Hub : Genes

PKIA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.3920	0.0580	0.0e+00	0.345	NA	0.407	NA	0.398	8.9e-27	NA	1.4e-32	NA	1.2e-31
2	GTEx	Uterus	0.3600	0.1340	6.2e-03	-0.013	NA	-0.013	NA	-0.013	7.4e-01	NA	7.3e-01	NA	7.1e-01
3	GTEx	Whole Blood	0.1120	0.0340	3.4e-05	0.056	NA	0.066	NA	0.074	6.2e-06	NA	9.9e-07	NA	2.4e-07
4	YFS	Blood	0.2896	0.0378	0.0e+00	0.355	0.375	0.394	0.39	0.385	1.6e-122	5.2e-131	1.4e-139	1.3e-137	1.3e-135
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0453	0.0205	3.4e-06	0.044	0.046	0.045	NA	0.039	1.0e-05	5.6e-06	7.9e-06	NA	2.8e-05
6	TCGA	Lung Adenocarcinoma	0.0340	0.0199	4.9e-03	0.000	0.013	0.008	NA	0.000	2.9e-01	1.1e-02	3.6e-02	NA	3.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.0	4.6	1.4	-0.7	2.1	1.6	1.2	1.0
Bipolar Disorder or Schizophrenia	0.7	1.7	3.1	1.1	-0.7	1.7	1.8	0.9	1.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.8	0.1	-0.7	1.4	0.1	-0.2	-0.0
Depression (Nagel 2018)	0.9	1.3	2.2	-1.0	-1.1	1.2	-1.3	-1.5	-0.2
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.6	1.3	-1.0	1.6	1.2	1.4	1.5
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.7	0.1	0.4	-0.7	-0.6	-0.6
Schizophrenia (2018)	0.2	0.4	1.0	0.3	-0.4	0.4	1.0	0.1	0.9
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	0.1	-0.2	-0.4	0.3	-0.1	0.1
Worry (Nagel 2018)	0.1	0.1	0.6	-0.0	0.2	0.7	-0.1	0.1	-0.3
Alzheimer’s Disease (in mother)	1.1	1.3	3.9	0.0	-0.7	-2.0	-0.3	-0.3	-1.8
Alzheimer’s Disease (in father)	0.4	0.4	0.9	0.3	-1.0	0.9	0.2	0.2	0.7
Alzheimer’s Disease (including proxy)	0.7	1.0	3.5	0.4	-1.9	-0.8	0.1	-0.3	-1.2
Crohns Disease (2017)	1.9	4.1	8.1	2.4	-0.8	0.5	2.4	2.8	1.9
Irritable Bowel Disease (IBD)	2.2	5.2	8.2	2.6	-1.3	0.8	2.8	2.9	2.4
Ulcerative Colitis (UC)	1.4	2.7	4.5	2.0	-1.1	0.8	2.1	1.8	1.6
Major Depression (MDD)	0.1	0.1	0.3	0.5	0.1	0.6	0.2	-0.1	0.2
Reaction Time	0.5	0.9	1.9	1.3	0.6	0.1	1.4	0.9	0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.2	1.1	-0.0	0.8	0.9	1.5	1.0
Breast Cancer	0.2	0.6	1.2	0.7	-1.1	-0.6	0.9	0.5	0.6
Ovarian Cancer	0.5	0.6	1.9	0.6	-0.1	1.4	0.8	0.6	0.5
Prostate Cancer	0.7	1.0	2.2	-0.7	-1.5	-1.0	-0.9	-1.1	-0.5
Age at First Birth	0.3	0.4	2.0	0.3	1.4	0.5	0.4	0.0	0.3
Bipolar Disorder (2011)	1.6	1.6	6.5	1.1	-0.6	2.5	1.1	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	0.9	0.7	-0.1	0.7	0.5	0.9	0.8
Coronary Artery Disease (CAD)	1.4	1.7	5.3	0.0	1.1	2.3	0.6	0.4	1.8
Crohns Disease (2012)	1.0	1.6	3.8	1.3	0.0	-0.4	1.5	2.0	1.3
Mean Putamen Volume	0.4	0.5	0.8	-0.8	0.4	-0.2	-0.8	-0.7	-0.9
Fasting Glucose	0.2	0.2	0.7	0.2	0.7	0.8	0.2	0.2	-0.2
HbA1C	0.2	0.2	0.7	-0.2	0.4	0.9	0.1	-0.2	0.6
HDL Cholesterol	0.5	0.8	1.7	1.3	-1.0	0.9	1.1	0.5	-0.1
LDL Cholesterol	0.2	0.4	0.9	-0.5	-0.3	0.9	-0.1	-0.2	1.0
Lupus	2.4	3.6	6.9	-1.4	-2.4	-1.1	-1.8	-1.7	-2.6
Neuroticism (2016)	0.6	0.8	1.8	-0.5	0.2	-1.4	-0.9	-0.3	-1.3
Primary Biliary Cirrhosis	0.2	0.2	0.7	-0.3	0.0	-0.0	0.1	-0.9	-0.8
Rheumatoid Arthritis	0.2	0.3	1.1	0.1	-0.2	0.4	0.5	0.4	1.0
Schizophrenia (2014)	0.1	0.2	0.7	-0.3	-0.4	0.8	0.4	-0.1	0.5
