1.0	1.8	1.8	1.1	1.5	1.8	-0.3	1.5	0.9
Chronotype (morning person)	0.7	1.7	3.0	1.4	1.7	1.2	-1.2	1.4	0.8	0.8	1.6	1.3	1.7
Vitamin and mineral supplements	0.7	0.9	2.2	-1.1	-0.2	-0.3	-1.1	-1.0	-0.4	-1.4	-1.3	-0.6	-1.5
Multivitamins +/- minerals	0.7	0.9	1.7	-1.3	0.5	-0.9	1.3	-1.0	-1.3	-0.4	-0.0	-1.1	1.2
Number of incorrect matches in round	0.7	1.2	4.0	0.5	0.2	1.5	0.9	1.5	2.0	1.4	0.3	1.4	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.0	-1.4	0.1	-0.9	-0.6	-1.3	-0.8	-1.1	-1.1	-0.9	-0.5
Alcohol intake versus 10 years previously	0.7	1.1	3.9	-1.3	2.0	1.1	-0.4	-0.1	1.0	0.5	1.2	1.2	0.5
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.4	-0.2	-1.2	-0.9	-0.2	-0.8	-0.7	-0.9	-1.8	-1.0	-1.1
Medication: Paracetamol	0.7	1.2	3.8	0.8	0.2	0.9	1.9	1.4	0.7	0.7	1.3	1.3	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.6	-0.3	-0.4	-1.2	0.7	-1.2	-1.5	-1.6	0.1	-1.0	0.2
Shortness of breath walking on level ground	0.7	0.8	1.7	0.6	-0.4	-0.7	1.3	-1.2	-0.7	-1.0	1.3	-0.1	1.2
Heart disease (mother)	0.7	0.9	2.8	0.8	0.5	1.2	0.6	-0.0	0.7	0.7	1.5	1.1	1.7
Chest pain or discomfort	0.7	1.0	3.0	-0.8	-0.1	-1.2	-0.4	0.1	-1.6	-1.7	-0.6	-1.6	-0.0
Asthma (self-reported)	0.7	1.4	3.8	-0.9	1.3	1.5	1.9	0.3	1.3	1.5	-0.6	1.2	1.0
Breast Cancer	0.6	1.3	3.9	-1.2	-0.3	-0.7	-0.1	-2.0	-1.9	-1.4	-1.1	-1.0	-0.8
Lupus	0.6	0.9	3.5	0.9	0.5	-0.5	0.9	0.4	-1.0	-0.6	1.9	0.1	1.5
Systolic blood pressure, automated reading	0.6	1.6	6.4	2.5	1.0	1.1	-0.4	1.9	1.5	1.5	0.2	0.9	-0.3
Pack years adult smoking proportion	0.6	1.0	3.1	0.6	0.6	1.5	0.1	0.9	1.0	0.6	1.4	1.8	0.5
Relative age voice broke	0.6	0.9	4.2	-0.9	1.5	0.3	-2.0	0.2	-0.2	0.6	0.1	-0.1	1.4
Qualifications: CSEs or equivalent	0.6	0.8	2.1	-1.2	-1.4	-1.2	-0.4	-0.8	-0.3	-1.2	-0.1	-1.0	-0.9
Hearing difficulty/problems with background noise	0.6	1.0	3.8	0.5	0.9	-0.7	1.9	-0.9	-1.1	-1.2	1.2	-0.2	1.1
Mouth/teeth dental problems	0.6	1.0	2.2	0.8	-0.6	-1.3	-1.0	-1.3	-1.0	-1.5	-0.7	-1.1	-0.6
Number of live births	0.6	0.8	4.6	-0.1	1.0	-0.7	2.1	0.6	-0.7	-0.3	0.8	-0.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.1	-0.9	1.0	-0.4	1.8	-0.7	-0.4	-0.9	-0.5	-1.0	0.2
Loud music exposure frequency	0.6	0.7	2.2	-0.4	0.1	-0.9	-0.5	-0.4	-1.5	-1.0	-0.8	-1.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.4	0.3	-1.0	-0.4	-1.1	-0.3	-0.0	-0.5	-1.4	-0.7	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	6.0	0.3	-0.2	-0.5	2.4	-0.1	-0.2	0.3	-0.4	-0.6	1.0
