Best TWAS P=3.09e-15 · Best GWAS P=8.43e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CPSF4 | 0.06 | 0.06 | blup | 313 | 0.07 | 6.6e-09 | -6.47 | -5.9 | 3.1e-09 | 0.77 | 0.80 | 0.20 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LOC100289187 | 0.08 | 0.02 | enet | 14 | 0.03 | 4.5e-05 | -7.71 | 7.2 | 8.3e-13 | -0.87 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | GS1-259H13.2 | 0.23 | 0.12 | lasso | 1 | 0.09 | 1.8e-05 | -7.65 | 7.7 | 2.1e-14 | -0.95 | 0.25 | 0.72 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | MBLAC1 | 0.45 | 0.09 | enet | 30 | 0.33 | 2.6e-09 | -0.55 | -5.9 | 2.8e-09 | 0.09 | 0.46 | 0.08 | TRUE |
| 5 | GTEx | Cells Transformed fibroblasts | CPSF4 | 0.08 | 0.03 | lasso | 4 | 0.03 | 1.8e-03 | -7.71 | -7.8 | 6.4e-15 | 0.96 | 0.02 | 0.95 | FALSE |
| 6 | GTEx | Esophagus Mucosa | GS1-259H13.2 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.7e-04 | -7.65 | 7.6 | 2.8e-14 | -0.95 | 0.20 | 0.71 | FALSE |
| 7 | GTEx | Lung | ZKSCAN5 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.7e-03 | -7.71 | 7.9 | 3.1e-15 | -0.96 | 0.04 | 0.91 | TRUE |
| 8 | GTEx | Lung | ZSCAN25 | 0.15 | 0.00 | enet | 25 | 0.00 | 4.7e-01 | 0.61 | 5.2 | 2.3e-07 | -0.37 | 0.04 | 0.13 | FALSE |
| 9 | GTEx | Lung | GS1-259H13.2 | 0.09 | 0.07 | lasso | 4 | 0.05 | 8.4e-05 | -7.65 | 7.7 | 1.8e-14 | -0.95 | 0.30 | 0.64 | FALSE |
| 10 | GTEx | Nerve Tibial | GS1-259H13.2 | 0.15 | 0.10 | lasso | 4 | 0.09 | 3.4e-07 | -7.65 | 7.6 | 3.3e-14 | -0.94 | 0.33 | 0.67 | FALSE |
| 11 | GTEx | Testis | PILRB | 0.23 | 0.13 | enet | 31 | 0.12 | 5.4e-06 | 4.52 | 5.3 | 1.4e-07 | -0.20 | 0.15 | 0.80 | FALSE |
| 12 | GTEx | Thyroid | ARPC1A | 0.11 | 0.03 | lasso | 5 | 0.06 | 4.6e-05 | -4.55 | -7.1 | 1.3e-12 | 0.88 | 0.33 | 0.64 | FALSE |
| 13 | GTEx | Thyroid | GS1-259H13.2 | 0.26 | 0.05 | enet | 30 | 0.08 | 7.6e-07 | -7.58 | 5.2 | 2.6e-07 | -0.59 | 0.30 | 0.68 | FALSE |
| 14 | METSIM | Adipose | ARPC1A | 0.02 | 0.02 | blup | 308 | 0.02 | 1.6e-03 | -6.00 | -5.6 | 2.5e-08 | 0.69 | 0.40 | 0.31 | FALSE |
| 15 | METSIM | Adipose | GS1-259H13.2 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | -7.58 | 7.6 | 2.9e-14 | -0.93 | 0.03 | 0.97 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | GS1-259H13.2 | 0.07 | 0.05 | bslmm | 305 | 0.06 | 6.9e-08 | -6.22 | 6.9 | 4.8e-12 | -0.89 | 0.04 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ZNF789 | 0.09 | 0.00 | blup | 25 | 0.05 | 1.4e-03 | -7.71 | -6.1 | 1.3e-09 | 0.86 | 0.01 | 0.51 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZKSCAN5 | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.0e-04 | -6.48 | -6.5 | 9.0e-11 | 0.81 | 0.47 | 0.34 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POP7 | 0.11 | 0.03 | enet | 10 | 0.04 | 3.9e-05 | 3.98 | 5.2 | 1.9e-07 | 0.00 | 0.01 | 0.20 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | ARPC1B | 0.06 | 0.07 | lasso | 2 | 0.06 | 2.0e-06 | -6.00 | -5.9 | 2.9e-09 | 0.65 | 0.87 | 0.10 | FALSE |