Triglycerides	0.7	1.1	3.0	-1.2	1.7	0.2	-1.1	-1.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.1	-1.4	0.3	-1.3	-1.1	-0.9	-0.3
Ulcerative Colitis	1.4	2.1	3.6	1.8	-1.1	0.2	1.9	1.6	1.2
Blood Eosinophil Count	0.3	2.2	7.1	-0.2	2.2	2.7	-0.5	-0.2	0.8
Blood Platelet Count	0.2	2.3	5.6	-2.4	1.2	-0.9	-2.1	-1.1	-0.6
Blood Red Count	0.4	3.6	7.3	-2.3	-0.2	-1.5	-2.7	-1.7	-1.9
Blood White Count	3.0	22.2	39.4	-4.8	-0.1	-3.2	-5.7	-5.3	-6.3
Heel T-Score	0.2	1.7	5.1	-0.8	0.4	-2.2	-1.1	-0.1	-1.7
BMI	0.3	1.7	7.0	-1.0	-0.9	-2.6	-0.7	-0.2	-0.8
Height	0.1	1.2	2.1	-0.8	-0.8	1.2	-0.8	-1.2	1.5
Waist Hip Ratio (WHR)	0.1	0.6	2.6	0.6	-1.6	-0.5	0.4	0.3	-0.5
Systolic Blood Pressure	0.4	1.8	4.1	2.0	-0.4	0.0	1.9	1.7	0.5
Smoking Status	0.1	0.2	0.7	0.4	-0.8	0.6	0.4	0.4	0.2
Allergy or Eczema	0.2	0.6	1.2	0.9	1.1	0.6	0.8	0.7	-0.3
Cardiovascular Disease	0.2	0.7	2.7	0.5	-1.6	-0.9	0.3	0.1	-0.1
Hypothyroidism (self reported)	0.9	2.0	6.1	-0.6	-0.4	2.2	-0.0	-0.5	2.5
Respiratory disease	0.3	0.8	4.4	-0.2	2.1	0.0	-0.2	-0.3	0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.4	0.1	0.2	0.5	0.4	0.6
Lung FEV1/FVC ratio	0.1	0.3	0.7	-0.5	-0.0	-0.2	-0.8	0.1	-0.8
Lung FVC	0.0	0.2	0.4	0.6	-0.2	-0.1	0.4	0.6	0.5
Neuroticism	0.1	0.3	0.5	-0.6	-0.0	0.7	-0.7	-0.6	-0.4
Chronotype (morning person)	0.2	0.5	1.1	-0.3	1.0	-0.9	-0.4	-0.1	-0.7
Hair Pigment	0.1	1.7	3.0	1.2	-1.4	-0.7	1.4	1.1	1.7
Tanning	0.1	1.4	2.6	1.2	-1.2	-0.1	1.4	1.6	0.9
Hand grip strength (left)	0.2	0.5	2.1	0.2	-1.4	-0.0	-0.3	-0.4	-0.7
Number of treatments/medications taken	0.0	0.1	0.4	0.2	0.1	0.6	-0.1	-0.1	0.2
Average weekly spirits intake	0.4	0.5	1.0	-0.5	-0.2	-1.0	-0.6	-0.8	-0.8
Sensitivity / hurt feelings	0.1	0.3	0.6	-0.2	-0.1	0.8	-0.3	-0.7	-0.5
Frequency of depressed mood in last 2 weeks	1.4	1.9	4.7	-1.3	-2.2	-0.0	-1.3	-1.7	-0.6
Hearing difficulty/problems: Yes	1.3	1.9	3.0	1.6	0.6	1.7	1.5	1.4	1.1
Relative age of first facial hair	0.3	0.7	3.2	-0.3	0.4	-1.8	-0.4	-0.5	0.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	3.1	-0.6	-1.7	1.8	-0.6	-1.4	-0.4
Ever used hormone-replacement therapy (HRT)	2.6	3.3	7.8	1.8	0.8	2.8	1.9	1.6	1.3
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	-0.6	0.2	-0.5	-0.3	-0.6	1.0
Systolic blood pressure, automated reading	0.8	2.3	4.5	1.9	0.4	-0.0	2.0	2.1	1.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.3	-1.1	-0.0	-0.8	-1.1	-1.1	-0.6
Angina	0.6	0.8	3.7	-0.4	0.1	-1.9	-0.7	-0.7	-0.5
Medication for hormone replacement therapy	0.3	0.4	1.6	0.2	-1.3	0.6	0.3	0.0	-0.4
Vitamin and mineral supplements	0.1	0.2	0.4	-0.3	0.6	-0.1	-0.5	0.1	0.4
Supplements: Zinc	0.7	0.8	3.2	-0.2	0.7	-1.8	0.5	0.4	0.8
Medication: Co-codamol	0.1	0.1	0.5	-0.0	0.4	0.2	0.1	-0.7	-0.1
Medication: Metformin	0.1	0.1	0.2	-0.5	0.2	-0.2	-0.5	-0.4	-0.4
Diabetes (father)	0.5	0.6	2.0	-0.6	0.9	-1.4	-0.5	-0.0	-0.6
Diabetes (mother)	0.6	0.7	2.3	0.5	-1.5	1.1	0.6	0.6	0.4
Severe depression (siblings)	0.3	0.4	1.4	0.3	-1.2	0.3	0.2	0.4	0.7
Pack years adult smoking proportion	0.1	0.1	0.3	0.3	0.2	-0.3	0.2	0.1	0.6
