Best TWAS P=5.84e-20 · Best GWAS P=2.54e-152 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 5.3 | 5.3 | 1.2e-07 | 0.21 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | GATAD1 | 0.21 | 0.14 | enet | 10 | 0.16 | 3.4e-13 | 7.1 | -5.8 | 4.9e-09 | 0.05 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | GATAD1 | 0.12 | 0.08 | lasso | 5 | 0.06 | 7.5e-04 | 7.1 | -7.7 | 1.0e-14 | 0.03 | 0.86 | 0.01 | FALSE |
| 4 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | 7.1 | -5.5 | 4.7e-08 | 0.00 | 0.72 | 0.02 | FALSE |
| 5 | GTEx | Artery Aorta | KRIT1 | 0.15 | 0.00 | enet | 24 | 0.03 | 1.3e-02 | -1.2 | -7.2 | 6.0e-13 | 0.18 | 0.10 | 0.22 | TRUE |
| 6 | GTEx | Artery Aorta | GATAD1 | 0.09 | 0.08 | enet | 4 | 0.07 | 7.4e-05 | 7.1 | -7.2 | 4.9e-13 | 0.01 | 0.53 | 0.03 | FALSE |
| 7 | GTEx | Artery Coronary | GATAD1 | 0.12 | 0.15 | lasso | 3 | 0.12 | 8.0e-05 | 7.1 | -7.3 | 2.7e-13 | 0.04 | 0.22 | 0.05 | TRUE |
| 8 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 2.7 | -7.8 | 6.5e-15 | 0.05 | 0.10 | 0.06 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 7.1 | -6.8 | 8.3e-12 | -0.04 | 1.00 | 0.00 | TRUE |
| 10 | GTEx | Esophagus Gastroesophageal Junction | CDK6 | 0.21 | -0.01 | enet | 18 | 0.01 | 1.6e-01 | -14.2 | -7.5 | 5.3e-14 | 0.17 | 0.12 | 0.04 | TRUE |
| 11 | GTEx | Esophagus Mucosa | GATAD1 | 0.16 | 0.05 | enet | 16 | 0.08 | 7.3e-06 | 7.1 | -7.2 | 7.9e-13 | 0.03 | 0.86 | 0.01 | FALSE |
| 12 | GTEx | Lung | GATAD1 | 0.15 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 7.1 | -7.2 | 7.0e-13 | 0.03 | 0.99 | 0.00 | FALSE |
| 13 | GTEx | Muscle Skeletal | GATAD1 | 0.05 | 0.00 | enet | 13 | 0.01 | 2.4e-02 | 4.8 | -5.4 | 5.9e-08 | 0.08 | 0.48 | 0.02 | FALSE |
| 14 | GTEx | Nerve Tibial | GATAD1 | 0.30 | 0.19 | lasso | 5 | 0.23 | 1.8e-16 | 7.1 | -6.0 | 1.5e-09 | 0.05 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Pancreas | GATAD1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.0e-06 | 7.1 | -5.4 | 5.7e-08 | 0.00 | 0.32 | 0.04 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | GATAD1 | 0.22 | 0.27 | lasso | 4 | 0.26 | 1.1e-14 | 7.1 | -6.9 | 5.4e-12 | 0.03 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Skin Not Sun Exposed Suprapubic | SAMD9L | 0.20 | 0.11 | enet | 19 | 0.06 | 3.6e-04 | 1.3 | -5.7 | 1.4e-08 | 0.09 | 0.35 | 0.06 | FALSE |
| 18 | GTEx | Skin Sun Exposed Lower leg | GATAD1 | 0.30 | 0.10 | enet | 14 | 0.16 | 7.0e-13 | 7.1 | -7.5 | 6.5e-14 | 0.08 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Stomach | GATAD1 | 0.30 | 0.13 | lasso | 5 | 0.15 | 8.6e-08 | 7.1 | -8.0 | 1.2e-15 | 0.03 | 0.98 | 0.00 | FALSE |
| 20 | GTEx | Testis | AC000120.7 | 0.05 | 0.03 | enet | 24 | 0.01 | 8.5e-02 | -2.7 | 6.2 | 7.1e-10 | -0.08 | 0.29 | 0.03 | TRUE |
| 21 | GTEx | Thyroid | GATAD1 | 0.18 | 0.06 | lasso | 4 | 0.06 | 3.3e-05 | 7.1 | -7.6 | 2.7e-14 | 0.02 | 0.97 | 0.00 | TRUE |
| 22 | METSIM | Adipose | GATAD1 | 0.10 | 0.05 | lasso | 7 | 0.06 | 9.4e-10 | 4.8 | -6.6 | 3.9e-11 | 0.07 | 1.00 | 0.00 | FALSE |
| 23 | ROSMAP | Brain Pre-frontal Cortex | GATAD1 | 0.17 | 0.15 | lasso | 4 | 0.16 | 6.0e-20 | 5.5 | -6.6 | 3.8e-11 | 0.03 | 1.00 | 0.00 | FALSE |
| 24 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 7.1 | -9.2 | 5.8e-20 | 0.08 | 0.81 | 0.00 | TRUE |