Best TWAS P=6.76e-41 · Best GWAS P=3.03e-53 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RAB2A | 0.05 | 0.02 | bslmm | 454 | 0.02 | 1.7e-03 | 8.9 | 7.2 | 6.3e-13 | -0.02 | 0.88 | 0.00 | FALSE |
2 | GTEx | Artery Aorta | RAB2A | 0.13 | 0.19 | lasso | 3 | 0.19 | 1.7e-10 | 9.0 | 9.0 | 2.7e-19 | 0.19 | 1.00 | 0.00 | FALSE |
3 | GTEx | Artery Tibial | RAB2A | 0.10 | 0.14 | lasso | 6 | 0.12 | 2.9e-09 | 8.9 | 8.8 | 9.4e-19 | 0.20 | 1.00 | 0.00 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | RAB2A | 0.26 | 0.15 | enet | 22 | 0.14 | 2.7e-05 | 8.9 | 8.8 | 1.3e-18 | 0.17 | 0.92 | 0.00 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | RAB2A | 0.35 | 0.21 | lasso | 9 | 0.24 | 2.5e-18 | 8.9 | 9.2 | 2.8e-20 | 0.17 | 1.00 | 0.00 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | CHD7 | 0.07 | 0.00 | lasso | 8 | 0.01 | 3.7e-02 | 6.6 | -7.2 | 4.6e-13 | -0.39 | 0.06 | 0.43 | TRUE |
7 | GTEx | Colon Transverse | RAB2A | 0.14 | 0.05 | enet | 11 | 0.08 | 1.7e-04 | 4.6 | 6.5 | 7.0e-11 | 0.14 | 0.52 | 0.02 | FALSE |
8 | GTEx | Esophagus Muscularis | RAB2A | 0.21 | 0.16 | lasso | 5 | 0.12 | 1.2e-07 | 9.2 | 8.9 | 4.9e-19 | 0.20 | 1.00 | 0.00 | FALSE |
9 | GTEx | Heart Left Ventricle | RAB2A | 0.25 | 0.14 | lasso | 7 | 0.10 | 3.1e-06 | 6.8 | 5.3 | 1.0e-07 | 0.17 | 0.83 | 0.01 | FALSE |
10 | GTEx | Lung | RAB2A | 0.06 | 0.03 | lasso | 6 | 0.02 | 9.1e-03 | 8.9 | 9.2 | 2.2e-20 | 0.16 | 0.51 | 0.03 | FALSE |
11 | GTEx | Muscle Skeletal | RAB2A | 0.11 | 0.06 | enet | 29 | 0.07 | 1.4e-07 | 4.3 | 9.2 | 5.6e-20 | 0.35 | 0.98 | 0.00 | TRUE |
12 | GTEx | Nerve Tibial | RAB2A | 0.10 | 0.02 | lasso | 6 | 0.02 | 1.4e-02 | 8.8 | 9.1 | 1.2e-19 | 0.20 | 0.52 | 0.10 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | RAB2A | 0.08 | 0.09 | lasso | 2 | 0.06 | 1.0e-05 | 9.0 | 9.0 | 2.5e-19 | 0.19 | 0.99 | 0.00 | FALSE |
14 | GTEx | Small Intestine Terminal Ileum | RAB2A | 0.32 | 0.10 | lasso | 10 | 0.04 | 4.5e-02 | 9.2 | -8.3 | 8.2e-17 | -0.22 | 0.14 | 0.05 | FALSE |
15 | GTEx | Spleen | RAB2A | 0.32 | 0.19 | lasso | 4 | 0.16 | 7.9e-05 | 9.2 | 9.2 | 3.7e-20 | 0.20 | 0.46 | 0.03 | FALSE |
16 | GTEx | Thyroid | RAB2A | 0.06 | 0.04 | enet | 8 | 0.04 | 9.5e-04 | 9.2 | 9.2 | 4.9e-20 | 0.16 | 0.67 | 0.04 | FALSE |
17 | GTEx | Whole Blood | CHD7 | 0.07 | 0.02 | enet | 18 | 0.01 | 6.4e-02 | -8.6 | -6.6 | 4.1e-11 | -0.49 | 0.02 | 0.88 | FALSE |