Impedance of leg (right)	0.2	1.1	5.4	0.6	2.3	0.5	0.4	0.5	0.4
Leg fat-free mass (left)	0.1	0.3	1.8	0.0	-1.3	0.3	0.1	-0.2	0.4
Trunk fat percentage	0.2	0.8	1.7	-1.3	0.1	-0.8	-1.2	-0.6	-0.6
Hand grip strength (right)	0.4	1.0	3.1	-0.4	-1.8	-0.2	-0.9	-0.8	-1.1
Townsend deprivation index at recruitment	0.5	0.7	1.9	0.2	-1.2	-1.4	0.6	0.3	0.8
Current tobacco smoking	0.3	0.4	1.8	0.4	-1.4	-0.0	0.0	0.4	-0.7
Average weekly fortified wine intake	1.0	1.1	3.8	-1.1	-0.0	-1.9	-1.0	-0.4	-0.7
Maternal smoking around birth	0.2	0.3	0.5	0.6	-0.7	-0.7	0.7	0.2	-0.2
Fed-up feelings	0.6	1.0	1.6	1.1	-1.0	0.3	1.3	1.1	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.0	-1.0	-1.8	1.0	-1.4	-2.0	-0.7
Relative age voice broke	1.8	2.8	5.6	-1.9	0.8	-2.4	-1.7	-1.7	-1.0
Taking other prescription medications	0.1	0.2	0.6	-0.0	-0.4	0.8	-0.3	-0.2	-0.2
Age when periods started (menarche)	1.9	4.5	6.9	-2.2	-1.1	-1.8	-2.3	-2.6	-2.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.0	0.0	-1.0	-0.2	0.1	0.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-0.9	-0.2	-0.0	-1.0	-1.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.8	1.2	0.9	-0.1	1.3	1.0	0.8
Qualifications: CSEs or equivalent	2.7	3.5	5.2	-1.9	-0.1	-1.7	-2.2	-2.1	-2.3
Serious illness, injury or assault to yourself	1.1	1.4	2.9	-1.1	-0.8	1.7	-1.3	-1.2	-0.7
High blood pressure	0.2	0.6	1.8	-0.3	-1.4	-1.0	-0.3	-0.4	-0.4
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.7	1.2	0.5	1.6	1.5	1.0	0.9
Multivitamins +/- minerals	0.1	0.2	0.7	0.4	-0.1	-0.1	0.4	-0.1	-0.9
Stomach or abdominal pain in last month	0.6	0.8	2.3	-0.1	-1.2	-0.4	-0.6	-0.5	-1.5
Supplements: Glucosamine	1.6	2.0	3.3	1.7	-1.6	0.2	1.8	1.6	0.9
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	3.5	1.6	-1.9	0.1	1.5	0.8	-0.1
Medication: Atenolol	0.7	0.8	1.4	1.0	-0.0	0.4	1.1	1.1	1.2
Medication: Levothyroxine sodium	0.7	1.1	2.8	-1.1	-1.0	0.9	-0.6	-0.8	1.7
Sitting height	0.0	0.3	0.6	-0.2	-0.7	0.8	-0.3	-0.6	0.1
Chronic bronchitis/emphysema (father)	1.4	1.6	4.2	-0.8	-0.0	1.4	-1.1	-2.0	-1.2
High blood pressure (mother)	2.3	3.2	5.6	2.4	0.3	1.7	2.2	1.9	1.5
Body mass index (BMI)	0.1	0.3	1.1	-0.6	-0.4	-1.1	-0.4	0.0	-0.4
Impedance of leg (left)	0.2	0.8	2.3	0.7	1.5	0.7	0.6	0.7	0.5
Leg predicted mass (left)	0.1	0.3	1.6	-0.0	-1.3	0.3	-0.0	-0.3	0.3
Trunk fat mass	0.1	0.4	1.0	-1.0	-0.3	-0.4	-0.9	-0.5	-0.3
Waist circumference	0.1	0.2	0.9	0.0	-0.9	-0.3	0.2	0.5	0.2
Number of incorrect matches in round	3.1	5.1	7.9	2.5	2.0	1.4	2.8	2.2	2.4
Past tobacco smoking	0.2	0.4	1.9	-0.3	0.3	-1.4	0.1	0.2	0.8
Alcohol usually taken with meals	0.3	0.5	1.3	0.6	0.7	0.5	0.6	1.1	0.7
Nervous feelings	1.8	3.4	5.6	-2.2	0.5	-0.4	-2.2	-2.2	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	4.6	0.0	-2.2	0.0	-0.1	0.1	0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.6	-0.1	0.4	0.2	-0.2	0.8	0.3
Hair/balding pattern: Pattern 2	0.7	0.9	3.2	-0.1	1.8	1.2	0.4	0.2	0.8
Had menopause	0.4	0.5	2.1	0.3	1.5	0.9	0.0	0.0	0.2
Had other major operations	2.8	3.5	5.7	2.4	-0.7	2.0	2.3	1.6	1.7