Average weekly red wine intake	0.6	0.9	2.9	0.1	0.2	-1.5	0.0	-1.3	-1.7	-1.0	0.7	-0.7	1.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	0.0	1.2	0.6	0.2	1.2	0.2	0.9	1.2	0.7	1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	3.1	-1.2	0.6	-0.8	1.8	-0.3	-0.8	-1.1	-0.3	-0.4	0.5
High cholesterol (Self-reported)	0.6	1.0	6.2	-0.1	2.5	1.0	-0.4	0.8	1.4	0.3	-0.1	0.8	-0.7
Average weekly beer plus cider intake	0.6	0.8	3.3	-0.4	-1.1	0.1	-1.4	-0.4	-0.2	-0.5	-1.3	-0.5	-1.8
Cholesterol lowering medication	0.6	0.9	4.6	-1.0	2.1	-0.9	0.4	-0.6	-0.5	-1.2	0.4	-0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.8	-0.2	-1.3	1.1	-0.8	1.4	1.2	0.6	-0.1	1.0	-0.5
Bipolar Disorder or Schizophrenia	0.5	1.3	4.8	1.1	-1.2	0.0	1.8	-0.4	0.2	0.4	-1.7	-0.2	-2.2
Neuroticism (Nagel 2018)	0.5	1.1	2.9	1.6	0.4	1.0	1.6	1.7	1.1	0.2	0.6	1.2	0.2
Ovarian Cancer	0.5	0.7	2.1	-0.4	-0.4	-1.1	0.8	-0.3	-1.1	-0.5	-1.2	-1.4	-0.2
Neuroticism (2016)	0.5	0.8	2.0	0.3	-1.1	-1.1	1.4	-0.0	-1.0	-0.7	-0.9	-1.2	-0.4
Schizophrenia (2014)	0.5	1.1	4.8	1.3	-1.3	-0.0	2.2	0.1	0.3	0.4	-0.6	0.1	-1.7
Severe depression (siblings)	0.5	0.6	4.6	0.5	0.2	0.7	-2.1	0.5	0.6	0.5	0.1	0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.9	2.2	0.7	-0.1	1.4	1.0	0.6	1.1	0.4	1.5	1.3	0.6
Pain all over the body in last month	0.5	0.5	3.2	1.8	-0.0	0.8	0.6	0.7	0.4	0.5	-0.6	0.1	-0.6
Father’s age at death	0.5	0.6	3.9	0.7	-0.4	0.2	2.0	1.1	0.3	0.3	-0.5	0.4	-0.7
Worrier / anxious feelings	0.5	0.9	3.5	0.1	0.2	-0.7	1.9	-0.9	-0.8	-1.2	-1.0	-1.2	-0.4
Medication: Lansoprazole	0.5	0.6	2.6	0.8	0.3	1.1	1.6	0.6	1.0	0.3	-0.1	0.8	-0.1
Gout (self-reported)	0.5	0.7	3.9	0.9	1.3	0.9	-0.3	2.0	0.5	0.3	-0.2	0.5	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.9	-0.4	0.9	1.2	1.0	1.3	0.6	0.2	0.3	1.4	-0.1
Age at first live birth	0.5	0.8	2.3	-1.1	-0.3	-1.5	0.6	-0.8	-1.2	-1.3	0.4	-0.8	0.5
Emphysema/chronic bronchitis	0.5	0.6	1.9	-0.4	0.8	-0.1	-1.2	-1.1	-0.8	-0.0	-0.0	-0.5	1.4
Neck or shoulder pain in last month	0.5	0.7	3.7	-1.9	1.0	0.3	1.6	-0.4	-0.6	-0.5	-0.2	-0.1	-0.0
Medication: Seretide 50 evohaler	0.5	0.6	2.8	-0.8	1.0	0.7	1.7	-0.3	0.2	0.2	-0.1	0.5	0.8
Alcohol intake frequency.	0.5	1.1	2.8	-0.2	0.3	1.7	-0.8	1.5	1.6	1.3	0.6	1.6	-0.0
Suffer from ‘nerves’	0.5	0.8	3.4	0.3	0.8	0.8	0.5	0.3	0.5	0.1	1.8	1.2	1.3
Had major operations	0.5	0.6	2.0	0.7	-1.4	0.6	0.2	1.0	1.1	0.6	0.1	0.8	-0.6
Age at last live birth	0.5	0.7	1.9	0.1	-0.1	-1.4	1.3	-0.5	-1.1	-0.7	0.6	-1.0	0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.5	0.0	0.1	0.9	-1.1	0.6	0.8	1.0	1.2	0.8	0.9
