Best TWAS P=9.65e-11 · Best GWAS P=7.26e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | PRUNE2 | 0.32 | 0.14 | lasso | 6 | 0.09 | 9.4e-04 | 6.4 | 6.5 | 9.7e-11 | 0.97 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Spleen | PRUNE2 | 0.34 | 0.12 | enet | 6 | 0.13 | 2.8e-04 | 6.0 | 6.0 | 2.4e-09 | 0.94 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Whole Blood | PRUNE2 | 0.51 | 0.47 | lasso | 6 | 0.47 | 3.8e-48 | 6.3 | 6.3 | 2.4e-10 | 0.98 | 0.02 | 0.98 | FALSE |
| 4 | METSIM | Adipose | PRUNE2 | 0.17 | 0.11 | bslmm | 732 | 0.11 | 2.9e-16 | 6.4 | 6.4 | 1.4e-10 | 0.96 | 0.01 | 0.99 | FALSE |
| 5 | NTR | Blood | PRUNE2 | 0.17 | 0.19 | bslmm | 742 | 0.20 | 4.7e-63 | 6.3 | 5.7 | 1.2e-08 | 0.94 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PRUNE2 | 0.06 | 0.04 | lasso | 2 | 0.04 | 4.0e-08 | 5.7 | 5.6 | 2.1e-08 | 0.95 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PRUNE2 | 0.10 | 0.06 | lasso | 5 | 0.05 | 3.2e-03 | 6.3 | 6.3 | 2.6e-10 | 0.99 | 0.01 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRUNE2 | 0.08 | 0.09 | lasso | 2 | 0.08 | 1.4e-09 | 6.5 | 6.5 | 9.7e-11 | 1.00 | 0.01 | 0.99 | FALSE |