Forced vital capacity (FVC)	0.3	1.1	4.5	0.8	-2.1	0.9	0.5	0.1	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.0	-0.2	-0.4	-0.2	0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.1	-0.9	-0.8	-0.1	-1.1	-1.0	-1.4
Qualifications: None of the above	0.6	1.4	3.0	-1.0	1.7	-1.4	-1.1	-0.8	-0.7
Financial difficulties in last 2 years	1.2	1.7	3.1	-1.6	0.5	-1.0	-1.7	-1.8	-0.4
Mouth/teeth dental problems	2.6	4.1	9.3	1.6	-0.2	1.6	2.4	2.1	3.0
Heart attack	0.2	0.3	1.5	-0.2	0.0	-1.2	-0.0	-0.0	0.5
Allergy	0.6	1.5	2.6	-1.0	-1.6	-1.5	-1.2	-1.1	-0.4
Pain all over the body in last month	0.7	0.7	1.4	-0.8	-1.2	0.2	-0.6	-1.2	-0.7
Diabetes (self-reported)	0.1	0.1	0.4	0.3	-0.2	-0.1	0.4	0.6	0.3
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	5.3	2.2	1.5	0.8	2.3	2.3	1.3
Medication: Ramipril	0.8	1.0	2.1	-1.0	0.7	-1.4	-1.0	-0.8	-0.9
Medication: Simvastatin	0.4	0.6	2.1	0.4	-1.4	0.1	0.5	0.2	0.9
Fluid intelligence score	1.3	2.7	5.0	1.8	-0.1	0.7	1.9	2.2	1.9
Illnesses of siblings	0.4	0.6	1.6	1.1	-1.3	-0.2	0.9	0.4	0.2
Neuroticism score	0.2	0.4	0.5	-0.7	-0.1	0.5	-0.7	-0.7	-0.7
Weight	0.0	0.2	0.7	-0.4	-0.9	0.1	-0.3	-0.2	0.2
Impedance of arm (right)	0.2	0.8	1.6	-0.9	1.0	0.1	-1.0	-1.3	-0.5
Arm fat percentage (right)	0.2	0.7	1.3	-1.1	0.0	-1.0	-1.0	-0.7	-0.6
Trunk fat-free mass	0.2	1.3	2.1	1.0	-1.0	1.4	1.1	0.7	1.4
Hip circumference	0.1	0.6	1.8	0.4	-0.1	0.6	0.7	0.9	1.3
Time employed in main current job	0.4	0.5	1.9	0.2	-0.4	-1.4	-0.0	0.3	-0.9
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.3	0.4	0.1	0.3	0.3	0.5
Father’s age at death	0.3	0.4	1.3	-0.3	1.1	1.1	0.0	-0.0	0.3
Worrier / anxious feelings	0.1	0.2	0.6	0.0	0.8	0.3	0.1	0.1	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.3	-0.8	0.4	0.3	0.3	-0.1
Falls in the last year	0.8	1.1	2.9	-0.9	-0.7	0.7	-1.3	-1.7	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.9	0.1	-0.2	-0.7	-0.6	-0.6
Number of live births	2.1	2.9	3.9	-2.0	-1.6	-0.7	-2.0	-1.8	-1.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.5	0.7	-2.1	0.7	0.4	0.0	0.3
Pulse rate	0.1	0.2	0.4	0.4	-0.4	-0.7	0.3	0.1	-0.4
Happiness	0.8	0.9	1.6	-1.1	0.8	-0.4	-1.1	-1.3	-0.8
Noisy workplace	5.9	7.3	11.7	-3.0	-1.0	-1.0	-3.3	-3.4	-3.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	0.8	0.1	0.6	0.6	0.9	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.9	1.0	-1.7	1.4	1.0	1.1	0.4
Mouth/teeth dental problems: Dentures	1.7	2.9	7.2	-1.3	0.3	-0.3	-2.0	-2.1	-2.7
Asthma	0.7	1.3	7.7	0.0	2.8	0.3	-0.1	0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	5.9	1.5	-0.1	1.1	1.9	2.4	2.0
Medication: Cholesterol lowering	0.2	0.3	1.2	-0.3	-1.1	-0.3	-0.2	-0.4	-0.0
Depression (self-reported)	2.1	2.5	4.2	2.1	-0.9	1.1	2.0	1.8	1.3
Medication: Lansoprazole	1.0	1.2	4.5	0.4	0.8	2.1	0.5	0.7	1.0
Prospective memory result	2.4	2.9	5.6	-2.1	0.3	-0.4	-2.1	-2.4	-1.7
Lung cancer (father)	0.6	0.7	1.9	0.5	1.4	-0.9	0.2	0.8	0.7
Illnesses of mother	0.5	0.6	1.7	-0.9	0.6	-1.3	-0.8	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.8	0.2	-2.0	1.0	0.1	-0.2	0.2
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	-0.3	0.6	-0.7	-0.5	-0.4	-1.4
