Best TWAS P=5.56e-13 · Best GWAS P=3.62e-29 conditioned to 1.17e-20
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | IL7 | 0.15 | 0.16 | enet | 25 | 0.16 | 1.5e-18 | 7.0 | -5.4 | 6.5e-08 | 0.05 | 1.00 | 0.00 | TRUE |
2 | GTEx | Adipose Subcutaneous | RP11-578O24.2 | 0.19 | 0.20 | lasso | 8 | 0.18 | 6.9e-15 | 7.0 | -7.0 | 3.3e-12 | 0.14 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RP11-578O24.2 | 0.10 | 0.03 | lasso | 2 | 0.05 | 1.5e-03 | 7.0 | -7.0 | 2.4e-12 | 0.15 | 0.55 | 0.04 | FALSE |
4 | GTEx | Artery Aorta | RP11-578O24.2 | 0.23 | 0.25 | lasso | 6 | 0.23 | 4.1e-13 | 7.0 | -6.8 | 1.4e-11 | 0.16 | 1.00 | 0.00 | FALSE |
5 | GTEx | Artery Coronary | RP11-578O24.2 | 0.18 | 0.14 | lasso | 6 | 0.13 | 5.1e-05 | 6.9 | -7.0 | 2.6e-12 | 0.15 | 0.72 | 0.02 | FALSE |
6 | GTEx | Artery Tibial | RP11-578O24.2 | 0.18 | 0.18 | lasso | 4 | 0.17 | 3.6e-13 | 7.0 | -7.0 | 2.8e-12 | 0.15 | 1.00 | 0.00 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | IL7 | 0.26 | 0.16 | enet | 18 | 0.18 | 2.4e-05 | 6.0 | -5.8 | 7.5e-09 | 0.10 | 0.72 | 0.02 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | RP11-578O24.2 | 0.33 | 0.20 | lasso | 11 | 0.15 | 1.1e-04 | 7.0 | -6.4 | 1.3e-10 | 0.13 | 0.33 | 0.04 | FALSE |
9 | GTEx | Brain Cerebellum | IL7 | 0.24 | 0.31 | enet | 11 | 0.31 | 7.4e-10 | 6.9 | -7.0 | 3.1e-12 | 0.15 | 0.99 | 0.00 | FALSE |
10 | GTEx | Brain Cerebellum | RP11-578O24.2 | 0.22 | 0.18 | lasso | 9 | 0.14 | 6.0e-05 | 7.0 | -7.1 | 1.6e-12 | 0.15 | 0.54 | 0.07 | FALSE |
11 | GTEx | Brain Cortex | RP11-578O24.2 | 0.34 | 0.03 | lasso | 13 | 0.05 | 1.9e-02 | 6.9 | -6.0 | 1.9e-09 | 0.06 | 0.12 | 0.13 | FALSE |
12 | GTEx | Breast Mammary Tissue | RP11-578O24.2 | 0.21 | 0.16 | lasso | 1 | 0.12 | 5.8e-07 | 6.9 | -6.9 | 4.0e-12 | 0.15 | 0.98 | 0.00 | FALSE |
13 | GTEx | Breast Mammary Tissue (Female) | RP11-578O24.2 | 0.29 | 0.17 | lasso | 2 | 0.11 | 3.3e-04 | 6.9 | -7.0 | 2.1e-12 | 0.15 | 0.26 | 0.11 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | RP11-578O24.2 | 0.20 | 0.22 | lasso | 7 | 0.22 | 2.2e-16 | 7.0 | -7.0 | 2.1e-12 | 0.15 | 1.00 | 0.00 | FALSE |
15 | GTEx | Esophagus Gastroesophageal Junction | RP11-578O24.2 | 0.22 | 0.03 | enet | 26 | 0.16 | 2.9e-06 | 4.9 | -6.1 | 1.2e-09 | 0.08 | 0.29 | 0.06 | FALSE |
16 | GTEx | Esophagus Muscularis | RP11-578O24.2 | 0.23 | 0.20 | lasso | 9 | 0.21 | 4.1e-13 | 7.0 | -7.1 | 1.3e-12 | 0.15 | 1.00 | 0.00 | FALSE |
17 | GTEx | Heart Atrial Appendage | RP11-578O24.2 | 0.12 | 0.10 | lasso | 3 | 0.08 | 2.1e-04 | 4.9 | -6.2 | 7.8e-10 | 0.07 | 0.78 | 0.02 | FALSE |