Mood swings	0.5	0.8	3.2	1.8	-0.5	0.6	1.5	0.7	1.1	0.6	0.3	0.8	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.0	0.4	1.4	-0.7	-0.2	0.2	-1.0	-0.3	-0.0	-0.7	1.4
Back pain experienced in last month	0.5	0.7	4.5	-2.1	0.9	-0.3	0.1	-0.5	-0.8	-0.7	0.6	-0.1	0.7
Osteoarthritis (self-reported)	0.5	0.7	4.0	0.7	-1.7	-0.1	2.0	-0.2	-0.0	0.1	0.1	0.2	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	2.7	-1.6	-0.4	-1.1	-0.9	-0.2	-1.0	-0.8	-0.4	-0.9	0.4
Miserableness	0.5	0.9	4.7	1.4	0.3	0.2	2.2	1.2	0.5	-0.3	1.0	0.8	-0.2
Mother’s age at death	0.5	0.6	1.2	0.0	1.0	-0.5	-0.6	-1.1	-1.0	-0.4	-0.7	-0.8	1.1
Illnesses of father: High blood pressure	0.5	0.6	2.2	-0.1	-0.4	-1.1	0.3	-1.1	-1.0	-1.5	-0.2	-0.7	-0.1
Ever smoked	0.5	0.9	2.9	-1.6	-0.8	-1.0	-1.7	0.5	-0.6	-0.7	0.2	-0.7	-0.8
Diastolic blood pressure, automated reading	0.5	1.5	4.1	2.0	-0.4	1.1	-0.1	2.0	1.6	1.7	-0.4	0.9	-0.7
Unable to work because of sickness or disability	0.5	0.6	1.9	-0.1	-0.3	-0.6	0.6	-1.2	-0.8	-0.8	1.4	0.2	1.2
Alzheimer’s Disease (in mother)	0.4	0.5	2.1	-1.4	0.6	-0.4	-0.2	-1.3	-0.4	-0.8	0.5	0.3	-0.0
Alzheimer’s Disease (in father)	0.4	0.4	2.0	-0.7	0.0	0.1	1.1	0.1	0.2	-0.0	-1.4	-0.5	-0.9
Age at First Birth	0.4	0.6	3.2	-0.5	1.8	-0.7	-1.2	-0.6	-0.3	-0.6	0.4	-0.7	0.5
Fasting Glucose	0.4	0.5	1.2	0.2	0.4	-1.0	-0.6	-1.1	-0.7	-0.7	0.9	-0.4	0.9
Ulcerative Colitis	0.4	0.5	2.2	-0.2	0.1	-0.3	-0.9	-0.6	-1.2	0.1	-0.4	-0.8	1.5
Hand grip strength (left)	0.4	0.9	2.7	-0.5	-0.7	-1.3	0.2	-1.6	-1.4	-0.8	1.2	-0.8	0.6
Ever had hysterectomy (womb removed)	0.4	0.5	1.6	1.3	-0.0	0.4	-0.7	1.0	0.7	0.5	-1.1	0.1	-0.5
Age when periods started (menarche)	0.4	1.1	4.2	-0.2	-2.1	1.0	-0.9	0.5	1.0	1.3	1.0	1.0	-0.3
High blood pressure (mother)	0.4	0.6	1.6	1.3	1.1	-0.8	1.0	-0.1	-0.8	-0.2	0.2	-0.4	1.2
Past tobacco smoking	0.4	0.7	2.0	1.4	1.1	0.8	1.2	-0.9	0.2	0.6	0.6	0.7	0.9
Diabetes (self-reported)	0.4	0.6	3.6	-1.9	0.2	-0.4	-1.2	-0.8	-0.5	-0.9	-0.3	-0.1	0.1
Fluid intelligence score	0.4	0.8	1.4	-1.0	-0.3	-1.1	0.9	-0.9	-1.1	-1.0	-1.0	-1.2	-0.8
Time employed in main current job	0.4	0.5	2.3	0.9	-0.2	0.7	0.7	1.5	0.3	0.7	0.6	0.4	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.4	-0.8	0.5	0.0	1.8	-0.2	-0.5	-0.4	0.9	0.5	0.9
Hair/balding pattern: Pattern 3	0.4	0.5	2.1	0.3	-1.4	0.8	-0.8	0.5	0.9	0.7	0.4	0.6	-0.5
Mouth/teeth dental problems: Dentures	0.4	0.7	3.3	-0.5	0.4	0.7	-0.7	1.8	0.8	1.0	0.3	0.4	0.9