Impedance of arm (left)	0.2	1.1	2.0	-1.3	0.5	-0.2	-1.3	-1.4	-0.7
Arm fat mass (right)	0.0	0.2	0.3	-0.5	-0.6	-0.6	-0.4	-0.2	-0.2
Trunk predicted mass	0.2	1.3	2.0	1.1	-1.0	1.4	1.1	0.8	1.4
Standing height	0.2	1.7	7.0	0.5	-1.1	2.6	0.4	-0.4	1.3
Length of working week for main job	0.7	0.8	1.5	1.2	0.7	-0.2	1.2	1.1	0.0
Exposure to tobacco smoke at home	1.6	1.8	2.8	-1.5	-0.7	-1.4	-1.3	-1.7	-1.3
Breastfed as a baby	2.3	2.8	5.7	-1.5	-2.4	0.5	-1.7	-2.2	-1.0
Tense / ‘highly strung’	0.2	0.3	0.7	-0.4	0.4	0.9	-0.6	-0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.3	0.7	-0.5	1.2	0.2	0.1	-1.5
Hair/balding pattern: Pattern 4	0.3	0.8	2.9	0.9	1.7	0.2	0.4	0.7	-0.0
Birth weight of first child	0.5	0.9	1.9	0.9	0.5	-0.1	1.0	1.4	1.1
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.7	-0.9	0.3	0.4	0.3	-0.3
Pulse wave reflection index	0.4	0.5	0.9	-0.6	0.5	-0.8	-0.7	-0.1	-1.0
Ever highly irritable/argumentative for 2 days	3.4	4.0	7.4	-2.1	-0.5	-0.4	-2.5	-2.4	-2.7
Loud music exposure frequency	0.4	0.5	1.2	-0.3	-1.0	0.3	-0.5	-1.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.4	0.8	0.2	1.5	0.8	0.9	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	3.0	-0.1	0.5	-1.7	-0.2	0.4	-0.0
Blood clot in the leg (DVT)	0.4	0.5	1.8	-0.0	1.4	-0.4	-0.2	0.0	-1.0
Medication: Paracetamol	0.2	0.3	1.0	0.3	1.0	0.8	-0.1	-0.3	-0.4
Headache pain in last month	0.2	0.4	1.0	0.8	0.3	1.0	0.3	0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	3.1	-0.1	1.8	-0.5	-0.1	0.3	0.1
Glaucoma (self-reported)	2.6	3.0	6.3	1.9	-0.2	0.7	2.4	2.5	1.5
Gout (self-reported)	1.4	2.0	2.9	1.6	-1.7	0.1	1.7	1.5	1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	6.8	-0.6	-0.3	1.7	0.1	-0.1	2.6
Medication: Amlodipine	1.0	1.3	2.3	1.2	-1.0	1.5	1.2	1.1	0.8
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.9	-1.6	0.5	-0.8	-1.5	-1.7	-1.1
Birth weight	0.6	1.2	2.9	1.1	0.4	0.1	1.2	1.4	1.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-0.3	-1.2	0.3	-0.7	-0.9	-0.8
High blood pressure (siblings)	0.7	1.0	2.3	-1.2	1.5	-0.6	-1.0	-0.6	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	4.8	0.0	-2.2	0.8	-0.1	-0.5	0.3
Body fat percentage	0.2	0.7	1.4	-1.2	0.3	-0.9	-1.1	-0.6	-0.8
Leg fat percentage (right)	0.0	0.2	0.7	-0.1	0.9	-0.3	-0.0	0.4	-0.0
Arm fat-free mass (right)	0.2	1.0	1.7	0.8	-1.3	1.1	0.8	0.7	1.1
Exposure to tobacco smoke outside home	1.1	1.5	4.8	-0.8	-0.4	-2.2	-0.9	-1.1	-1.1
Comparative body size at age 10	0.5	1.4	5.6	-1.0	-2.4	-1.0	-0.3	0.3	0.7
Number of full brothers	0.5	0.7	3.6	-0.3	-0.5	1.9	0.0	0.0	0.5
Worry too long after embarrassment	1.4	2.4	3.6	-1.9	-0.1	-1.2	-1.8	-1.9	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.1	-0.9	0.8	-0.2	0.0	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.4	0.7	0.6	0.3	-0.2	0.4
Number of children fathered	0.3	0.3	0.8	-0.4	-0.3	0.9	-0.5	-0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	-0.5	-0.7	-0.9	-0.5	-0.3	-0.8
Age at first live birth	2.2	3.9	5.9	2.2	1.8	0.9	2.4	2.4	1.6