18 | GTEx | Heart Left Ventricle | RP11-578O24.2 | 0.10 | 0.09 | lasso | 7 | 0.09 | 1.3e-05 | 7.0 | -7.0 | 2.6e-12 | 0.14 | 0.55 | 0.03 | FALSE |
19 | GTEx | Lung | RP11-578O24.2 | 0.16 | 0.18 | lasso | 2 | 0.18 | 1.9e-13 | 7.0 | -7.0 | 2.4e-12 | 0.15 | 1.00 | 0.00 | FALSE |
20 | GTEx | Muscle Skeletal | RP11-578O24.2 | 0.07 | 0.05 | enet | 17 | 0.06 | 7.3e-07 | 7.0 | -7.0 | 2.0e-12 | 0.14 | 0.99 | 0.00 | FALSE |
21 | GTEx | Nerve Tibial | IL7 | 0.15 | 0.12 | lasso | 3 | 0.11 | 4.7e-08 | 7.0 | -7.0 | 2.2e-12 | 0.15 | 1.00 | 0.00 | FALSE |
22 | GTEx | Nerve Tibial | RP11-578O24.2 | 0.31 | 0.32 | lasso | 5 | 0.32 | 4.8e-23 | 7.0 | -7.2 | 5.6e-13 | 0.15 | 1.00 | 0.00 | TRUE |
23 | GTEx | Ovary | IL7 | 0.26 | 0.20 | lasso | 10 | 0.16 | 7.7e-05 | 6.9 | -7.2 | 8.1e-13 | 0.15 | 0.25 | 0.08 | FALSE |
24 | GTEx | Ovary | RP11-578O24.2 | 0.24 | 0.23 | lasso | 5 | 0.20 | 1.2e-05 | 7.0 | -7.0 | 3.7e-12 | 0.15 | 0.33 | 0.04 | FALSE |
25 | GTEx | Pituitary | RP11-578O24.2 | 0.24 | 0.21 | lasso | 8 | 0.20 | 7.6e-06 | 7.0 | -7.0 | 3.4e-12 | 0.15 | 0.38 | 0.03 | FALSE |
26 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-578O24.2 | 0.23 | 0.17 | lasso | 7 | 0.16 | 3.2e-09 | 6.8 | -7.0 | 2.8e-12 | 0.15 | 1.00 | 0.00 | FALSE |
27 | GTEx | Skin Sun Exposed Lower leg | RP11-578O24.2 | 0.16 | 0.22 | enet | 17 | 0.22 | 1.8e-18 | 7.0 | -7.2 | 6.5e-13 | 0.15 | 1.00 | 0.00 | FALSE |
28 | GTEx | Stomach | RP11-578O24.2 | 0.09 | 0.05 | lasso | 2 | 0.02 | 3.3e-02 | 6.9 | -7.2 | 9.0e-13 | 0.15 | 0.61 | 0.02 | FALSE |
29 | GTEx | Testis | RP11-578O24.2 | 0.19 | 0.16 | enet | 14 | 0.15 | 3.1e-07 | 7.0 | -5.6 | 1.9e-08 | 0.09 | 0.96 | 0.01 | FALSE |
30 | GTEx | Thyroid | RP11-578O24.2 | 0.15 | 0.18 | lasso | 7 | 0.18 | 4.4e-14 | 6.9 | -7.0 | 3.2e-12 | 0.15 | 1.00 | 0.00 | FALSE |
31 | GTEx | Whole Blood | ZC2HC1A | 0.07 | 0.08 | lasso | 2 | 0.06 | 1.9e-06 | 7.0 | -7.0 | 2.4e-12 | 0.15 | 0.99 | 0.00 | FALSE |
32 | NTR | Blood | FAM164A | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.6e-18 | 6.9 | -6.7 | 2.2e-11 | 0.15 | 1.00 | 0.00 | FALSE |
33 | YFS | Blood | PKIA | 0.29 | 0.36 | enet | 41 | 0.39 | 1.4e-139 | 4.3 | -5.7 | 1.3e-08 | 0.09 | 1.00 | 0.00 | FALSE |
34 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PKIA | 0.05 | 0.04 | blup | 54 | 0.05 | 5.6e-06 | 4.1 | -5.3 | 8.8e-08 | 0.09 | 0.20 | 0.79 | FALSE |
35 | The Cancer Genome Atlas | Lung Adenocarcinoma | PKIA | 0.03 | 0.00 | blup | 54 | 0.01 | 1.1e-02 | 6.9 | -6.3 | 3.5e-10 | 0.04 | 0.00 | 0.74 | FALSE |
36 | The Cancer Genome Atlas | Thyroid Carcinoma | IL7 | 0.04 | 0.02 | enet | 8 | 0.02 | 2.1e-03 | 6.1 | -6.7 | 1.5e-11 | 0.18 | 0.08 | 0.38 | FALSE |