Prospective memory result	0.4	0.5	1.3	0.6	0.5	0.7	-0.3	0.3	1.0	0.9	0.7	0.6	1.1
Impedance of arm (left)	0.4	1.8	6.5	0.2	-0.4	-1.9	0.7	-2.6	-1.9	-1.3	-0.7	-1.8	0.1
Breastfed as a baby	0.4	0.5	1.8	1.0	0.5	0.4	1.3	0.9	0.9	0.5	0.7	0.7	-0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	4.7	0.5	1.1	0.1	1.2	2.2	0.2	-0.1	0.6	0.2	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	0.9	0.9	0.3	1.3	0.5	1.0	0.1	0.1	0.4	-0.5
High blood pressure (siblings)	0.4	0.6	2.2	0.6	1.2	0.0	0.6	-0.8	-0.4	0.4	1.1	0.0	1.5
Wheeze or whistling in the chest in last year	0.4	0.7	3.7	-1.0	1.2	0.8	1.9	0.3	0.2	0.5	-0.2	0.6	0.7
Qualifications: College or University degree	0.4	1.2	3.6	-0.2	-0.4	-1.6	0.7	-1.0	-1.9	-1.8	-0.9	-1.0	-0.7
Medication: Allopurinol	0.4	0.5	2.3	0.5	-0.1	-0.1	-0.6	1.0	-0.1	-0.9	-0.9	-0.3	-1.5
Ever had bowel cancer screening	0.4	0.5	1.8	0.0	-0.3	0.6	-0.3	0.5	0.6	-0.3	1.4	1.1	0.8
Diabetes diagnosed by doctor	0.4	0.7	3.0	-1.7	0.2	-0.0	-1.5	-0.4	-0.1	-0.8	-1.0	-0.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	4.1	-0.9	0.7	0.7	2.0	-0.4	-0.1	0.5	0.1	0.3	0.2
Smoking status: Current	0.4	0.6	2.6	-1.6	-0.0	-0.7	-1.3	-0.0	-0.5	-1.2	0.3	-0.7	-0.1
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	-1.0	1.6	0.9	0.5	0.7	0.9	0.4	-1.2	0.2	-0.3
Ever taken oral contraceptive pill	0.4	0.5	1.8	1.1	-1.3	0.2	0.6	1.3	0.1	0.7	-0.0	0.1	-0.2
Financial situation satisfaction	0.4	0.4	2.2	-0.1	0.1	-0.3	-0.9	0.3	-0.0	-0.5	-1.5	-0.8	-0.8
Irritability	0.4	0.7	4.3	0.2	-1.2	0.1	0.2	0.3	0.2	-0.5	-1.4	-0.1	-2.1
Alcohol drinker status: Previous	0.4	0.5	1.8	-1.0	-0.2	0.1	0.4	0.8	0.8	-0.5	-0.7	0.4	-1.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.8	-1.2	0.6	-1.2	0.5	-1.1	-1.4	-1.2	-0.4	-1.1	0.6
Worry (Nagel 2018)	0.3	0.6	1.8	0.7	0.5	1.1	0.3	0.9	0.8	0.6	1.1	1.4	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.9	0.7	-0.4	0.6	-0.8	-0.5	-1.0	-0.5	-0.2	-0.6
Crohns Disease (2017)	0.3	0.7	2.2	-0.5	0.5	-0.6	0.2	-1.5	-1.3	-0.2	-1.1	-1.0	0.5
Irritable Bowel Disease (IBD)	0.3	0.7	2.6	-0.2	-0.1	-0.7	0.2	-1.0	-1.6	0.1	-0.4	-1.0	1.6
Ulcerative Colitis (UC)	0.3	0.6	3.2	0.2	-0.5	-0.5	-0.3	-0.5	-1.2	0.1	0.4	-0.6	1.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	0.9	0.3	-0.0	0.8	-1.0	-0.4	0.5	0.2	-0.4	1.0
Mean Putamen Volume	0.3	0.3	1.2	1.1	-0.5	0.5	0.8	-0.3	0.4	0.6	-0.3	0.1	0.4
HbA1C	0.3	0.3	1.3	-0.4	-1.1	-0.7	0.1	-0.6	-0.6	0.1	0.7	-0.2	0.3