Pulse wave peak to peak time	0.6	0.7	2.1	0.3	-0.8	1.0	0.4	0.3	1.5
Health satisfaction	0.2	0.3	0.6	0.6	-0.4	0.5	0.7	0.1	0.8
Shortness of breath walking on level ground	5.5	6.5	11.0	-2.9	-0.1	-1.9	-3.0	-3.3	-2.7
Qualifications: College or University degree	0.6	1.8	2.6	1.5	0.2	1.1	1.6	1.5	1.4
Eye problems/disorders: None of the above	2.1	2.4	3.7	1.7	0.1	1.1	1.7	1.9	1.9
Mouth/teeth dental problems: Loose teeth	1.5	1.7	3.2	-0.8	-0.8	-1.8	-1.0	-1.3	-1.8
Emphysema/chronic bronchitis	0.2	0.3	1.1	-0.5	-0.3	-1.0	0.1	0.1	0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	-0.3	-1.0	-0.8	-0.0	-0.2	-0.0
Neck or shoulder pain in last month	0.8	1.2	2.4	1.2	0.2	-0.4	1.4	1.6	0.9
Medication: Blood pressure	0.2	0.3	0.9	0.2	-0.9	0.8	0.1	-0.4	0.4
Angina (self-reported)	0.6	0.8	3.7	-0.4	0.2	-1.9	-0.7	-0.7	-0.3
Migraine (self-reported)	0.6	0.8	3.4	0.4	-1.8	1.0	0.2	-0.2	0.2
Medication: Ibuprofen	2.6	3.1	5.7	1.5	0.6	1.5	1.8	2.2	2.4
Medication: Allopurinol	1.0	1.3	4.6	0.3	-2.1	-1.6	0.5	0.7	0.4
Medication: Omeprazole	0.5	0.6	1.5	-0.7	-0.9	1.2	-0.6	-0.7	0.0
Medication: Seretide 50 evohaler	0.7	0.8	1.4	-1.2	1.0	-0.2	-1.2	-0.9	0.1
Mean time to correctly identify matches	0.2	0.4	1.1	1.0	0.1	0.2	1.0	0.5	0.5
Heart disease (mother)	0.6	0.7	3.2	0.3	0.4	1.8	0.3	-0.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.4	0.9	-0.9	0.0	0.9	1.5	0.4
Whole body fat mass	0.1	0.3	0.5	-0.7	-0.4	-0.5	-0.7	-0.2	-0.4
Leg fat mass (right)	0.0	0.0	0.1	-0.1	0.3	-0.2	-0.1	0.3	-0.1
Arm predicted mass (right)	0.3	1.3	2.0	1.0	-1.4	1.2	1.1	1.0	1.2
Pulse rate, automated reading	0.2	0.6	1.6	0.4	-1.3	-0.7	0.2	0.2	-1.0
Alcohol intake frequency.	0.3	0.6	1.3	-0.9	1.1	-0.7	-1.0	-0.2	-0.3
Comparative height size at age 10	1.3	7.3	14.6	2.4	0.4	3.4	2.7	2.1	3.8
Number of full sisters	1.0	1.3	2.6	-1.6	0.6	-0.4	-1.5	-1.5	-0.3
Suffer from ‘nerves’	0.1	0.2	0.3	0.6	-0.5	-0.4	0.5	0.6	0.1
Overall health rating	1.6	3.5	6.4	-1.6	-1.4	0.1	-2.1	-2.5	-2.4
Chest pain or discomfort	1.6	2.3	4.1	1.7	2.0	0.8	1.5	1.1	1.6
Had major operations	0.5	0.6	1.3	-0.9	-0.0	-0.5	-1.1	-1.0	-0.7
Age at last live birth	1.7	2.4	4.2	1.8	0.6	0.5	2.0	2.0	1.6
Family relationship satisfaction	0.5	0.6	1.4	0.1	-1.2	0.3	-0.2	-0.7	-1.2
Leg pain on walking	0.7	0.8	1.2	-1.0	-0.3	-1.1	-0.6	-1.1	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	1.1	-0.7	-1.5	1.2	1.1	-0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.7	-1.4	0.5	-0.9	-1.3	-1.9	-0.7
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.4	1.5	1.9	0.3	1.5	1.4	1.0
Medication: Aspirin	0.7	1.0	1.9	-0.7	-0.6	-1.4	-0.9	-1.1	-1.1
Supplements: Vitamin C	0.3	0.3	0.6	0.5	0.2	-0.6	0.8	0.8	0.1
Knee pain experienced in last month	0.2	0.3	0.7	0.5	0.8	0.4	0.6	0.2	0.4
Hypertension (Self-reported)	0.3	0.7	2.2	-0.3	-1.5	-1.2	-0.3	-0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.0	0.7	-1.4	1.2	0.9	1.3	1.4
Illnesses of father: Heart disease	0.3	0.4	1.5	-0.1	-0.6	-1.2	-0.2	0.0	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-1.0	-0.4	-0.4	-0.8	-0.7	-0.5
