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chr8:78,733,701-80,414,641

Best TWAS P=5.56e-13 · Best GWAS P=3.62e-29 conditioned to 1.17e-20

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Nerve Tibial	RP11-578O24.2	0.31	0.32	lasso	5	0.32	4.8e-23	7.0	-7.2	5.6e-13	0.15	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	IL7	0.15	0.16	enet	25	0.16	1.5e-18	7.0	-5.4	6.5e-08	0.05	1.00	0.00	TRUE
27	GTEx	Skin Sun Exposed Lower leg	RP11-578O24.2	0.16	0.22	enet	17	0.22	1.8e-18	7.0	-7.2	6.5e-13	0.15	1.00	0.00	FALSE
23	GTEx	Ovary	IL7	0.26	0.20	lasso	10	0.16	7.7e-05	6.9	-7.2	8.1e-13	0.15	0.25	0.08	FALSE
28	GTEx	Stomach	RP11-578O24.2	0.09	0.05	lasso	2	0.02	3.3e-02	6.9	-7.2	9.0e-13	0.15	0.61	0.02	FALSE
16	GTEx	Esophagus Muscularis	RP11-578O24.2	0.23	0.20	lasso	9	0.21	4.1e-13	7.0	-7.1	1.3e-12	0.15	1.00	0.00	FALSE
10	GTEx	Brain Cerebellum	RP11-578O24.2	0.22	0.18	lasso	9	0.14	6.0e-05	7.0	-7.1	1.6e-12	0.15	0.54	0.07	FALSE
20	GTEx	Muscle Skeletal	RP11-578O24.2	0.07	0.05	enet	17	0.06	7.3e-07	7.0	-7.0	2.0e-12	0.14	0.99	0.00	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RP11-578O24.2	0.29	0.17	lasso	2	0.11	3.3e-04	6.9	-7.0	2.1e-12	0.15	0.26	0.11	FALSE
14	GTEx	Cells Transformed fibroblasts	RP11-578O24.2	0.20	0.22	lasso	7	0.22	2.2e-16	7.0	-7.0	2.1e-12	0.15	1.00	0.00	FALSE
21	GTEx	Nerve Tibial	IL7	0.15	0.12	lasso	3	0.11	4.7e-08	7.0	-7.0	2.2e-12	0.15	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-578O24.2	0.10	0.03	lasso	2	0.05	1.5e-03	7.0	-7.0	2.4e-12	0.15	0.55	0.04	FALSE
19	GTEx	Lung	RP11-578O24.2	0.16	0.18	lasso	2	0.18	1.9e-13	7.0	-7.0	2.4e-12	0.15	1.00	0.00	FALSE
31	GTEx	Whole Blood	ZC2HC1A	0.07	0.08	lasso	2	0.06	1.9e-06	7.0	-7.0	2.4e-12	0.15	0.99	0.00	FALSE
5	GTEx	Artery Coronary	RP11-578O24.2	0.18	0.14	lasso	6	0.13	5.1e-05	6.9	-7.0	2.6e-12	0.15	0.72	0.02	FALSE
18	GTEx	Heart Left Ventricle	RP11-578O24.2	0.10	0.09	lasso	7	0.09	1.3e-05	7.0	-7.0	2.6e-12	0.14	0.55	0.03	FALSE
6	GTEx	Artery Tibial	RP11-578O24.2	0.18	0.18	lasso	4	0.17	3.6e-13	7.0	-7.0	2.8e-12	0.15	1.00	0.00	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	RP11-578O24.2	0.23	0.17	lasso	7	0.16	3.2e-09	6.8	-7.0	2.8e-12	0.15	1.00	0.00	FALSE
9	GTEx	Brain Cerebellum	IL7	0.24	0.31	enet	11	0.31	7.4e-10	6.9	-7.0	3.1e-12	0.15	0.99	0.00	FALSE
30	GTEx	Thyroid	RP11-578O24.2	0.15	0.18	lasso	7	0.18	4.4e-14	6.9	-7.0	3.2e-12	0.15	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-578O24.2	0.19	0.20	lasso	8	0.18	6.9e-15	7.0	-7.0	3.3e-12	0.14	1.00	0.00	FALSE
25	GTEx	Pituitary	RP11-578O24.2	0.24	0.21	lasso	8	0.20	7.6e-06	7.0	-7.0	3.4e-12	0.15	0.38	0.03	FALSE
24	GTEx	Ovary	RP11-578O24.2	0.24	0.23	lasso	5	0.20	1.2e-05	7.0	-7.0	3.7e-12	0.15	0.33	0.04	FALSE
12	GTEx	Breast Mammary Tissue	RP11-578O24.2	0.21	0.16	lasso	1	0.12	5.8e-07	6.9	-6.9	4.0e-12	0.15	0.98	0.00	FALSE
4	GTEx	Artery Aorta	RP11-578O24.2	0.23	0.25	lasso	6	0.23	4.1e-13	7.0	-6.8	1.4e-11	0.16	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	IL7	0.04	0.02	enet	8	0.02	2.1e-03	6.1	-6.7	1.5e-11	0.18	0.08	0.38	FALSE
32	NTR	Blood	FAM164A	0.06	0.06	lasso	3	0.06	3.6e-18	6.9	-6.7	2.2e-11	0.15	1.00	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RP11-578O24.2	0.33	0.20	lasso	11	0.15	1.1e-04	7.0	-6.4	1.3e-10	0.13	0.33	0.04	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	PKIA	0.03	0.00	blup	54	0.01	1.1e-02	6.9	-6.3	3.5e-10	0.04	0.00	0.74	FALSE
17	GTEx	Heart Atrial Appendage	RP11-578O24.2	0.12	0.10	lasso	3	0.08	2.1e-04	4.9	-6.2	7.8e-10	0.07	0.78	0.02	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	RP11-578O24.2	0.22	0.03	enet	26	0.16	2.9e-06	4.9	-6.1	1.2e-09	0.08	0.29	0.06	FALSE
11	GTEx	Brain Cortex	RP11-578O24.2	0.34	0.03	lasso	13	0.05	1.9e-02	6.9	-6.0	1.9e-09	0.06	0.12	0.13	FALSE
7	GTEx	Brain Cerebellar Hemisphere	IL7	0.26	0.16	enet	18	0.18	2.4e-05	6.0	-5.8	7.5e-09	0.10	0.72	0.02	FALSE
33	YFS	Blood	PKIA	0.29	0.36	enet	41	0.39	1.4e-139	4.3	-5.7	1.3e-08	0.09	1.00	0.00	FALSE
29	GTEx	Testis	RP11-578O24.2	0.19	0.16	enet	14	0.15	3.1e-07	7.0	-5.6	1.9e-08	0.09	0.96	0.01	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PKIA	0.05	0.04	blup	54	0.05	5.6e-06	4.1	-5.3	8.8e-08	0.09	0.20	0.79	FALSE