Rheumatoid Arthritis	0.3	0.4	1.2	0.9	0.4	0.5	0.8	1.1	0.8	0.7	-0.0	0.2	-0.4
Triglycerides	0.3	0.6	3.5	0.3	0.5	0.2	-0.2	-1.0	-0.2	1.1	0.4	-0.4	1.9
Height	0.3	5.7	9.9	2.5	0.3	2.9	-1.2	3.1	2.7	3.1	3.0	3.1	1.2
Hypothyroidism (self reported)	0.3	0.6	2.5	0.7	1.0	-0.0	1.4	1.6	0.4	-0.4	-0.6	-0.2	-0.2
Neuroticism	0.3	0.8	2.0	1.0	0.0	1.1	1.1	1.4	1.2	0.8	0.1	1.1	0.2
Average weekly spirits intake	0.3	0.3	1.1	0.9	-0.4	0.7	-1.0	0.1	0.8	0.3	-0.2	0.6	0.2
Hearing difficulty/problems: Yes	0.3	0.5	2.2	0.2	0.1	-0.1	1.0	-0.8	-0.5	-0.1	1.5	0.3	1.0
Current tobacco smoking	0.3	0.6	2.5	-1.6	0.2	-0.6	-1.0	0.2	-0.6	-1.1	0.1	-0.8	-0.0
Fed-up feelings	0.3	0.5	2.8	1.2	0.3	0.1	1.7	-0.2	0.4	-0.1	0.8	0.4	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.3	1.3	-0.4	1.1	0.6	0.2	0.6	1.5	-0.3	0.6	-0.3
Stomach or abdominal pain in last month	0.3	0.4	1.5	0.8	0.0	-0.4	1.2	0.6	-0.0	-0.2	1.1	-0.1	-0.2
Supplements: Glucosamine	0.3	0.3	1.0	0.8	-0.9	0.3	0.5	1.0	0.5	0.4	-0.4	0.4	-0.3
Medication: Levothyroxine sodium	0.3	0.5	4.1	0.6	-0.0	-0.4	-0.2	2.0	0.4	-0.5	0.3	0.1	-0.5
Heart attack	0.3	0.4	1.8	-0.3	-1.2	-0.3	-0.2	-0.0	0.3	-0.5	0.1	0.1	-1.4
Allergy	0.3	0.6	2.2	-0.6	-0.1	-1.4	-0.7	-0.1	-0.9	-1.5	0.1	-1.0	-0.5
Medication: Simvastatin	0.3	0.4	1.2	0.4	0.9	0.7	0.2	1.1	1.0	0.2	-0.0	0.6	-0.3
Neuroticism score	0.3	0.5	4.2	-0.0	0.3	0.4	2.0	0.4	0.3	-0.5	-0.7	0.4	-0.6
Trunk fat-free mass	0.3	1.5	3.5	0.2	0.1	1.6	-0.2	1.9	1.7	1.3	1.2	1.9	0.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.2	0.4	-0.2	-1.2	0.1	-1.8	-1.4	-1.6	1.2	-0.8	0.1
Pulse rate	0.3	0.5	3.9	-0.5	-2.0	-0.1	-0.3	-0.7	-0.1	-0.3	-0.4	0.0	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	0.1	1.2	-1.1	-0.7	-0.3	-1.4	-0.7	-0.6	-1.4	-0.3
Trunk predicted mass	0.3	1.6	4.0	0.4	0.0	1.7	-0.3	2.0	1.8	1.3	1.3	1.9	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.7	-0.1	0.4	0.7	1.3	-0.6	0.4	-0.5	0.3	1.0	0.2
Peak expiratory flow (PEF)	0.3	0.8	2.5	1.6	0.9	-0.5	1.3	-0.5	-0.7	-1.0	1.0	-0.1	0.6
Pulse wave reflection index	0.3	0.4	1.2	-0.1	0.4	-0.7	1.0	0.3	-0.9	-0.3	1.1	0.1	0.8
Comparative body size at age 10	0.3	0.9	2.9	0.7	-0.7	0.6	1.7	1.4	0.9	0.2	-0.4	1.0	-1.1
Migraine (self-reported)	0.3	0.4	1.4	-0.9	0.3	-0.9	-0.3	-0.6	-0.6	-1.2	-0.2	-0.9	-0.3
Number of full sisters	0.3	0.4	1.8	1.3	0.3	-0.1	0.2	-0.1	-0.0	-0.4	1.3	0.3	0.3
Family relationship satisfaction	0.3	0.4	2.1	-0.8	-0.2	-0.5	-0.5	-1.5	-0.4	-0.5	0.5	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	4.3	-0.6	-2.1	0.1	0.4	0.3	0.5	0.4	0.0	-0.1	-0.9