18 | METSIM | Adipose | CA8 | 0.12 | 0.06 | blup | 386 | 0.06 | 1.0e-08 | 3.2 | -7.7 | 1.3e-14 | -0.15 | 1.00 | 0.00 | FALSE |
19 | METSIM | Adipose | RAB2A | 0.09 | 0.10 | lasso | 8 | 0.09 | 9.3e-14 | 8.8 | 9.1 | 1.1e-19 | 0.19 | 1.00 | 0.00 | FALSE |
20 | NTR | Blood | CHD7 | 0.02 | 0.02 | lasso | 4 | 0.02 | 8.7e-07 | 15.4 | -13.4 | 6.8e-41 | -0.90 | 0.00 | 1.00 | TRUE |
21 | YFS | Blood | CA8 | 0.05 | 0.04 | enet | 18 | 0.05 | 1.3e-14 | 8.8 | -8.1 | 4.3e-16 | -0.25 | 1.00 | 0.00 | TRUE |
22 | YFS | Blood | CHD7 | 0.05 | 0.05 | bslmm | 486 | 0.05 | 8.9e-17 | 15.4 | -12.2 | 2.7e-34 | -0.95 | 0.00 | 1.00 | FALSE |
23 | YFS | Blood | RAB2A | 0.08 | 0.08 | bslmm | 447 | 0.11 | 4.5e-34 | 8.8 | 7.5 | 8.1e-14 | 0.19 | 1.00 | 0.00 | FALSE |
24 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RAB2A | 0.08 | 0.05 | lasso | 2 | 0.06 | 7.3e-06 | 8.9 | 7.9 | 3.8e-15 | 0.15 | 0.02 | 0.97 | TRUE |
25 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAB2A | 0.01 | 0.02 | lasso | 3 | 0.01 | 7.5e-04 | 8.8 | 8.5 | 2.3e-17 | 0.15 | 0.02 | 0.96 | FALSE |
26 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RAB2A | 0.07 | 0.08 | lasso | 2 | 0.06 | 9.0e-04 | -7.4 | 7.7 | 1.5e-14 | 0.22 | 0.03 | 0.50 | FALSE |
27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAB2A | 0.03 | 0.02 | blup | 53 | 0.03 | 3.0e-04 | 9.2 | 8.8 | 1.5e-18 | 0.19 | 0.02 | 0.97 | TRUE |
28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAB2A | 0.05 | 0.09 | lasso | 7 | 0.08 | 2.0e-09 | 6.6 | 7.6 | 3.2e-14 | 0.16 | 0.14 | 0.86 | FALSE |
29 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RAB2A | 0.10 | 0.06 | blup | 51 | 0.07 | 3.4e-04 | 8.9 | 9.6 | 7.2e-22 | 0.22 | 0.02 | 0.95 | TRUE |
30 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB2A | 0.03 | 0.03 | enet | 4 | 0.03 | 6.1e-05 | -6.7 | 7.3 | 1.9e-13 | 0.17 | 0.05 | 0.92 | TRUE |
31 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RAB2A | 0.07 | 0.06 | blup | 51 | 0.06 | 2.5e-07 | 9.2 | 9.3 | 1.8e-20 | 0.24 | 0.02 | 0.98 | FALSE |
32 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RAB2A | 0.04 | 0.04 | blup | 51 | 0.04 | 5.3e-04 | 9.2 | 8.8 | 1.5e-18 | 0.20 | 0.02 | 0.96 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | CA8 | 0.05 | 0.04 | lasso | 3 | 0.03 | 3.8e-04 | -5.5 | -5.5 | 4.4e-08 | -0.09 | 0.09 | 0.86 | FALSE |
34 | The Cancer Genome Atlas | Thyroid Carcinoma | RAB2A | 0.06 | 0.03 | blup | 53 | 0.05 | 6.1e-06 | 5.0 | 8.6 | 8.3e-18 | 0.22 | 0.02 | 0.98 | FALSE |