Smoking status: Previous	0.3	0.4	1.6	-0.2	0.1	1.3	-0.3	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.2	0.5	-1.5	0.7	0.4	0.1	0.3
Whole body fat-free mass	0.1	0.7	1.5	0.6	-1.2	1.1	0.7	0.3	0.9
Leg fat-free mass (right)	0.1	0.7	3.8	0.2	-2.0	0.5	0.3	-0.1	0.4
Arm fat percentage (left)	0.2	0.9	1.7	-1.3	-0.2	-1.3	-1.1	-0.7	-0.8
Average weekly red wine intake	0.2	0.3	0.6	-0.4	-0.5	0.5	-0.6	-0.8	-0.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.2	1.3	-0.5	-0.1	1.2	1.5	1.0
Mood swings	0.4	0.8	3.4	-0.2	-1.8	-0.5	-0.2	-0.3	-1.0
Loneliness, isolation	0.5	0.7	3.5	-0.1	0.7	1.9	-0.1	-0.4	-0.0
Long-standing illness, disability or infirmity	0.4	0.5	2.1	0.0	-0.7	1.4	-0.1	-0.8	-0.1
Ever had bowel cancer screening	0.6	0.7	4.0	0.2	0.3	2.0	-0.2	-0.5	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.5	-0.6	-0.1	-0.4	-0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.5	-0.3	0.4	0.7	1.0	1.1
Friendships satisfaction	0.4	0.5	1.4	-0.5	0.7	0.5	-0.7	-1.2	-0.5
Qualifications: nursing, teaching	0.3	0.5	1.8	-1.3	-0.1	-0.6	-0.8	-0.4	-0.3
Commuting to job workplace: Walk	0.6	0.6	1.5	0.0	-1.2	0.7	-0.4	-0.8	-1.0
Eye problems/disorders: Cataract	1.2	1.4	4.6	-0.7	0.6	-2.1	-0.6	-0.8	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.0	-1.1	0.1	-1.2	-1.0	-0.5	-1.4
Medication for cholesterol	0.2	0.3	0.5	0.7	-0.2	0.5	0.5	0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.7	-0.7	-1.6	0.0	-0.7	-1.4	-0.8
Back pain experienced in last month	1.3	1.9	2.9	1.5	-0.9	1.7	1.5	1.3	1.3
Mineral and other dietary supplements	0.4	0.5	2.3	-0.4	1.5	0.3	-0.6	-0.2	-0.3
Breast cancer (self-reported)	0.4	0.4	1.2	-0.1	0.4	0.8	-0.2	-0.7	-1.1
Asthma (self-reported)	0.6	1.2	6.8	-0.0	2.6	-0.0	-0.1	0.2	0.3
Osteoporosis (self-reported)	0.4	0.5	0.8	0.7	-0.8	0.2	0.9	0.7	0.7
Osteoarthritis (self-reported)	0.4	0.6	0.9	0.6	0.9	-0.0	0.9	0.7	1.0
Medication: Aspirin	0.6	0.7	1.4	-0.4	-0.6	-1.2	-0.7	-1.0	-1.0
Medication: Gliclazide	2.6	2.9	6.3	-2.5	-0.2	-1.6	-2.2	-1.7	-1.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.5	0.2	0.0	0.3	0.8	0.6
Smoking status: Current	0.2	0.3	1.3	0.5	-1.1	-0.0	0.2	0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.6	-0.5	-0.0	-0.6	-0.5	-0.3
Whole body water mass	0.2	0.9	1.7	0.7	-1.3	1.0	0.8	0.5	1.1
Leg predicted mass (right)	0.1	0.7	3.5	0.2	-1.9	0.5	0.3	-0.1	0.4
Arm fat mass (left)	0.1	0.4	0.9	-0.8	-0.5	-0.9	-0.6	-0.4	-0.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-0.6	-0.3	-0.7	-0.7	-0.5	-1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.7	0.8	0.5	0.5	0.8	0.3	1.3
Miserableness	0.5	0.9	3.1	0.8	-1.8	0.4	1.1	-0.2	0.2
Guilty feelings	1.7	2.5	4.3	-1.8	0.9	-1.1	-1.8	-1.5	-2.1
Wears glasses or contact lenses	0.3	0.4	0.7	-0.7	-0.1	-0.4	-0.8	-0.8	-0.5
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.5	-0.3	0.0	0.4	0.5	-0.2
Hearing aid user	0.8	0.9	1.7	0.8	0.7	0.4	1.1	0.9	1.3
Mother’s age at death	0.7	0.8	3.5	0.4	-1.9	0.3	0.8	0.8	0.3
Financial situation satisfaction	1.2	1.4	4.1	-1.1	-1.1	0.2	-1.0	-2.0	-1.0
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.0	-1.6	0.3	-0.2	-2.0	-2.0	-1.4