Loneliness, isolation	0.3	0.5	3.4	0.7	0.5	-0.3	1.8	0.1	-0.1	-0.3	0.4	0.1	0.8
Friendships satisfaction	0.3	0.4	1.1	1.0	-0.1	-0.7	-0.9	-0.3	-0.5	-1.0	-0.1	-0.4	-1.0
Qualifications: nursing, teaching	0.3	0.4	0.8	0.8	-0.8	-0.5	-0.6	-0.7	-0.6	0.0	0.7	-0.8	0.9
Wears glasses or contact lenses	0.3	0.4	1.3	1.1	-0.4	-0.1	-0.4	0.9	-0.4	0.6	-0.6	-0.5	0.6
Medication: Paracetamol	0.3	0.5	1.9	0.2	-0.9	0.4	1.4	0.5	-0.2	0.1	0.8	0.6	1.0
Age started oral contraceptive pill	0.3	0.4	1.2	0.2	1.1	-0.6	0.2	-1.0	-0.3	0.0	-0.3	-0.9	0.7
Commuting to job workplace: Cycle	0.3	0.4	2.8	-0.0	0.8	-0.1	1.7	-0.3	-0.0	-0.2	-0.8	-0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.2	-0.2	-1.1	0.2	-0.2	0.5	0.8	-0.2	0.3	0.6	-1.5
Impedance of whole body	0.3	1.5	6.3	-0.5	-0.0	-1.6	0.3	-2.5	-1.6	-1.3	-0.4	-1.8	0.2
LDL Cholesterol	0.2	0.3	0.9	0.2	-0.0	-0.5	0.7	-0.3	-1.0	-0.6	-0.8	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.7	0.0	-0.6	0.5	0.7	-0.2	0.1	-0.3	-0.3	-0.5
Heel T-Score	0.2	1.3	7.5	-0.6	-0.1	-1.3	-2.7	-1.1	-1.0	-1.2	0.8	-0.5	0.2
BMI	0.2	0.9	4.1	-0.1	0.5	1.1	1.1	2.0	1.2	0.6	-0.8	0.8	-0.3
Allergy or Eczema	0.2	0.5	1.3	0.4	0.3	1.0	1.0	0.4	0.8	1.2	-0.9	0.4	-0.2
Lung FEV1/FVC ratio	0.2	1.2	2.7	-0.5	-0.5	-0.7	1.6	0.3	-0.7	-1.4	-1.6	-1.1	-1.6
Sensitivity / hurt feelings	0.2	0.4	1.1	-0.3	-0.3	-0.6	0.8	-0.7	-0.6	-1.0	-0.5	-0.5	0.6
Relative age of first facial hair	0.2	0.5	2.8	-1.7	0.1	-0.3	-0.8	0.8	0.1	0.4	-1.0	-0.3	-0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	-0.6	-0.9	-0.4	0.2	-0.0	-0.2	-0.4	-0.6	-0.3	-0.6
Angina	0.2	0.3	0.7	-0.8	-0.7	-0.2	0.4	-0.3	-0.1	-0.6	-0.7	-0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.3	0.8	0.9	0.3	0.2	1.1	0.3	0.5	1.0	0.7	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	0.4	-0.3	-0.7	-0.7	-0.5	-0.1	-1.0	0.8	-0.1	-0.5
Medication: Atenolol	0.2	0.3	0.8	0.7	0.5	0.9	-0.1	0.2	0.4	0.9	0.5	0.6	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	1.0	0.5	0.4	0.3	0.1	0.0	0.4	1.0	-0.1	0.3	1.0
Body mass index (BMI)	0.2	0.7	3.1	-0.2	0.1	0.7	0.6	1.3	0.9	0.1	-1.8	0.3	-0.9
Waist circumference	0.2	0.9	2.6	0.5	-0.4	0.9	0.8	1.5	1.3	0.5	-1.6	0.6	-0.9
Forced vital capacity (FVC)	0.2	0.9	4.6	0.4	0.2	-0.6	-0.8	-1.5	-0.9	-0.6	2.2	-0.1	1.1
Financial difficulties in last 2 years	0.2	0.2	0.7	-0.8	0.6	0.0	0.8	0.5	0.3	-0.1	0.3	-0.5	-0.1
Impedance of arm (right)	0.2	1.1	3.8	0.3	0.0	-1.4	0.3	-1.9	-1.7	-1.2	-0.5	-1.4	0.1
Arm fat percentage (right)	0.2	0.6	4.2	-0.2	0.2	0.4	0.8	0.8	0.4	-0.0	-2.0	-0.1	-0.8
Birth weight	0.2	0.3	1.5	-0.2	-1.0	-0.1	-0.4	-1.2	-0.7	-0.8	-0.3	0.0	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.6	3.0	1.4	-0.7	0.1	-0.3	-0.7	-0.1	0.6	1.7	0.2	0.5
Leg fat percentage (right)	0.2	0.7	3.0	-0.7	1.1	0.9	0.9	0.7	0.9	0.5	-1.7	0.1	-0.4
Angina (self-reported)	0.2	0.3	1.0	-0.8	-1.0	-0.2	0.0	-0.2	0.1	-0.6	-0.6	-0.2	-1.0
Leg pain on walking	0.2	0.3	2.2	-1.5	-0.7	-0.1	-0.3	-0.1	-0.3	-0.6	0.3	0.1	0.4
Smoking status: Previous	0.2	0.4	1.4	-0.7	-1.0	-0.3	-0.5	1.2	0.1	0.1	-0.7	-0.4	-0.6
Whole body fat-free mass	0.2	0.9	2.5	0.2	0.1	1.2	-0.1	1.6	1.4	0.8	1.0	1.6	0.1
Arm fat percentage (left)	0.2	0.7	5.0	-0.4	0.0	-0.0	1.0	0.2	0.2	-0.4	-2.2	-0.4	-0.9
Eye problems/disorders: Cataract	0.2	0.3	1.0	-0.6	-1.0	-0.4	0.4	-0.8	-0.2	-0.2	0.6	-0.2	0.5
Whole body water mass	0.2	0.9	2.6	0.2	-0.1	1.2	-0.1	1.6	1.4	0.8	1.0	1.6	0.1
Leg fat percentage (left)	0.2	0.7	2.4	-0.3	0.9	1.0	0.7	0.9	1.2	0.7	-1.5	0.2	-0.2
Arm fat-free mass (left)	0.2	1.1	3.2	0.2	0.1	1.3	-0.2	1.8	1.6	0.8	0.9	1.5	-0.1
Number of operations (self-reported)	0.2	0.2	1.0	0.8	-0.2	0.4	0.0	-0.2	0.2	0.7	0.2	-0.0	1.0
Risk taking	0.2	0.4	2.3	-1.5	-0.4	-0.5	-0.2	-0.7	-0.4	-0.2	-0.2	-0.8	0.0
Fractured/broken bones in last 5 years	0.2	0.3	1.6	-0.9	-0.2	-0.5	1.3	-0.5	-0.2	-0.4	-0.4	-0.3	0.0
Arm predicted mass (left)	0.2	0.9	3.0	-0.0	0.3	1.2	-0.1	1.7	1.6	0.8	0.8	1.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.1	1.0	-0.1	1.0	-0.1	0.2	-0.2	-0.3	0.1	-0.2	-0.3	0.2
Blood Red Count	0.1	1.4	7.5	2.0	2.7	0.5	1.2	1.3	0.3	-0.0	0.3	0.2	0.1
Waist Hip Ratio (WHR)	0.1	0.4	1.4	1.1	-0.3	0.3	0.4	0.7	1.2	0.5	-0.7	0.4	-0.5
Lung FVC	0.1	0.3	1.2	0.3	0.1	-0.4	0.1	-1.1	-1.0	-0.3	0.4	-0.6	0.1
Hair Pigment	0.1	2.6	8.2	1.1	0.2	1.9	-0.5	1.4	2.4	1.5	2.3	2.9	0.9
Tanning	0.1	1.0	2.9	0.2	-1.5	1.1	-0.6	0.0	0.9	1.7	1.6	1.0	0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.5	-0.7	0.3	-0.3	0.1	-0.5	0.1	-0.2	-0.1	-0.1	-0.6
Impedance of leg (right)	0.1	0.5	2.6	-0.8	0.5	-0.6	0.2	-1.6	-0.6	-0.3	0.3	-0.9	0.4
Trunk fat percentage	0.1	0.3	2.5	0.0	-0.0	0.1	0.9	-0.0	0.2	-0.2	-1.6	-0.3	-0.2
Hand grip strength (right)	0.1	0.4	1.7	-0.0	-0.1	-0.0	-0.1	-1.0	-0.3	0.3	1.3	0.2	1.1
Impedance of leg (left)	0.1	0.3	1.8	-0.4	0.4	-0.4	0.1	-1.3	-0.3	-0.1	0.5	-0.8	0.5
Trunk fat mass	0.1	0.3	1.5	0.1	0.0	0.6	0.7	0.4	0.7	0.3	-1.2	0.3	-0.3