Commuting to job workplace: Public transport	2.2	2.6	4.3	2.1	0.2	2.1	1.8	1.8	0.7
Eye problems/disorders: Glaucoma	2.2	2.6	5.1	1.7	-0.4	1.1	2.3	2.1	1.3
Medication: Blood pressure	0.3	0.6	1.3	-0.9	-0.0	-0.4	-1.2	-1.0	-0.7
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.5	1.6	-0.3	0.5	1.5	1.1	1.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.2	0.3	-0.4	-1.1	0.5	0.3	0.0
High cholesterol (Self-reported)	0.3	0.5	1.4	0.4	-1.1	-1.2	0.5	0.4	0.1
Medication: Bendroflumethiazide	1.1	1.6	2.6	-1.4	-1.6	-0.9	-1.5	-1.2	-0.7
Medication: Paracetamol	0.4	0.6	2.4	-0.2	1.5	0.8	-0.5	-0.7	-0.0
Medication: Lisinopril	0.9	1.2	3.7	-0.9	-1.9	0.7	-0.9	-1.1	-0.3
Medication: Atorvastatin	0.2	0.3	0.5	-0.7	0.3	0.1	-0.7	-0.4	-0.7
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.2	-0.5	-0.6	0.5	0.6	0.4
Alcohol drinker status: Never	1.8	2.1	4.8	1.4	0.0	1.1	1.4	1.7	2.2
Ever smoked	0.1	0.2	0.4	0.4	-0.6	0.7	-0.1	0.2	-0.6
Basal metabolic rate	0.1	0.5	1.4	0.5	-1.2	0.8	0.5	0.3	0.8
Leg fat percentage (left)	0.0	0.1	0.1	-0.3	0.2	-0.2	-0.2	0.4	-0.1
Arm fat-free mass (left)	0.2	1.0	1.8	0.9	-0.9	0.9	1.0	1.0	1.3
Number of operations (self-reported)	0.5	0.7	2.0	0.9	-1.4	0.8	0.7	0.3	-0.0
Average weekly beer plus cider intake	0.5	0.7	2.0	-0.8	-0.5	-1.4	-0.4	-0.8	-0.7
Irritability	0.2	0.3	1.0	-0.3	-1.0	-0.3	-0.4	-0.3	-0.5
Risk taking	0.6	0.9	3.2	0.8	1.8	0.9	0.2	0.5	0.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.7	0.6	1.6	0.7	0.9	1.6	1.4
Fractured/broken bones in last 5 years	1.3	1.7	2.3	1.5	-1.4	0.9	1.5	0.9	1.5
Age started oral contraceptive pill	1.9	2.3	2.7	1.5	1.6	1.3	1.5	1.6	1.6
Diastolic blood pressure, automated reading	0.1	0.3	0.7	0.3	0.1	-0.8	0.5	0.7	0.8
Ever depressed for a whole week	1.2	1.4	3.8	-0.6	-2.0	-0.6	-0.6	-0.8	-1.7
Unable to work because of sickness or disability	0.7	0.9	4.1	-0.5	-2.0	-0.5	-0.5	-0.8	-0.1
Commuting to job workplace: Cycle	0.1	0.1	0.5	0.3	-0.2	-0.7	0.2	0.3	-0.1
Myopia	0.8	1.1	3.7	1.0	-0.2	0.6	0.9	1.9	1.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.9	-0.0	1.4	0.9	0.0	0.0	-0.1
Cholesterol lowering medication	0.3	0.4	0.7	0.5	-0.6	-0.6	0.6	0.9	0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.8	-0.6	-0.2	2.0	-0.5	-0.7	0.0
Pain experienced in last month	0.6	1.0	1.8	-0.9	-0.2	-1.4	-1.0	-1.0	-1.0
Supplements: Calcium	0.6	0.7	1.9	-0.7	-0.9	-1.4	-0.1	-0.6	-0.8
Basal cell carcinoma (self-reported)	0.7	0.9	2.9	0.8	-1.7	0.5	0.8	0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.3	-0.0	-0.0	-1.2	0.2	0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.0	1.0	-0.4	-0.1	-0.1	-1.0
Heart disease (siblings)	0.3	0.4	1.1	-0.8	0.4	1.0	-0.6	-0.4	-0.3
Alcohol drinker status: Previous	3.7	4.2	6.4	-2.4	0.1	-1.0	-2.4	-2.5	-2.5
Pack years of smoking	0.1	0.1	0.4	0.1	0.7	-0.1	-0.0	-0.2	0.5
Impedance of whole body	0.1	0.4	1.2	-0.5	1.1	-0.0	-0.6	-0.7	-0.3
Leg fat mass (left)	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.2	-0.1
Arm predicted mass (left)	0.2	0.9	1.5	0.9	-1.0	0.7	0.9	0.7	1.2