Nervous feelings	0.1	0.2	0.6	0.6	-0.4	0.3	-0.2	0.6	0.2	-0.1	0.7	0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.6	0.4	0.1	-0.2	0.8	0.3	0.6	0.7	0.4	0.8
Weight	0.1	0.3	0.9	0.1	-0.0	0.6	0.4	0.9	0.8	0.1	-0.9	0.5	-0.5
Lung cancer (father)	0.1	0.2	0.9	-0.9	0.6	0.2	0.0	0.2	-0.3	-0.3	-0.2	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	1.1	-0.9	-0.4	0.4	-1.0	-0.6	-0.3	0.9	-0.3	-0.2
Arm fat mass (right)	0.1	0.4	2.1	-0.2	0.2	0.5	0.5	1.0	0.7	0.1	-1.5	0.2	-0.7
Standing height	0.1	0.5	3.2	0.7	-0.5	0.1	-0.6	-0.3	0.2	0.1	1.8	0.6	0.8
Tense / ‘highly strung’	0.1	0.2	0.9	-0.4	0.4	0.4	0.9	0.0	0.0	-0.3	0.3	0.6	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.5	1.2	-0.2	-0.2	1.2	-0.2	-0.1	-0.2	-0.1	-0.6	0.2
Birth weight of first child	0.1	0.3	1.7	0.2	-0.5	0.4	1.3	0.4	-0.5	-0.0	-0.1	0.6	-0.3
Body fat percentage	0.1	0.4	2.8	0.1	0.4	0.4	0.8	0.2	0.5	0.0	-1.7	-0.2	-0.3
Arm fat-free mass (right)	0.1	0.8	2.0	-0.1	0.2	1.1	-0.3	1.1	1.4	0.7	1.1	1.4	0.3
Health satisfaction	0.1	0.1	0.8	0.0	-0.3	-0.2	-0.5	-0.1	-0.5	-0.9	0.1	-0.2	-0.2
Whole body fat mass	0.1	0.4	2.1	0.1	0.3	0.7	0.6	0.7	0.9	0.3	-1.4	0.2	-0.6
Leg fat mass (right)	0.1	0.6	1.6	-0.5	0.6	1.0	0.6	0.9	1.1	0.5	-1.3	0.5	-0.4
Arm predicted mass (right)	0.1	0.6	1.7	0.0	-0.1	0.9	-0.1	1.0	1.3	0.5	0.8	1.2	0.0
Pulse rate, automated reading	0.1	0.3	0.9	-1.0	-0.4	-0.3	0.7	-1.0	-0.6	-0.5	0.4	-0.0	0.6
Comparative height size at age 10	0.1	0.5	2.3	0.8	-1.5	0.3	0.7	-0.9	0.8	0.4	0.3	0.2	-0.1
Overall health rating	0.1	0.3	1.1	-0.4	1.0	0.4	0.7	0.9	0.6	-0.0	0.4	0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.1	0.5	0.5	0.6	-0.7	0.0	0.7	0.1	0.1	-0.1
Leg predicted mass (right)	0.1	0.3	1.0	0.5	-0.2	0.5	0.3	1.0	0.7	0.1	0.4	0.9	0.0
Arm fat mass (left)	0.1	0.4	2.6	-0.3	0.1	0.2	0.6	0.6	0.6	-0.1	-1.6	-0.0	-0.8
Basal metabolic rate	0.1	0.6	1.9	0.1	0.1	1.1	0.0	1.4	1.2	0.6	0.6	1.3	0.0
Leg fat mass (left)	0.1	0.6	1.5	-0.3	0.4	1.0	0.5	1.0	1.2	0.6	-1.2	0.5	-0.4
Blood Platelet Count	0.0	0.2	0.8	-0.2	-0.9	0.4	-0.1	0.8	0.1	0.5	-0.1	0.6	-0.2
Leg fat-free mass (left)	0.0	0.3	0.9	0.2	-0.2	0.5	0.3	1.0	0.7	0.1	0.2	0.9	-0.1
Sitting height	0.0	0.3	1.8	-0.3	-0.4	-0.0	-0.4	-0.3	-0.2	-0.0	1.4	0.5	0.6
Leg predicted mass (left)	0.0	0.3	0.9	0.2	-0.2	0.5	0.3	0.9	0.7	0.1	0.3	1.0	-0.1
Hip circumference	0.0	0.2	1.1	-0.2	-0.3	0.1	0.6	0.2	0.0	-0.1	-1.1	0.0	0.0
Leg fat-free mass (right)	0.0	0.2	0.8	0.4	-0.3	0.4	0.3	0.9	0.6	0.1	0.4	0.9	0.0

Hub : Genes

UPP1

Models

Trait associations